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14 pages, 7639 KB  
Article
Advanced Parameter Optimization for Laser Engraving Machines via Genetic Algorithms
by Chen-Yu Lee, Chuin-Mu Wang and Jia-Xian Jian
Appl. Sci. 2025, 15(22), 11925; https://doi.org/10.3390/app152211925 - 10 Nov 2025
Viewed by 417
Abstract
Laser engraving may be used in a variety of industries, from medicine to defense, and it has many uses that require high-quality precision production. However, in practice, operators have to adjust the laser settings manually, which can result in wasted material and poor [...] Read more.
Laser engraving may be used in a variety of industries, from medicine to defense, and it has many uses that require high-quality precision production. However, in practice, operators have to adjust the laser settings manually, which can result in wasted material and poor color quality and even decrease productivity. Current optimization approaches mostly concentrate on single objectives, making it impossible to co-optimize engraving quality and production efficiency simultaneously. In this paper, an approach based on a multi-objective genetic algorithm, a combination of NSGA-II, SPEA2, and MOEA/D, is proposed to automatically establish the relationship between CMYK color attributes, which are extracted from images of engravings, and laser parameters (power, speed, and frequency). Anodized aluminum 6061 was laser-processed using an SPI 30W fiber laser. While the proposed framework is general, the experimental validation in this study was specifically constrained to this material. The results also indicate that MOEA/D converges in a short time and becomes relatively stable after 20 generations. NSGA-II results in solutions that are more diverse, and SPEA2 offers a good trade-off between the speed of convergence and solution size. This approach resulted in optimization in terms of both a decrease in material used and color matching between manual operations, with the average CMYK improvement being up to 28%. Our results indicate that multi-objective evolutionary optimization is feasible for the optimization of efficiency and quality in laser cutting. Full article
(This article belongs to the Special Issue Innovative Applications of Big Data and Cloud Computing, 2nd Edition)
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30 pages, 2274 KB  
Article
Biologically Based Intelligent Multi-Objective Optimization for Automatically Deriving Explainable Rule Set for PV Panels Under Antarctic Climate Conditions
by Erhan Arslan, Ebru Akpinar, Mehmet Das, Burcu Özsoy, Gungor Yildirim and Bilal Alatas
Biomimetics 2025, 10(10), 646; https://doi.org/10.3390/biomimetics10100646 - 25 Sep 2025
Viewed by 514
Abstract
Antarctic research stations require reliable low-carbon power under extreme conditions. This study compiles a synchronized PV-meteorological time-series data set on Horseshoe Island (Antarctica) at 30 s, 1 min, and 5 min resolutions and compares four PV module types (monocrystalline, polycrystalline, flexible mono, and [...] Read more.
Antarctic research stations require reliable low-carbon power under extreme conditions. This study compiles a synchronized PV-meteorological time-series data set on Horseshoe Island (Antarctica) at 30 s, 1 min, and 5 min resolutions and compares four PV module types (monocrystalline, polycrystalline, flexible mono, and semitransparent) under controlled field operation. Model development adopts an interpretable, multi-objective framework: a modified SPEA-2 searches rule sets on the Pareto front that jointly optimize precision and recall, yielding transparent, physically plausible decision rules for operational use. For context, benchmark machine-learning models (e.g., kNN, SVM) are evaluated on the same splits. Performance is reported with precision, recall, and complementary metrics (F1, balanced accuracy, and MCC), emphasizing class-wise behavior and robustness. Results show that the proposed rule-based approach attains competitive predictive performance while retaining interpretability and stability across panel types and sampling intervals. Contributions are threefold: (i) a high-resolution field data set coupling PV output with solar radiation, temperature, wind, and humidity in polar conditions; (ii) a Pareto-front, explainable rule-extraction methodology tailored to small-power PV; and (iii) a comparative assessment against standard ML baselines using multiple, class-aware metrics. The resulting XAI models achieved 92.3% precision and 89.7% recall. The findings inform the design and operation of PV systems for harsh, high-latitude environments. Full article
(This article belongs to the Section Biological Optimisation and Management)
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23 pages, 4093 KB  
Article
Multi-Objective Optimization with Server Load Sensing in Smart Transportation
by Youjian Yu, Zhaowei Song and Qinghua Zhang
Appl. Sci. 2025, 15(17), 9717; https://doi.org/10.3390/app15179717 - 4 Sep 2025
Viewed by 668
Abstract
The rapid development of telematics technology has greatly supported high-computing applications like autonomous driving and real-time road condition prediction. However, the limited computational resources and dynamic topology of in-vehicle terminals pose challenges such as delay, load imbalance, and bandwidth consumption. To address these, [...] Read more.
