Search Results (22)

Food labels are common elements of everyday life. However, from the point of view of communication researchers (especially visual communication), they are incredibly interesting cultural artifacts, located at the intersection of communication, design, technology, and regulation. This article analyzes the evolution of the labels of Muszynianka, a leading mineral water brand in Poland, from the perspective of media archaeology. It treats labels as dual artifacts—media (information carriers, regulatory objects) and artistic (elements of applied art, design). This article emphasizes the importance of materiality, the non-linearity of history and the analysis of the technological–regulatory “archive.” It develops concepts of labels as complex, multimodal messages, especially in a historical context. The authors conducted a visual analysis of the evolution of Muszynianka’s labels, placing them within broader design trends. To explore recurring visual and narrative motifs, a topoi analysis method was used to identify three basic topoi: Topos of Nature/Mountain Origin, Topos of Health/Vitality/Purity, and Topos of Modernity/Technology. Full article

The present study looks at how gentilics, usually attested in traditional biblical topoi from the Pentateuch, are re-contextualized in Ezekiel to provide a mental map of the peoples of the known Earth during the Exilic period. The basic constituents of Ezekiel’s mental map of foreign peoples recall some of the configurations known from the Babylonian mental map tradition. One known iteration of the latter is the Babylonian World Map (BM 92687). The document presents several interesting features as to how mental maps are formed in the Babylonian context. Its composition may date back to the late eighth century BCE. It is an iteration of the Babylonian mental map with a unique unmarked epicentre. Furthermore, it was probably impressed on clay on the occasion of a military campaign or itinerant work concerning specific toponyms in southern Babylonia. Finally, it was copied for scribal purposes in the Neo-Babylonian period. The present study proposes that these dynamics of the Babylonian mental map help understand Ezekiel’s mental map of foreign peoples. Aspects of Ezekiel’s mental map owe to an older Hebrew tradition partly known from the Pentateuch, although it is a unique iteration for Ezekiel’s oracles against the nations with historical references to the Exilic period. Jerusalem is the epicentre. Two main rings of foreign peoples encircle Jerusalem. The first circle comprises Judah’s neighbours from the east, south, west, and northwest. The second circle picks up from the northwest going up the coast, then south to Egypt, and finally east and northeast with Gog of Magog. Ezekiel concludes with the Temple Vision confirming Jerusalem’s central position. This case study implies that Ezekiel encountered and independently adapted aspects of the Mesopotamian mental map. Comparisons such as the one attempted here can illustrate the potential of ancient Near Eastern intertextuality and cultural hybridity. Full article

Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their impact on cell growth inhibition, induction of apoptosis, and cell cycle distribution were assessed in three different cell lines. Their inhibitory effects on the topoisomerase (Topo) I and II were investigated in vitro. Molecular docking studies were conducted to predict the binding affinities of these compounds for crystallized downloaded topoisomerases. Results: The compounds were examined in vitro for their anticancer activity against human hepatic (HepG2) colon (HCT-8) and breast (MCF-7) carcinoma cell lines. Compound 8b was the most active against HepG2, HCT-116, and MCF-7 with IC₅₀ 14.51, 9.39, and 8.83 µM, respectively, compared to Doxorubicin as reference. In addition, it demonstrated the highest potency among the tested compounds against Topo-I, with an IC₅₀ value of 3.41 µg/mL compared to the control camptothecin (IC₅₀ of 1.46 μM). Compound 7c displayed a significant inhibitory effect on Topo-II, with an IC₅₀ of 7.33 μM, compared to an IC₅₀ value of 6.49 μM via Doxorubicin, the control. Compounds 7c and 8b were assessed against topoisomerases showing induction of apoptosis and a reduction in the S phase of the cell cycle. Molecular docking demonstrated interaction with the active site as with those exhibited by the co-crystallized ligands of the crystallized proteins in both topoisomerases. Conclusion: Compounds 7c and 8b hold promise as potential anticancer drugs due to their anti-proliferative and proapoptotic effects, which are mediated by their action on the topoisomerase enzyme, particularly Topo II. Full article

