Search Results (559)

Background/Objectives: Perceived physical literacy (PPL) appears to be a relevant strategy for combating the prevalent sedentary lifestyle among young people. Therefore, understanding their PPL levels will facilitate the implementation of appropriate strategies for this purpose. Therefore, this study aimed to analyze the differences in PPL considering the sex dimension (i.e., males and females) and the age-group (i.e., early compulsory secondary education, late compulsory secondary education and baccalaureate). Methods: Seven-hundred-and-four Spanish students (age = 14.3 ± 1.6 years old) belonging to three different Spanish secondary schools voluntarily participated in this study. To assess adolescents’ perceptions of their physical literacy, the Spanish Adolescents’ Perceived Physical Literacy Assessment (S-PPLI) was used. This instrument consists of nine items equally distributed across three categories: self-perception and self-confidence, self-expression and communication with others, and knowledge and understanding. Results: Males obtained higher scores in all the indicators of PPL, except for items 1, 8 and 9, compared to their female counterparts (p < 0.05), while the oldest age-group reported higher scores in the indicators of knowledge and understanding category compared to students in the early years of compulsory secondary education (p < 0.01). Conclusions: Programs based on increasing the PPL should be implemented specifically for females. Also, similar programs must be included into scholar curriculums from the beginning of secondary education, with the aim of promoting improvements in the health and physical condition of Spanish adolescents. Full article

Introduction: The main purpose of this study was to test a hierarchical model of motivation that integrates Achievement Goal Theory and Self-Determination Theory to explain and predict exercise adherence. Method: In total, 2180 exercisers (1020 female, 1160 male) aged between 18 and 60 years, from different gyms and health clubs, completed several scales validated in exercise settings, regarding perceived motivational climate, basic psychological need satisfaction, behavioral regulation, and exercise adherence. For the last measure, weekly computer access to a control system over a 6-month period before and after data collection was consulted. Results: Through structural equation models (SEM), it was verified that (1) task-involving climate positively predicted basic psychological needs. In turn, the satisfaction of these needs predicted autonomous motivation, which led to a positive prediction of adherence; (2) a small variation in exercise adherence was explained by the motivational model under analysis. Nevertheless, models significantly improved their analytical power when past adherence was inserted in the model increasing the explained variance in future behavior from 9.2% to 64%. Conclusions: In conclusion, autonomous motivation can predict people’s exercise adherence, and past behavior increases that predictive effect. The present study brings scientific evidence to the popular saying “tell me what you’ve done and, and I’ll predict what you’ll do”. Full article

The Chromobox (CBX) family comprises key epigenetic regulators involved in transcriptional repression through chromatin modifications. Dysregulation of polycomb CBX proteins has been linked to epigenetic gene silencing and cancer progression. However, the specific roles and prognostic value of CBX family members in colorectal cancer (CC) remain unclear. In this study, we show that CBX genes are significantly dysregulated in CC tissues and cell models compared to normal colorectal tissue. Among them, CBX4 and CBX8 emerged as the most upregulated isoforms in tumors. Functional analyses revealed that CBX4 overexpression enhances CC cell proliferation, while its silencing reduces tumor growth. Similarly, pharmacological inhibition of CBX4 in patient-derived tumor organoids led to decreased proliferation, supporting its pro-tumorigenic role. Immunofluorescence analysis further revealed alterations in NF-κB signaling upon CBX4 inhibition, along with reduced mRNA levels of pathway components including NF-κB, TNF, IL-1, and c-Myc. These findings point to a potential interplay between CBX4 and inflammation-related pathways in CC. Overall, our study highlights the oncogenic role of CBX4 in colorectal cancer and supports its potential as a novel therapeutic target and early biomarker for disease progression. Full article

The uptake of the COVID-19 and seasonal influenza (SI) vaccines have decreased in Europe and especially in Malta. The present study aimed to investigate the attitudes toward COVID-19 and SI vaccines and determine if individuals perceive that these vaccines are relevant to protect their health and identify reasons for their responses. A cross-sectional study using an anonymous questionnaire, informed by the Theory of Planned Behavior, addressing behavior beliefs and attitudes, and targeted at adult residents in Malta, was designed on Google Forms and disseminated using social media between January and March 2024. A total of 555 responses were received. The majority of respondents did not take/intend to take the COVID-19 (75%, n = 417) or SI (64.3%, n = 362) vaccines, with females being less likely to do so (p = 0.033). Perceived lack of safety (31.3%, n = 174) was the primary reason for rejecting the COVID-19 vaccine, and perceived lack of a threat from SI (26%, n = 144) was the reason for rejecting the SI vaccine. Those having chronic conditions were positively associated with uptake of both vaccines. In the post-pandemic era, these vaccines are not envisaged as having a major role in protecting one’s health. A high degree of skepticism especially toward the combined COVID-19 and SI vaccine in terms of safety, mostly in women, is still present. Full article