The rapid development of telematics technology has greatly supported high-computing applications like autonomous driving and real-time road condition prediction. However, the limited computational resources and dynamic topology of in-vehicle terminals pose challenges such as delay, load imbalance, and bandwidth consumption. To address these, a three-layer vehicular network architecture based on cloud–edge–end collaboration was proposed, with V2X technology used for multi-hop transmission. Models for delay, energy consumption, and edge caching were designed to meet the requirements for low delay, energy efficiency, and effective caching. Additionally, a dynamic pricing model for edge resources, based on load-awareness, was proposed to balance service quality and cost-effectiveness. The enhanced NSGA-III algorithm (ADP-NSGA-III) was applied to optimize system delay, energy consumption, and system resource pricing. The experimental results (mean of 30 independent runs) indicate that, compared with the NSGA-II, NSGA-III, MOEA-D, and SPEA2 optimization schemes, the proposed scheme reduced system delay by 21.63%, 5.96%, 17.84%, and 8.30%, respectively, in a system with 55 tasks. The energy consumption was reduced by 11.87%, 7.58%, 15.59%, and 9.94%, respectively. Full article
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30 pages, 4687 KB  
Article
A Multi-Agent Optimization Approach for Multimodal Collaboration in Marine Terminals
by Ilias Alexandros Parmaksizoglou, Alessandro Bombelli and Alexei Sharpanskykh
Logistics 2025, 9(3), 110; https://doi.org/10.3390/logistics9030110 - 8 Aug 2025
Viewed by 1294
Abstract
Background: The rapid growth of international maritime trade has intensified operational challenges at marine terminals due to increased interaction between vessels, trucks, and trains. Key issues include berth congestion, inefficient truck arrivals, and underutilization of terminal resources. Ensuring coordinated planning among transport modes [...] Read more.
Background: The rapid growth of international maritime trade has intensified operational challenges at marine terminals due to increased interaction between vessels, trucks, and trains. Key issues include berth congestion, inefficient truck arrivals, and underutilization of terminal resources. Ensuring coordinated planning among transport modes and fostering collaboration between stakeholders such as vessel operators, logistics providers, and terminal managers is critical to mitigating these inefficiencies. Methods: This study proposes a multi-agent, multi-objective coordination model that synchronizes vessel berth allocation with truck appointment scheduling. A solution method combining prioritized planning with a neighborhood search heuristic is introduced to explore Pareto-optimal trade-offs. The performance of this approach is benchmarked against well-established multi-objective evolutionary algorithms (MOEAs), including NSGA-II and SPEA2. Results: Numerical experiments demonstrate that the proposed method generates a greater number of Pareto-optimal solutions and achieves higher hypervolume indicators compared to MOEAs. These results show improved balance among objectives such as minimizing vessel waiting times, reducing truck congestion, and optimizing terminal resource usage. Conclusions: By integrating berth allocation and truck scheduling through a transparent, multi-agent approach, this work provides decision-makers with better tools to evaluate trade-offs in port terminal operations. The proposed strategy supports more efficient, fair, and informed coordination in complex multimodal environments. Full article
(This article belongs to the Section Maritime and Transport Logistics)
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26 pages, 2599 KB  
Article
Optimal Scheduling of a Hydropower–Wind–Solar Multi-Objective System Based on an Improved Strength Pareto Algorithm
by Haodong Huang, Qin Shen, Wan Liu, Ying Peng, Shuli Zhu, Rungang Bao and Li Mo
Sustainability 2025, 17(15), 7140; https://doi.org/10.3390/su17157140 - 6 Aug 2025
Cited by 1 | Viewed by 1100
Abstract
Under the current context of the large-scale integration of wind and solar power, the coupling of hydropower with wind and solar energy brings significant impacts on grid stability. To fully leverage the regulatory capacity of hydropower, this paper develops a multi-objective optimization scheduling [...] Read more.