In the spring and summer of 1906, while visiting the rural village of Gósol in the Spanish Pyrenees, Picasso executed his first woodcut, made two sculptures out of boxwood, and began to focus on the topoi of wood and the forest as avatars of primal matter and of that which lies beyond civilization. In a subsequent series of paintings, he used wooden supports for images that depict male and female heads that look as if they had been chiseled out of wood. Others represent nude figures in forest settings, with explicitly sexual gestures and poses connoting a range of attitudes. These little studied works provide an optic into Picasso’s early exploration of the emergence of sexual identity as an inner psychic state, but one whose signs can be read through the body. Later, responding to the proliferation of cheap, industrially produced materials, including trompe l’oeil woodgrain wallpaper, Picasso began to treat woodgrain as a mere surrogate, one that marks its distance from actual wood through a variety of painterly and mechanical effects. No longer associated with “primitive” authenticity and the primordial forces of the forest, woodgrain now appears as a false sign open to conceptual play and metamorphosis. Full article

Topoisomerase I (TopoI) in Streptococcus pneumoniae, encoded by topA, is a suitable target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks this enzyme. We obtained the topARA mutant, which encodes an enzyme less active than the wild type (topAWT) and more resistant to SCN inhibition. Likely due to the essentiality of TopoI, we were unable to replace the topAWT allele by the mutant topARA version. We compared the in vivo activity of TopoIRA and TopoIWT using regulated overexpression strains, whose genes were either under the control of a moderately (P_Zn) or a highly active promoter (P_Mal). Overproduction of TopoIRA impaired growth, increased SCN resistance and, in the presence of the gyrase inhibitor novobiocin (NOV), caused lower relaxation than TopoIWT. Differential transcriptomes were observed when the topAWT and topARA expression levels were increased about 5-fold. However, higher increases (10–15 times), produced a similar transcriptome, affecting about 52% of the genome, and correlating with a high DNA relaxation level with most responsive genes locating in topological domains. These results confirmed that TopoI is indeed the target of SCN in S. pneumoniae and show the important role of TopoI in global transcription, supporting its suitability as an antibiotic target. Full article

From the Late Ming to the Republican period, Chinese Catholics living in Jiangnan (present-day Shanghai, Jiangsu, and Anhui) progressively appropriated the sacramental doctrine and practices of the Church. This study examines the implementation and evolution of the sacraments of baptism, marriage, and extreme unction, and it focuses on each of them at a different moment in the process of acculturation. The latter can be analyzed in terms of both localization and globalization: on the one hand, the religiosity displayed by the grassroots communities integrated elements proper to Chinese tradition and sensitivity. On the other hand, local believers developed a consciousness of their participation in the global Church through active sacramental practice. Sacramental acculturation and identity building were mediated by a “ritual rhetoric” that provided communities with topoi through which to endow their existence with accrued meaning and blessings. Full article

The DNA topoisomerases gyrase and topoisomerase I as well as the nucleoid-associated protein HU maintain supercoiling levels in Streptococcus pneumoniae, a main human pathogen. Here, we characterized, for the first time, a topoisomerase I regulator protein (StaR). In the presence of sub-inhibitory novobiocin concentrations, which inhibit gyrase activity, higher doubling times were observed in a strain lacking staR, and in two strains in which StaR was over-expressed either under the control of the ZnSO₄-inducible P_Zn promoter (strain ΔstaRP_ZnstaR) or of the maltose-inducible P_Mal promoter (strain ΔstaRpLS1ROMstaR). These results suggest that StaR has a direct role in novobiocin susceptibility and that the StaR level needs to be maintained within a narrow range. Treatment of ΔstaRP_ZnstaR with inhibitory novobiocin concentrations resulted in a change of the negative DNA supercoiling density (σ) in vivo, which was higher in the absence of StaR (σ = −0.049) than when StaR was overproduced (σ = −0.045). We have located this protein in the nucleoid by using super-resolution confocal microscopy. Through in vitro activity assays, we demonstrated that StaR stimulates TopoI relaxation activity, while it has no effect on gyrase activity. Interaction between TopoI and StaR was detected both in vitro and in vivo by co-immunoprecipitation. No alteration of the transcriptome was associated with StaR amount variation. The results suggest that StaR is a new streptococcal nucleoid-associated protein that activates topoisomerase I activity by direct protein-protein interaction. Full article

