Search Results (10)

Background: The effect of differing post-contrast phases on CT body composition measurements is not yet known. Methods: A fully automated AI-based body composition analysis using DAFS was performed on a retrospective cohort of 278 subjects undergoing pre-treatment triple-phase CT for pancreatic intraductal papillary mucinous neoplasm. The CT contrast phases included noncontrast (NON), arterial (ART), and venous (VEN) phases. The software selected a single axial CT image at mid-L3 on each phase for body compartment segmentation. The areas (cm²) were calculated for skeletal muscle (SM), intermuscular adipose tissue (IMAT), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). The mean Hounsfield units of skeletal muscle (SMHU) within the segmented regions were calculated. Bland–Altman and Chi Square analyses were performed. Results: SM-NON had a lower percentage of bias [LOA] than SM-ART, −0.7 [−7.6, 6.2], and SM-VEN, −0.3 [−7.6, 7.0]; VAT-NON had a higher percentage of bias than ART, 3.4 [−18.2, 25.0], and VEN, 5.8 [−15.0, 26.6]; and this value was lower for SAT-NON than ART, −0.4 [−14.9, 14.2], and VEN, −0.5 [−14.3, 13.4]; and higher for IMAT-NON than ART, 5.9 [−17.9, 29.7], and VEN, 9.5 [−17.0, 36.1]. The bias in SMHU NON [LOA] was lower than that in ART, −3.8 HU [−9.8, 2.1], and VEN, −7.8 HU [−14.8, −0.8]. Conclusions: IV contrast affects the voxel HU of fat and muscle, impacting CT analysis of body composition. We noted a relatively smaller bias in the SM, VAT, and SAT areas across the contrast phases. However, SMHU and IMAT experienced larger bias. During threshold risk stratification for CT-based measurements of SMHU and IMAT, the IV contrast phase should be taken into consideration. Full article

Shrimp farming and exporting is the main income source for the southern coastal districts of the Mekong Delta. Monitoring these shrimp ponds is helpful in identifying losses incurred due to natural calamities like floods, sources of water pollution by chemicals used in shrimp farming, and changes in the area of cultivation with an increase in demand for shrimp production. Satellite imagery, which is consistent with good spatial resolution and helpful in providing frequent information with temporal imagery, is a better solution for monitoring these shrimp ponds remotely for a larger spatial extent. The shrimp ponds of Cai Doi Vam township, Ca Mau Province, Viet Nam, were mapped using DMC-3 (TripleSat) and Jilin-1 high-resolution satellite imagery for the years 2019 and 2022. The 3 m spatial resolution shrimp pond extent product showed an overall accuracy of 87.5%, with a producer’s accuracy of 90.91% (errors of omission = 11.09%) and a user’s accuracy of 90.91% (errors of commission = 11.09%) for the shrimp pond class. It was noted that 66 ha of shrimp ponds in 2019 were observed to be dry in 2022, and 39 ha of other ponds had been converted into shrimp ponds in 2022. The continuous monitoring of shrimp ponds helps achieve sustainable aquaculture and acts as crucial input for the decision makers for any interventions. Full article

The environmental conditions of snow particles with different particle sizes and bulk effective densities over the ocean are explored using a coincidence dataset of National Aeronautics and Space Administration (NASA) CloudSat Cloud Profiling Radar (CPR) and Global Precipitation Mission (GPM) Dual-frequency Precipitation Radar (DPR). Observed triple-frequency radar signatures for snow particles over the ocean are firstly derived. Based on modeled triple-frequency signatures for various snow particles, DFR Ku/Ka and the ratio of DFR Ku/Ka to DFR Ku/W from observations are selected to indicate the snow particle size and bulk effective density, respectively. The dependences of two indicators on temperature, relative humidity and cloud liquid water content are presented. The snow particle size range becomes wider at warmer temperatures, higher relative humidities or lower cloud liquid water contents. At cold temperatures, low relative humidities or high cloud liquid water contents, large snow particles are prevalent. At high cloud liquid water contents, the riming process mainly contributes to the increase in snow particle bulk effective density. When supersaturation occurs, a large portion of snow particles have large sizes and low bulk effective densities at cold temperatures. This study can improve the understanding of snow microphysics and demonstrate the potential of spaceborne radar measurements in global snowfall retrievals. Full article

