Search Results (2,180)

This study explores how Brazilian logistics companies manage road safety by identifying key practices, motivators, and barriers. While traffic safety has been widely studied, few investigations adopt an organizational perspective, especially in the logistics sector. Addressing this gap, we applied a mixed-methods approach combining expert input (qualitative phase) and a structured survey of industry professionals (quantitative phases). The findings reveal that practices such as infrastructure development, driver training, and compliance monitoring are perceived as most effective. Motivators include operational planning and economic incentives, while major barriers involve lack of internal motivation, awareness, and resource constraints. Factor analysis confirmed the structure of practices, motivators, and barriers, while a SWOT framework provided strategic insights into internal strengths and external challenges. This study offers practical recommendations for integrating safety into strategic planning, improving training, and strengthening collaboration with public actors. By aligning safety efforts with long-term business goals, logistics providers can enhance both operational performance and social responsibility. These results contribute to global discussions on sustainable logistics by supporting key Sustainable Development Goals, including SDG 3.6 (road safety), SDG 8.8 (safe working environments), SDG 9.1 (sustainable infrastructure), and SDG 11.2 (safe and accessible transport). Full article

While MOOCs have gained prominence in higher education, their role in fostering pedagogical and technological readiness among teachers remains underexplored. This study addresses this gap by leveraging the Technology Acceptance Model to investigate how MOOCs influence teachers’ digitally inclined attitudes and therefore professional growth. By employing a mixed-methods approach, the research explores how perceived usefulness and perceived ease of use influence participants’ behavioural intentions, the emergence and use of MOOCs in teacher education and learning practices from MOOCs. A total of (n = 144) primarily teachers, in their pre-service and in-service stage, completed the “Teaching Thinking” MOOC. Data collection involved pre- and post-course surveys, as well as open-ended questionnaires for a subset of participants. Quantitative findings revealed initial ambivalence toward MOOCs, with moderate Perceived Usefulness and Perceived Ease of Use scores, tempered by concerns over time management and platform usability. Post-course analysis showed significant improvements in participants’ perceptions, highlighting increased acceptance and acknowledgment of MOOCs’ flexibility and access to diverse resources. Qualitative insights underscored key factors driving these shifts, including instructor support, peer interactions, and self-directed learning environment. Results suggest that MOOCs foster critical skills such as time management, problem-solving, and professional engagement while contributing to participants’ self-efficacy and readiness to integrate technology into teaching practices. Challenges identified include technical barriers, lack of personalised feedback, and initial reluctance to adopt online learning. This study underscores MOOCs’ transformative potential in teacher education, emphasising the importance of tailored course design, supportive learning environments, and strategic policy initiatives to enhance engagement and outcomes. Full article

Background/Objectives: Ocular drug delivery faces significant challenges due to anatomical and physiological barriers that limit drug bioavailability, particularly with conventional eye drops. Levofloxacin (LEVO), a broad-spectrum antibiotic, is widely used in the treatment of bacterial conjunctivitis, but its therapeutic efficacy is hindered by rapid precorneal clearance and short residence time. Methods: This study introduces a biorelevant 2 mL dissolution model to simulate ocular conditions better and evaluate the release kinetics of LEVO-loaded nanofibrous ophthalmic inserts. Compared to the conventional 40 mL setup, the 2 mL system demonstrated a slower and more sustained drug release profile, with kinetic modeling confirming a more controlled release behavior. Difference and similarity factor analysis further validated the distinct release profiles, highlighting the impact of dissolution volume on release dynamics. Results: Preliminary pharmacokinetic modeling suggested that the nanofiber inserts, particularly when applied twice daily, maintained levofloxacin concentrations above minimum inhibitory and bactericidal levels for extended durations across three bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus), potentially outperforming traditional eye drops. Conclusions: These findings suggest that small-volume dissolution testing may provide a more realistic method for evaluating ophthalmic insert formulations, though in vivo validation is needed. Moreover, the nanofibrous inserts show potential as a sustained-release alternative that warrants further investigation to improve patient compliance and therapeutic outcomes in ocular disease management. Full article

