6,272 Results Found

The present paper proposes the application of the safe-by-design concept to crop breeding innovation with the aim to accommodate safety considerations for new agricultural food and feed products. Safe-by-design can be implemented in all stages of the...

In this paper, we provide an overview of how Safe-by-Design is conceived and applied in practice in a large number of engineering disciplines. We discuss the differences, commonalities, and possibilities for mutual learning found in those practices a...

Manufactured nanomaterials (MNMs) are regarded as key components of innovations in various fields with high potential impact (e.g., energy generation and storage, electronics, photonics, diagnostics, theranostics, or drug delivery agents). Widespread...

In recent years, Safe-by-Design (SbD) has been launched as a concept that supports science and engineering such that a broad conception of safety is embraced and structurally embedded. The present study explores the extent to which academics in a dis...

Although both the Inherent Safety Principles (ISPs) and the Safe-by-Design (SbD) approach revolve around the central value of safety, they have a slightly different focus in terms of developing add-on features or considering initial design choices. T...

The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D-printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. First, the applicability of FFF in lab-on-a-chip device developme...

The Safe-by-Design (SbD) concept aims to facilitate the development of safer materials/products, safer production, and safer use and end-of-life by performing timely SbD interventions to reduce hazard, exposure, or both. Early hazard screening is a c...

The production and use of engineered nanomaterials and nano-enabled products is increasing, enabling innovations in many application areas, e.g., in the sector of food contact materials. However, nanosafety-relevant information for chemical risk asse...

In the biomedical field, gold nanoparticles (GNPs) have attracted the attention of the scientific community thanks to their high potential in both diagnostic and therapeutic applications. The extensive use of GNPs led researchers to investigate their...

Silver nanoparticles (Ag NPs) are among the most widely used metal-based nanomaterials (NMs) and their applications in different products, also as antibacterial additives, are increasing. In the present manuscript, according to an adverse outcome pat...

It is acknowledged that the physicochemical properties of nanomaterials (NMs) have an impact on their toxicity and, eventually, their pathogenicity. These properties may include the NMs’ surface chemical composition, size, shape, surface charge, surf...

This study introduces a systems-theoretic methodology to meet the requirements of a major national infrastructure for safety and security-based design by enhancing the alignment of stakeholders and actors in the project. Safe-by-Design (SbD) is an en...

Nanomaterials have found extensive interest in the development of novel vaccines, as adjuvants and/or carriers in vaccination platforms. Conjugation of protein antigens at the particle surface by non-covalent adsorption is the most widely used approa...

Predictive toxicity and structure–activity relationships (SARs) are raising interest since the number of nanomaterials has become unmanageable to assess their toxicity with a classical case-by-case approach. Graphene-based materials (GBMs) are among...

In the last few years, the materials research community has shown increased interest in Advanced Materials (AdMas) that are specifically designed to substitute the traditionally used materials, not only with a view to their sustainability, sourcing c...

One of the key interesting features of collaborative robotic applications is the potential to lighten the worker workload and potentiate better working conditions. Moreover, developing robotics applications that meets ergonomic criteria is not always...

Security in public spaces has long been the subject of debate and extensive experimentation. With the exponential growth in risks (both expected and unexpected) that public spaces are exposed to, further exacerbated by the pandemic crisis, urban secu...

Several attempts have been made to replace the critical raw material platinum (Pt) with other metals, mainly focusing on its functional performance, while safety and sustainability criteria are often overlooked. Here, the substitution of Pt by nickel...

In this paper, we explore solution directions for the implementation of Safe by Design (SbD) in safety regimes for academic experimentation. SbD is a dynamic and anticipatory strategy for safety regulation in academic research. In this strategy, safe...

Bone infections are a key health challenge with dramatic consequences for affected patients. In dentistry, periodontitis is a medically compromised condition for efficient dental care and bone grafting, the success of which depends on whether the sur...

Integrated circuits are the core building components of virtually all communication systems. Wireless communication systems are becoming increasingly common. They require specialized transmission components to reduce electromagnetic interference. Thi...

In recent years, the issue of coral bleaching has led to restrictions in some tropical locations (i.e., Palau, Hawaii, etc.) on the use of some organic UV sunscreen filters, such as oxybenzone and ethyl hexyl methoxycinnamate. In contrast, ZnO is con...

Industry and scientists develop new nanomaterials and nano-enabled products to make use of the specific properties that the nanoscale can bring. However, the benefit of a nano-enabled product over a conventional product is not always a given. This pa...

This manuscript describes an innovative approach to socio-economic assessment of (advanced) engineered nanomaterials and nano-enabled products (NEPs) to support safe-and-sustainable-by-design (SSbD) decision making by industries in the early stages o...