Obesity measured by anthropometrics is associated with increased risk of triple-negative breast cancer (TNBC). It is unclear to what extent specific adipose tissue components, aside from muscle, are associated with TNBC. This retrospective study included 350 breast cancer patients who received treatment between October 2011 and April 2020 with archived abdominal or pelvic computed tomography (CT) images. We measured the areas of adipose tissue and five-density levels of skeletal muscle on patients’ third lumbar vertebra (L3) image. Logistic regression was performed to examine the associations of specific adiposity and skeletal muscles components and a four-category body composition phenotype with the TNBC subtype. Results showed that higher vs. lower areas (3rd vs. 1st tertiles) of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were associated with increased odds of TNBC vs. non-TNBC after adjusting for age, race, stage, tumor grade, tumor size, and skeletal muscle areas (adjusted odds ratio [AOR], 11.25 [95% CI = 3.46–36.52]) and (AOR, 10.34 [95% CI = 2.90–36.90]) respectively. Higher areas of low density muscle was also associated with increased odds of TNBC (AOR, 3.15 [95% CI = 1.05–10.98]). Compared to normal body composition (low adipose tissue/high muscle), high adiposity/high muscle was associated with higher odds of TNBC (AOR, 5.54 [95% CI = 2.12–14.7]). These associations were mainly in premenopausal women and among patients with the CT performed after breast cancer surgery. Specific adipose tissue and low-density muscle can be associated with the TNBC subtype in breast cancer patients. The direction of association warrants confirmation by prospective studies. Full article

Consumption of dietary natural components such as genistein (GE) found in soy-rich sources is strongly associated with a lower risk of breast cancer. However, bioactive dietary component-based therapeutic strategies are largely understudied in breast cancer treatment. Our investigation sought to elucidate the potential mechanisms linking bioactive dietary GE to its breast cancer chemotherapeutic potential in a special subtype of aggressive breast cancer—triple-negative breast cancer (TNBC)—by utilizing two preclinical patient-derived xenograft (PDX) orthotopic mouse models: BCM-3204 and TM00091. Our study revealed that administration of GE resulted in a delay of tumor growth in both PDX models. With transcriptomics analyses in TNBC tumors isolated from BCM-3204 PDXs, we found that dietary soybean GE significantly influenced multiple tumor-regulated gene expressions. Further validation assessment of six candidate differentially expressed genes (DEGs)—Cd74, Lpl, Ifi44, Fzd9, Sat1 and Wwc1—demonstrated a similar trend at gene transcriptional and protein levels as observed in RNA-sequencing results. Mechanistically, GE treatment-induced Cd74 downregulation regulated the NF-κB/Bcl-xL/TAp63 signal pathway, which may contribute to soybean GE-mediated therapeutic effects on TNBC tumors. Additionally, our findings revealed that GE can modify expression levels of key epigenetic-associated genes such as DNA methyltransferases (Dnmt3b), ten-eleven translocation (Tet3) methylcytosine dioxygenases and histone deacetyltransferase (Hdac2), and their enzymatic activities as well as genomic DNA methylation and histone methylation (H3K9) levels. Collectively, our investigation shows high significance for potential development of a novel therapeutic approach by using bioactive soybean GE for TNBC patients who have few treatment options. Full article

This article presents the first results obtained from the use of high-resolution images from the SAR-X sensor of the PAZ satellite platform. These are in result of the application of various radar image-treatment techniques, with which we wanted to carry out a non-invasive exploration of areas of the archaeological site of Clunia (Burgos, Spain). These areas were analyzed and contrasted with other sources from high-resolution multispectral images (TripleSat), or from digital surface models obtained from Laser Imaging Detection and Ranging (LiDAR) data from the National Plan for Aerial Orthophotography (PNOA), and treated with image enhancement functions (Relief Visualization Tools (RVT)). Moreover, they were compared with multispectral images created from the Infrared Red Blue (IRRB) data contained in the same LiDAR points. Full article

The Global Precipitation Measurement (GPM) Dual-Frequency Precipitation Radar (DPR) (Ku- and Ka-band, or 14 and 35 GHz) provides the capability to resolve the precipitation structure under moderate to heavy precipitation conditions. In this manuscript, the use of near-coincident observations between GPM and the CloudSat Profiling Radar (CPR) (W-band, or 94 GHz) are demonstrated to extend the capability of representing light rain and cold-season precipitation from DPR and the GPM passive microwave constellation sensors. These unique triple-frequency data have opened up applications related to cold-season precipitation, ice microphysics, and light rainfall and surface emissivity effects. Full article

