Search Results (8)

Multiple organs and tissues coordinate to respond to dietary and environmental challenges. It is interorgan crosstalk that contributes to systemic metabolic homeostasis. The liver and brain, as key metabolic organs, have their unique dialogue to transmit metabolic messages. The interconnected pathogenesis of liver and brain is implicated in numerous metabolic and neurodegenerative disorders. Recent insights have positioned the liver not only as a central metabolic hub but also as an endocrine organ, capable of secreting hepatokines that transmit metabolic signals throughout the body via the bloodstream. Metabolites from the liver or gut microbiota also facilitate a complex dialogue between liver and brain. In parallel to humoral factors, the neural pathways, particularly the hypothalamic nuclei and autonomic nervous system, are pivotal in modulating the bilateral metabolic interplay between the cerebral and hepatic compartments. The term “liver–brain axis” vividly portrays this interaction. At the end of this review, we summarize cutting-edge technical advancements that have enabled the observation and manipulation of these signals, including genetic engineering, molecular tracing, and delivery technologies. These innovations are paving the way for a deeper understanding of the liver–brain axis and its role in metabolic homeostasis. Full article

In a forcedly global system, we are facing a more and more regulated, sustainable coffee market. The International Coffee Organization is the only coffee intergovernmental organization working to face the numerous challenges of this polyhedric world, from producing fields to consuming markets. Coffee statistics, a unique table for discussion, starting from multilateral up to bilateral dialogue, involving private entities and civil society, cooperation and development projects, and the circular economy are some of the main issues for this intense year 2023. In Europe, one of the main issues for coffee contaminants is the renewal of the authorization as an active substance for glyphosate, which is a chemical widely used in herbicide products, especially in the coffee sector. The use of glyphosate is approved in the EU until 15 December 2023, subject to each product being authorized by national authorities following a safety evaluation. In July 2023, EFSA published the results of a risk assessment for the active substance glyphosate, where no critical areas of concern for the health of humans, animals, or the environment have been identified. Due Diligence: On 1 June 2023, the European Parliament agreed on its position on the Directive on Corporate Sustainability Due Diligence (CSDDD), which requires in-scope companies to conduct due diligence on and take responsibility for human rights abuses and environmental harm throughout their global value chains. The European Coffee Federation has supported the proposal in May 2022 through a position paper, as it is an important step toward the development and promotion of more socially and environmentally sustainable and responsible coffee value chains, sustainable sourcing approaches, and the prevention of loss of biodiversity and natural resources. Deforestation EU regulation: changes to food systems are required to halt deforestation and forest degradation to slow the rate of climate change and the threat to global diversity. Henceforth, the EU deforestation regulation aims to minimize the risk of placing products and commodities on the EU market that cause deforestation and forest degradation. There is a strong need to conduct country-level assessments on the readiness to fulfill the new EU legislation, especially on how smallholder coffee farming families would be affected. To be prepared, producing countries, coffee farmers (and particularly small-holder farmers) and their producer organizations need timely information on guidelines and capacity building on regulatory due diligence. Data requirements on geo-localization and traceability need to feed a discussion on how data should be managed and by whom, as well as on data ownership. Sector-specific guidelines are required, and for the coffee sector specifically, on how to differentiate between forest and coffee agroforestry systems such that coffee farm management is not seen as deforestation. As evident, more and more issues for a sustainable coffee world are arising, impacting the whole global coffee market; traceability is becoming a pillar on which it needs to be developed, stimulating multilateral and bilateral dialogue to help all countries align their capacities to reach this important common target. Full article

From the formal dialogue between China and ASEAN in 1991 to the establishment of the China–ASEAN FTA in 2010, the economic and trade relations between China and ASEAN countries have developed rapidly. With the continuous development of economic and trade relations, the infrastructural level between China and ASEAN has far lagged behind the needs of exchanges and trade. How to promote the development of bilateral trade through infrastructure construction and interconnection has become a concern of governments of all countries. In the context of China’s “Belt and Road” Initiative and the “Master Plan for ASEAN Connectivity”, new ideas and opportunities are provided for ASEAN infrastructure construction and its interconnection with China. Based on panel data from 2004 to 2020, this paper analyzes the impact of ASEAN infrastructure on the China–ASEAN trade volume. The analysis finds that road, port, shipping and communication infrastructure positively impact the bilateral trade volume, among which ports exert the greatest impact on the bilateral trade volume and roads have the least impact. For a more in-depth study, the transportation infrastructures of land and island countries are compared and analyzed separately. The impact of road infrastructure on trade is significant for land countries, while the impact of port infrastructure on trade is more remarkable for island countries. Finally, measures and suggestions on how to promote the development of bilateral trade are proposed on the basis of the above analysis. Full article

