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Keywords = central nucleus theory

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40 pages, 5904 KB  
Article
Biomimetic Planning and Design of Five-Minute Living Circle Residential Areas Inspired by Cellular Structure
by Pan Pei, Yihan Wang, Feijie Xia, Yueqing Wang and Yangyang Wei
Biomimetics 2026, 11(5), 342; https://doi.org/10.3390/biomimetics11050342 - 14 May 2026
Viewed by 557
Abstract
Biological cellular structures exhibit a high degree of systematic organization in both morphological configuration and functional coordination, providing important biomimetic insights for urban spatial organization. To address issues in traditional high-density residential areas, such as homogeneous spatial structures and insufficient accessibility of public [...] Read more.
Biological cellular structures exhibit a high degree of systematic organization in both morphological configuration and functional coordination, providing important biomimetic insights for urban spatial organization. To address issues in traditional high-density residential areas, such as homogeneous spatial structures and insufficient accessibility of public spaces, this study proposes a planning method for five-minute living circle residential areas based on a biomimetic cellular structure within the framework of space syntax theory. Taking a residential area in Wuhan, China, as a case study, a cell-like spatial structure model was constructed. Convex space analysis, axial analysis, and visibility analysis were conducted using Depthmap software to quantitatively evaluate key syntactic indicators, including integration, connectivity, mean depth, and choice. The results show that, compared with the original planning scheme, the biomimetic cellular planning model significantly optimized the spatial structure of the residential area by relying on the functionally synergistic mechanisms of selective permeability of the cell membrane, whole-area permeation of the cytoplasm, central regulation of the nucleus, distributed coordination of organelles, and efficient transport through cellular microfilaments. In the sample living circle, the overall integration increased from 1.27 to 1.64, the mean depth decreased from 3.79 to 3.18, and spatial connectivity increased from 3.74 to 5.44. Meanwhile, the synergy of the road network increased from 0.44 to 0.86, indicating marked improvements in spatial accessibility, connectivity, and the degree of coordination within the spatial structure. In addition, the visibility analysis showed that the pedestrian aggregation capacity of the public core space was enhanced, and the spatial vitality of public activity spaces in the residential area was improved. The findings demonstrate that the spatial organization model based on biomimetic cellular principles can effectively enhance spatial efficiency and social vitality in five-minute living circle residential areas, providing a quantifiable design method and theoretical framework for bio-inspired urban planning. Full article
(This article belongs to the Section Biomimetic Design, Constructions and Devices)
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21 pages, 6612 KB  
Article
Functional Connectivity of Auditory, Motor, and Reward Networks at Rest and During Music Listening
by Kai Yi (Kaye) Han, Jinyu Wang, Benjamin M. Kubit, Corinna Parrish and Psyche Loui
Brain Sci. 2026, 16(1), 15; https://doi.org/10.3390/brainsci16010015 - 22 Dec 2025
Viewed by 2057
Abstract
Background/Objectives: Music engages multiple brain networks simultaneously, yet most studies examine these networks in isolation. Methods: We investigated functional connectivity among the auditory, motor, and reward networks during music listening in different contexts using fMRI data from two samples (N = 39 [...] Read more.