Psychological stress and dietary behavior are interdependent forces that greatly influence mental and physical health. Thus, both what and how we eat impact our well-being. Maladaptive eating patterns, such as eating in response to emotional cues rather than physiological hunger, have become increasingly common amid modern stressors and an ultra-processed food environment. This narrative review synthesizes interdisciplinary findings from nutritional psychiatry, microbiome science, and behavioral nutrition to explore how stress physiology, gut–brain interactions, and dietary quality shape emotional regulation and eating behavior. It highlights mechanisms (e.g., HPA-axis dysregulation, blunted interoception, and inflammatory and epigenetic pathways) and examines the evidence for mindful and intuitive eating; phytochemical-rich, whole-food dietary patterns; and the emerging role of precision nutrition. Trauma-informed approaches, cultural foodways, structural barriers to healthy eating, and clinical implementation strategies (e.g., interprofessional collaboration) are considered in the context of public health equity to support sustainable mental wellness through dietary interventions. Ultimately, restoring a healthy relationship with food positions nutrition not only as sustenance but as a modifiable regulator of affect, cognition, and stress resilience, central to mental and physical well-being. Full article

Mental health disorders, particularly depression and anxiety, have become increasingly prevalent among elite athletes, exacerbated by factors such as competitive pressure and the Coronavirus Disease 19 (COVID-19) pandemic. This study analyzes trends in the use of antidepressants, anxiolytics, and cannabinoids (delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD)) among Italian athletes from 2011 to the first half of 2023 (FH2023), referring to anti-doping reports published by the Italian Ministry of Health. Data from 13,079 athletes were examined, with a focus on non-prohibited medications, banned substances, and regulatory impacts, including threshold adjustments for THC since 2013 and the legalization of CBD. The results show fluctuating use of antidepressants/anxiolytics, with peaks in 2021 and the FH2023, coinciding with post-pandemic awareness. Positive THC cases rose following regulatory changes, reflecting socio-cultural trends. Gender disparities emerged, with THC use predominantly among males (e.g., nine males vs. one female in 2013), though female athletes were underrepresented in testing. This study highlights the need for personalized, evidence-based strategies that balance therapeutic efficacy and anti-doping compliance. Clinicians should carefully consider prescribing selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines to address depression and anxiety and should monitor the risks of CBD contamination. Future research should adopt longitudinal, gender-sensitive approaches to refining guidelines and combating stigma in professional sports. Full article

This article focuses on how rising nativism, manifested through immigrants’ experiences of everyday discrimination, and Florida’s legal context (ascertained through immigrants’ fears of deportation), are related to immigrants’ hesitation when seeking healthcare services. Hesitation to seek healthcare, or healthcare hesitancy, is examined in the context of Florida’s SB1718, a law passed in 2023 that criminalized many aspects of being an immigrant. Based on a survey of 466 Florida immigrants and U.S. citizen adult children of immigrants, logistic regression analysis reveals that everyday experiences with discrimination are associated with a reluctance to seek healthcare services among this population. In particular, those with insecure legal immigrant status (i.e., undocumented and temporary statuses), those with financial hardship, and women demonstrate reluctance to engage with healthcare systems when controlling for other sociodemographic factors. Findings from this study exemplify how immigration policies that restrict access to healthcare and social services not only create logistical barriers to seeking care but also foster a climate of fear and exclusion that deters even those with legal status from seeking medical attention. Full article