Under the current context of the large-scale integration of wind and solar power, the coupling of hydropower with wind and solar energy brings significant impacts on grid stability. To fully leverage the regulatory capacity of hydropower, this paper develops a multi-objective optimization scheduling model for hydropower, wind, and solar that balances generation-side power generation benefit and grid-side peak-regulation requirements, with the latter quantified by the mean square error of the residual load. To efficiently solve this model, Latin hypercube initialization, hybrid distance framework, and adaptive mutation mechanism are introduced into the Strength Pareto Evolutionary Algorithm II (SPEAII), yielding an improved algorithm named LHS-Mutate Strength Pareto Evolutionary Algorithm II (LMSPEAII). Its efficiency is validated on benchmark test functions and a reservoir model. Typical extreme scenarios—months with strong wind and solar in the dry season and months with weak wind and solar in the flood season—are selected to derive scheduling strategies and to further verify the effectiveness of the proposed model and algorithm. Finally, K-medoids clustering is applied to the Pareto front solutions; from the perspective of representative solutions, this reveals the evolutionary trends of different objective trade-off schemes and overall distribution characteristics, providing deeper insight into the solution set’s distribution features. Full article
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34 pages, 1253 KB  
Article
A Discrete Improved Gray Wolf Optimization Algorithm for Dynamic Distributed Flexible Job Shop Scheduling Considering Random Job Arrivals and Machine Breakdowns
by Chun Wang, Jiapeng Chen, Binzi Xu and Sheng Liu
Processes 2025, 13(7), 1987; https://doi.org/10.3390/pr13071987 - 24 Jun 2025
Cited by 1 | Viewed by 1087
Abstract
Dueto uncertainties in real-world production, dynamic factors have become increasingly critical in the research of distributed flexible job shop scheduling problems. Effectively responding to dynamic events can significantly enhance the adaptability and quality of scheduling solutions, thereby improving the resilience of manufacturing systems. [...] Read more.
Dueto uncertainties in real-world production, dynamic factors have become increasingly critical in the research of distributed flexible job shop scheduling problems. Effectively responding to dynamic events can significantly enhance the adaptability and quality of scheduling solutions, thereby improving the resilience of manufacturing systems. This study addresses the dynamic distributed flexible job shop scheduling problem, which involves random job arrivals and machine breakdowns, and proposes an effective discrete improved gray wolf optimization (DIGWO) algorithm-based predictive–reactive method. The first contribution of our work lies in its dynamic scheduling strategy: a periodic- and event-driven approach is used to capture the dynamic nature of the problem, and a static scheduling window is constructed based on updated factory and workshop statuses to convert dynamic scheduling into static scheduling at each rescheduling point. Second, a mathematical model of multi-objective distributed flexible job shop scheduling (MODDFJSP) is established, optimizing makespan, tardiness, maximal factory load, and stability. The novelty of the model is that it is capable of optimizing both production efficiency and operational stability in the workshop. Third, by designing an efficacious initialization mechanism, prey search, and an external archive, the DIGWO algorithm is developed to solve conflicting objectives and search for a set of trade-off solutions. Experimental results in a simulated dynamic distributed flexible job shop demonstrate that DIGWO outperforms three well-known algorithms (NSGA-II, SPEA2, and MOEA/D). The proposed method also surpasses completely reactive scheduling approaches based on rule combinations. This study provides a reference for distributed manufacturing systems facing random job arrivals and machine breakdowns. Full article
(This article belongs to the Section AI-Enabled Process Engineering)
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17 pages, 775 KB  
Article
A Multi-Objective Bio-Inspired Optimization for Voice Disorders Detection: A Comparative Study
by Maria Habib, Victor Vicente-Palacios and Pablo García-Sánchez
Algorithms 2025, 18(6), 338; https://doi.org/10.3390/a18060338 - 4 Jun 2025
Viewed by 1141
Abstract
As early detection of voice disorders can significantly improve patients’ situation, the automated detection using Artificial Intelligence techniques can be crucial in various applications in this scope. This paper introduces a multi-objective bio-inspired, AI-based optimization approach for the automated detection of voice disorders. [...] Read more.
