Search Results (63)

Brain-derived neurotrophic factor (BDNF) is associated with nicotine use behaviours, the intensity of nicotine cravings, and the experience of withdrawal symptoms. Given the established influence of sex, brain-derived neurotrophic factor variants, personality traits and anxiety levels on nicotine use, this study aimed to conduct a comprehensive association analysis of these factors within a cohort of women who use nicotine. The study included 239 female participants: 112 cigarette users (mean age = 29.19, SD = 13.18) and 127 never-smokers (mean age = 28.1, SD =10.65). Study participants were examined using the NEO Five-Factor Inventory and the State–Trait Anxiety Inventory. Genotyping of rs6265, rs10767664, and rs2030323 was performed by real-time PCR using an oligonucleotide assay. We did not observe significant differences in the distribution of either genotype or allele of rs6265, rs10767664 and rs2030323 between groups. However, compared to the never-smokers, cigarette users scored significantly lower on the Agreeableness (5.446 vs. 6.315; p = 0.005767; d_Cohen’s = 0.363; η² = 0.032) and the Conscientiousness (5.571 vs. 6.882; p = 0.000012; d_Cohen’s = 0.591; η²= 0.08) scales. There was significant linkage disequilibrium between all three analysed polymorphic variants—between rs6265 and rs10767664 (D′ = 0.9994962; p < 2.2204 × 10⁻¹⁶), between rs6265 and rs2030323 (D′ = 0.9994935; p < 2.2204 × 10⁻¹⁶) and between rs10767664 and rs20330323 (D′ = 0.9838157; p < 2.2204 × 10⁻¹⁶), but the haplotype association analysis revealed no significant differences. While our study did not reveal an association between the investigated brain-derived neurotrophic factor polymorphisms (rs6265, rs10767664 and rs2030323) and nicotine use, it is essential to acknowledge that nicotine dependence is a complex, multifactorial phenotype. Our study expands the current knowledge of BDNF ’s potential role in addictive behaviours by exploring the understudied variants (rs10767664 and rs2030323), offering a novel contribution to the field and paving the way for future research into their functional relevance in addiction-related phenotypes. The lower Agreeableness and Conscientiousness scores observed in women who use nicotine compared to never-smokers suggest that personality traits play a significant role in nicotine use in women. The observed relationship between personality traits and nicotine use lends support to the self-medication hypothesis, suggesting that some women may initiate or maintain nicotine use as a coping mechanism for stress and negative affect. Public health initiatives targeting women should consider personality and psychological risk factors in addition to biological risks. Full article

Background/Objective: Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the time. Methods: To understand the evolution of scientific publications on fentanyl and its relationship to the opioid crisis, a search using Web of Science Core Collection and PubMed was conducted. A total of 53,670 documents were retrieved related to opioid scientific production, among which 1423 articles (3%) focused specifically on fentanyl. The 21,546 MeSH terms identified in these documents were analysed by publication year and specific fields: Psychiatry and Psychology, Chemicals and Drugs, Healthcare, Diseases, and Phenomena and Processes. R-statistical/FactoMineR libraries were used for the correspondence analysis. Results: In the first overdose death wave, research focused on improving therapies and reducing side effects. The second wave emphasised detoxification methods with naltrexone, methadone, and behavioural therapies. The third wave addressed psychological treatments and HIV-syringe-sharing prevention. The fourth wave prioritised less addictive analogues and understanding consumer profiles to combat the epidemic. Conclusions: Fentanyl research has evolved alongside real-world challenges, reinforcing the connection between patients’ needs, healthcare professionals’ roles, illicit users, policymakers, and the research community’s contributions to addressing both therapeutic use and its broader societal impact. These findings highlight the necessity for an interdisciplinary approach to scientific research integrating prevention, treatment, education, legal reform, and social support, emphasising the need for public health policies and collaborative research to mitigate its impact. Full article