Krystyna Miłobędzka (born 1932) is one of the most interesting and unique phenomena of the Polish poetry scene of the 20th and 21st centuries. Two characteristics of her poetry, the visual character of her many poems and her preoccupation with the concept of the garden-world, are worth a closer look. Miłobędzka’s poetry refers to the topoï of the garden-world in single poems and cycles of poetic texts. Her hortus mirabilis, inserts itself into the sphere of the metaphysical reflection of nature, giving Miłobędzka’s poetry a specific dynamic in which the “I”—the gardener—has a significant role as an observer, and as a creator of entities. The activity of looking, which happens, in fact, in all types of verbs and aspects, is in this specific sphere (look, watch, see), fundamental to defining oneself in the world and the world’s relationship to oneself. In this perspective, the image of the garden from childhood, is confronted by a necessary new visualization. The temporal aspect of the garden is at the center of existence, in the cyclical return of nature’s laws of rebirth and death, which are relevant to the personal, singular perspective of the end in many of Miłobędzka’s volumes. In Anaglify (Anaglyphs), some poems particularly fit the issue of visuality in poetry, not only at the conceptual level, the place granted to observation, the poet-particular observer, but the poem itself. They are conceived as graphic and pictorial realizations. Poems from the volume dwanaście wierszy w kolorze (twelve poems in color) or wszystkowiersze (omnipoems) are special cases of these. The selected words are conceived in color, and their arrangement on the space of the page has meaning. The parallel between looking and writing, which Miłobędzka consistently uses in her writing method and poetically admits, is also very important. Although her poetic diction alludes to historical avant-garde and linguistic poetry achievements, her lyrical savoir-faire is characterized by a certain new minimalist construction and a separate, recognizable style. Miłobędzka’s innovativeness lies in combining seemingly distant and sometimes poetically opposite categories: full, ambiguous image-in-poem and asceticism by means of expression, such as a minimal number of words. Her poetry is deeply rooted in perceiving, seeing, watching, and contemplating the world—faithful to its physicality but also open to the most essential questions of philosophy asking about existence and its limits. This new visibility of elements is reflected in authentic poetic delight and in the “visualizing” form, where the poem also becomes an image on the plane of a sheet of paper or becoming one side of the house wall as a mural poem. Full article

The massive amount of available neurodata suggests the existence of a mathematical backbone underlying neuronal oscillatory activities. For example, geometric constraints are powerful enough to define cellular distribution and drive the embryonal development of the central nervous system. We aim to elucidate whether underrated notions from geometry, topology, group theory and category theory can assess neuronal issues and provide experimentally testable hypotheses. The Monge’s theorem might contribute to our visual ability of depth perception and the brain connectome can be tackled in terms of tunnelling nanotubes. The multisynaptic ascending fibers connecting the peripheral receptors to the neocortical areas can be assessed in terms of knot theory/braid groups. Presheaves from category theory permit the tackling of nervous phase spaces in terms of the theory of infinity categories, highlighting an approach based on equivalence rather than equality. Further, the physical concepts of soft-matter polymers and nematic colloids might shed new light on neurulation in mammalian embryos. Hidden, unexpected multidisciplinary relationships can be found when mathematics copes with neural phenomena, leading to novel answers for everlasting neuroscientific questions. For instance, our framework leads to the conjecture that the development of the nervous system might be correlated with the occurrence of local thermal changes in embryo–fetal tissues. Full article

The paper focuses on the structure of an advertising image for a 2010s computer company in the neo-capitalist Moscow, Russia. The analysis looks back to the pioneering studies of advertising as a commercial “applied art” by Sergei Eisenstein, Leo Spitzer and Roland Barthes. The picture’s plot and composition are shown to be a consistent and sophisticated near-artistic design that uses textual puns, poetic topoi and visual stereotypes (in particular, sex appeal) for the promotion of the advertised merchandise (a smartphone). The psychological naturalization of the design is clarified with references to the insights of Sigmund Freud, Heinz Kohut and Gerard Genette into the dynamics of narcissism. In a widening circle, the contextualization of the design involves: the literary topos of using birds in love poetry (made famous by its treatment in the lyrics of the Roman poet Catullus) and in painterly variations on the theme; the narcissist discourse of a modern Russian poet (Eduard Limonov); and the grand pictorial tradition of portraying a nude (Venus) before the mirror (relevant classical canvases are considered briefly). Full article