Global warming is driving significant changes in aquatic ecosystems, where temperature fluctuations influence biological processes across multiple levels of organisation. As ectothermic organisms, fish are particularly susceptible, with even minor thermal shifts affecting their metabolism, behaviour, and overall fitness. Understanding these responses is essential for evaluating the ecological and evolutionary consequences of climate change. This study investigates the effects of acute (4-day) and chronic (21-day) exposure to three temperature regimes—18 °C (low), 26 °C (control), and 34 °C (high)—on the spatio-temporal shoaling behaviour of adult zebrafish (Danio rerio). Groups of four fish were tested for six minutes in water maintained at the same temperature as their prior acclimation. Shoaling behaviour was assessed by analysing shoal structure—encompassing shoal dimensions and cohesion—as well as spatial positioning. Parameters measured included inter-fish distance, shoal volume, shoal area, homogeneity index, distance to the centroid, and the shoal’s vertical and horizontal distribution. Results revealed complex behavioural changes influenced by both temperature and duration of exposure. At 18 °C, zebrafish showed a marked preference for the bottom zone and exhibited no significant temporal modulation in exploratory behaviour—patterns indicative of heightened anxiety-like responses. In contrast, exposure to 34 °C resulted in increased shoal cohesion, particularly under chronic conditions, and a progressive increase in environmental exploration over the six-minute test period. This enhancement in exploratory activity was especially evident when compared to the first minute of the test and was characterised by greater vertical movement—reflected in the increased use of the upper zone—and broader horizontal exploration, including more frequent occupation of peripheral areas. These findings align with previous research linking thermal variation to neurobiological and proteomic alterations in zebrafish. By elucidating how temperature modulates social behaviour in ectotherms, this study offers valuable insights into the potential behavioural impacts of climate change on aquatic ecosystems. Full article

Resilience, the ability to adapt and thrive in the face of adversity, is an essential yet under-recognized determinant of outcomes in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), particularly those undergoing home-based peritoneal dialysis (PD). While studies have shown that PD can enhance autonomy and quality of life compared to in-center hemodialysis (IHD), it also places substantial emotional, physical and self-management demands on patients. Despite this, resilience is rarely assessed or systematically supported in PD care. This narrative review highlights the importance of resilience in CKD and dialysis populations and extends its application to the unique psychosocial challenges faced by PD patients. This review also introduces psychological frameworks of resilience, in particular the GROW model (Good emotions, Reason and purpose, Others and connections, Wellness flexibility), as tools for clinicians to support PD patients in developing optimism, purpose, strong social networks, and emotional adaptability. We also explore how routine, longitudinal assessment of resilience using validated tools can help improve patient well-being, treatment adherence, and long-term outcomes. Full article

Moral injury is increasingly recognized as a significant concern among medical personnel and first responders, particularly in high-stress healthcare and emergency settings. This review aims to synthesize current evidence on the prevalence, risk factors, and outcomes of moral injury among medical personnel and first responders across diverse healthcare and emergency response environments. We included peer-reviewed studies reporting on moral injury among medical personnel or first responders in any healthcare or emergency response setting, excluding studies that did not report original data or focused solely on military populations. We systematically searched PubMed, Google Scholar, and Central, up to April 2025. Risk of bias was assessed directly from the manuscripts. Data were synthesized narratively and, where possible, pooled using random-effects meta-analysis. A total of 41 studies involving 14,500 participants were included. The prevalence of moral injury ranged from 4.1% to 69.44% across settings. Key risk factors identified included exposure to traumatic events, organizational constraints, and lack of support. Meta-analysis indicated a significant association between moral injury and symptoms of PTSD. The evidence is limited by heterogeneity in measurement tools and study designs, as well as a moderate risk of bias in several included studies. In conclusion, moral injury is prevalent among medical personnel and first responders, with important implications for mental health interventions and organizational policy. This review was not funded externally, and is registered in PROSPERO (CRD420251019492). Full article

Background/Objectives: The use of buoyant equipment in water fitness sessions appears to elicit a more intense physiological response in water exercises. However, it remains unknown whether the shape of the equipment influences these responses. The present study aimed to analyze and compare the physiological responses and perceived effort while older women using different buoyant dumbbells during horizontal adduction/abduction of the upper limbs (HA exercise). Methods: Ten older women (76.1 ± 5.3 years of age) attended two assessment sessions to perform HA exercise at a music cadence of 120 bpm with different buoyant dumbbells (one pair for each session): round hydro and hydro crystal. Mean heart rate (HR), systolic and diastolic blood pressures (SBP and DBP, respectively), double product (DPr), blood lactate concentration ([La⁻), and rate of perceived effort (RPE) were assessed according to pre-exercise (rest), warm-up and the HA exercise (five min effort). Results: The mean HR was also analyzed according to the percentage (%) of the predicted maximal theoretical HR (HRmax). Older women reached ~56 and 61% of HRmax using crystal and round dumbbells, respectively. Differences were found in mean HR, [La⁻], and RPE with the round dumbbell showing greater values than the crystal dumbbell. Although no differences were found in SBP and DBP, DPr was higher when women used the round dumbbells. Conclusions: The shape of buoyant dumbbells seems to define acute responses of older women as the round dumbbell promotes a more intense physiological response and perceived effort when compared to the crystal dumbbell. Full article

