Search Results (7)

Graphitic carbon nitride-supported L-arginine (g-C₃N₄@L-arginine) has been prepared as a heterogeneous catalyst for synthesizing heterocyclic compounds such as pyranopyrazole and acridinedione derivatives. High efficiency, short reaction time, and easy separation are significant features that are reasons for using g-C₃N₄@L-arginine as a catalyst in one-pot multicomponent reactions. Synthesized nanocatalyst was detected by numerous analyses, such as FE-SEM (Field Emission Scanning Electron Microscopy), EDX (Energy Dispersive X-ray spectroscopy), XRD (X-Ray Diffraction analysis), TGA (Thermo Gravimetric Analysis), and FT-IR (Fourier Transform Infrared Spectroscopy). G-C₃N₄@L-arginine nanocatalyst was reused 5 times in the reaction with no apparent decrease in reaction yield, which shows acceptable recyclability. Full article

Bioinformatics as a newly emerging discipline is considered nowadays a reference to characterize the physicochemical and pharmacological properties of the actual biocompounds contained in plants, which has helped the pharmaceutical industry a lot in the drug development process. In this study, a bioinformatics approach known as in silico was performed to predict, for the first time, the physicochemical properties, ADMET profile, pharmacological capacities, cytotoxicity, and nervous system macromolecular targets, as well as the gene expression profiles, of four compounds recently identified from Centaurea tougourensis via the gas chromatography–mass spectrometry (GC–MS) approach. Thus, four compounds were tested from the n-butanol (n-BuOH) extract of this plant, named, respectively, Acridin-9-amine, 1,2,3,4-tetrahydro-5,7-dimethyl- (compound 1), 3-[2,3-Dihydro-2,2-dimethylbenzofuran-7-yl]-5-methoxy-1,3,4-oxadiazol-2(3H)-one (compound 2), 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione (compound 3), and 3-[3-Bromophenyl]-7-chloro-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione (compound 4). The insilico investigation revealed that the four tested compounds could be a good candidate to regulate the expression of key genes and may also exert significant cytotoxic effects against several tumor celllines. In addition, these compounds could also be effective in the treatment of some diseases related to diabetes, skin pathologies, cardiovascular, and central nervous system disorders. The bioactive compounds of plant remain the best alternative in the context of the drug discovery and development process. Full article

In the present investigation, an efficient heterogeneous catalyst system made of a polyaniline-derived polymer (Poly [anthranilic acid]-[N-(1′,3′-phenylenediamino) −3-butane sulfonate]) and iron oxide nanoparticles (Fe₃O₄ NPs) is presented. Firstly, this novel catalytic system (Fe₃O₄@Polyaniline-SO₃H) has been fabricated via a convenience method and magnetized via an in situ process. The as-prepared solid acid catalyst was also carefully analyzed by Fourier transfer infrared spectroscopy (FTIR) and energy-dispersive X-ray spectroscopy (EDX). It has been suitably applied for the one-pot multicomponent synthesis of acridinediones as an important class of heterocyclic compounds. The first and foremost advantage of this catalytic system is that the (Fe₃O₄@Polyaniline-SO₃H) is magnetically separated from the reaction mixture through their high paramagnetic behavior. The main attractive characteristics of the presented green protocol are very short reaction times, excellent yields, and the avoidance of hazardous or toxic reagents and solvents. Easy separation, high reusability, cost-effective and mild catalyst are important advantages of the new catalyst in comparison to other catalysts for the synthesis of acridinedione derivatives via one-pot four-component reaction. Full article

We describe herein the synthesis and laccase mediated oxidation of six novel 1,4-dihydropyridine (DHP)-based hexahydroquinolines (DHP1-DHP3) and decahydroacridines (DHP4-DHP6). We employed different laccase enzymes with varying redox potential to convert DHP1-DHP3 and DHP4-DHP6 to the corresponding pyridine-containing tetrahydroquinoline and octahydroacridine derivatives, respectively. Intensively coloured products were detected in all biocatalytic reactions using laccase from Trametes versicolor (TvLacc), possibly due to the presence of conjugated chromophores formed in products after oxidation. The NMR assessment confirmed that the oxidation product of DHP1 was its corresponding pyridine-bearing tetrahydroquinoline derivative. Laccase from Bacillus subtillis (BacillusLacc) was the most efficient enzyme for this group of substrates using HPLC assessment. Overall, it could be concluded that DHP2 and DHP5, bearing catecholic structures, were easily oxidized by all tested laccases, while DHP3 and DHP6 containing electron-withdrawing nitro-groups are not readily oxidized by laccases. DHP4 with decahydroacridine moiety consisting of three condensed six-membered rings that contribute not only to the volume but also to the higher redox potential of the substrate rendered this compound not to be biotransformed with any of the mentioned enzymes. Overall, we showed that multiple analytical approaches are needed in order to assess biocatalytical reactions. Full article

In this study, Bi₂O₃ nanoparticles were successfully synthesized through a facile hydrothermal procedure. The structure of the Bi₂O₃ nanoparticles was analyzed by Fourier transfer infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The synthesized Bi₂O₃ nanoparticles have unique properties, such as high activity, high purity, and high surface area. Hence, we have reported the Bi₂O₃ nanoparticles as an efficient, cost-effective, and mild catalyst for the synthesis of acridinedione derivatives via a one-pot four-component reaction. In addition, the effect of the morphology of the Bi₂O₃ nanostructure was investigated on catalytic performance. Therefore, Bi₂O₃ nanoparticles were prepared and applied as a heterogeneous catalyst in the synthesis of acridinedione derivatives. The present approach offers several advantages, such as excellent yields within short times, green catalyst, and ease of recovery. Full article

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields. Full article