Recent years have witnessed the emergence of a new strand of British fiction that grapples with the causes and consequences of the United Kingdom’s vote to leave the European Union. Building on Kristian Shaw’s pioneering work in this new literary field, this article shifts the focus from literary fiction to science fiction. It analyzes Dave Hutchinson’s Fractured Europe quartet—comprised of Europe in Autumn (pub. 2014), Europe at Midnight (pub. 2015), Europe in Winter (pub. 2016) and Europe at Dawn (pub. 2018)—as a case study in British science fiction’s response to the recent nationalistic turn in the UK. This article draws on a bespoke interview with Hutchinson and frames its discussion within a range of theories and studies, especially the European hermeneutics of Hans-Georg Gadamer. It argues that the Fractured Europe quartet deploys science fiction topoi to interrogate and criticize the recent rise of English nationalism. It further contends that the Fractured Europe books respond to this nationalistic turn by setting forth an estranged vision of Europe and offering alternative modalities of European identity through the mediation of photography and the redemptive possibilities of cooking. Full article

The purpose of this paper is to promote new methods in mathematical modeling inspired by neuroscience—that is consciousness and subconsciousness—with an eye toward artificial intelligence as parts of the global brain. As a mathematical model, we propose topoi and their non-standard enlargements as models, due to the fact that their logic corresponds well to human thinking. For this reason, we built non-standard analysis in a special class of topoi; before now, this existed only in the topos of sets (A. Robinson). Then, we arrive at the pseudo-particles from the title and to a new axiomatics denoted by Intuitionistic Internal Set Theory ($\mathbf{IIST}$); a class of models for it is provided, namely, non-standard enlargements of the previous topoi. We also consider the genetic–epigenetic interplay with a mathematical introduction consisting of a study of the Yang–Baxter equations with new mathematical results. Full article

Since the earliest studies of Islam by non-Muslims were carried out, variant traditions (aḥādīth) have been regarded as a proof of forgery or editing within the ḥadīth material. Early studies have shown that variances are the result of different processes, some intentionally and others mistakenly; some caused by editing processes, while others through the process of transmission across the first centuries of Islam. During the transmission process, or the genesis of a tradition, accounts are constantly shaped and adjusted. The use of topoi forms a part of this process as well as the inclusion of motifs in different accounts. The present article will explore one of these motifs, specifically, the instruction of the Prophet Muḥammad, on his deathbed, to bring him writing materials so that he could prepare a document for his community. This motif appears in a number of accounts with different settings, characters and details on the nature of the document itself. This article examines whether there exists a direct relationship between the different accounts and, if so, what does this mean. Through this study, we will see that additional motifs have been added to this tradition during its transmission process and that some of these motifs can be attributed to regionalisation or specific transmitters. Full article

The Mandalorian is a very popular science-fiction show (two seasons, 2019–2020) set in the famous Star Wars Universe. Studies have shown that myth and religious thought played a crucial role in the creation of the Star Wars Universe. This article continues that tradition, albeit from a particular perspective that highlights religious language: by viewing The Mandalorian through a New Testament lens, it is argued that while many elements of popular culture reference Biblical or mythological sources, The Mandalorian’s use of these referents illustrates the way in which ancient religious and New Testament literature are still very much a shared phenomenon. Both The Mandalorian and the New Testament share certain timeless topoi: a mysterious character with extraordinary abilities, a connection to life-giving powers of the universe that give extraordinary abilities, choosing a certain way of life and the costs thereof, and also themes such as “debt”, “redemption”, and “beliefs” and how these are challenged. By using these themes, The Mandalorian presents itself as a modern myth. Full article

The METAPOLIS as the polycentric network of urban–rural settlement is undergoing constant transformation and urbanization processes. In particular, the associated imbalance of the shrinkage and growth of different settlement types in relative geographical proximity causes negative effects, such as urban sprawl and the divergence of urban–rural lifestyles with their related resource, land and energy consumption. Implicitly related to these developments, national and global sustainable development goals for the building sector lead to the question of how a region can be assessed without detailed research and surveys to identify critical areas with high potential for sustainable development. In this study, the TOPOI method is used. It classifies settlement units and their interconnections along the urban–rural gradient, in order to quantify and assess the land-uptake and global warming potential driven by residential developments. Applying standard planning parameters in combination with key data from a comprehensive life cycle assessment of the residential building stock, a detailed understanding of different settlement types and their associated resource and energy consumption is achieved. Full article