Conventional permanent magnet-assisted synchronous reluctance machine (PMaSynRM) suffers from limited power factor and efficiency. To boost these, the use of sintered rare earth permanent magnets (PMs) is an option, with respect to sintered ferrite, resulting in a high-performance PMaSynRM (HP-PMaSynRM). However, the increasing price of rare earth PM can lead to an overall increase in machine cost. To overcome this issue, a novel HP-PMaSynRM is presented in this paper. Structurally, the proposed four-pole HP-PMaSynRM rotor is characterized by two fluid-shaped flux barriers filled with sintered ferrite, as well as a cut-off region. Based on the finite element analysis (FEA) results, the proposed HP-PMaSynRM exhibits higher performance compared with the conventional HP-PMaSynRM with rare earth PMs. It is shown that the proposed HP-PMaSynRM has higher power factor, efficiency, and better torque quality over a wide range of operating conditions. Moreover, the HP-PMaSynRM presented incurs lower cost. Finally, the proposed HP-PMaSynRM is manufactured, tested, and compared with the conventional benchmark HP-PMaSynRM, proving its advantages, including higher power factor, higher efficiency, lower torque oscillation, and lower cost. Full article

In many disaster-prone regions, lower-income communities face disproportionate impacts due to the prevalence of informal housing. Informal housing, characterized by substandard construction and lack of adherence to building codes, exacerbates vulnerabilities during disasters, leading to widespread destruction and hampered recovery efforts. This study examines the multifaceted causes of informal housing in Puerto Rico using a qualitative content analysis of applicable literature. Seven interdisciplinary factors were derived from 42 relevant manuscripts with identifiable factors linked to informal housing in Puerto Rico: Knowledge, Perception, Government Dynamics, Institutional Support, Enforcement, Culture, and Resources. Despite post-disaster efforts advocating for building back better, systemic challenges perpetuate informal housing practices, reinforcing cycles of vulnerability. This research underscores the need for integrated decision making in pre-disaster preparation and post-disaster reconstruction efforts. This research presents a detailed understanding of the Informal Housing Cycle, demonstrates how interdisciplinary factors are barriers to safe and sustainable housing, and explores the complex relationships between these factors. This study aims to guide policy and practice to reduce future disaster impacts on Puerto Rico housing, thus breaking the cycle of vulnerability, empowering communities, and fostering sustainable resilience in post-disaster reconstruction efforts. Full article

The objective of this article is to identify and analyze the factors shaping the behavior of Chinese consumers in the organic product market, with a particular focus on young members of Generations Y and Z. These factors are examined in the context of organic consumption and sustainable development, taking into account global and local trends in the organic food market as well as the role of consumers in stimulating clean production and a circular economy. The article applies a research approach that combines a review of the literature with an analysis of quantitative data. In 2022, an online survey was conducted among 1012 Chinese users of the most popular social media platforms, primarily WeChat and Sina Weibo. The respondents were young consumers from Generations Y and Z. The sample was drawn from the IMAS International online panel. The study identified the characteristics attributed to organic food, the frequency and structure of purchases (product categories and share of organic products in the shopping basket), key motives and choice criteria, barriers to purchase, sources of information on organic products, and the role of promotional tools in shaping attitudes and behaviors. The results show that pro-environmental consumption fosters sustainable development and cleaner production, with younger generations emerging as the driving force behind sustainable consumption. The analysis revealed both stimulating and limiting factors influencing the development of sustainable consumption, and highlighted the critical role of digital channels in shaping consumer attitudes and decisions. The study also discusses implications for market stakeholders (producers, distributors, educational institutions, and policymakers) in leveraging the potential of young Chinese consumers as a catalyst for cleaner production and the circular economy. Full article