Background/Objectives: Music engages multiple brain networks simultaneously, yet most studies examine these networks in isolation. Methods: We investigated functional connectivity among the auditory, motor, and reward networks during music listening in different contexts using fMRI data from two samples (N = 39 each): focused music listening and background music during cognitive tasks. ROI-to-ROI, seed-based, and graph theory analyses examined connectivity patterns among 46 regions spanning the three networks. Results: Both contexts showed enhanced within-auditory network connectivity compared to rest, suggesting that this is fundamental to music processing. However, between-network patterns diverged markedly. Background music listening during cognitive tasks preserved reward-motor coupling while reducing auditory-motor and auditory-reward connectivity. Focused music listening produced widespread negative correlations between motor regions and both the auditory and reward networks, potentially reflecting motor suppression in the scanner environment. Graph theory measures revealed context-specific hub reorganization: reward regions (nucleus accumbens, caudate) showed increased centrality during background music listening, while the amygdala and frontal orbital cortex were selectively enhanced during focused listening. Conclusions: These findings demonstrate that music engagement involves context-dependent network reorganization beyond simple attention effects. The same musical stimulus engages different neural mechanisms depending on concurrent cognitive demands, motor requirements, and listening goals. Enhanced within-auditory connectivity appears consistent across contexts, but between-network interactions are shaped by the broader cognitive-behavioral context. These results highlight the importance of considering ecological context when studying music processing and designing music-based interventions, as network connectivity patterns during music listening reflect complex interactions between task demands, attentional resources, and musical engagement rather than music processing alone. Full article
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8 pages, 1295 KB  
Article
Bubble Structure in Isotopes of Lu to Hg
by Changhoon Song, Yongbeom Choi, Youngman Kim and Chang-Hwan Lee
Particles 2025, 8(2), 37; https://doi.org/10.3390/particles8020037 - 2 Apr 2025
Cited by 1 | Viewed by 1398
Abstract
Bubble nuclei, characterized by a depletion in nucleon density at the nuclear center, are investigated within the atomic number range 71Z80 using the Deformed Relativistic Hartree–Bogoliubov theory in continuum. This study extends previous investigations, which were limited to even–even [...] Read more.
Bubble nuclei, characterized by a depletion in nucleon density at the nuclear center, are investigated within the atomic number range 71Z80 using the Deformed Relativistic Hartree–Bogoliubov theory in continuum. This study extends previous investigations, which were limited to even–even isotopes, by incorporating even–odd, odd–even, and odd–odd nuclei within this range. The extension is achieved by introducing the blocking effect into the point-coupling approach to ensure self-consistency. Following previous studies, we define a nucleus as a bubble candidate if the bubble parameter exceeds Bp=20%, and identify five bubble nuclei in both even-Z and odd-Z nuclei groups, based on the highest Bp values. The formation of bubble structures is confirmed through an analysis of proton single-particle energy levels of the most centrally depleted nuclei across four categories: even–odd, even–even, odd–even, and odd–odd. Full article
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30 pages, 769 KB  
Article
Is Cultured Meat a Case of Food or Technological Neophobia? On the Usefulness of Studying Social Representations of Novel Foods
by Roberto Fasanelli, Ernesto Casella, Sofia Foglia, Sonia Coppola, Assunta Luongo, Giuliana Amalfi and Alfonso Piscitelli
Appl. Sci. 2025, 15(5), 2795; https://doi.org/10.3390/app15052795 - 5 Mar 2025
Cited by 9 | Viewed by 3663
Abstract
In recent years, many studies have examined “novel foods” from various perspectives; however, the theoretical framework of social representations has been underutilized in this research. This paper denotes an initial attempt to study the socio-symbolic impact of synthetic foods using this framework. Specifically, [...] Read more.
In recent years, many studies have examined “novel foods” from various perspectives; however, the theoretical framework of social representations has been underutilized in this research. This paper denotes an initial attempt to study the socio-symbolic impact of synthetic foods using this framework. Specifically, the study aims to explore how different audiences—such as carnivores versus vegetarians—interpret unfamiliar foods, focusing on a new food technology: synthetic meat. The research seeks to describe and compare the social representations of cultured meat that are co-constructed and shared among these social groups (n = 350). The study adopts the structural approach, analyzing both the structure and content of the social representations in question. This was achieved through a mixed-methods strategy, which included hierarchical evocation, a food neophobia scale, checklists, open-ended questions, and a projective sensory analysis technique. Data analysis employed both qualitative and quantitative methods. The main findings indicate the significant roles of generative processes, cognitive polyphasia, and sensory anchors in the co-construction of social representations of cultured meat. The use of chemical-genetic objectification, metaphors, and clichés reflects ongoing debates about the possible implications of synthetic meat consumption for the environment and society. Our findings encourage consideration of social knowledge and cultural variables in food studies. Full article
(This article belongs to the Special Issue Sensory Evaluation and Flavor Analysis in Food Science)
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9 pages, 983 KB  
Article
Exploring the Neutron Magic Number in Superheavy Nuclei: Insights into N = 258
by Pengxiang Du and Jian Li
Particles 2024, 7(4), 1086-1094; https://doi.org/10.3390/particles7040066 - 12 Dec 2024
Cited by 3 | Viewed by 2469
Abstract
In the framework of axial symmetric relativistic Hartree–Bogoliubov (RHB) theory and the Skyrme Hartree–Fock–Bogoliubov (HFB) theory, the evolution of shell structure, density distribution, and ground state deformation in superheavy nuclei proximate to N=258 are investigated within the relativistic functionals DD-PC1 and [...] Read more.
