The purpose of this work is to investigate the binding state of inorganic elements to flavonoid components in aqueous extract of Silybum marianum (SM) seeds, as well as the antioxidant activity of the extract. This study employed reversed-phase high-...
This is the first study on the modeling of the controlled release of the estimated antioxidants (flavonoids or flavonolignans) from β-cyclodextrin (β-CD)/hydrophilic vegetable extract complexes and the modeling of transdermal pharmaceutical...
Silybum marianum L., commonly known as milk thistle, is traditionally recognized for its hepatoprotective properties. This is primarily due to silymarin, a mixture of flavonolignans with strong antioxidant and anti-inflammatory activities. Although m...
Silybum marianum (L.) Gaertn. (aka milk thistle) constitutes the source of silymarin (SILM), a mixture of different flavonolignans and represents a unique model for their extraction. Here we report on the development and validation of an ultrasound-a...
In this work, leaves of Silybum marianum (L.) Gaertn were extracted by a one-step extraction method using ethanol as a solvent, and the Silybum marianum (L.) Gaertn extract (SMGE) was firstly employed as a green corrosion inhibitor for carbon steel i...
Silybum marianum (L.) Gaertn, viz. milk thistle, has been the focus of research efforts in the past few years, albeit almost exclusively restricted to the medicinal properties of its fruits (achenes). Given that other milk thistle plant organs and ti...
Biotic elicitors such as Aloe vera extract (ALE) have been shown to stimulate growth and modify the bioactive composition of various plant species. ALE has a unique mixture of nutrients that support plant production and growth. In this study, the bio...
Early growth water stress reduces the extract and fresh oil of Silybum marianum L. (S. marianum) shoots. Two experiments were conducted to reduce the effects of early growth drought. Treatments in the first experiment were organic seed cover fillers...
The present study aimed to investigate the enzymatic potential of Silybum marianum leaves to bioconvert phenolic acids produced in S. marianum callus into silymarin derivatives as chemopreventive agent. Here we demonstrate that despite the fact that...
Silybin A and B are two major hepatoprotective flavonolignans produced predominantly in Silybum marianum fruits. Similar to other plant secondary metabolites, silybin production is enhanced by biotic or abiotic stresses under the expanse of plant gro...
Modern poultry production looks for feed and water additives that improve the welfare of chickens. The utilization of herbs as additives in feed or drinking water is becoming increasingly well known. The aim of this study was to determine the effect...
Background/Objectives: Silybum marianum extract, obtained via microwave-enhanced extraction, was evaluated for its antioxidant, antidiabetic, and antimicrobial activities to explore its therapeutic potential. Methods: The extraction was performed usi...
In the present study, extract (E) and bio-ferment (B) were obtained from ground and defatted thistle seeds of Silybum marianum. Their antioxidant activity was assessed using the DPPH, ABTS, and FRAP techniques, while total polyphenols were measu...
Overweight and obese dogs can develop metabolic dysfunction, characterized by an inflammatory response and involvement of liver functions. If a modulation of the gut microbiome and its interaction with the gut–liver axis is implicated in the de...
Background: Gastroparesis, a chronic digestive disorder characterized by delayed gastric emptying, often results from diabetes, post-surgical complications, autoimmune diseases, and neurological disorders. In approximately 50% of cases, the cause is...
Wound infections became a great challenge, especially after the emergence of bacterial resistance to commonly used antibiotics. Medicinal plants can be the source of alternative antibacterial agents effective against multi drug resistant (MDR) bacter...
Fusarium head blight (FHB) is a disease that poses a major challenge in cereal production that has important food and feed safety implications due to trichothecene contamination. In this study, the effect of stevioside—a glycoside found in the...
Silybum marianum (L.) Gaertn is a rich source of antioxidants and anti-inflammatory flavonolignans with great potential for use in pharmaceutical and cosmetic products. Its biotechnological production using in vitro culture system has been proposed....
Multifactorial pathogenesis of non-alcoholic steatohepatitis (NASH) disease, a wide-spread liver pathology associated with metabolic alterations triggered by hepatic steatosis, should be hit by multitarget therapeutics. We tested a multicomponent foo...
Background: Homeostasis in the differentiation programme of sebaceous stem cells has been identified as a key step in comedogenesis and should be a target for acne-prone skin care. Objective: To report on a multicentre, year-long/real-life use study...
Microbotryum silybum, a smut fungus, is studied as an agent for the biological control of Silybum marianum (milk thistle) weed. Confirmation of the systemic infection is essential in order to assess the effectiveness of the biological control applica...
The objective of this study was to develop solid self-emulsifying pellets to deliver the poorly bioavailable Milk Thistle extract (Silybum Marianum) [1]. [...]
There is a need to enhance the production of bioactive secondary metabolites and to establish new production systems, e.g., for liver-protective compounds of Silybum marianum seeds. Quantifying and identifying the produced phytochemicals, and examini...
Background: Phytoestrogens are promising alternatives to menopausal hormone therapy, but their clinical application is limited by poor solubility and bioavailability. Silybum marianum (milk thistle) contains flavonolignans with reported estrogenic po...
Medicinal plants extracts are a rich natural source of bioactive phytochemicals (mainly polyphenols). This study aims at determining the total polyphenols content (TPC) of nine medicinal plants extracted using the UV-visible (UV-Vis) spectroscopic me...
