Search Results (14)

RBFOX1 is an RNA-binding protein that regulates alternative splicing and RNA processing in the neurons, skeletal muscle, and heart. We intended to define the role of RBFOX1 in regulating calcium homeostasis to maintain normal cardiac function. We generated cardiomyocyte-specific Rbfox1 gene-deletion mice (cKO). The cardiomyocyte-specific deletion of RBFOX1 was confirmed by Western blotting and immunohistochemistry. The cKO mice showed mild hypertrophy and depressed cardiac function under homeostatic conditions, which did not deteriorate with age. Pressure overload by trans-aortic constriction (TAC) caused exaggerated cardiac hypertrophy and accelerated heart failure in cKO compared with wild-type mice. We performed Western blotting to assess the expression of important Ca²⁺-handling proteins, which showed alterations in the phosphorylation of PLN and CAMKII and decreased expression of SERCA2. We measured the Ca²⁺ dynamics and noted significantly delayed Ca²⁺ reuptake into the sarcoplasmic reticulum. Importantly, the decrease in SERCA2 expression was not due to reduced mRNA expression or altered splicing. To assess the possibility of the post-transcriptional regulation of SERCA2 expression by RBFOX1, we performed RNA immunoprecipitation (RIP), which showed the binding of RBFOX1 protein to Serca2 mRNA, which was confirmed in luciferase assays with the Serca2a 3′-untranslated region fused to luciferase. Finally, we performed a puromycin incorporation experiment, which showed that RBFOX1 enhances SERCA2 protein translation. Our results show that RBFOX1 plays a crucial role in regulating the expression of Ca²⁺-handling genes to maintain normal cardiac function. We show an important post-transcriptional role of RBFOX1 in regulating SERCA2 expression. Full article

The reception of the Decree Perfectae caritatis in Latin America can be understood in connection with the emergence of the preferential option for the poor and the call for consecrated religious life to the insertion since the 1960s. As part of the existing link between conciliar texts and renewal movements, it is worth highlighting the testimony of religious life lived in solidarity with the poor as a way of practicing chastity and incorporating sexuality. This topic is explored through the life stories of two individuals, Alice Domon in Argentina (1937–1977) and José Aldunate Lyon in Chile (1917–2019), within the framework of related studies on ethnographic ecclesiology and the theology of renewed religious life. Amidst military governments, institutional violence, abuses of power, and human rights violations, the lives of these two consecrated individuals showcase an alternative path marked by self-emptying, unwavering fidelity, non-violent action, and prophetic denunciation. The pursuit of integration between contemplative and apostolic aspects in the love for God and the poor, along with the defense of human rights in solidarity with the victims and their families, are some of the keys that define an adapted understanding of religious life in the Latin American context. Full article

Ancient thinking conceived Temperance as the enemy of pleasures and excesses, mainly bodily pleasures. This idea was the source of Temperance’s depictions in the Middle Ages. Attributes such as the torch and jug, castle, tower, bit, salamander, ermine, or the presence of Cupid accompany Temperance’s personification as controlling elements of bodily pleasures. The combinations of attributes relative to chastity give rise to two different iconographic types. These iconographic types translate theoretical considerations about this virtue visually. Full article

This paper focuses on the life of Liu Shu (1520–1657), a woman warrior who lived through the social and political turmoil of the violent dynastic transition from the Ming (1368–1644) dynasty to the Qing (1636–1911) dynasty. Drawing on the writings of Liu Shu and on different versions of accounts of her life written by male literati in different time periods, this paper intends to reveal the multiplicity and complexity of how a woman could exert her agency and interact with the dominant structure. Commonly, women’s agency has been understood as resistance against the male-dominant patriarchal system. However, recently, scholars such as Saba Mahmood have problematized universalizing overtly resistant acts against the patriarchal society to bring radical changes as demonstrations of women’s agency. These scholars argue that this approach fails to recognize that through their autonomy and while living a life of self-fulfillment, women have the capacity to reproduce, sustain, or subtly change the social norms and views of values that justify and support the patriarchal structure. In light of these scholars’ studies, this paper explores Liu Shu’s engagement in political and military activities and her Buddhist practices to analyze how she transgressed established gender norms in order to uphold rather than reject the virtues promoted by patriarchal ideology. The paper also discusses how conflicting demands on women by a male-centered society in the drastic dynastic transition enabled her to negotiate with or challenge the dominant structure. It also considers how her disobedient acts were accepted and applauded by some male literati to address their own agenda in different cultural, historical, and political contexts. Full article

The early Lingbao scriptures incorporate pluralistic gender discourses. On the one hand, the early Lingbao scriptures accept the social gender system of “differences between men and women” as the decision of all deities, and incorporate the “chastity” virtue of women advocated by Confucianism. The auspiciousness of giving birth to a boy and the masculine perspective of the Daoist discipline are not immune to correlative sexism. On the other hand, the early Lingbao scriptures actively borrow the Buddhist individualized gender, take the term “transforming a female into a male” as one of the “eight difficult situations” and the merit of worshipping the Daoist scriptures and illustrate the cultivated journey of women beyond gender in the stories of past actions, in an attempt to overcome the correlative sexism caused by the dominant gender system. The Dao unifies the concept of correlative gender and the concept of individualized gender, makes men and women equal objects of teachings, gives the perfected transcendent the freedom to choose gender, and integrates family ethics and individual transcendence with the images of a Daoist wife. The early Lingbao scriptures echo the Daoist principle of softness and femininity, use gender as an opportunity for Daoist cultivation, and explore possible ways to resolve gender trouble. Full article

Honor killing is a violent crime committed by one or more perpetrators, in which the crime’s intention is to restore honor to their family. In this narrative review, the authors investigate the epidemiology of honor killing in the Eastern Mediterranean Region. Furthermore, the social, cultural, and legal aspects of honor killing are discussed. Numerous socio-cultural factors lead to the action of killing for honor in this region. They include deeply rooted patriarchal dominance, the desire to maintain social status, and being poorly educated. Honor killing perpetrators have similar characteristics, such as rating female chastity at a higher price and justifying violence against women. The impact of honor killing on family members is much greater than the perceived families’ beliefs of the community’s rejection of the female’s dishonorable behavior. Silence culture dominates these societies, and many crimes are under-reported in this region. Often, a judicial trial is not conducted for such heinous crimes. Penal code reforms, campaigns to promote human rights, steps to improve the education level, and active participation of civil society in condemning such crimes are a few essential measures that need to be considered in order to curb the social evil of honor killing. Full article

In late modernity both religion and sexuality are being elaborated in terms of reflexivity. In this article, we present findings from our research on the topic of constructions of gender, intimacy and sexuality by sisters and brothers in Catholic monasteries in Poland. The findings are based on the mixed-method transformative connection between qualitative (n = 92) and representative sample quantitative research (n = 1543) conducted in 2020. We studied reflexivity on gender, intimacy and sexuality within Catholic religious communities in Poland in order to understand how gender, intimacy and sexuality are presented in the institutionalized framework of religious life. Our study demonstrates that reflexivity on gender, intimacy and sexuality is highly institutionalised and deeply privatized within Catholic religious communities. The article shows that reflexivity of consecrated persons in Poland on gender, intimacy and sexuality is strongly shaped by religious norms (chastity) and subordinated to their religious roles. Full article

There is an ignored, misunderstood, and complex reality within the broader clergy sexual abuse scandal within the Roman Catholic Church (RCC)—that of clergy sexual misconduct against adults (CSMAA). Estimates and calculations of numbers of victims/survivors over the last half-century reach into the early millions. Furthermore, evidence reveals that CSMAA does produce many serious personal, relational, and practical harms. This article presents and discusses the many expressions of such harms. However, even with the evidence of such harms CSMAA events are, for the most part, still generally perceived as consensual affairs. Such a perception is challenged when CSMAA is contextualised within a professional misconduct framework, and even more so, when survivors thereof participate in the research. Furthermore, CSMAA is clearly not just one type of event. Accordingly, this article also presents a continuum of expressions of CSMAA to assist with perceptual accuracy of this issue along with an unambiguous definition of CSMAA. Full article

Disney’s Mulan (1998) has generated much scholarly interest in comparing the film with its hypotext: the Chinese legend of Mulan. While this comparison has produced meaningful criticism of the Orientalism inherent in Disney’s cultural appropriation, it often ironically perpetuates the Orientalist paradigm by reducing the legend into a unified, static entity of the “authentic” Chinese “original”. This paper argues that the Chinese hypotext is an accumulation of dramatically conflicting representations of Mulan with no clear point of origin. It analyzes the Republican-era film adaptation Mulan Joins the Army (1939) as a cultural palimpsest revealing attributes associated with different stages of the legendary figure’s millennium-long intertextual metamorphosis, including a possibly nomadic woman warrior outside China proper, a Confucian role model of loyalty and filial piety, a Sinitic deity in the Sino-Barbarian dichotomy, a focus of male sexual fantasy, a Neo-Confucian exemplar of chastity, and modern models for women established for antagonistic political agendas. Similar to the previous layers of adaptation constituting the hypotext, Disney’s Mulan is simply another hypertext continuing Mulan’s metamorphosis, and it by no means contains the most dramatic intertextual change. Productive criticism of Orientalist cultural appropriations, therefore, should move beyond the dichotomy of the static East versus the change-making West, taking full account of the immense hybridity and fluidity pulsing beneath the fallacy of a monolithic cultural “authenticity”. Full article

This paper analyzes two philosophers’ views on chastity as a virtue, comparing Song Siyeol, a Korean neo-Confucian philosopher of the east, and David Hume, a Scottish philosopher. Despite the importance in and impact on women’s lives, chastity has been understated in religio-philosophical fields. The two philosophers’ understandings and arguments differ in significant ways and yet share important common aspects. Analyzing the views of Song and Hume helps us better understand and approach the issue of women’s chastity, not only as a historical phenomenon but also in the contemporary world, more fully and deeply. The analysis will provide an alternative way to re-appropriate the concept of chastity as a virtue. Full article

The Roman Catholic Church has received a remarkable amount of press attention regarding clerical perpetrated sexual abuse with child victims as well as other clerical behavioral scandals in recent years. Much has been reported in both the popular and professional press about the various aspects and elements of priestly formation and ministry that might contribute to behavioral problems among clerics. Additionally, much has also been written and discussed about the challenging religious, spiritual, and behavioral struggles among clerics when clerical misbehavior significantly contradicts expected behavior in terms of sexual, behavioral, and relational ethics. Since Catholic priests are dedicated to chastity, obedience, and, among religious order clerics, poverty, both Catholics and non-Catholics alike expect and demand highly virtuous behavior from these men that they believe should be beyond reproach. Clericalism contributes to the gap between expected and actual behavior and creates an environment and culture where problem behavior and struggles are too often ignored. This article seeks to unpack some of the challenging dynamics of clericalism and demonstrate how it negatively contributes to religious, spiritual, moral, and behavioral struggles among Catholic clerics. Full article

This essay maps out a constellation of early modern English feminine gatekeeper tropes that represent female sexual consent and imagine a gendered Cartesian dualism. This trope’s inherent mind–body divide grants the female subject’s mind a greater measure of rationality and autonomy from the body than other early modern discourses of feminine virtue, such as humoralism. However, it can also undercut feminine agency in self-regulation by placing all the responsibility and blame on the woman’s mind in cases of sexual harrassment and assault. Hadrian Dorrell’s Avisa, Shakespeare’s Lucrece, Thomas Heywood’s Jane Shore, and Christopher Marlowe’s Hero represent a spectrum of feminine mental complicity in extramarital sex, yet their mental “gatekeepers” are all suspected of failure. Shakespeare’s Juliet and Cressida literalize this gatekeeper trope and render it a material allegory when they negotiate with male suitors at literal portals on stage, a window and a chamber door. Examining the extraordinary pressures put on feminine “gatekeeper” minds in early modern texts allows us to discern contemporary willingness to blame the victims of sexual assault. Full article

This article describes and analyzes father-daughter purity balls in the context of the contemporary U.S. American conservative Christian sexual purity movement, with an emphasis on taking the self-understanding of those involved in the movement into account. It shows the ways that the idealization of a hierarchical father-daughter relationship both constructs and reflects sexual purity ideals. The Christian sexual purity teachings frame this father-daughter relationship as an essential part of forming the ideal subject, and as reflective of the right order of the kingdom of God. In the logic of sexual purity, a good man is the strong high-priest leader of the household and the ideal girl is princess-like: white, non-poor, attractive, pure, feminine, delicate, and receptive. She is preparing, under her father’s guidance, for heterosexual marriage. Attention to the father-daughter relationship in the sexual purity movement highlights the ways that sexual purity is primarily about subject formation and the ordering of relationships—in families, in the nation, and in the church—and less about the specifics of when particular sexual acts take place or the public health risks that might come from those acts. This exploration also brings into relief the ways that contemporary conservative Christian sexual purity teachings draw from and build on two prominent aspects of contemporary U.S. American popular culture: the important role of the princess figure, and the buying of goods as indispensable to the formation of the subject. Full article

Body piercing has been practiced for thousands of years all over the world for beautification, religion, initiation rites or status reasons. Genital piercings also have a significant background and have been practiced for enhancing sexual pleasure, chastity, shocking or as a protest against a conservative society. As the popularity of genital piercings increased in the last years, the number of complications is also on the rise. It is therefore important for the medical professionals to have at least basic knowledge regarding this practice, as it might be required in the management of unpredictable complications. Full article