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Keywords = childhood/adolescent environmental health

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20 pages, 651 KiB  
Review
Communication Disorders and Mental Health Outcomes in Children and Adolescents: A Scoping Review
by Lifan Xue, Yifang Gong, Shane Pill and Weifeng Han
Healthcare 2025, 13(15), 1807; https://doi.org/10.3390/healthcare13151807 - 25 Jul 2025
Viewed by 469
Abstract
Background/Objectives: Communication disorders in childhood, including expressive, receptive, pragmatic, and fluency impairments, have been consistently linked to mental health challenges such as anxiety, depression, and behavioural difficulties. However, existing research remains fragmented across diagnostic categories and developmental stages. This scoping review aimed [...] Read more.
Background/Objectives: Communication disorders in childhood, including expressive, receptive, pragmatic, and fluency impairments, have been consistently linked to mental health challenges such as anxiety, depression, and behavioural difficulties. However, existing research remains fragmented across diagnostic categories and developmental stages. This scoping review aimed to synthesise empirical evidence on the relationship between communication disorders and mental health outcomes in children and adolescents and to identify key patterns and implications for practice and policy. Methods: Following the PRISMA Extension for Scoping Reviews (PRISMA-ScR) and Arksey and O’Malley’s framework, this review included empirical studies published in English between 2000 and 2024. Five databases were searched, and ten studies met the inclusion criteria. Data were charted and thematically analysed to explore associations across communication profiles and emotional–behavioural outcomes. Results: Four interconnected themes were identified: (1) emotional and behavioural manifestations of communication disorders; (2) social burden linked to pragmatic and expressive difficulties; (3) family and environmental stressors exacerbating child-level challenges; and (4) a lack of integrated care models addressing both communication and mental health needs. The findings highlight that communication disorders frequently co-occur with emotional difficulties, often embedded within broader social and systemic contexts. Conclusions: This review underscores the need for developmentally informed, culturally responsive, and interdisciplinary service models that address both communication and mental health in children. Early identification, family-centred care, and policy reforms are critical to reducing inequities and improving outcomes for this underserved population. Full article
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23 pages, 1366 KiB  
Review
The Biological Value of Proteins for Pediatric Growth and Development: A Narrative Review
by Marlene Fabiola Escobedo-Monge, Joaquín Parodi-Román, María Antonieta Escobedo-Monge and José Manuel Marugán-Miguelsanz
Nutrients 2025, 17(13), 2221; https://doi.org/10.3390/nu17132221 - 4 Jul 2025
Viewed by 1558
Abstract
In personalized nutrition, dietary guidelines must be adapted to the physiological and developmental needs of individuals across the lifespan, especially during childhood and adolescence. These should account for nutritional status, health conditions, and early-life risk factors, including those that emerge during pregnancy. This [...] Read more.
In personalized nutrition, dietary guidelines must be adapted to the physiological and developmental needs of individuals across the lifespan, especially during childhood and adolescence. These should account for nutritional status, health conditions, and early-life risk factors, including those that emerge during pregnancy. This narrative review synthesizes recent evidence (2020–2025) on the biological value of protein sources in supporting pediatric growth and development. While adequate protein intake is essential for physical and cognitive development in individuals under nineteen, excessive intake may accelerate growth and increase the long-term risks of overweight and obesity. Compared to animal-based proteins (ABPs), plant-based proteins (PBPs) carry a higher risk of nutrient deficiencies in vulnerable populations due to lower digestibility and incomplete amino acid profiles. Although plant-based diets are encouraged for environmental reasons—particularly to reduce the ecological impact of livestock—protein intake must remain appropriate for age, sex, health status, and context. Nutritional strategies must ensure an adequate supply of essential amino acids and proper micronutrient supplementation, regardless of whether children follow diets rich in ABPs, PBPs, or a combination of both. Attention to these factors is vital to balancing nutritional adequacy with long-term health and sustainability goals. Full article
(This article belongs to the Special Issue Food Fortification and Nutritional Policies)
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14 pages, 301 KiB  
Article
What Shapes Quality of Life in Youth? A Multidimensional Approach from Lifestyle to Residential Context—Cor-School Study
by Alvaro Pano-Rodriguez, Saül Aixa-Requena, Jose Vicente Beltran-Garrido, Abraham Batalla-Gavaldà, Vicenç Hernández-González, Enric Conesa-Milian, Isaac López-Laval and Joaquin Reverter-Masia
Healthcare 2025, 13(11), 1256; https://doi.org/10.3390/healthcare13111256 - 26 May 2025
Viewed by 464
Abstract
Background: Health-related quality of life is a key indicator of well-being that integrates physical, emotional, and social dimensions. Identifying its determinants during childhood and adolescence is essential to guide effective health promotion strategies. Objective: To analyze the association between health-related quality [...] Read more.