Theologians have been engaged in the reflections of the eschatological in the social and moral conditions of the world for some years now, but the emphasis on the indisputable need for an interfaith dialogue at such a moment is evidently absent. Arguably, the apocalyptic times of pandemic, induced communal hatred, bilateral hostility, and racial discriminations, on a global level, which are also accompanied with many instances by increased charitable behavior and a heightened sense of human responsibility. This paper focuses on apocalyptic theologies in the context of Hindu and Christian settings in India and how they interact, creating the possibility for an interfaith dialogue. Based on Raimon Panikkar’s neologism ‘cosmotheandric vision,’ the paper establishes a relation between intercultural theologies and interfaith dialogue. The apocalypse can be studied as being a constant reminder of the cosmotheandric nature of the universe, for Hindus and Christians alike, fostering a dialogue between the two religions, entirely cognizant of their hermeneutical differences. The moment of apocalypse can be analyzed as a point of cosmotheandric union and absolute togetherness, wherein cultural and religious differences disappear with the consciousness of the whole, the One. Full article

The Community of a Shared Future for Mankind seeks to mitigate the world’s current challenges, and to create a more sustainable future through better global governance. Some of the philosophical arguments of the Community of a Shared Future for Mankind, and its foundations, which this article traces, are grounded in the philosophical teachings of Confucius and Mencius. The five pillars of Confucianism are benevolence (Ren), righteousness (Yi), propriety (Li), wisdom (Zhi) and fidelity (Xin). The five pillars have their equivalents in the philosophy of the Community of a Shared Future for Mankind: benevolence has its equivalents in multilateral and bilateral agreements; righteousness shows justice; propriety’s equivalents are international standards and regulations; wisdom is the problem-solving dialogues; and trustworthiness is equated to international organizations that safeguard global integrity. The Confucian principle of harmony is congruent with the objective of the Community of a Shared Future for Mankind, of creating a world of harmony, peace and cooperation. The Golden Rule has been observed in the Community of a Shared Future for Mankind, through its insistence on reciprocal bilateral and multilateral cooperation. Mencius’ philosophical contribution to the Community of a Shared Future for Mankind is in his theory of human nature, where humaneness is seen as developmental—as would be the community built by the Community of a Shared Future for Mankind. Mencius’ principle of governance is congruent with the Community of a Shared Future for Mankind’s insistence on responsible governance. These congruences and similarities, between the Community of a Shared Future for Mankind and the philosophies of Confucius and Mencius, point to the foundations for the Community of a Shared Future for Mankind. Full article

The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit. Among these, extracellular vesicles have emerged as a focus of study in the last few years. Extracellular vesicles contain soluble proteins, DNA, mRNA and non-coding RNAs with which they can modulate the phenotypes of recipient cells. In this review we summarize recent findings on the extracellular vesicles-mediated bilateral communication established between glioblastoma cells and their tumor microenvironment, and the impact of this dialogue for tumor progression and recurrence. Full article

This article explores the implications for Christian unity from the perspective of the lived faith community, the ekklesia. While bilateral and multilateral dialogues have borne great fruit in bringing Christian denominations closer together, as indeed it will continue to do so, considering how the ecclesiological identity of the faith community both forms and reflects its members may be helpful in moving forward in our ecumenical efforts. This calls for a ground-up approach as opposed to a top-down approach. By “ground-up” it is meant that the starting point for theological reflection on ecumenism begins not with doctrine but with praxis, particularly as it relates to the common believer in the pew. The ecclesiological model “Body of Christ” provides a helpful vocabulary in this exploration for a number of reasons, none the least that it is scripturally-based, presumes diversity and employs concrete imagery relating to everyday life. Further, “Body of Christ” language is used by numerous Christian denominations in their statements of self-identity, regardless of where they lie on the doctrinal or political spectrum. In this article, potential benefits and challenges of this ground-up perspective will be considered, and a way forward will be proposed to promote ecumenical unity across denomination borders. Full article

International bi-lateral agreements to support the conservation of rainforests to reduce greenhouse gas emissions are growing in prevalence. In 2009, the governments of Guyana and Norway established Guyana’s Low Carbon Development Strategy (LCDS). We examine the extent to which the participation and inclusion of Guyana’s indigenous population within the LCDS is being achieved. We conducted a single site case study, focussing on the experiences and perceptions from the Amerindian community of Chenapou. Based on 30 interviews, we find that a deficit of adequate dialogue and consultation has occurred in the six years since the LCDS was established. Moreover, key indigenous rights, inscribed at both a national and international level, have not been upheld with respect to the community of Chenapou. Our findings identify consistent shortcomings to achieve genuine participation and the distinct and reinforced marginalisation of Amerindian communities within the LCDS. A further critique is the failure of the government to act on previous research, indicating a weakness of not including indigenous groups in the Guyana-Norway bi-lateral agreement. We conclude that, if the government is to uphold the rights of Amerindian communities in Guyana, significant adjustments are needed. A more contextualised governance, decentralising power and offering genuine participation and inclusion, is required to support the engagement of marginal forest-dependent communities in the management of their natural resources. Full article