Substance Use Disorders (SUDs) are frequently associated with impairments in emotional regulation and behavioural control. Among the most prevalent substances of abuse, alcohol and cocaine are known to exert distinct effects on neuropsychological functioning. This study aimed to compare individuals with Alcohol Use Disorder (AUD) and Cocaine Use Disorder (CUD) in terms of impulsivity and alexithymia, and to examine the clinical implications of poly-substance use involving both alcohol and cocaine. Participants completed standardized psychometric assessments, including the Barratt Impulsiveness Scale (BIS-11), the Brief Psychiatric Rating Scale (BPRS), and the Toronto Alexithymia Scale (TAS-20). Group comparisons were conducted using non-parametric tests, and logistic regression models were applied to control for demographic covariates. The findings showed that impulsivity levels were comparable across groups, whereas alexithymia scores were significantly higher in individuals with AUD and in those with poly-substance use, relative to CUD-only participants. These findings underscore the relevance of targeting emotional regulation difficulties, particularly alexithymia, in the assessment and treatment of SUDs. Integrating emotion-focused interventions may enhance treatment outcomes, especially for individuals with co-occurring substance use patterns. Future research is needed to clarify the underlying neuropsychological mechanisms contributing to these differences and to inform more personalized approaches to addiction care. Full article

Psychedelic substances have recently emerged as a promising method for treating mental health conditions, despite a history of stigmatization and restriction in use. The present review synthesizes existing literature on the therapeutic potential of psychedelics such as LSD, psilocybin, and MDMA in addressing specific mental health conditions like depression, anxiety, and addiction. On reviewing the existing literature, it became apparent that when administered in controlled settings with psychological support, psychedelics can induce profound psychological insights, leading to long-lasting and positive changes in mood, cognition, and behaviour. This review discusses the ethical, social, and regulatory challenges linked to using psychedelics within the mental health sector across different countries, and how these might influence societal beliefs towards their efficacy and use. Further research would be beneficial for eliciting a deeper understanding of the use of psychedelics in the field of mental health, leading to the development of standardized administration protocols and a thorough appreciation of societal implications and long-term outcomes. This review discusses the potential for psychedelics to revolutionize mental health treatment while underlining the urgent need for rigorous scientific inquiry on this topic and the ethical considerations surrounding the use of psychedelics for therapeutic purposes. Full article

There is growing evidence that public hospitals in high-income countries—in particular, Anglo-Saxon neoliberal countries (USA, UK, Canada, New Zealand, and Australia)—have been engaging with food retailers to attract private capital and maximise their incomes in a drive to reduce costs. Added to which, public hospital food can have a substantial influence on the health of children and young people. However, there is still relatively little research on food for young people in healthcare settings. This is concerning, as an appropriate food intake is vital not only for the prevention of and recovery from diseases, but also for the physical growth and psychological development of young people. This critical narrative review examined the available evidence on hospital food provision, practices, and environments, as well as children’s experiences of hospitalization in high-income countries, drawing on both peer-reviewed articles and the grey literature. Our analytical lens for this review was the Commercial Determinants of Health (CDOH), a framework that necessitates a critical examination of commercial influences on individual, institutional, and policy practices relevant to health. Our findings illustrate the mechanisms through which the CDOH act as a barrier to healthy food and eating for children in hospitals in high-income countries. Firstly, hospital food environments can be characterised as obesogenic. Secondly, there is a lack of culturally inclusive and appropriate foods on offer in healthcare settings and an abundance of processed and convenience foods. Lastly, individualised eating is fostered in healthcare settings at the expense of commensal eating behaviours that tend to be associated with healthier eating. Public hospitals are increasingly facing commercial pressures. It is extremely important to resist these pressures and to protect patients, especially children and adolescents, from the marketing and selling of foods that have been proven to be addictive and harmful. Full article

According to ontological addiction theory, the root cause of mental suffering is a dysfunctional conceptualisation of the self. Typically, an individual with such a flawed self-concept deems themselves to be intrinsically separate from their surroundings, with their beliefs, choices and behaviours structured in order to reinforce their sense of an independently existing self. The Ontological Addiction Scale (OAS) was developed to measure ontological addiction and demonstrates good psychometric properties for the original version validated in English. The present study aimed to validate a French language version of the OAS. The 24-item OAS was administered to 492 French adults with emotional and/or mood disorders. The French OAS demonstrated good internal consistency (Cronbach’s alpha: 0.89) and strong test–retest reliability. We suggest a single-factor structure, aligning with the original English version. The 12-item OAS also showed good internal consistency (Cronbach’s alpha: 0.81). Construct validity was confirmed by medium to large correlations with self-esteem, shame, perfectionism and mindfulness. These results support the use of the French OAS in research and clinical practice, offering a robust measure for assessing ontological addiction as well as a dimensional assessment of psychiatric symptoms. Full article