Background: Health-related quality of life is a key indicator of well-being that integrates physical, emotional, and social dimensions. Identifying its determinants during childhood and adolescence is essential to guide effective health promotion strategies. Objective: To analyze the association between health-related quality of life and demographic, anthropometric, biochemical, lifestyle, and environmental variables in school-aged children and adolescents. Methods: A cross-sectional study was conducted during the 2023–2024 academic year in northeastern Spain. A total of 571 children and adolescents participated in the study (mean age = 11.64 ± 1.64 years), of whom 254 were girls (44.48%). Health-related quality of life was assessed using the Revised Children’s Quality of Life Questionnaire (KINDL-R), a validated instrument for assessing perceived well-being in pediatric populations. Independent variables included waist-to-height ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, adherence to the Mediterranean diet, weekly physical activity, sleep quality, and residential context (i.e., large urban areas, small urban areas, and municipalities). Multiple linear regression analysis was performed to explore the associations. Results: Older age was associated with lower health-related quality of life (β = −1.07; 95% CI: −1.61 to −0.53; p < 0.001). In contrast, better adherence to the Mediterranean diet (β = 0.72; 95% CI: 0.09 to 1.37; p = 0.023), better sleep quality (b = −2.48; p < 0.001), and participants living in cities and large urban areas reported compared to those in municipalities were associated with higher HRQoL (p < 0.05), with moderate effect sizes. No significant associations were found for sex, waist-to-height ratio, cholesterol levels, or physical activity. Conclusions: This study highlights the importance of adopting a multidimensional approach to promote health-related quality of life in young populations, addressing dietary habits, sleep quality, and environmental factors within health promotion strategies. Full article
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21 pages, 686 KiB  
Article
Dietary Patterns in Relation to Asthma and Wheeze Among Adolescents in a South African Rural Community
by Funzani Rathogwa-Takalani, Thabelo Rodney Mudau, Sean Mark Patrick, Joyce Shirinde and Kuku Voyi
Int. J. Environ. Res. Public Health 2025, 22(4), 502; https://doi.org/10.3390/ijerph22040502 - 26 Mar 2025
Viewed by 576
Abstract
Background: The rise of asthma prevalence in recent decades has been attributed to changes in dietary patterns, especially in developing countries. Studies have also suggested that dietary patterns play an important role in both asthma development and management. This study aimed to investigate [...] Read more.