In the framework of axial symmetric relativistic Hartree–Bogoliubov (RHB) theory and the Skyrme Hartree–Fock–Bogoliubov (HFB) theory, the evolution of shell structure, density distribution, and ground state deformation in superheavy nuclei proximate to N=258 are investigated within the relativistic functionals DD-PC1 and DD-ME2, as well as the non-relativistic functional UNEDF0. The results from DD-ME2 and UNEDF0 indicate that N=258 is a neutron magic number, whereas DD-PC1 does not anticipate the existence of a bound N=258 magic nucleus. Further discussion suggests that the emergence of the magic number N=258 is related to the depression of the central density. Full article
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17 pages, 14408 KB  
Article
The Collapse of the Vaults of the Ambato Matriz Church in the 1949 Earthquake: A Response with a Technical Approach
by Fabián S. López-Ulloa, Esther Redondo Martínez, Ignacio Javier Gil Crespo, Andrea Goyes-Balladares and Luis Enrique Chávez-Rubio
Sustainability 2024, 16(10), 3918; https://doi.org/10.3390/su16103918 - 8 May 2024
Viewed by 5718
Abstract
This research examines the structural behavior of the central vault of the Matriz church that collapsed during the 1949 earthquake in Ambato, Ecuador. Following the disaster, the church and Episcopal Palace were demolished. The central vault lacked buttresses and had large cracks two [...] Read more.
This research examines the structural behavior of the central vault of the Matriz church that collapsed during the 1949 earthquake in Ambato, Ecuador. Following the disaster, the church and Episcopal Palace were demolished. The central vault lacked buttresses and had large cracks two years before the collapse. A study was conducted using graphic restitution and the theory of limit analysis of structures to analyze the mechanical behavior of the central vault. The aim was to provide a technical explanation for the cause of the collapse beyond the impact of the earthquake. The limit analysis of structures is a tool that determines the technical stability conditions of a masonry structure using graphic statics. In this case, the respective checks of the structural behavior could be made, concluding that the structural ensemble of the central vault was unstable and could have collapsed at any moment, not necessarily due to an earthquake. The article is based on the research project “Architectural analysis of the central nucleus of Ambato between 1895 and 1949: styles, types, techniques, losses, and continuities”, which was conducted at the Universidad Técnica de Ambato, Ecuador, from 2021 to 2023. Full article
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38 pages, 6475 KB  
Article
Theory of Majorana-Type Heavy Ion Double Charge Exchange Reactions by Pion–Nucleon Isotensor Interactions
by Horst Lenske, Jessica Bellone, Maria Colonna and Danilo Gambacurta
Universe 2024, 10(5), 202; https://doi.org/10.3390/universe10050202 - 30 Apr 2024
Cited by 10 | Viewed by 2867
Abstract
The theory of heavy ion double charge exchange (DCE) reactions proceeding by effective rank-2 isotensor interactions is presented. Virtual pion–nucleon charge exchange interactions are investigated as the source for induced isotensor interactions, giving rise to the Majorana DCE (MDCE) reaction mechanism. MDCE is [...] Read more.