The growth seen in the number of addictive behaviours related to substance and drug use among adolescents has become one of society’s major problems. Several research studies have tried to find answers to this problem, highlighting the potential of physical activity as a prevention method for substance abuse. The aims of this study were (1) to conduct a systematic review analysing the effects of physical activity, exercise or sports-based interventions on substance use among young people and adolescents and (2) to describe and analyse these interventions. To this end, the guidelines of the PRISMA Declaration were followed, and six databases were searched: PubMed, Web of Science (WOS), PsycINFO, ERIC, SPORTDiscus, and SCOPUS. After screening and meeting the proposed eligibility criteria, a total of 10 articles were included. The results provided scientific evidence of the benefits of physical activity in preventing and reducing substance use, most significantly in interventions based on yoga and structured physical activity. Full article

Background: The role of emotional intelligence on the experience of behavioural addictions is a growing area of research interest. However, there are operationalisation issues in studying both emotional intelligence and behavioural addictions separately. This review aims to report on the existing literature of studies exploring the relationship between these two concepts, and to identify gaps in research practice in order to inform future studies. Methods: A search, covering the date range of 2013–2024, conducted in five databases in August 2024 identified 43 articles, reported according to PRISMA 2020 guidelines. The findings are discussed under four subheadings: technology-related behavioural addiction, internet gaming disorder, eating disorders, and consumer behaviour and compulsive buying. Results: Overall, the results show that emotional intelligence is negatively correlated with behavioural addictions and plays both a moderating and mediating role in the associations between behavioural addictions and other negative outcomes such as suicidal ideation, rumination, fear of missing out, and depression. Conclusions: In addition to summarising studies and controversial discussions on emotional intelligence and behavioural addictions, this review suggests possible roadmaps to ensure more accurate research outcomes by highlighting the importance of theoretical and methodological distinctions between trait and ability models of emotional intelligence. Full article

This study examines the association between problematic internet use, or internet addiction, and adolescent mental health, focusing on key psychological variables, assessing the strength of these associations, and identifying potential moderating factors. Methods: A search of the Web of Science databases over the past five years identified 830 articles. Of these, 33 met the inclusion criteria, involving 303,243 participants (average age 14.57; 49.44% female). The selection process was verified by two researchers. Results: Nine psychological variables were analyzed: depression, anxiety, stress, suicidal behaviour, psychological well-being, self-esteem, externalizing problems, aggressiveness, and impulsiveness. Internet addiction showed positive correlations with aggressiveness (r+ = 0.391), depression (r+ = 0.318), anxiety (r+ = 0.252), and suicidal behaviour (r+ = 0.264). Negative correlations were observed with psychological well-being (r+ = −0.312) and self-esteem (r+ = −0.306). No significant associations were found for externalizing problems, impulsiveness, or stress. None of the moderators showed a significant correlation with internet addiction and depression. Conclusions: Although limited by small sample sizes for some variables and the cross-sectional design of most studies, the findings confirm that there is a negative relationship between internet addiction and adolescent mental health. It is related to poorer self-perceived health, greater psychological distress, and greater aggression. Full article

This study aimed to explore students’ perspectives on integrating artificial intelligence (AI) into scientific collaboration, specifically on writing academic articles and creating scientific posters. The research employed open-ended interviews conducted among 61 civil and military students. Opinions were labelled, coded, and gathered into the following categories: positive impact on collaboration, challenges faced, and educational impact. Among the positives were improving efficiency, enhancing the quality of work, and generating new ideas. The challenges concerned experiencing technical difficulties with AI tools, inconsistency in AI outputs, and AI dependence, which may lead to behaviours on the verge of addiction. Regarding educational impact, students noticed that AI helps improve learning new skills, increases engagement in the task, and enhances critical thinking. As one researcher performed the thematic analyses, Cohen’s Kappa statistic was used to ensure intra-coder reliability. This study highlights the need for further research to optimize the use of AI in scientific collaboration while addressing ethical concerns related to students’ motivations for using AI tools, promoting responsible use, and researching students’ emotions, cognitive processes, and behaviours resulting from their interactions with AI tools. The research provides valuable insights for educators and policymakers to integrate AI effectively into academic practice. Full article

