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Molecules 2012, 17(5), 5339-5345; https://doi.org/10.3390/molecules17055339

Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

School of Materials and Chemical Engineering, Anhui University of Architecture, Hefei 230601, China
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Received: 13 March 2012 / Revised: 24 April 2012 / Accepted: 28 April 2012 / Published: 7 May 2012
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Abstract

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields. View Full-Text
Keywords: acridinedione; polyhydroquinoline; one-pot reaction; water acridinedione; polyhydroquinoline; one-pot reaction; water
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xia, J.-J.; Zhang, K.-H. Synthesis of N-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water. Molecules 2012, 17, 5339-5345.

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