The theory of heavy ion double charge exchange (DCE) reactions proceeding by effective rank-2 isotensor interactions is presented. Virtual pion–nucleon charge exchange interactions are investigated as the source for induced isotensor interactions, giving rise to the Majorana DCE (MDCE) reaction mechanism. MDCE is of a generic character, proceeding through pairs of complementary (π±,π) reactions in the projectile and target nucleus. The dynamics of the elementary processes is discussed, where the excitation of pion–nucleon resonances are of central importance. Investigations of initial and final state ion–ion interactions show that these effects are acting as vertex renormalizations. In closure approximation, well justified by the finite pion mass, the second-order transition matrix elements reduce to pion potentials and effective two-body isotensor DCE interactions, giving rise also to two-body correlations in either of the participating nuclei. Connections to neutrinoless Majorana double beta decay (MDBD) are elucidated at various levels of the dynamics, from the underlying fundamental electro-weak and QCD scales to the physical scales of nuclear MDBD and MDCE physics. It is pointed out that heavy ion MDCE reactions may also proceed by competing electro-weak charge exchange processes, leading to lepton MDCE by electrons, positrons, and neutrinos. Full article
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11 pages, 3432 KB  
Communication
Five Bonds to Carbon through Tri-Coordination in Al3C3/0
by Abdul Hamid Malhan, Venkatesan S. Thimmakondu and Krishnan Thirumoorthy
Chemistry 2023, 5(2), 1113-1123; https://doi.org/10.3390/chemistry5020076 - 9 May 2023
Cited by 2 | Viewed by 5899
Abstract
Here, five bonds to carbon through tri-coordination are theoretically established in the global minimum energy isomers of Al3C3 anion (1a) and Al3C3 neutral (1n) for the first time. Various isomers of [...] Read more.
Here, five bonds to carbon through tri-coordination are theoretically established in the global minimum energy isomers of Al3C3 anion (1a) and Al3C3 neutral (1n) for the first time. Various isomers of Al3C3/0 are theoretically identified using density functional theory at the PBE0-D3/def2-TZVP level. Chemical bonding features are thoroughly analyzed for these two isomers (1a and 1n) with different bonding and topological quantum chemical tools, such as adaptive natural density partitioning (AdNDP), Wiberg Bond Indices (WBIs), nucleus-independent chemical shifts (NICS), and atoms in molecules (AIM) analyses. The structure of isomer 1a is planar with C2v symmetry, whereas its neutral counterpart 1n is non-planar with C2 symmetry, in which its terminal aluminum atoms are out of the plane. The central allenic carbon atom of isomers 1a and 1n exhibits tri-coordination and thus makes it a case of five bonds to carbon, which is confirmed through their total bond order as observed in WBI. Both the isomers show σ- and π-aromaticity and are predicted with the NICS and AdNDP analyses. Further, the results of ab initio molecular dynamics simulations reveal their kinetic stability at room temperature; thus, they are experimentally viable systems. Full article
(This article belongs to the Special Issue Hypercoordinate Carbon)
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17 pages, 23717 KB  
Article
Spatial Characteristics of Suburban Villages Based on Spatial Syntax
by Ran Li and Liang Mao
Sustainability 2022, 14(21), 14195; https://doi.org/10.3390/su142114195 - 31 Oct 2022
Cited by 15 | Viewed by 3706
Abstract
(1) Background: In the process of urbanization, current suburban village spaces are undergoing drastic changes. Many villages have lost their original rural appearances, and their unique rural cultures have been destroyed. (2) Methods: In this study, we used the Depthmap software to analyze [...] Read more.
(1) Background: In the process of urbanization, current suburban village spaces are undergoing drastic changes. Many villages have lost their original rural appearances, and their unique rural cultures have been destroyed. (2) Methods: In this study, we used the Depthmap software to analyze the integration and comprehensibility of the village spaces in the central suburbs of Jilin province. Based on spatial syntax theory, we quantitatively interpreted the suburban village spaces, and we analyzed the correlations between their spatial morphological characteristics and industrial structures. (3) Results: Fishbone and radial villages each have one spatial nucleus, while comprehensive villages have multiple spatial nuclei. The comprehensibility of the villages with industrial structures that are dominated by the secondary and tertiary industries expressed higher results, with the highest comprehensibility value for the village of Nianshan (0.874). (4) Conclusions: The spatial characteristics of the suburban villages in central Jilin province generally have a high correlation with their industrial structures. We can use the spatial syntax measurement index as a basis for the spatial-form adjustment and reconstruction of the villages, with the aim of providing a reference for the industrial selection of suburban villages with different landforms and industrial structures, as well as the sustainable development of rural cultural tourism, in order to contribute to the revitalization of the countryside in the new era. Full article
(This article belongs to the Special Issue Circular Economy and Sustainable Rural Development)
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19 pages, 3320 KB  
Article
Sustainability and the Social Representation of the COVID-19 Pandemic: A Missing Link
by Luiz Antonio Joia, Flavia Michelotto and Manuela Lorenzo
Sustainability 2022, 14(17), 10527; https://doi.org/10.3390/su141710527 - 24 Aug 2022
Cited by 5 | Viewed by 3439
Abstract
The COVID-19 pandemic highlighted the importance for countries to preserve a sustainable health system. Unfortunately, the emergency nature of the COVID-19 pandemic has led to economic and social disasters, putting global health at risk. Thus, through the Social Representation Theory, our aim is [...] Read more.