Background/Objectives: Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis and infant hospitalization in the US. RSV prevention evolved in 2023 as nirsevimab and maternal RSV pre-fusion vaccine became available for healthy newborns and infants. This study investigates sociodemographic characteristics associated with RSV immunoprophylaxis. Methods: A cross-sectional survey was conducted from November 2023 through March 2024 among a convenience sample of parents of infants aged <8 months who received newborn care or pediatric ambulatory care at a single academic institution in Central Pennsylvania, USA. Logistic regression examined sociodemographic factors associated with RSV immunoprophylaxis uptake. Given the nirsevimab shortage during the 2023–2024 RSV season, a sensitivity analysis was completed for intended immunoprophylaxis. Results: Among 118 participants, 66.9% received RSV immunoprophylaxis while 74.5% intended to receive nirsevimab. Higher income, private insurance, out-of-home childcare, and an adult/partner working in healthcare were associated with intended nirsevimab receipt. Participation in the Women, Infants and Children program was associated with lower rates of intended nirsevimab receipt. Out-of-home childcare was associated with both RSV immunoprophylaxis uptake and intended nirsevimab receipt. Conclusions: Sociodemographic factors significantly influence the intent to receive nirsevimab and RSV immunoprophylaxis uptake. Having an adult/partner in healthcare was the most significant predictor for intent, suggesting that greater health literacy drives immunization intention. Enrollment in out-of-home childcare was the sole predictor of RSV immunoprophylaxis uptake. These findings highlight the importance of policy initiatives that promote equitable access to RSV immunoprophylaxis, including strategies to address socioeconomic barriers, improve health literacy, and ensure consistent availability of preventive agents for all infants. Full article

This study examines the role of fintech adoption in enhancing financial inclusion in Qatar, with a particular focus on the mediating influence of access barriers. A structured questionnaire was administered to 220 respondents, of which 200 valid responses were retained for analysis after screening for completeness and outliers. The constructs of fintech adoption (FA), financial inclusion (FI), and access barriers (AB) were measured using validated multi-item scales adapted from prior literature. Measurement reliability and validity were confirmed through Cronbach’s alpha, composite reliability, and average variance extracted (AVE), alongside confirmatory factor analysis (CFA) for construct validity. A structural equation modeling (SEM) approach was employed to test the hypothesized relationships, using maximum likelihood estimation with bootstrap standard errors and confidence intervals. Model fit indices indicated excellent fit (χ² = 48.983, df = 51, p = 0.554; CFI = 1.000; TLI = 1.003; RMSEA = 0.000; SRMR = 0.036). Factor loadings were all significant (p < 0.001), supporting convergent validity. However, the structural paths from FA to FI (β = −0.020, p = 0.827), AB to FI (β = −0.077, p = 0.394), and FA to AB (β = 0.054, p = 0.527) were not significant. The indirect mediation effect of AB was also statistically insignificant (β = −0.004, p = 0.700). Full article

Inequalities in enrollment in STEM persist for those entering higher education as first-generation college students, underserved racial and ethnic groups, female and nonbinary individuals, and those from lower socioeconomic backgrounds. The current study aims to better understand the relationship students have with graduate school success factors by redistributing the Graduate Student Success Survey+ (GSSS+) at an R2 institution in the southeastern United States. Exploratory factor analysis was used to test the survey’s validity, with 242 participants. A 7-factor, 40-item model was developed, comprising the following subscales: mentor support, peer support, imposter phenomenon, financial support, microaggressions (related to race and gender), access and opportunity (for research, writing, and presentations), and resilience. Item analysis identified perceived barriers (e.g., microaggressions, imposter phenomenon, and financial stress) for underserved students (i.e., females, underserved racial and ethnic groups, and part-time students). Regression analysis on resilience revealed a positive relationship with mentor support, peer support, and financial support. A negative relationship with resilience was associated with a greater perception of imposter phenomenon. Findings from this study underscore the need for additional support from mentors and other university entities to foster a stronger sense of resilience in students, along with increased opportunities for participation in research, academic writing, and publication. Full article

