Search Results (16)

For over a century, the somatic gene mutation theory of cancer has been a scientific orthodoxy. The recent failures of causal explanations using this theory and the lack of significant progress in addressing the cancer problem medically have led to a new competition of ideas about just what cancer is. This essay presents an alternative view of cancer as a developmental process gone wrong. More specifically, cancer is a breakdown in the autopoietic process of organ maintenance and the multicellular coordination of tissues. Breast cancer is viewed through a systems science perspective as an example of the importance of framing one’s theoretical assumptions before making empirical judgments. Finally, a new understanding of the histoarchitecture of the interstitium is presented as a first principle of cancer: a process of cells coming from cells, invading the space between cells. Full article

Biological systems have a unique ability inherited through their genome. It allows them to build, operate, and manage a society of cells with complex organizational structures, where autonomous components execute specific tasks and collaborate in groups to fulfill systemic goals with shared knowledge. The system receives information from various senses, makes sense of what is being observed, and acts using its experience while the observations are still in progress. We use the General Theory of Information (GTI) to implement a digital genome, specifying the operational processes that design, deploy, operate, and manage a cloud-agnostic distributed application that is independent of IaaS and PaaS infrastructure, which provides the resources required to execute the software components. The digital genome specifies the functional and non-functional requirements that define the goals and best-practice policies to evolve the system using associative memory and event-driven interaction history to maintain stability and safety while achieving the system’s objectives. We demonstrate a structural machine, cognizing oracles, and knowledge structures derived from GTI used for designing, deploying, operating, and managing a distributed video streaming application with autopoietic self-regulation that maintains structural stability and communication among distributed components with shared knowledge while maintaining expected behaviors dictated by functional requirements. Full article

The changes on the Louisiana coast due to land loss can be understood as a process, and the social construction of these processes is highly complex. Due to this complexity, we will examine these social patterns of interpretation as well as individual experiences of coastal land loss in Louisiana within a neopragmatic meta-theoretical framework using several methods, data, researcher perspectives, forms of representation, and theories, with a special focus on the construction of coastal land loss by the media. For this purpose, comments below a YouTube video on a hurricane event on Grand Isle, Louisiana, as well as on-site interviews with people affected by coastal land loss, were qualitatively analyzed. The results were interpreted with the help of various theories such as the theory of three landscapes, Dahrendorf’s conflict theory, Bourdieu’s theory of social capital, and Luhmann’s autopoietic systems theory. The research reveals patterns of interpretation, categorization, and evaluation of processes from an internal and external perspective that are highly morally charged. Full article

With 500+ papers and 20+ books spanning many scientific disciplines, Mark Burgin has left an indelible mark and legacy for future explorers of human thought and information technology professionals. In this paper, I discuss his contribution to the evolution of machine intelligence using his general theory of information (GTI) based on my discussions with him and various papers I co-authored during the past eight years. His construction of a new class of digital automata to overcome the barrier posed by the Church–Turing Thesis, and his contribution to super-symbolic computing with knowledge structures, cognizing oracles, and structural machines are leading to practical applications changing the future landscape of information systems. GTI provides a model for the operational knowledge of biological systems to build, operate, and manage life processes using 30+ trillion cells capable of replication and metabolism. The schema and associated operations derived from GTI are also used to model a digital genome specifying the operational knowledge of algorithms executing the software life processes with specific purposes using replication and metabolism. The result is a digital software system with a super-symbolic computing structure exhibiting autopoietic and cognitive behaviors that biological systems also exhibit. We discuss here one of these applications. Full article

Resilience is a basic trait of cognitive systems and fundamentally connected to their autopoietic organization. It plays a vital role in maintaining the identity of cognitive systems in the face of external threats and perturbances. However, when examining resilience in the context of autopoiesis, an overlooked issue arises: the autopoietic theory formulated by Maturana and Varela (1980) renders traditional Shannon information obsolete, highlighting that information should not be ascribed a role in cognitive systems in a general sense. This paper examines the current situation and suggests a possible way forward by exploring an affordance-based view on information, derived from radical cognitive science, which is exempted from Maturana and Varela’s critique. Specifically, it argues that the impact of social influence on affordance use is crucial when considering how resilience can manifest in informational relations pertaining to the human cognitive ecology. Full article

The general theory of information (GTI) tells us that information is represented, processed and communicated using physical structures. The physical universe is made up of structures combining matter and energy. According to GTI, “information is related to knowledge as energy is related to matter.” GTI also provides tools to deal with transformation of information and knowledge. We present here the application of these tools for the design of digital autopoietic machines with higher efficiency, resiliency and scalability than the information processing systems based on the Turing machines. We discuss the utilization of these machines for building autopoietic and cognitive applications in a multi-cloud infrastructure. Full article

All living beings use autopoiesis and cognition to manage their “life” processes from birth through death. Autopoiesis enables them to use the specification in their genomes to instantiate themselves using matter and energy transformations. They reproduce, replicate, and manage their stability. Cognition allows them to process information into knowledge and use it to manage its interactions between various constituent parts within the system and its interaction with the environment. Currently, various attempts are underway to make modern computers mimic the resilience and intelligence of living beings using symbolic and sub-symbolic computing. We discuss here the limitations of classical computer science for implementing autopoietic and cognitive behaviors in digital machines. We propose a new architecture applying the general theory of information (GTI) and pave the path to make digital automata mimic living organisms by exhibiting autopoiesis and cognitive behaviors. The new science, based on GTI, asserts that information is a fundamental constituent of the physical world and that living beings convert information into knowledge using physical structures that use matter and energy. Our proposal uses the tools derived from GTI to provide a common knowledge representation from existing symbolic and sub-symbolic computing structures to implement autopoiesis and cognitive behaviors. Full article

Active inference theory (AIT) is a corollary of the free-energy principle, which formalizes cognition of living system’s autopoietic organization. AIT comprises specialist terminology and mathematics used in theoretical neurobiology. Yet, active inference is common practice in human organizations, such as private companies, public institutions, and not-for-profits. Active inference encompasses three interrelated types of actions, which are carried out to minimize uncertainty about how organizations will survive. The three types of action are updating work beliefs, shifting work attention, and/or changing how work is performed. Accordingly, an alternative starting point for grasping active inference, rather than trying to understand AIT specialist terminology and mathematics, is to reflect upon lived experience. In other words, grasping active inference through autoethnographic research. In this short communication paper, accessing AIT through autoethnography is explained in terms of active inference in existing organizational practice (implicit active inference), new organizational methodologies that are informed by AIT (deliberative active inference), and combining implicit and deliberative active inference. In addition, these autoethnographic options for grasping AIT are related to generative learning. Full article

This paper seeks to explain the nature of autopoiesis and its capacity to be efficacious, and to do this, it uses agency theory as embedded in metacybernetics. Agency, as a generalised intelligent adaptive living system, can anticipate the future once it has internalised a representation of an active contextual situation through autopoiesis. The role of observation and the nature of internalisation will be discussed, explaining that the latter has two states that determine agency properties of cognition. These are assimilation and accommodation. Assimilation is an information process and results in implicit cognition and recognition, whereas accommodation uses assimilated information delivering explicit cognition, recognition, and conscious awareness with rationality. Similarly, anticipation, a required property of the living, has two states, weak and strong, and these correspond to the two states of internalisation. Autopoiesis has various properties identifiable through the lenses of three autonomous but configurable schemas: General Collective Intelligence (GCI), Eigenform, and Extreme Physical Information (EPI). GCI is a pragmatic evolutionary approach concerned with a contextually connected purposeful and relatable set of task processes, each undertaken by a team of subagencies seeking collective fitness. Eigenform is a symbolic approach that is concerned with how observations can be suitably internalised and thus be used as a token to determine future behaviour, and how that which has been internalised can be adopted to anticipate the future. Extreme Physical Information (EPI) is an empirical approach concerned with acquiring information through observation of an unknown parameter through sampling regimes. The paper represents the conceptualisations of each schema in terms of autopoietic efficacy, and explores their configurative possibilities. It will adopt the ideas delivered to enhance explanations of the nature of autopoiesis and its efficacy within metacybernetics, providing a shift in thinking about autopoiesis and self-organisation. Full article

The declining discovery rate of world-class ore deposits represents a significant obstacle to future global metal supply. To counter this trend, there is a requirement for mineral exploration to be conducted in increasingly challenging, uncertain, and remote environments. Faced with such increases in task and environmental complexity, an important concern in exploratory activities are the behavioural challenges of information perception, interpretation and decision-making by geoscientists tasked with discovering the next generation of deposits. Here, we outline the Dynamics model, as a diagnostic tool for situational analysis and a guiding framework for designing working and training environments to maximise exploration performance. The Dynamics model is based on an Ecological Dynamics framework, combining Newell’s Constraints model, Self Determination Theory, and including feedback loops to define an autopoietic system. By implication of the Dynamics model, several areas are highlighted as being important for improving the quality of exploration. These include: (a) provision of needs-supportive working environments that promote appropriate degrees of effort, autonomy, creativity and technical risk-taking; (b) an understanding of the wider motivational context, particularly the influence of tradition, culture and other ‘forms of life’ that constrain behaviour; (c) relevant goal-setting in the design of corporate strategies to direct exploration activities; and (d) development of practical, representative scenario-based training interventions, providing effective learning environments, with digital media and technologies presenting decision-outcome feedback, to assist in the development of expertise in mineral exploration targeting. Full article

In this article, we attempt at developing a scenario for the self-organization of goal-directed systems out of networks of (chemical) reactions. Related scenarios have been proposed to explain the origin of life starting from autocatalytic sets, but these sets tend to be too unstable and dependent on their environment to maintain. We apply instead a framework called Chemical Organization Theory (COT), which shows mathematically under which conditions reaction networks are able to form self-maintaining, autopoietic organizations. We introduce the concepts of perturbation, action, and goal based on an operationalization of the notion of change developed within COT. Next, we incorporate the latter with notions native to the theory of cybernetics aimed to explain goal directedness: reference levels and negative feedback among others. To test and refine these theoretical results, we present some examples that illustrate our approach. We finally discuss how this could result in a realistic, step-by-step scenario for the evolution of goal directedness, thus providing a theoretical solution to the age-old question of the origins of purpose. Full article

This paper explores the link between the current vision of the “smart city” and the notion of urban autopoiesis understood as self-organized/managed urban systems. It seeks to highlight how the use of GIS analysis, applied to the study of informal settlements, can provide useful information to understand the smart city paradigm. The paper argues the key idea that a smart city should not be seen only as a high-tech urban environment because the transition to smartness will need major changes in its inner structure. Using a combination of quantitative and qualitative GIS analysis methods, this study examines the case of the BaSECo Compound, one of the densest informal settlements in Metro Manila (Philippines), with the aim of both generating a comprehensive morphological analysis of this dynamic urban area as well as contributing to the configurational theory of the smart city. The results suggest that the analysis of autopoietic urban systems could expand our understanding of how the structure of the city could evolve to accommodate the needs of its citizens and creating more resilient and inclusive communities. Full article

Knowledge processing is an important feature of intelligence in general and artificial intelligence in particular. To develop computing systems working with knowledge, it is necessary to elaborate the means of working with knowledge representations (as opposed to data), because knowledge is an abstract structure. There are different forms of knowledge representations derived from data. One of the basic forms is called a schema, which can belong to one of three classes: operational, descriptive, and representation schemas. The goal of this paper is the development of theoretical and practical tools for processing operational schemas. To achieve this goal, we use schema representations elaborated in the mathematical theory of schemas and use structural machines as a powerful theoretical tool for modeling parallel and concurrent computational processes. We describe the schema of autopoietic machines as physical realizations of structural machines. An autopoietic machine is a technical system capable of regenerating, reproducing, and maintaining itself by production, transformation, and destruction of its components and the networks of processes downstream contained in them. We present the theory and practice of designing and implementing autopoietic machines as information processing structures integrating both symbolic computing and neural networks. Autopoietic machines use knowledge structures containing the behavioral evolution of the system and its interactions with the environment to maintain stability by counteracting fluctuations. Full article

Life is more than the sum of its constituent molecules. Living systems depend on a particular chemical organization, i.e., the ways in which their constituent molecules interact and cooperate with each other through catalyzed chemical reactions. Several abstract models of minimal life, based on this idea of chemical organization and also in the context of the origin of life, were developed independently in the 1960s and 1970s. These models include hypercycles, chemotons, autopoietic systems, (M,R)-systems, and autocatalytic sets. We briefly compare these various models, and then focus more specifically on the concept of autocatalytic sets and their mathematical formalization, RAF theory. We argue that autocatalytic sets are a necessary (although not sufficient) condition for life-like behavior. We then elaborate on the suggestion that simple inorganic molecules like metals and minerals may have been the earliest catalysts in the formation of prebiotic autocatalytic sets, and how RAF theory may also be applied to systems beyond chemistry, such as ecology, economics, and cognition. Full article

A transdisciplinary theory for cognition and communication has at least been described from the following paradigms (1) An objective information processing view or info-mechanicism; (2) A social constructivist view; (3) A systemic cybernetic view of self-organization; (4) Semiotic paradigms of experience and interpretation (phenomenological and hermeneutical aspects) including biosemiotic going into animal, plant, bacterial and cellular living systems. They all have their transdisciplinary shortcomings. A transdisciplinary framework called Cybersemiotics that integrate phenomenological and hermeneutical aspect in Peircean semiotic logic with cybernetic and systemic autopoietic emergentist process-informational view, is suggested. Full article