The COVID-19 pandemic highlighted the importance for countries to preserve a sustainable health system. Unfortunately, the emergency nature of the COVID-19 pandemic has led to economic and social disasters, putting global health at risk. Thus, through the Social Representation Theory, our aim is to replicate a previous study carried out in Brazil in mid-2020 on how Brazilian society has perceived the significance of the COVID-19 pandemic in order to investigate whether this perception changed almost a year after the publication of the former study. The results show that the perception of Brazilian society about the COVID-19 pandemic in Brazil was, at the end of 2021, mainly shaped by the political polarization that existed at the time in the country. Thus, politics and government, social distancing, death, and fear were the categories that composed the central nucleus of the social representation of the COVID-19 pandemic. On the other hand, categories such as economy and employment and changes and the new normal were mentioned less. Surprisingly, the sustainability category was practically disregarded by Brazilians, thus constituting a missing link. In this way, with this research, we hope to contribute to a better understanding of this scenario, expanding the understanding of how society’s interpretation of the COVID-19 pandemic in an emerging country such as Brazil has changed over time. Finally, understanding the dynamics of society’s perception of the COVID-19 pandemic can contribute to better planning of local initiatives, both at a managerial and public levels, with the aim of mitigating this and other possible future pandemics in a sustainable way. Full article
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36 pages, 1125 KB  
Review
Objective Detection of Tinnitus Based on Electrophysiology
by Shuwen Fan and Shufeng Li
Brain Sci. 2022, 12(8), 1086; https://doi.org/10.3390/brainsci12081086 - 16 Aug 2022
Cited by 9 | Viewed by 5921
Abstract
Tinnitus, a common disease in the clinic, is associated with persistent pain and high costs to society. Several aspects of tinnitus, such as the pathophysiology mechanism, effective treatment, objective detection, etc., have not been elucidated. Any change in the auditory pathway can lead [...] Read more.
Tinnitus, a common disease in the clinic, is associated with persistent pain and high costs to society. Several aspects of tinnitus, such as the pathophysiology mechanism, effective treatment, objective detection, etc., have not been elucidated. Any change in the auditory pathway can lead to tinnitus. At present, there is no clear and unified mechanism to explain tinnitus, and the hypotheses regarding its mechanism include auditory plasticity theory, cortical reorganization theory, dorsal cochlear nucleus hypothesis, etc. Current theories on the mechanism of tinnitus mainly focus on the abnormal activity of the central nervous system. Unfortunately, there is currently a lack of objective diagnostic methods for tinnitus. Developing a method that can detect tinnitus objectively is crucial, only in this way can we identify whether the patient really suffers from tinnitus in the case of cognitive impairment or medical disputes and the therapeutic effect of tinnitus. Electrophysiological investigations have prompted the development of an objective detection of tinnitus by potentials recorded in the auditory pathway. However, there is no objective indicator with sufficient sensitivity and specificity to diagnose tinnitus at present. Based on recent findings of studies with various methods, possible electrophysiological approaches to detect the presence of tinnitus have been summarized. We analyze the change of neural activity throughout the auditory pathway in tinnitus subjects and in patients with tinnitus of varying severity to find available parameters in these methods, which is helpful to further explore the feasibility of using electrophysiological methods for the objective detection of tinnitus. Full article
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18 pages, 957 KB  
Article
Going beyond Cryptocurrencies: The Social Representation of Blockchain
by Luiz Antonio Joia and Juliana Aparecida Pinto Vieira
Sustainability 2021, 13(24), 14054; https://doi.org/10.3390/su132414054 - 20 Dec 2021
Cited by 10 | Viewed by 4409
Abstract
This study investigates the social representation of Blockchain from the perspective of professionals in Brazil, herein considered as a proxy for emerging markets, and then compares the results found with the existing academic literature on the concept of Blockchain. To do that, the [...] Read more.
This study investigates the social representation of Blockchain from the perspective of professionals in Brazil, herein considered as a proxy for emerging markets, and then compares the results found with the existing academic literature on the concept of Blockchain. To do that, the social representation theory was applied, operationalized through the words evocation technique. Security, bitcoin and decentralization were the categories located in the central nucleus of the social representation of Blockchain, while innovation, data, network, cryptocurrency, and technology were the categories located in the peripheral system. Based on the results obtained, there was a perceived strong association of Blockchain with bitcoin, one of its applications, and a dissonance between the existing academic literature and the perception of Brazilian professionals about the concept of Blockchain, as the latter is a privilege of the technical and operational issues of Blockchain to the detriment of its strategic potential. This dissonance can cause Blockchain initiatives to have results below expectations. Finally, Brazilian professionals did not realize the potential for inclusion of Blockchain in an emerging market such as Brazil and did not notice the need and relevance of a specific legal governance for Blockchain, an issue also forgotten by academia. Full article
(This article belongs to the Collection Blockchain Technology)
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15 pages, 84547 KB  
Article
In Silico Studies on Selected Neutral Molecules, CGa2Ge2, CAlGaGe2, and CSiGa2Ge Containing Planar Tetracoordinate Carbon
by Prasenjit Das and Pratim Kumar Chattaraj
Atoms 2021, 9(3), 65; https://doi.org/10.3390/atoms9030065 - 10 Sep 2021
Cited by 18 | Viewed by 4258
Abstract
Density functional theory (DFT) was used to study the structure, stability, and bonding in some selected neutral pentaatomic systems, viz., CGa2Ge2, CAlGaGe2, and CSiGa2Ge containing planar tetracoordinate carbon. The systems are kinetically stable, as [...] Read more.
Density functional theory (DFT) was used to study the structure, stability, and bonding in some selected neutral pentaatomic systems, viz., CGa2Ge2, CAlGaGe2, and CSiGa2Ge containing planar tetracoordinate carbon. The systems are kinetically stable, as predicted from the ab initio molecular dynamics simulations. The natural bond orbital (NBO) analysis showed that strong electron donation occurs to the central planar carbon atom by the peripheral atoms in all the studied systems. From the nucleus independent chemical shift (NICS) analysis, it is shown that the systems possess both σ- and π- aromaticity. The presence of 18 valence electrons in these systems, in their neutral form, appears to be important for their stability with planar geometries rather than tetrahedral structures. The nature of bonding is understood through the adaptive natural density partitioning analysis (AdNDP), quantum theory of atoms in molecules (QTAIM) analysis, and also via Wiberg bond index (WBI) and electron localization function (ELF). Full article
(This article belongs to the Special Issue Planar Tetracoordinate Carbon—Fifty Years and Beyond)
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58 pages, 11951 KB  
Review
Understanding Emotions: Origins and Roles of the Amygdala
by Goran Šimić, Mladenka Tkalčić, Vana Vukić, Damir Mulc, Ena Španić, Marina Šagud, Francisco E. Olucha-Bordonau, Mario Vukšić and Patrick R. Hof
Biomolecules 2021, 11(6), 823; https://doi.org/10.3390/biom11060823 - 31 May 2021
Cited by 428 | Viewed by 95481
Abstract
Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. Feelings are conscious, emotional experiences [...] Read more.
Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. Feelings are conscious, emotional experiences of these activations that contribute to neuronal networks mediating thoughts, language, and behavior, thus enhancing the ability to predict, learn, and reappraise stimuli and situations in the environment based on previous experiences. Contemporary theories of emotion converge around the key role of the amygdala as the central subcortical emotional brain structure that constantly evaluates and integrates a variety of sensory information from the surroundings and assigns them appropriate values of emotional dimensions, such as valence, intensity, and approachability. The amygdala participates in the regulation of autonomic and endocrine functions, decision-making and adaptations of instinctive and motivational behaviors to changes in the environment through implicit associative learning, changes in short- and long-term synaptic plasticity, and activation of the fight-or-flight response via efferent projections from its central nucleus to cortical and subcortical structures. Full article
(This article belongs to the Collection Feature Papers in Section 'Molecular Medicine')
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