As a critical ecological barrier and key dryland agricultural zone in China, the Loess Plateau is faced with acute tensions between food security risks arising from cropland abandonment (CA) and the imperatives of ecological conservation. Yet, existing research has failed to adequately capture the long-term, high-spatiotemporal-resolution dynamics of abandonment in this region or to quantitatively couple its driving mechanisms with implications for food security. To address these gaps, this study establishes a high-precision identification system for CA tailored to the Plateau’s complex topographic conditions, distinguishing among interannual abandonment, multiyear abandonment, conversion to forest/grassland, and reclamation. Leveraging long-term data from 2000 to 2023 and integrating the Mann–Kendall test with the random forest algorithm, we examine the spatiotemporal trajectories, driving forces, and food security consequences of CA. Guided by a “type differentiation–grade classification–temporal tracking” framework, the analysis reveals a marked transition in dominant drivers from “socioeconomic factors” to “topographic–climatic factors.” It further identifies an “increasing loss–slowing growth” effect of abandonment on grain production, alongside a “pressure alleviation” trend in per capita carrying capacity. The results showed that: (1) Between 2000 and 2023, the area of CA on the Loess Plateau expanded from 2.72 million ha to 6.96 million ha, with high-grade abandonment (≥8 years) accounting for 58.9% of the total and being spatially concentrated in the hilly–gully regions of northern Shaanxi and eastern Gansu; (2) The Grain for Green Project (GFGP) peaked at approximately 340,000 hectares in 2018, followed by a slight decline, but has generally remained at around 300,000 hectares since then; (3) The reclamation rate of CA remained between 5% and 12% during 2003–2015, with minimal overall fluctuations, but after 2016, it gradually increased and peaked at 23.4% in 2022; (4) In terms of driving forces, population density (14.99%) was the primary determinant in 2005, whereas by 2020, slope (15.43%) and mean annual precipitation (15.63%) emerged as core factors; and (5) Grain yield losses attributable to abandonment increased from less than 100 t to nearly 450 t, though the growth rate slowed after 2016, accompanied by gradual alleviation of pressure on per capita carrying capacity. Overall, the study offers robust empirical evidence to inform cropland protection, food security strategies, and sustainable agricultural development policies on the Loess Plateau. Full article

Despite notable progress in HIV prevention and treatment, men who have sex with men (MSM) continue to bear a disproportionate burden of HIV, particularly in sub-Saharan Africa, where systemic barriers restrict access to HIV testing. This study draws on data from the 2017 Ghana Men’s Study II (GMS II), to examine the socio-demographic, behavioural, and structural factors influencing HIV testing among MSM. The Ghana Men’s Study II dataset, involving 4095 MSM, was de-identified and analysed using STATA (software version 17). Before the analysis, missing information for categorical variables were treated using the mode imputation technique. Chi-square test was done to describe relevant characteristics of the study population, such as socio-demographic/socio-economic variables and behavioural practices. Multivariable logistic regression analysis was performed for variables with p < 0.05 to determine significant predictors of HIV testing among MSM. All the statistical analyses were performed at a 95% confidence interval, with significant differences at p < 0.05. In multivariable logistic regression analysis, age 25–34 (AOR: 1.43; 95% CI: 1.18–1.74, p < 0.001), having a senior high school education (AOR: 1.69; 95% CI: 1.02–2.80, p = 0.040), tertiary education (AOR: 2.03; 95% CI: 1.17–3.55, p = 0.012), being a light drinker of alcohol (AOR: 1.28; 95% CI: 1.04–1.58, p = 0.020), and having a comprehensive knowledge of HIV (AOR: 1.50; 95% CI: 1.26–1.78, p < 0.001) had higher odds for HIV testing. Other factors such as being a Muslim (AOR: 0.69; 95% CI: 0.54–0.90, p = 0.005) and sold sex to other males (AOR: 0.67; 95% CI: 0.50–0.90, p = 0.007) were also positively associated with HIV testing among Ghanaian MSM. The findings revealed a number of socio-demographic and behavioural factors associated with HIV testing among the MSM population in Ghana. Full article

This study systematically identifies and prioritizes barriers to Industry 4.0 adoption in manufacturing within a developing economy. We used a mixed-methods approach—combining a systematic literature review and PLS-SEM. The research synthesizes 45 critical factors across nine I4.0 pillars, mapped to five sustainability dimensions. Data from 160 professionals show the technological dimension (β = 0.218) to be the most significant broad barrier. Analysis of high outer loadings (≥0.80) highlights key specific barriers: IT infrastructure gaps and poor technological leverage; a lack of organizational and digital readiness; cultural fragmentation and weak knowledge systems; high implementation and cyber threat costs; and low customization demands with absent data standards. The study proposes a maturity model and strategic framework to help policymakers address these barriers and promote sustainable digital transformation. Full article