Background: The rise of asthma prevalence in recent decades has been attributed to changes in dietary patterns, especially in developing countries. Studies have also suggested that dietary patterns play an important role in both asthma development and management. This study aimed to investigate the association between consumption of various foods and environmental factors with asthma and wheeze among adolescents. Methods: A self-administered standardized International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to collect data on demographics, respiratory health, exposure to air pollution, and diet on n = 2855 adolescents residing in Vhembe District, South Africa. Results: The prevalence of asthma and wheeze were 18.91% and 37.69%, respectively. Consuming various foods such as fast foods (OR = 1.41; 95% CI: 1.06–1.88), bread (OR = 0.60; 95% CI: 0.45–1.81), pasta (OR = 1.39; 95% CI: 1.06–1.84), seafood (OR = 1.79; 95% CI: 0.65–1.24), and nuts (OR = 0.85; 95% CI: 0.65–1.12) were significantly associated with asthma in the crude logistic regression analysis. Further analysis in the multiple regression model indicated a strong association of asthma with consumption of nuts (OR = 1.55; 95% CI: 1.11–2.17), seafood (OR = 1.60; 95% CI: 1.03–2.49), and cereal (OR = 0.67; 95% CI: 0.45–0.99). In relation to wheeze, consumption of meat (red) (OR = 0.77; 95% CI: 0.60–0.99) was a protective factor in the crude analysis. The multiple logistic regression model showed that, seafood (OR = 0.76; 95% CI: 0.59–0.96), fruit (OR = 0.55; 95% CI: 0.32–0.94), nuts (OR = 1.88; 95% CI: 1.50–2.66), and olive oil (OR = 1.48; 95% CI: 1.09–2.00) were significantly associated with wheeze. Conclusion: Diet plays a major role in respiratory health, especially in asthma and wheeze. Dietary changes may play a role in reducing the burden of asthma and other respiratory symptoms in adolescents. Full article
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34 pages, 438 KiB  
Review
Why Do They Do It? The Psychology Behind Antisocial Behavior in Children and Adolescents
by Marianna Mazza, Francesco Maria Lisci, Ester Maria Marzo, Valeria De Masi, Francesca Abate and Giuseppe Marano
Pediatr. Rep. 2025, 17(2), 26; https://doi.org/10.3390/pediatric17020026 - 25 Feb 2025
Cited by 1 | Viewed by 5987
Abstract
Antisocial Personality Disorder (ASPD) is a complex and often debilitating condition that can emerge from early behavioral disturbances in childhood and adolescence. This narrative review provides a comprehensive overview of the current understanding of ASPD in pediatric and adolescent populations, examining key diagnostic [...] Read more.
Antisocial Personality Disorder (ASPD) is a complex and often debilitating condition that can emerge from early behavioral disturbances in childhood and adolescence. This narrative review provides a comprehensive overview of the current understanding of ASPD in pediatric and adolescent populations, examining key diagnostic challenges, developmental trajectories, and emerging treatment approaches. Recent research underscores the critical role of the early identification of conduct disorder (CD) and oppositional defiant disorder (ODD) as precursors to ASPD. Specific attention is given to biological, environmental, and psychosocial risk factors, including genetic predispositions, family dynamics, and socio-economic adversity. Additionally, neuro-psychological research highlights deficits in executive function, emotion regulation, and social cognition, which may underline the persistent antisocial patterns. Neuroimaging studies suggest atypical neural activity in regions associated with empathy, reward processing, and impulse control. Effective intervention remains a challenge, as treatment options are limited and often complicated by co-occurring conditions, such as attention deficit hyperactivity disorder (ADHD) and mood disorders. Promising evidence supports the efficacy of integrative, multimodal approaches combining behavioral therapy, family interventions, and pharmacotherapy to reduce symptom severity and improve long-term outcomes. The review concludes by advocating for a public health approach that emphasizes prevention and early intervention, aiming to mitigate the progression to full ASPD in adulthood. Full article
(This article belongs to the Special Issue Mental Health and Psychiatric Disorders of Children and Adolescents)
37 pages, 642 KiB  
Review
Risk Factors and Consequences of Food Neophobia and Pickiness in Children and Adolescents: A Systematic Review
by Carmen del Campo, Cristina Bouzas and Josep A. Tur
Foods 2025, 14(1), 69; https://doi.org/10.3390/foods14010069 - 30 Dec 2024
Cited by 2 | Viewed by 3710
Abstract
Food neophobia and pickiness are the resistance or refusal to eat and/or avoid trying new foods due to a strong reaction of fear towards the food or an entire group of foods. This systematic review aims to assess evidence on the risk factors [...] Read more.