The joint CloudSat–Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) climatology remains the only dataset that provides a global, vertically-resolved cloud amount statistic. However, data are affected by uncertainty that is the result of a combination of infrequent sampling, and a very narrow, pencil-like swath. This study provides the first global assessment of these uncertainties, which are quantified using bootstrapped confidence intervals. Rather than focusing on a purely theoretical discussion, we investigate empirical data that span a five-year period between 2006 and 2011. We examine the 2B-Geometric Profiling (GEOPROF)-LIDAR cloud product, at typical spatial resolutions found in global grids (1.0°, 2.5°, 5.0°, and 10.0°), four confidence levels (0.85, 0.90, 0.95, and 0.99), and three time scales (annual, seasonal, and monthly). Our results demonstrate that it is impossible to estimate, for every location, a five-year mean cloud amount based on CloudSat–CALIPSO data, assuming an accuracy of 1% or 5%, a high confidence level (>0.95), and a fine spatial resolution (1°–2.5°). In fact, the 1% requirement was only met by ~6.5% of atmospheric volumes at 1° and 2.5°, while the more tolerant criterion (5%) was met by 22.5% volumes at 1°, or 48.9% at 2.5° resolution. In order for at least 99% of volumes to meet an accuracy criterion, the criterion itself would have to be lowered to ~20% for 1° data, or to ~8% for 2.5° data. Our study also showed that the average confidence interval: decreased four times when the spatial resolution increased from 1° to 10°; doubled when the confidence level increased from 0.85 to 0.99; and tripled when the number of data-months increased from one (monthly mean) to twelve (annual mean). The cloud regime arguably had the most impact on the width of the confidence interval (mean cloud amount and its standard deviation). Our findings suggest that existing uncertainties in the CloudSat–CALIPSO five-year climatology are primarily the result of climate-specific factors, rather than the sampling scheme. Results that are presented in the form of statistics or maps, as in this study, can help the scientific community to improve accuracy assessments (which are frequently omitted), when analyzing existing and future CloudSat–CALIPSO cloud climatologies. Full article

The UK’s TechDemoSat-1 (TDS-1), launched 2014, has demonstrated the use of global positioning system (GPS) signals for monitoring ocean winds and sea ice. Here it is shown, for the first time, that Galileo and BeiDou signals detected by TDS-1 show similar promise. TDS-1 made seven raw data collections, recovering returns from Galileo and BeiDou, between November 2015 and March 2019. The retrieved open ocean delay Doppler maps (DDMs) are similar to those from GPS. Over sea ice, the Galileo DDMs show a distinctive triple peak. Analysis, adapted from that for GPS DDMs, gives Galileo’s signal-to-noise ratio (SNR), which is found to be inversely sensitive to wind speed, as for GPS. A Galileo track transiting from open ocean to sea ice shows a strong instantaneous SNR response. These results demonstrate the potential of future spaceborne constellations of GNSS-R (global navigation satellite system–reflectometry) instruments for exploiting signals from multiple systems: GPS, Galileo, and BeiDou. Full article

Pan-sharpening aims at integrating spectral information from a multi-spectral (MS) image and spatial information from a panchromatic (PAN) image in a fused image with both high spectral and spatial resolutions. Numerous pan-sharpening methods are based on intensity-hue-saturation (IHS) transform, which may cause evident spectral distortion. To address this problem, an IHS-based pan-sharpening method using ripplet transform and compressed sensing is proposed. Firstly, the IHS transform is applied to the MS image to separate intensity components. Secondly, discrete ripplet transform (DRT) is implemented on the intensity component and the PAN image to obtain multi-scale sub-images. High-frequency sub-images are fused by a local variance algorithm and, for low-frequency sub-images, compressed sensing is introduced for the reconstruction of the intensity component so as to integrate the local information from both the intensity component and the PAN image. The specific fusion rule is defined by local difference. Finally, the inverse ripplet transform and inverse IHS transform are coupled to generate the pan-sharpened image. The proposed method is compared with five state-of-the-art pan-sharpening methods and also the Gram-Schmidt (GS) method through visual and quantitative analysis of WorldView-2, Pleiades and Triplesat datasets. The experimental results reveal that the proposed method achieves relatively higher spatial resolution and more desirable spectral fidelity. Full article