Hemophilia, an X-linked recessive bleeding disorder, results from mutations in the F8 or F9 genes, leading to factor VIII (hemophilia A) or factor IX (hemophilia B) deficiency. While conventional treatment relies on regular factor replacement therapy, gene therapy has emerged as a promising alternative, offering the potential for sustained endogenous factor production after a single administration. This review provides an in-depth analysis of recent advances in gene therapy for both hemophilia A and B, with a focus on AAV-mediated liver-directed approaches and other approved modalities. Key limitations—such as vector immunogenicity, hepatic toxicity, waning transgene expression, and limited re-dosing capacity—are discussed. Additional gene delivery platforms, including lentiviral and retroviral vectors, genome editing techniques (e.g., CRISPR/Cas9), and non-viral systems like transposons and lipid nanoparticles, are also examined. Although gene therapy for hemophilia B demonstrates greater clinical durability, hemophilia A presents unique challenges due to factor VIII’s size, poor expression efficiency, and the need for higher vector doses. Future efforts will focus on overcoming immune barriers, improving delivery technologies, and developing approaches suitable for pediatric patients and individuals with pre-existing immunity. This review provides not only a descriptive overview but also a critical comparison of gene therapy approaches for hemophilia A and B. We emphasize that the durability of response is currently superior in hemophilia B, whereas hemophilia A still faces unique barriers, including declining FVIII expression and higher immunogenicity. By analyzing cross-platform challenges (AAV, lentiviral, CRISPR, and emerging LNPs), we highlight the most promising strategies for overcoming these limitations and provide a forward-looking perspective on the future of gene therapy. Full article

In recent years, as the number of cats has increased, the intestinal health of cats has receied increasing amounts of attention. Probiotics have positive effects on maintaining intestinal homeostasis. This study was conducted to investigate the effects of probiotics Bacillus licheniformis (B. licheniformis) and Bacillus subtilis (B. subtilis) on cat immunity, inflammation, antioxidants, intestinal barrier and microbiota, and serum metabolites. Thirty-six cats (over one year old, 3.48 ± 0.71 kg) were randomly divided into 3 groups and fed with a basal diet (CON group), a basal diet + B. licheniformis (BL group), and a basal diet + B. subtilis (BS Group). The experiment lasted 35 days. Fecal scoring indicates that B. licheniformis and B. subtilis can improve fecal scores. Serum analysis indicated that the addition of both substances increased levels of IgA, IgM, T-AOC, and SOD, while reducing levels of the pro-inflammatory factor TNF-α. Moreover, 16S rRNA gene sequencing revealed that B. licheniformis and B. subtilis altered the fecal microbiota composition, characterized by the elevated abundance of Bacillus. Adding B. licheniformis to the diet increased the level of Faecalibacterium and decreased the level of Mogibacterium. Serum metabolomics revealed that levels of L-Glycine and Sn-Glycero-3-phosphocholine exhibited marked elevation in both the BL and BS groups, respectively. Furthermore, the study demonstrated that differential metabolites in the BL group were mainly enriched in amino acid metabolism pathways, while those in the BS group were chiefly concentrated in lipid metabolism pathways. However, this study acknowledges the limitations of its exclusive use of Ragdoll cats and its 35-day intervention period. It highlights the need for future research involving diverse breeds and longer durations. Overall, the data highlight B. licheniformis and B. subtilis as cat nutritional supplements that improve immunity and maintain intestinal health. Full article

The increasing use of wooden cladding in multi-storey buildings raises critical fire safety concerns, especially in ventilated façade systems where the chimney effect can accelerate vertical flame spread. This study combines theoretical analysis with three full-scale fire tests to investigate key factors influencing fire propagation, including the influence of façade design details. Results show that poorly constructed lintels and jambs significantly accelerate flame entry into ventilated cavities, while wooden fire barriers—despite being combustible—can delay flame spread if properly installed. These findings inform design recommendations and underscore the need for more robust fire safety strategies in modern timber construction. Full article