The authors present changes in the content and teaching methods of religious education (RE) in the third decade of the 21st century, as proposed by the current curricular reform of compulsory education in Slovakia. First, they analyse the reform documents in terms of social competence development as one of the RE content requirements. Second, they seek a teaching methodology that applies a balanced approach to the use of information and communication technologies (ICT) while protecting RE pupils and their building of healthy human relationships from the potential threat of digital addiction. The authors based their teaching ideas on the findings from their research. To explore the relationship between addictive Internet behaviour and social intelligence, they used a questionnaire including the Internet Addiction Test and the TSIS Scale. The Mann–Whitney U test was used for statistical analysis. Data on 386 adolescent respondents revealed a statistically significant difference between males and females in social awareness, with males performing significantly better. A weak positive relationship (ρ = 0.240) was identified between social awareness and addictive Internet behaviour. In the discussion, the authors suggest teaching methods for developing social competence via RE without resisting the opportunities provided by ICT, while also avoiding an increase in the risk of online social media addiction. They suggest that even denominational RE should prioritize cultivating healthy relationships not only with God but also relationships with other people, the outside world, and oneself. Full article

Introduction: Methamphetamine is a highly stimulating psychoactive drug that causes life-threatening addictions and affects millions of people around the world. Its effects on the brain are complex and include disturbances in the neurotransmitter systems and neurotoxicity. There are several known treatment methods, but their effectiveness is moderate. It must be emphasised that no drugs have been approved for treatment. For this reason, there is an urgent need to develop new, effective, and safe treatments for methamphetamine. One of the potential treatments is mindfulness meditation. In recent years, this technique has been researched extensively in the context of many neurological and psychiatric disorders. Methods: This review explores the use of mindfulness in the treatment of methamphetamine addiction. Searches were conducted in the PubMed/Medline, Research Gate, and Cochrane databases. Results: Ten studies were identified that used mindfulness-based interventions in the treatment of methamphetamine addiction. The results show that mindfulness is an effective form of reducing hunger, risk of relapses, stress indicators, depression, and aggression, alone or in combination with transcranial direct current stimulation (tDCS). Mindfulness also improved the cognitive function in addicts. The included studies used only behavioural measures. The potential mechanisms of mindfulness in addiction were explained, and it was proposed that it can induce neuroplasticity, alleviating the symptoms of addiction. Conclusions: Evidence from the studies suggest that mindfulness may be an effective treatment option for methamphetamine addiction, used alone or in combination with tDCS. However, further high-quality research is required to establish the role of this treatment option in this field. The use of neuroimaging and neurophysiological measures is fundamental to understand the mechanisms of mindfulness. Full article