This study aims to explore the potential of Algerian milk thistle (Silybum marianum) seeds for food application. Solid–liquid extraction and Soxhlet extraction methods were employed to obtain both aqueous and fatty fractions using different sol...
Silymarin is the standardized extract from the fruits of Silybum marianum (L.) Gaertn., a well-known hepatoprotectant and antioxidant. Recently, bioactive compounds of silymarin, i.e., silybins and their 2,3-dehydro derivatives, have been shown to ex...
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The main component of S. marianum fruit extract (silymarin) is a flavonolignan called silybin, which is not only the...
Silybum marianum fruit extract silymarin displays various biological activities, which are attributed mostly to its major component silybin. However, silymarin contain several other isomeric flavonolignans (isosilybin, silychristin, silydianin) and t...
The health-promoting properties of Silybum marianum have been acknowledged since antiquity. This plant is credited with substantial hepatoprotective properties and is also protective in cardiovascular diseases, diabetes mellitus, and neurodegeneratio...
Silybum marianum is a medicinal plant that produces silybins A and B, which exhibit liver-protective activities. The He–Ne laser pre-sowing seed treatment has been used as a physical biostimulator in numerous plants to promote seed germination,...
Cancer is one of the major causes of death globally, which involves uncontrollable growth and spread of abnormal cells. Cytotoxic plant extracts may act on various cancer cells. In this study cytotoxicity of five cultivated Asteraceae plant extracts...
Silybum marianum (L.) Gaertn. is a well-known medicinal herb, primarily used in liver protection. Light strongly affects several physiological processes along with secondary metabolites biosynthesis in plants. Herein, S. marianum was exploited for in...
The fatty acid composition of some seed oils from plants of emerging interest was studied. The benefits towards human health were evaluated by taking into account current recommendations regarding dietary intake of essential, polyunsaturated, and mon...
Silybum marianum (L.) is a medicinal plant traditionally used in treatment of liver disorders. In last decades, silymarin (SM), a standardized extract from S. marianum seeds has been studied for its dermatological application, namely for UVB-protecti...
This study aimed to evaluate the inhibitory potential of phenolic-rich extracts from selected medicinal plants belonging to the Lamiaceae and Asteraceae families against the furin protease enzyme, a key target in viral and oncogenic pathways. Extract...
Plant extracts rich in phenolic compounds have been reported to exert different bioactive properties. Despite the fact that there are plant extracts with completely different phenolic compositions, many of them have been reported to have similar bene...
The manipulation of allelopathic mechanisms, such as the isolation of plant allelochemicals for bioherbicide production, is currently providing a new tool for weed management methods of reducing or potentially eliminating the use of synthetic herbici...
Silymarin is a hepatoprotective mixture of flavonolignans and flavonoids extracted from the seeds of milk thistle (Silybum marianum L. Gaertn). This study investigates the effect of major bioactive constituents from silymarin, silybin A, silybin B, i...
The purpose of the current study was green synthesis of ZnO-nanoparticles (NPs) from different tissues of Silybum marianum (L.) Gaernt. (i.e., seeds, wild plant, in vitro derived plantlets and callus cultures) followed by extensive characterization a...
Silybum marianum L. is a therapeutic plant belonging to the family Asteraceae, which has exhibited silymarin, a principal component used to cure various physiochemical disorders. The study appraised the phytochemical analysis, antioxidant activity an...
Phenolic compounds during recent decades have been the object of study by the scientific community due to their high and diverse bioactive potential, with their antioxidant capacity being one of their most studied properties since, due to their struc...
Silybin, which belongs to the flavonolignan group, is the major component of the fruit extract of Silybum marianum (common name: milk thistle). Silybin is a medicinal compound with hepatoprotective, antioxidant, and anticancer properties. In this stu...
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, has anti-oxidant, anti-inflammatory, anti-cancer and anti-viral activities potentially useful in the treatment of sever...
Milk thistle-based dietary supplements have become increasingly popular. The extract from milk thistle (Silybum marianum) is often used for the treatment of liver diseases because of the presence of its active component, silymarin. However, the co-oc...
Silymarin, salvianolic acids B, and puerarin were considered healthy food agents with tremendous potential to ameliorate non-alcoholic fatty liver disease (NAFLD). However, the mechanisms by which they interact with gut microbiota to exert benefits a...
Milk thistle (Silybum marianum (L.)) is a wild medicinal herbal plant that is widely used in folk medicine due to its high content of secondary metabolites (SMs) and silymarin; however, the data regarding the response of milk thistle to salinity are...
Glycation is an ageing reaction of naturally occurring sugars with dermal proteins, with clinical signs appearing in vivo around age 30, and increasing steadily/regularly with age. The suppleness of the dermis is affected by the formation of bridges...
Milk thistle is one of the most popular ingredients in the liver protection products market. Silymarin is the main component of milk thistle and contains multiple isomers. There have been few studies focusing on the compositional ratios of silymarin...
Silymarin (SM) is a mixture of flavolignans extracted from the seeds of species derived from Silybum marianum, commonly known as milk thistle or St. Mary’sthistle. These species have been widely used in the treatment of liver disorders in tradi...
of 3