The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns that applications of NBMs for...

Nanomedicine is a rapidly growing field that uses nanomaterials for the diagnosis, treatment and prevention of various diseases, including cancer. Various biocompatible nanoplatforms with diversified capabilities for tumor targeting, imaging, and the...

CuO nanoparticles produced by methods from inorganic chemistry and physics are applied as biocides and applications thereof in solar stills, solar collectors, catalysis, sensing and diesel fuels have been proposed. Such CuO nanoparticles are hazardou...

The enormous technological relevance of titanium dioxide (TiO₂) nanoparticles (NPs) and the consequent concerns regarding potentially hazardous effects that exposure during production, use, and disposal can generate, encourage material scientists to...

Hyaluronic acid (HA) is a polymer with unique biological properties that has gained in interest over the years, with applications in pharmaceutical, cosmetic, and biomedical fields; however, its widespread use has been limited by its short half-life....

Attention to environmental issues has become increasingly important in recent years and also massively affects the cosmetics sector. In this context, sunscreens are questioned due to the proven or believed ecotoxicity of organic ultraviolet (UV) filt...

Phosphorus (P) is a key nutrient for agriculture [...]

Functional coatings for food packaging offer innovative approaches to extend shelf life, preserve quality and introduce active properties such as antimicrobial or antioxidant effects. These coatings include natural bio-based films (e.g., polysacchari...

Nanotechnology is a key enabling technology bringing together chemists, biologists, physicists, and materials science engineers, among others [...]

The photocatalytic oxidation (PCO) of pollutants using TiO₂-based materials can significantly improve indoor air quality (IAQ), which in turn, has a significant impact on human health and life expectancy. TiO₂-based nanoparticles (NPs) are widely use...

Soil invertebrates have been widely used in ecotoxicology studies for decades, although their use as in vitro models, albeit promising, has not been pursued as much. The immune cells of earthworms (coelomocytes) and the coelomic fluid can be used, an...

Thinking in patient safety has evolved over time from more simplistic accident causation models to more robust frameworks of work system design. Throughout this evolution, less consideration has been given to the role of the built environment in supp...

Ubiquitous intelligence of Internet of Things (IoT) objects and new sensors provide innovative solutions for a variety of health issues. Unintentional child poisoning represents an increasingly important health issue worldwide, partially because of a...

A prerequisite for the proper and safe designing of a grounding system is the full knowledge of the ground structure in the terrain of installation. Through soil resistivity measurements, engineers are able to illustrate the ground profile, which con...

Aiming at the unreliability resulting from ignoring the temperature effect and randomness of switching frequency in the traditional design method of an intrinsically safe Buck converter, a reliable design method based on the minimum frequency and con...

This paper investigates how security-by-design principles can be integrated into urban planning to achieve a balance between protective measures and the openness, accessibility, and aesthetic quality of public spaces. Addressing a current gap in urba...

In flammable or explosive environments, an ultrasonic sensor for distance measurement poses an important engineering safety challenge, because the driving circuit uses an intermediate frequency transformer as an impedance transformation element, in w...

Recently, there has been extensive research and development in the field of smart cars, including technologies related to autonomous driving. Various industries are actively working towards creating efficient and safe self-driving cars. Sensor techno...

Safe design is an increasingly influential approach due to a growing recognition of the contribution of design to workplace safety. It aims to eliminate workplace hazards by systematically involving end-users in the design or redesign process. In thi...

In advanced industrial automation, industrial robots have been widely utilized on assembly lines in order to reduce labor dependence. However, many related layout design approaches proposed are prone to generating unsafe layouts: there generally lack...

Ensuring user safety while enabling independent mobility is crucial to autonomous healthcare and rehabilitation robots, such as active lower-limb orthoses and exoskeletons. A key requirement for these devices is to provide full assistance without sup...

Safe navigation is a key objective for autonomous applications, particularly those involving mobile tasks, to avoid dangerous situations and prevent harm to humans. However, the integration of a risk management process is not yet mandatory in robotic...

Many jurisdictions globally have adopted a zero road trauma target by 2050 and an interim target of a 50% reduction by 2030. The objective of this study was to investigate what the road system will need to look like in order to achieve these respecti...

Real-time detection of liquid level in complex environments has always been a knotty issue. In this paper, an intrinsically safe liquid-level sensor system for flammable and explosive environments is designed and implemented. The poly vinyl chloride...

There are a number of empirical methods for determining the width of safe maneuvering areas for ships on waterways. These methods are relatively accurate for straight sections of waterways and less accurate for curves of the waterways. When designing...

Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicol...