Search Results (139)

Permeable pavement is an alternative to conventional impermeable pavement for various applications. However, a common issue with permeable pavement is clogging over time. Permeability is a parameter that reflects the capacity of the pavement to reduce surface runoff; a decline in permeability implies the occurrence of clogging. In this study, permeability data collected on pervious concrete (PC) and JW Eco-Technology (JW) revealed that JW maintained consistent permeability over time. However, PC displayed reduced values, and several locations along the edges had zero permeability, despite no regular vehicular and pedestrian use. Therefore, a portable pressure washer was used to clean the pavements. The cleaning procedure was able to recover the permeability of the areas that showed signs of clogging (0 to 2.69 cm/s) and restore the permeability of PC up to 4.60–5.58 cm/s for corner and center areas, respectively. Moreover, visual inspection using a borescope further revealed the full function of the JW pores (aqueducts), regardless of cleaning. Regardless, it is recommended that periodic cleaning maintenance be performed for both PC and JW using a pressure washer due to its convenience and efficacy, which will be discussed. Full article

Objective: Ventriculomegaly is the main prenatal imaging feature for diagnosing fetal central nervous system anomalies in humans. Many ventriculomegalies can be related to genetic causes, regardless of their imaging presentations. Among these, MPDZ variants have been reported to cause severe ventriculomegaly inherited in an autosomal recessive manner (OMIM#615219). Several hypotheses have been put forward linking MPDZ variants to ventriculomegaly, but the precise underlying mechanisms, in particular whether its origin is obstructive or non-obstructive, are yet to be elucidated. Methods: To address this question, we retrospectively analyzed pre- and postnatal neuro-imaging and neuropathological data for cases of ventriculomegaly in which MPDZ variants were found through exome or genome sequencing. We performed anti-MPDZ immunostaining on fetal brain samples. Results: We analyzed six cases (four fetuses and two children) of ventriculomegaly of variable severities with MPDZ variants. The precise analysis of brain MRI data, corroborated by fetopathological examinations, demonstrated an obstructive pattern of ventriculomegaly upstream from partial fusion of the thalami, also called diencephalosynapsis, with partial atresia of the third ventricle, which could extend to Sylvius’s aqueduct. Conclusions: The morphological analysis using targeted brain magnetic resonance imaging (MRI) and neuropathological data allowed us to unravel the underlying mechanisms of congenital ventriculomegaly related to MDPZ variants. Full article

Environmental impacts, such as elevated temperatures due to urban heat islands (UHIs), associated with land cover change due to urbanization, should not be ignored. In contrast to conventional impermeable concrete, permeable pavements have been implemented as green infrastructure strategies for achieving environmental benefits, such as stormwater management. Their impacts and benefits on other environmental aspects should not be ignored, especially for those with limited discussion in the literature. Therefore, this study monitored the surface and air temperatures of three types of pavements: conventional impermeable concrete (IC), pervious concrete (PC), and the patented JW Eco-technology (JW). As UHIs are more intense in the summer, temperature profiles during targeted periods when surface temperatures exceeded 40 °C for consecutive days were examined. In addition, as an available option at the study site, shade was created to evaluate its effect on surface temperatures across the pavement systems. Overall, the annual average surface and air temperatures of the three pavements were similar. However, seasonal and diurnal variations in temperatures were both observed, suggesting summer was the season when the differences in temperatures among pavements were most noticeable. Investigation during the targeted periods revealed that the average surface temperatures of PC were 2.4–2.7 °C and 3.2–3.3 °C higher than those observed on IC and JW, and the average air temperature of PC was 1.8 °C greater than that of IC and JW between 12:00 and 16:00. On the contrary, the average surface temperatures of PC were significantly lower than those on IC (1.3–1.4 °C) and JW (1.5 °C) between 21:00 and 5:00. Results also indicate that shade was an effective way to alleviate the high surface temperatures during the warm hours by lowering surface temperatures 21.0 °C, 15.4 °C, and 15.0 °C, for PC, IC, and JW, respectively. Finally, temperatures associated with the aqueducts of JW Eco-technology and the impacts on overall surface temperatures will be discussed. Full article

Recessive variants of SLC26A4 are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic SLC26A4 variants often suffer from fluctuating hearing loss and recurrent vertigo, ultimately leading to severe to profound hearing impairment. However, there are currently no satisfactory prevention or treatment options for this condition. The CRISPR/Cas9 genome-editing technique is a well-known tool for correcting point mutations or manipulating genes and shows potential therapeutic applications for hereditary disorders. In this study, we used the homology-independent targeted integration (HITI) strategy to correct the SLC26A4 c.919-2A>G variant, the most common SLC26A4 variant in the Han Chinese population. Next-generation sequencing was performed to evaluate the editing efficiency of the HITI strategy. The results showed that only 0.15% of the reads successfully exhibited HITI integration, indicating that the c.919-2 region may not be a suitable region for HITI selection. This suggests that other site selection or insertion strategies may be needed to improve the efficiency of correcting the SLC26A4 c.919-2A>G variant. This experience may serve as a valuable reference for other researchers considering CRISPR target design in this region. Full article

Brain stem cavernomas are exceedingly rare in pediatric populations, with limited literature addressing their natural history, treatment guidelines, and counseling. We report the case of a 5-year-old girl presenting with acute neurological symptoms, including diplopia, gait ataxia, headache, and altered consciousness. Initial imaging revealed obstructive hydrocephalus caused by a hemorrhagic lesion near the pineal region. After emergency external ventricular drainage (EVD), most symptoms resolved except for diplopia. A subsequent MRI suggested a space-occupying hemorrhagic cyst in the tectal lamina, leading to endoscopic third ventriculostomy (ETV). During ETV, a large hemorrhagic mass at the aqueduct entrance was identified but not removed due to its fragility. Following ETV, the patient improved rapidly and was discharged. However, she was readmitted with recurrent symptoms and altered consciousness. An emergency MRI indicated a progressive hemorrhagic mass lesion compressing the midbrain, necessitating surgical intervention. The patient underwent suboccipital craniotomy using a telovelar approach. The intraoperative findings included cavernoma-like tissue within the aqueduct, which was successfully resected. Histopathology confirmed hemorrhagic and angiomatous tissue, excluding a primary brain tumor. Postoperatively, the patient showed significant, progressive neurological improvement, with mild internuclear strabism, trunk ataxia, and fatigue at the last follow-up. Six months later, a follow-up MRI and cerebral angiography showed no cavernoma remnants but identified a midbrain deep venous anomaly. This case underscores the feasibility of the microsurgical resection of midbrain cavernomas in symptomatic pediatric patients, highlighting the importance of the thorough assessment of atypical hemorrhagic midbrain lesions to exclude rare vascular malformations from differential diagnoses. Full article

Introduction: Neurodegenerative diseases like progressive supranuclear palsy (PSP) present challenges concerning their diagnosis. Neuroimaging using magnetic resonance (MRI) may add diagnostic value. However, modern techniques such as volumetric assessment using Voxel-Based Morphometry (VBM), although proven to be more accurate and superior compared to MRI, have not gained popularity among scientists in the investigation of neurological disorders due to their higher cost and time-consuming applications. Conventional brain MRI methods may present a quick, practical, and easy-to-use imaging rating tool for the differential diagnosis of PSP. The purpose of this study is to evaluate a string of existing visual MRI rating scales and signs regarding their impact for the diagnosis of PSP. Materials and Methods: The population study consisted of 30 patients suffering from PSP and 72 healthy controls. Each study participant underwent a brain MRI, which was subsequently examined by two independent researchers in a double-blinded fashion. Fifteen visual rating scales and signs were evaluated, including pontine atrophy, cerebellar atrophy, midbrain atrophy, aqueduct of Sylvius enlargement, cerebellar peduncle hyperintensities, enlargement of the fourth ventricle (100% sensitivity and 71% specificity) and left temporal lobe atrophy (97% sensitivity and 78% specificity). Conclusions: Enlargement of the Sylvius aqueduct, enlargement of the fourth ventricle and atrophy of both temporal lobes together with the presence of morning glory and hummingbird signs can be easily and quickly distinguished and identified by an experienced radiologist without involving any complex analysis, making them useful tools for PSP diagnosis. MRI visual scale measurements could be added to the diagnostic criteria of PSP and may serve as an alternative to highly technical and more sophisticated quantification methods. Full article

At the beginning of human history, surface water, especially from rivers and springs, was the most frequent water supply source. Groundwater was used in arid and semi-arid regions, e.g., eastern Crete (Greece). As the population increased, periodic water shortages occurred, which led to the development of sophisticated hydraulic structures for water transfer and for the collection and storage of rainwater, as seen, for example, in Early Minoan times (ca 3200–2100 BC). Water supply and urban planning had always been essentially related: the urban water supply systems that existed in Greece since the Bronze Age (ca 3200–1100 BC) were notably advanced, well organized, and operable. Water supply systems evolved considerably during the Classical and Hellenistic periods (ca 480–31 BC) and during the Roman period (ca 31 BC–480 AD). Also, early Indian society was an amazing vanguard of technology, planning, and vision, which significantly impacted India’s architectural and cultural heritage, thus laying the foundation for sustainable urban living and water resource management. In ancient Egypt, the main source of freshwater was the Nile River; Nile water was conveyed by open and closed canals to supply water to cities, temples, and fields. Underground stone-built aqueducts supplied Nile water to so-called Nile chambers in temples. The evolution of water supply and urban planning approaches from ancient simple systems to complex modern networks demonstrates the ingenuity and resilience of human communities. Many lessons can be learned from studying traditional water supply systems, which could be re-considered for today’s urban sustainable development. By digging into history, measures for overcoming modern problems can be found. Rainwater harvesting, establishing settlements in proximity of water sources to facilitate access to water, planning, and adequate drainage facilities were the characteristics of ancient civilizations since the ancient Egyptian, Minoan, Mohenjo-Daro, Mesopotamian, and Roman eras, which can still be adopted for sustainability. This paper presents significant lessons on water supply around the world from ancient times to the present. This diachronic survey attempts to provide hydro-technology governance for the present and future. Full article

In recent years, the number of incidents involving aqueduct damage due to vehicle impact has steadily increased, significantly affecting the safe operation of water transfer projects. To investigate the dynamic response characteristics of aqueduct structures under vehicle impact, a numerical model of vehicle impact on an aqueduct was developed using ANSYS/LS-DYNA software. The influence of impact eccentricity and concrete strength on the dynamic response of the aqueduct structure was then analyzed. The results indicate that the aqueduct bent frame exhibits a pronounced torsional response under eccentric impact, exacerbating the damage and deformation of the aqueduct structure. The peak impact force is positively correlated with concrete strength, whereas the maximum lateral displacement and residual displacement at the top of the impacted bent frame show a negative correlation with concrete strength. Finally, three anti-collision measures are proposed: a rubber concrete outer box with a rubber filling layer, an ultra-high-performance concrete (UHPC) outer box with a foam aluminum filling layer, and a rubber concrete outer box with a foam aluminum filling layer. The energy dissipation, internal force response, displacement response, and aqueduct damage characteristics of these measures are compared and analyzed, and compared to the aqueduct structure without anti-collision measures, the peak impact force is reduced by at least 17%. The lateral residual displacements at the bottom, the impact area, and the top of the aqueduct bent frame are reduced by at least 88.3%, 97.8%, and 88.5%. The damage and severity of damage to the aqueduct are significantly reduced, providing valuable insights for the anti-collision design of aqueducts. Full article

We review the research on L. fortunei over the past 22 years, systematically elucidating its impacts on ecological environments and water engineering structures. We explored the effects of external factors on the invasion and spread of L. fortunei, as well as the internal factors that impact the ecological environment and water engineering structures. We also provide new perspectives and directions for L. fortunei control. The major research findings include the following: (1) L. fortunei negatively impacts hydraulic structures, being hard to remove and capable of damaging them, disrupting normal operations. (2) L. fortunei’s ecological impact is multifaceted: it reduces water cloudiness and organic matter by filtering suspended particles and depositing feces, but its decay after death consumes dissolved oxygen, increasing chemical oxygen demand and lowering water quality. (3) L. fortunei control techniques are effective for localized use in small bodies of water and aqueducts, but their control in large open reservoirs is difficult to achieve with one method. Existing control methodologies for L. fortunei were systematically evaluated across multiple dimensions, including engineering applicability and feasibility, technical advantages and limitations, and economic cost-effectiveness. This comprehensive analysis establishes a decision-support framework for optimizing control strategy selection in diverse engineering scenarios and application contexts. Full article

Water stress has induced many environmental and developmental conflicts in the arid basins in the Middle East region under the context of climate change and increasing anthropogenic influence. Quantifying the anthropogenic influence on water stress at the basin scale is very challenging because of insufficient anthropogenic-related spatial data. Given that climate change is a global impact that is hard to mitigate at the basin scale, quantifying anthropogenic influence is practical to inform strategies for alleviating regional water stress. Thus, this study attempts to quantify the contribution of potential anthropogenic factors driving the water stress in the Tigris–Euphrates river basin (TERB) using pure spatial data. The water stress level in the studied basin was evaluated via the water stress index (WSI), which can be obtained as the ratio of water demand to water availability, from the Aqueduct 4.0 dataset. The driving contributions of social development (population, POP; fine particulate matter, PM2.5), economic development (gross domestic product, GDP; electricity consumption, EC), and landscape modification (urban expansion index, UEI; cultivated land expansion index, CEI) factors were quantitatively evaluated based on a spatial statistical geographical detector model (GDM). Assessment showed that nearly 66.13% of the TERB area was under severe water stress, particularly in Syria, Iraq, Saudi Arabia, and Iran. The q statistic of the GDM, adopted to quantify the contribution of driving factors, revealed that CEI (0.174), EC (0.145), and GDP (0.123) were the dominant factors driving water stress. These individual influences were further enhanced particularly in the interaction between economic development and landscape modification factors such as UEI and CEI (0.566), PM2.5 and UEI (0.350), EC and CEI (0.346), GDP and CEI (0.323), and PM2.5 and GDP (0.312). The findings of this research can provide some beneficial references to alleviate the TERB’s water stress for its future sustainable development. Full article

This study presents part of a pilot work for the structural health monitoring of a large tied-arch reinforced concrete aqueduct in eastern China. Based on field-monitored data for over a year, it mainly focuses on the effect of air temperature and water load variations on the static behavior of a typical span of the aqueduct through field monitoring and 3D FE model analysis. It is found that the longitudinal deformation of the composite tied-arch shows a good linear relationship with the air temperature during the non-operation period and also has a good bilinear correlation with the air temperature and water level during operation. However, isolation of the air temperature effect from the second bilinear correlation using the first linear relationship results in a poor correlation between the longitudinal deformation and water level due to the dominance of the temperature effect. Therefore, it is recommended to use the bilinear regression to predict the longitudinal deformation of the tied-arch during operation. The vertical deformation of the tied-arch is insignificantly affected by air temperature, whereas it shows a fair bilinear correlation with the air temperature and water level during operation, which can be used to provide a reasonable estimation of the vertical deformation of the tied-arch. The strain measurements of the tied-arch using vibrating-string gauges are more complicated due to the notable influence of the ambient temperature and solar radiation, but the relatively consistent bilinear regression of the strains versus the air temperature and water level can still give fair predictions for the strains of the bottom tension rods during operation. The 3D FE model can provide a fair estimation for the vertical deformation of the tied-arch under water load, but its predictions for longitudinal deformation and strains are less satisfactory when compared to monitored data excluding temperature effects. Full article

Water transport pipelines in the mining industry face significant corrosion challenges due to extreme environmental conditions, such as arid climates, temperature fluctuations, and abrasive soils. This study evaluates the effectiveness of three advanced inspection technologies—Guided Wave Ultrasonic Testing (GWUT), Metal Magnetic Memory (MMM), and In-Line Inspection (ILI)—in maintaining pipeline integrity under such conditions. A structured methodology combining diagnostic assessment, technology research, and comparative evaluation was applied, using key performance indicators like detection capability, operational impact, and feasibility. The results show that GWUT effectively identifies surface anomalies and wall thinning over long pipeline sections but faces depth and diameter limitations. MMM excels at detecting early-stage stress and corrosion in inaccessible locations, benefiting from minimal preparation and strong market availability. ILI provides comprehensive internal and external assessments but requires piggable pipelines and operational adjustments, limiting its use in certain systems. A case study of critical aqueducts of mining site water supply illustrates real-world technology selection challenges. The findings underscore the importance of an integrated inspection approach, leveraging the complementary strengths of these technologies to ensure reliable pipeline integrity management. Future research should focus on quantitative performance metrics and cost-effectiveness analyses to optimize inspection strategies for mining infrastructure. Full article

Workplace safety, particularly in the construction industry, is a moral and legal imperative, prioritizing the protection of workers’ health and well-being. In Italy, Legislative Decree 81/08 (and subsequent modifications) serves as a regulatory framework for workplace safety, defining the duties of employers and employees and promoting accident prevention measures. Building information modeling technology, which has revolutionized the global construction industry by offering an integrated approach to design, construction, and management through intelligent digital models, has only recently started gaining traction in Italy as part of Industry 4.0. This article examines the potential of integrating the current prevention strategies with BIM technology to optimize safety design on construction sites. A case study demonstrates the use of the BIM software REVIT to model a water reservoir for an aqueduct, including structural and plant components, the surrounding context, and proposed construction site organization. The research methodology involves creating a contextualized 3D model to support preliminary safety assessments, work process organization, and the drafting of a safety and coordination plan. Through detailed analysis and critical discussion, this work contributes to understanding how the interaction of regulations and BIM technology can improve construction site safety, offering insights that are applicable beyond the Italian context to the global construction industry. Full article

This study proposes a time-dependent reliability analysis method for aqueduct structures based on concrete carbonation and finite element analysis. The primary goal of this study is to improve the reliability assessment of reinforced concrete aqueducts by incorporating environmental factors such as carbonation over time. First, a three-dimensional finite element model of a reinforced concrete aqueduct is established using the Midas 2022 Civil software, incorporating a time-varying function derived from a predictive model of concrete carbonation depth. Point estimation is then integrated with structural finite element analysis to calculate the first four moments of random variables as functions of concrete carbonation. Additionally, the original performance function is transformed into a normal distribution using dual power transformation and the Jarque–Bera test. The high-order unscented transformation (HUT) is subsequently employed to estimate the first four moments of the transformed performance function, facilitating the calculation of time-varying reliability indices for the carbonated concrete aqueduct. Based on the time-varying reliability index data, a reliability function corresponding to different time points is fitted and applied to service life prediction. The results demonstrate that the proposed method effectively reduces large errors associated with the fourth-moment method in calculating large reliability indices. Furthermore, the comparison with Monte Carlo simulation (MCS) results validates the high efficiency and accuracy of the proposed method, offering a valuable tool for addressing the reliability challenges of aqueducts exposed to carbonation and other environmental factors over time. Full article

The El Valle Volcanic Complex, located in the province of Cocle, Panama, presents geological characteristics that could be linked to public health problems. This study focuses on the municipalities of San Juan de Dios, Pajonal, and Caballero, where water is consumed directly from springs (groundwater outcrops). The region has a high incidence of non-traditional chronic kidney disease (nt-CKD) that may be associated with the natural presence of potentially toxic elements (PTEs) in the water. This study aimed to analyze the concentration of PTEs in groundwater and assess the carcinogenic (CR) and non-carcinogenic (HQ) risk to human health from the direct ingestion of water. Sediments, rocks, and water samples were collected. Major ions and PTEs (As, Al, Ba, Co, Cu, Fe, Mn, Sr, Sb, Pb, V, and Zn) were measured, and the mineralogical composition of the rocks was analyzed. The results showed that Fe was the only PTE that exceeded the recommended concentration for drinking water, according to Panama regulations, and Pb according to USEPA. In Caballero and Pajonal, the acceptable threshold for CR and HQ was exceeded, a higher percentage than in San Juan de Dios. The PTEs that contribute most to the risk are Co, Cu, Pb, and As. This study suggests that the region’s historical volcanic activity, involving the release of minerals rich in these PTEs, along with the interaction between groundwater and volcanic rocks, may be contributing to the presence of PTEs in the water. This geological phenomenon could be what has led to prolonged exposure to these elements, which correlates with the high prevalence of chronic kidney disease in the area. This is a novel study, the first conducted in Panama, as it seeks to uncover the relationship between the geology of the site, the presence of PTEs in the groundwater of springs for human consumption, and the implication of health risks, with the aim of generating new information for decision makers for the generation of public policies on health issues such as nt-CKD and cancer in the region. Full article