Food neophobia and pickiness are the resistance or refusal to eat and/or avoid trying new foods due to a strong reaction of fear towards the food or an entire group of foods. This systematic review aims to assess evidence on the risk factors and effects of food neophobia and picky eating in children and adolescents, giving elements to avoid the lack of some foods that can cause nutritional deficiencies, leading to future pathologies when they are adults. A systematic literature search was performed in Medlars Online International Literature (MEDLINE) via Pubmed and EBSCOhost, LILACS and IBECS via Virtual Health Library (VHL), Scopus, and Google Scholar. MeSH terms used were: ((food neophobia [Title/Abstract]) OR (picky eating [Title/Abstract]) OR (food selectivity [Title/Abstract])) NOT ((anorexia nervosa [MeSH Terms]) OR (bariatric surgery [MeSH Terms]) OR (avoidant restrictive food intake disorder [MeSH Terms]) OR (autism spectrum disorder [MeSH Terms])). One hundred and forty-two (n = 142) articles were selected for children and adolescents (0–18 years old). They were structured according to contents: prevalence, risk factors, consequences, strategies and treatment. The studies showed a prevalence of the need for intervention on modifiable risk factors. Food neophobia and pickiness developed in childhood are conditioned by risk factors related to biological, social, and environmental characteristics, as well as family education and skills. Strategies to minimize or avoid these disorders should be aimed at implementing healthy habits at these levels. Full article
(This article belongs to the Section Food Nutrition)
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18 pages, 321 KiB  
Review
Planetary Health Diet for Childhood Obesity Prevention: Integrating Nutritional Health with Environmental Stewardship
by Maria Vittoria Conti, Alessandra Vincenti, Alice Beretta, Valeria Calcaterra, Silvia Taranto, Marianna Diotti, Gianvincenzo Zuccotti and Hellas Cena
Nutrients 2024, 16(24), 4316; https://doi.org/10.3390/nu16244316 - 13 Dec 2024
Viewed by 2226
Abstract
Background: Childhood obesity is a critical public health challenge with a rising prevalence worldwide, contributing to numerous health risks and long-term societal burdens. Concurrently, climate change and environmental degradation demand sustainable approaches to dietary patterns. The Planetary Health Diet (PHD), initially designed for [...] Read more.
Background: Childhood obesity is a critical public health challenge with a rising prevalence worldwide, contributing to numerous health risks and long-term societal burdens. Concurrently, climate change and environmental degradation demand sustainable approaches to dietary patterns. The Planetary Health Diet (PHD), initially designed for adults, emphasizes plant-based foods and sustainable practices. Objectives: This review explores the suitability of the PHD for addressing childhood obesity by assessing its nutritional adequacy and proposing necessary adaptations for pediatric populations. Methods: A narrative review methodology was employed, examining data from global and regional nutritional guidelines and evaluating the PHD’s bromatological composition against age-specific requirements. Results: The findings indicate that while the PHD aligns with environmental goals, it may not fully meet the energy and specific nutrient needs of children and adolescents without modifications. Key challenges include ensuring adequate intake of bioavailable protein, iron, calcium, vitamin B12, and vitamin D. Strategies such as incorporating fortified foods, optimizing food pairings, and gradual adaptation to high-fiber diets are critical for successful implementation. This review also highlights the importance of cultural adaptability, family involvement, and regional food systems in promoting adherence. Tailored interventions, such as school meal programs and educational initiatives, can bridge gaps in nutrition while fostering sustainable dietary behaviors. Conclusions: Adapting the PHD for pediatric needs presents an opportunity to integrate nutritional health with environmental stewardship, contributing to obesity prevention and a sustainable future. Further research is required to validate these adaptations and develop comprehensive frameworks for global implementation. Full article
(This article belongs to the Section Pediatric Nutrition)
15 pages, 266 KiB  
Review
Amplifying School Mental Health Literacy Through Neuroscience Education
by Peter J. Vento, Steven B. Harrod, Brittany Patterson, Kristen Figas, Tucker Chandler, Brooke Chehoski and Mark D. Weist
Behav. Sci. 2024, 14(11), 996; https://doi.org/10.3390/bs14110996 - 25 Oct 2024
Viewed by 2303
Abstract
Children and adolescents face a wide variety of developmental changes and environmental challenges, and it is estimated that at least one in five children aged 3–17 will experience behavioral or mental health issues. This period of life coincides with major changes in brain [...] Read more.