Melanoma is the most aggressive form of skin cancer, and despite significant therapeutic advances over the past decade, a substantial number of patients still progress to a fatal outcome. The initiation and progression of melanoma are strongly influenced by interactions between melanoma cells and other components of the tumor microenvironment (TME). In this review, we focus on the interplay between fibroblasts resident in the tumor microenvironment and tumor cells. In particular, we examine the molecular mechanisms through which melanoma cells induce the transformation of resident fibroblasts into their active form, known as cancer-associated fibroblasts (CAFs). We also explore the role of CAFs in shaping the melanoma microenvironment (MME) and in organizing the pre-metastatic niche, a specialized microenvironment that forms in distant organs or tissues to support the survival and expansion of metastatic melanoma cells. Finally, we discuss emerging therapeutic strategies aimed at disrupting the interactions between CAFs, melanoma cells, and other components of the tumor microenvironment to improve treatment outcomes. Full article

Humans and nature have always been connected. Meanwhile, with the industrial revolution, landscapes have become more artificial, reducing the human–nature relationship. Urban design should follow biophilic principles to reconnect people with nature, mitigate climate change, improve air quality, restore biodiversity loss, and solve social problems. Poor air quality affects people’s health, and vegetation plays a crucial role in purifying the air. Similarly, contact with nature benefits physical and mental health and well-being. However, there is no consensus on how urban design can be beneficial for improving air quality and human health. This review paper aims to provide a comprehensive evaluation of evidence linking nature-based solutions (NBSs), air quality, carbon neutrality, and human health and well-being. Five hundred articles published between 2000 and 2024 were analysed. A number of publications studied the benefits of green infrastructure in improving air quality, carbon sequestration, or the influence of green spaces on human health. The topic of NBSs has recently emerged related to air quality, health, and promoting physical activity, as has accessibility to green spaces and mental health, also associated with blue spaces and residential gardens. The results revealed the gaps in the literature on how to design green and blue spaces to tackle environmental and public health crises simultaneously. Full article

Background: Low back pain (LBP) and musculoskeletal disorders are highly prevalent among agricultural workers. However, there is limited epidemiological evidence from rural regions of Ecuador, where working and living conditions may differ substantially from those in other settings. This study aimed to identify predictors of LBP among farmers in rural Ecuador to inform locally relevant prevention strategies. Methods: Participants aged 30 to 60 years (n = 103) were recruited through a traveling health clinic. Participants were assessed with behavioral and sociodemographic self-report questionnaires and anthropometric measurements. Low back pain (LBP) was assessed using the Standardized Nordic Musculoskeletal Questionnaire, which asked about symptoms experienced in the past 12 months. Bivariate (Chi-square and Fisher exact tests) and multivariate (binary logistic regression) analyses were conducted to explore associations between risk factors and LBP in individuals aged 30 to 60 years. Results: LBP was highly prevalent, affecting 78.6% of participants. Behavioral patterns were mixed, with low rates of smoking and moderate alcohol and coffee consumption associated with LBP. A normal body mass index (BMI) was observed in 66% of the sample, and over half reported stable mood and good self-perceived health. In the binary logistic regression analysis, only education level significantly predicted LBP, with secondary education acting as a protective factor. Conclusions: While lower back pain was widespread in the population studied, most risk factors that were analyzed were not significantly associated with its presence. Full article

The demand for maritime–coastal tourism has been intensifying, but its offerings are sometimes limited to a few activities. Some of these activities do not require specific skills or certifications, while others do. This study aimed to investigate what type of activities are carried out by tourism and recreational vessels in the coastal area of the central Algarve (Portugal). To this end, data from the automatic identification system (AIS) of recreational vessels was used to monitor and categorise these activities in a non-intrusive manner. A model (TORMA) was defined to facilitate the analysis of AIS data and relate them to five independent variables (distance from the coast, boat speed, bathymetry, seabed type, and number of pings). The results of the analysis of more than 11 thousand hourly AIS records for passenger, sailing, and charter vessels showed that the 14 most regular ones had strong seasonal patterns, greater intensity in summer, and spatial patterns with more records near some coastal cliffs. This study provides valuable information on the management of motorised nautical activities near the coast and at sea, contributing to more informed and effective tourism regulation and planning. Full article