Eating behaviour (EB) is a complex system affected by different factors, including food liking and psychology. Researchers have highlighted the importance of genetics in EB, but little is known. Therefore, this study aimed to investigate the genetic factors involved in EB in Italian cohorts, Friuli-Venezia Giulia (FVG) and Val Borbera (VB). Genome-Wide Association Studies (GWAS) on food liking were performed in FVG (n = 575). The relationships between the genetic findings and other variables of interest (i.e., psychological outcomes) were evaluated using linear regression models. A replication study was carried out in an independent cohort (VB, n = 701). GWAS revealed a significant association between the liking of milk chocolate and a region on chromosome 5. The most associated single nucleotide polymorphism (SNP) was rs73280705 (p = 1.02 × 10⁻⁹), an eQTL for the LARP1 gene in the nucleus accumbens (NAc). Subjects carrying the minor allele of the SNP show a reduced liking for milk chocolate, as well as a minor overall liking for a milk-based food group. The latter finding was replicated in VB (p = 0.026). Regarding the psychological data, these subjects also present a reduced impulsivity (p = 0.031). On the other hand, carriers of the counterpart allele show an increased liking for milk-based food and a high impulsivity (p = 0.023). These data are not influenced by the lactose deficiency allele. The results suggest that this genetic region could play a role in both impulsivity and food liking. Indeed, individuals carrying the LARP1 gene variant show a decrease in liking for milk chocolate and milk-based food, as well as in impulsivity, while the others are more impulsive, like more milk-based foods and, in general, sweet and fatty foods. LARP1 is expressed in the NAc, which is a central driver of reward response controlling the pleasantness and gratification given by food (mostly triggered by highly palatable foods). Moreover, the NAc also plays a role in integrating limbic system stimulation into the motor system, which can lead to addictive and impulsive behaviours. Additional studies are needed to increase our knowledge on this extremely interesting gene association and, overall, on the LARP1 gene’s relationship with milk and mTORC1, food liking, and EB. Full article

Background and objectives: Research about exercise addiction, perfectionism and orthorexia within endurance sports is emerging. Endurance sports athletes might have a higher risk of exercise addiction and eating disorders. Cycling is a popular endurance sport, but research in this population is lacking. The present study aimed to explore the relationship between exercise addiction, perfectionism, and orthorexia within cycling. Methods: A cross-sectional survey was applied, including validated questionnaires assessing the cognitions, behaviors, and feelings related to an extreme focus on healthy eating (Eating Habits Questionnaire; EHQ), compulsion to exercise (CET-A Questionnaire), and perfectionistic tendencies (Multidimensional Perfectionism Questionnaire). Demographic information such as age, training hours, gender, and competition level were also collected. Results: Sixty-one male (n = 5; 8.2%) and female (54; 88.5%) cyclists with a mean age of 32 ± 7 years completed the survey. Higher scores in orthorexia were significantly associated with higher exercise addiction (β = 0.41; p < 0.001) and total perfectionism scores (β = 0.38; p < 0.01). Higher orthorexia was also associated with higher scores for self-oriented perfectionism (β = 0.34, p < 0.05) and higher weight control (β = 0.39, p < 0.01). Higher EHQ-Knowledge was associated with higher self-oriented (β = 0.33, p < 0.05) and other-oriented perfectionism (β = 0.30, p < 0.05) and higher EHQ-Problems and EHQ-Feelings were associated with higher weight control (β = 0.39, p < 0.01 and β = 0.41, p < 0.01 respectively). Cyclists who trained 16–20 h per week had significantly lower scores on total perfectionism and socially prescribed perfectionism than those who trained 6–10 h per week (p < 0.05). No other significant effects of training hours on exercise addiction or orthorexia were observed. Discussion: The potential risk of an individual developing orthorexia may be significantly predicted by high levels of exercise addiction and perfectionism within the cycling population. The high levels of self-oriented perfectionism observed highlight a potential predisposition or susceptibility within certain populations to the adoption of maladaptive behaviours in relation to diet. Further research is needed to explore the role of perfectionism and exercise addiction as risk factors for orthorexia in amateur and professional cyclists. Full article

Research into the complexities of addictive eating behaviours continues to develop, as a deeper understanding of this construct beyond self-report diagnostic tools emerges. In this study, we undertook structured interviews with 40 participants engaged in a personality-based management program for addictive eating, to gain insight into what situations lead people with addictive eating behaviours to overeat, and how they believe their lives would be different if they had control over their eating. A phenomenological analysis to explore compulsion and control in the context of food experiences for participants was used to construct two main themes of the addictive eating paradox and striving to transition from ‘other’ to ‘normal’. The addictive eating paradox identified multiple contradictory experiences of a situation, e.g., ‘loving food’ but ‘hating food’. Striving to transition from ‘other’ to ‘normal’ encompassed the idea that participants envisaged that by gaining control over their eating they could become ‘normal’. This study emphasises the need to provide support and strategies to help people navigate paradoxical thoughts and presents new ideas to increase the effectiveness of interventions for individuals struggling with the complex self-beliefs held by those with addictive eating behaviours. Full article