Children and adolescents face a wide variety of developmental changes and environmental challenges, and it is estimated that at least one in five children aged 3–17 will experience behavioral or mental health issues. This period of life coincides with major changes in brain structure and function that have profound long-term consequences for learning, decision-making (including risk taking), and emotional processing. For example, continued development of the prefrontal cortex in adolescence is a sensitive period during which individuals are particularly susceptible to risky behaviors, environmental stressors, and substance use. While recent advances in mental health literacy programs have paved the way for increased awareness of the benefits of mental health curricula in schools, these efforts could be greatly bolstered with support in basic neuroscience education in developmentally appropriate and area-specific content. Here, we provide a discussion on the basic structural and functional changes occurring in the brain throughout childhood, how this contributes to changes in cognitive function, and the risk factors posed by early life adversity, stress, and drug use. Finally, we provide a perspective on the benefits of integrating findings from the field of neuroscience and suggestions for tools to better equip students, teachers, administrators, and school mental health staff to provide new directions for addressing the mental health crises faced by millions of children and youth each year. Full article
(This article belongs to the Section Social Psychology)
14 pages, 313 KiB  
Article
I Was the Violence Victim, I Am the Perpetrator: Bullying and Cyberbullying Perpetration and Associated Factors among Adolescents
by Barbara Jankowiak, Sylwia Jaskulska, Vanesa Pérez-Martínez, Jacek Pyżalski, Belén Sanz-Barbero, Nicola Bowes, Karen De Claire, Sofia Neves, Joana Topa, Estefânia Silva, Veronica Mocanu and Carmen Vives-Cases
Soc. Sci. 2024, 13(9), 452; https://doi.org/10.3390/socsci13090452 - 28 Aug 2024
Cited by 1 | Viewed by 4189
Abstract
Bullying and cyberbullying significantly threaten the development and mental health of both victims and perpetrators. This study aimed to analyze the associations between socioeconomic characteristics, personal experiences of violence, perceived social support from peers, and acceptance of violence and (cyber)bullying perpetration. The study [...] Read more.
Bullying and cyberbullying significantly threaten the development and mental health of both victims and perpetrators. This study aimed to analyze the associations between socioeconomic characteristics, personal experiences of violence, perceived social support from peers, and acceptance of violence and (cyber)bullying perpetration. The study involved 1146 secondary school students, consisting of 698 females and 448 males, aged 13 to 16. Prevalence ratios (PRs) were calculated using Poisson regression with robust variance. The results indicated that 12.32% of girls and 18.97% of boys reported engaging in bullying and/or cyberbullying. The likelihood of perpetration was lower among adolescents who had not experienced physical and/or sexual abuse before age 15, but higher among those in romantic relationships who had been victims of dating violence or had experienced (cyber)bullying victimization. Additionally, perceived social support from classmates was associated with a lower likelihood of becoming a perpetrator, whereas acceptance of violence was positively associated with (cyber)bullying perpetration. Preventing adolescents from becoming perpetrators of bullying and/or cyberbullying requires early intervention to prevent all forms of violence in childhood and adolescence, as well as bolstering personal and environmental resources by providing social support. Full article
(This article belongs to the Section Family Studies)
7 pages, 196 KiB  
Opinion
Parental Neglect and Childhood Obesity Amidst COVID-19: A Developmental Psychopathology Perspective on Health and Developmental Risks
by Silvia Cimino
Nutrients 2024, 16(13), 2162; https://doi.org/10.3390/nu16132162 - 7 Jul 2024
Cited by 2 | Viewed by 2543
Abstract
The COVID-19 pandemic has profoundly impacted the mental health and developmental trajectories of children and adolescents, catalyzing a range of psychological and behavioral issues due to enforced lockdowns and other restrictions. This text explores these impacts through the lens of developmental psychopathology, which [...] Read more.
The COVID-19 pandemic has profoundly impacted the mental health and developmental trajectories of children and adolescents, catalyzing a range of psychological and behavioral issues due to enforced lockdowns and other restrictions. This text explores these impacts through the lens of developmental psychopathology, which integrates clinical psychology and developmental science to examine the emergence and evolution of psychological disorders across a lifespan. This paper highlights how pandemic-related disruptions have exacerbated conditions such as anxiety and depression and, notably, increased childhood obesity due to changes in lifestyle and reductions in physical activity. The analysis includes a discussion of how isolation has not only restricted access to educational and psychological resources but also increased the risk of parental mental illness and related familial stress, thereby intensifying issues of neglect and their consequent impact on child health. By employing a developmental psychopathology framework, this paper argues for the necessity of targeted interventions that address these complex interplays of genetic, environmental, and psychological factors. Such interventions aim to support children through structured educational and health-oriented strategies, ensuring their well-being amidst the ongoing challenges posed by the pandemic. This approach underscores the importance of early, multifaceted strategies involving parents, educators, and healthcare providers to foster healthier developmental outcomes for children facing unprecedented global health crises. Full article
19 pages, 1309 KiB  
Article
Cohort Profile: Chongqing Pubertal Timing and Environment Study in China with 15 Follow-Ups since 2014
by Di Wu, Jie Luo, Qin Zhang, Shudan Liu, Xuan Xi, Wenyi Wu, Yuanke Zhou, Yu Tian, Yujie Wang, Zongwei He, Jie Zhang, Hong Wang and Qin Liu
Future 2024, 2(3), 107-125; https://doi.org/10.3390/future2030009 - 4 Jul 2024
Cited by 5 | Viewed by 3074
Abstract
Background: Puberty is a life milestone that marks the transition from childhood to adulthood. An ambispective Chongqing Pubertal Timing (CQPT) cohort was started in 2014 to understand pubertal timing and identify environmental risk factors. Methods: A total of 1429 children and adolescents were [...] Read more.
Background: Puberty is a life milestone that marks the transition from childhood to adulthood. An ambispective Chongqing Pubertal Timing (CQPT) cohort was started in 2014 to understand pubertal timing and identify environmental risk factors. Methods: A total of 1429 children and adolescents were recruited and have been followed up once every 6 months for 8 years in a district of Chongqing, China. Data were collected via questionnaires for social and family environment, health conditions, gestational and maternal information, and in-person physical examinations by trained medical school graduate students in follow-ups. Environmental exposures of polycyclic aromatic hydrocarbons (PAHs), neonicotinoids, and heavy metals in urine samples were measured at different time points. Results: The mean ages at pubertal onset were 10.20 for thelarche, 11.62 for pubic hair development, and 11.84 for menarche in girls, and 11.16 for genital development, 11.66 for testicular enlargement, and 12.71 for first spermatorrhea in boys. Four OH-PAHs were associated with delayed timing of menarche, thelarche, pubic hair, and axillary hair development in girls, and thiacloprid was found to potentially impact genital stages in boys and axillary hair development in girls. Conclusions: We built a cohort to provide evidence of regional pubertal timing of boys and girls and the significant environmental factors. Further health outcomes, especially mental health and women’s health and its long-term health implications, will be followed. Full article
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27 pages, 2010 KiB  
Article
Assessing Lifestyle Patterns and Their Influence on Weight Status in Students from a High School in Sibiu, Romania: An Adaptation of ISCOLE Questionnaires and the Child Feeding Questionnaire
by Mihai Octavian Negrea, Gabriel Octavian Negrea, Gabriela Săndulescu, Bogdan Neamtu, Adelaida Solomon, Mirela Livia Popa, Oana Stoia, Carmen Daniela Domnariu and Minodora Teodoru
Nutrients 2024, 16(10), 1532; https://doi.org/10.3390/nu16101532 - 20 May 2024
Viewed by 2052
Abstract
The escalation of global obesity is driving research to understand environmental influences on this process, particularly during vulnerable developmental stages such as childhood and adolescence. Efforts include the development of various structured data collection tools. We aimed to adapt a series of previously [...] Read more.
The escalation of global obesity is driving research to understand environmental influences on this process, particularly during vulnerable developmental stages such as childhood and adolescence. Efforts include the development of various structured data collection tools. We aimed to adapt a series of previously validated questionnaires from the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE), the Child Feeding Questionnaire, and elements from the World Health Organization Childhood Obesity Surveillance Initiative (COSI) in order to assess local lifestyle patterns among Romanian high school students and their families that may predispose them to obesity. To this goal, an expert committee was formed as part of a research partnership to oversee the questionnaire’s translation and adaptation. It consisted of education and school management specialists, clinical research professionals, language experts, and public health experts. The adapted questionnaires were then applied to 114 students enrolled in the 9th and 10th grades attending a high school situated in Sibiu, and their parents. The variables measured were investigated for correlations with overweight and obesity and, as a secondary objective, academic performance. The study revealed several critical findings, including suboptimal sleep durations and physical activity levels among students, a significant amount of screen time, and correlations between weight status and physical activity, sedentary time, and maternal weight status and education levels. The adapted questionnaires proved to be effective tools in capturing the multifaceted factors implicated in adolescent obesity, providing a foundation for targeted interventions and broader public health strategies to address this issue. Full article
(This article belongs to the Special Issue Nutrition Interventions for Pediatric Obesity Prevention)
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15 pages, 1192 KiB  
Review
Obesogens in Adolescence: Challenging Aspects and Prevention Strategies
by Marina Nicolaou, Meropi Toumba, Alexandros Kythreotis, Habib Daher and Nicos Skordis
Children 2024, 11(5), 602; https://doi.org/10.3390/children11050602 - 16 May 2024
Cited by 2 | Viewed by 2577
Abstract
Childhood obesity has become a global epidemic, with significant increases in prevalence over recent decades. While excessive calorie consumption and physical inactivity are known factors, emerging research highlights the role of endocrine-disrupting chemicals (EDCs), particularly obesogens, in obesity’s pathogenesis. This review explores the [...] Read more.
Childhood obesity has become a global epidemic, with significant increases in prevalence over recent decades. While excessive calorie consumption and physical inactivity are known factors, emerging research highlights the role of endocrine-disrupting chemicals (EDCs), particularly obesogens, in obesity’s pathogenesis. This review explores the historical context of the environmental obesogens hypothesis, their sources, mechanism of action, impact on prenatal and postnatal development, and epigenetics. Additionally, it discusses the long-term consequences of childhood obesity and proposes prevention strategies that will mitigate negative health effects. Obesogens were found to disrupt hormonal balance and metabolic processes through various mechanisms such as altering gene expression, hormonal interference, and inflammation. Especially significant was exposure during critical windows of development, which correlates with an increased risk of obesity in childhood or adolescence. Long-term effects of childhood obesity include chronic health conditions and psychosocial issues. A comprehensive approach is necessary to address childhood obesity encompassing genetic, environmental, and lifestyle factors. Prevention strategies should focus on reducing obesogen exposure, promoting healthy lifestyles, and implementing regulatory policies. Future research should investigate obesogens–diet interactions, microbiome impacts, and combined obesogens effects. Long-term human studies are also crucial for validating findings from animal models and allowing for informed decision-making to combat the obesity pandemic. Full article
(This article belongs to the Special Issue Adolescent Weight Management: Advances and Future Challenges)
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15 pages, 530 KiB  
Article
Longitudinal Analysis of Latvian Child Growth: Anthropometric Parameters Dynamics from Birth to Adolescence
by Silvija Umbraško, Liene Martinsone-Berzkalne, Liana Plavina, Vinita Cauce, Edgars Edelmers, Aleksandrs Starikovs and Janis Vetra
Children 2024, 11(4), 426; https://doi.org/10.3390/children11040426 - 3 Apr 2024
Viewed by 1957
Abstract
This study provides a comprehensive analysis of the physical development patterns from birth to adolescence, utilizing a longitudinal dataset of 70 children monitored from birth until 17 years of age. The research focuses on the variability of growth trajectories, emphasizing the role of [...] Read more.
This study provides a comprehensive analysis of the physical development patterns from birth to adolescence, utilizing a longitudinal dataset of 70 children monitored from birth until 17 years of age. The research focuses on the variability of growth trajectories, emphasizing the role of genetic and environmental factors in influencing these patterns. Key findings indicate that most children undergo one or two periods of accelerated growth, with significant variability in the timing and magnitude of these growth spurts. The study also highlights the adaptive nature of growth changes over generations, influenced by ecological, nutritional, and socio-economic conditions. The longitudinal approach reveals critical insights into the timing of peak growth velocities, demonstrating that girls reach their growth peak approximately one year earlier than boys. The analysis of intergenerational growth patterns suggests a significant increase in average height over the century, attributed to genetic diversity and changes in lifestyle and nutrition. This study’s findings emphasize the importance of updating physical development standards regularly to reflect the changing genetic and environmental landscape. The variability in growth patterns and their correlation with health outcomes in later life highlights the need for targeted public health strategies that address the underlying socio-economic and environmental determinants of health. This research contributes to the understanding of physical development trajectories and provides a foundation for future studies aimed at optimizing health outcomes from early childhood through adolescence. The primary objective of this article is to meticulously analyze the dynamics of height growth and accurately identify the periods of accelerated bodily development within the context of longitudinal research. Full article
(This article belongs to the Section Pediatric Endocrinology & Diabetes)
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22 pages, 1537 KiB  
Review
Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder
by Yousef Tizabi, Samia Bennani, Nacer El Kouhen, Bruk Getachew and Michael Aschner
Biomolecules 2023, 13(10), 1549; https://doi.org/10.3390/biom13101549 - 19 Oct 2023
Cited by 23 | Viewed by 4911
Abstract
Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interaction and communication, manifests in early childhood and is followed by restricted and stereotyped behaviors, interests, or activities in adolescence and adulthood (DSM-V). Although genetics and environmental factors have been [...] Read more.
Autism Spectrum Disorder (ASD), a neurodevelopmental disorder characterized by persistent deficits in social interaction and communication, manifests in early childhood and is followed by restricted and stereotyped behaviors, interests, or activities in adolescence and adulthood (DSM-V). Although genetics and environmental factors have been implicated, the exact causes of ASD have yet to be fully characterized. New evidence suggests that dysbiosis or perturbation in gut microbiota (GM) and exposure to lead (Pb) may play important roles in ASD etiology. Pb is a toxic heavy metal that has been linked to a wide range of negative health outcomes, including anemia, encephalopathy, gastroenteric diseases, and, more importantly, cognitive and behavioral problems inherent to ASD. Pb exposure can disrupt GM, which is essential for maintaining overall health. GM, consisting of trillions of microorganisms, has been shown to play a crucial role in the development of various physiological and psychological functions. GM interacts with the brain in a bidirectional manner referred to as the “Gut–Brain Axis (GBA)”. In this review, following a general overview of ASD and GM, the interaction of Pb with GM in the context of ASD is emphasized. The potential exploitation of this interaction for therapeutic purposes is also touched upon. Full article
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