As early detection of voice disorders can significantly improve patients’ situation, the automated detection using Artificial Intelligence techniques can be crucial in various applications in this scope. This paper introduces a multi-objective bio-inspired, AI-based optimization approach for the automated detection of voice disorders. Different multi-objective evolutionary algorithms (the Non-dominated Sorting Genetic Algorithm (NSGA-II), Strength Pareto Evolutionary Algorithm (SPEA-II), and the Multi-Objective Evolutionary Algorithm based on Decomposition (MOEA/D)) have been compared to detect voice disorders by optimizing two conflicting objectives: error rate and the number of features. The optimization problem has been formulated as a wrapper-based algorithm for feature selection and multi-objective optimization relying on four machine learning algorithms: K-Nearest Neighbour algorithm (KNN), Random Forest (RF), Multilayer Perceptron (MLP), and Support Vector Machine (SVM). Three publicly available voice disorder datasets have been utilized, and results have been compared based on Inverted-Generational Distance, Hypervolume, spacing, and spread. The results reveal that NSGA-II with the MLP algorithm attained the best convergence and performance. Further, the conformal prediction is leveraged to quantify uncertainty in the feature-selected models, ensuring statistically valid confidence intervals for predictions. Full article
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21 pages, 3324 KB  
Article
A Web-Interface Based Decision Support System for Optimizing Home Healthcare Waste Collection Vehicle Routing
by Kubra Sar and Pezhman Ghadimi
Logistics 2024, 8(4), 119; https://doi.org/10.3390/logistics8040119 - 18 Nov 2024
Cited by 2 | Viewed by 2362
Abstract
Background: The significant increase in home healthcare (HHC) driven by technological advancements, an ageing population, and heightened disease outbreaks—especially evident during the COVID-19 pandemic—has created an urgent need for improved medical waste management. Methods: This paper presents the development of a decision [...] Read more.
Background: The significant increase in home healthcare (HHC) driven by technological advancements, an ageing population, and heightened disease outbreaks—especially evident during the COVID-19 pandemic—has created an urgent need for improved medical waste management. Methods: This paper presents the development of a decision support system with a web-based interface designed for efficient medical waste collection in the HHC sector. Results: The system utilises Flask for backend operations, with HTML and CSS for the user interface, and manages data using JSON files. Its flexible design supports real-time adjustments for various vehicle types and changing waste production locations. It incorporates dynamic routing by employing two sophisticated metaheuristic algorithms: the Strength Pareto Evolutionary Algorithm (SPEA-2) and the Non-Dominated Sorting Genetic Algorithm (NSGA-II). This setup supports different dataset sizes and vehicle fleets, including Internal Combustion Engine (ICE) vehicles and Electric Vehicles (EVs). Conclusions: The automation reduces uncertainties in waste collection by minimising human intervention. The system is built to be easily adaptable for other sectors with minor modifications and can be expanded to test various scenarios with new selectable parameters. Full article
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29 pages, 2212 KB  
Article
A Robust Multi-Objective Evolutionary Framework for Artificial Island Construction Scheduling Under Dynamic Constraints
by Tianju Zheng, Liping Sun, Mingwei Li, Guangyao Yuan and Shuqi Li
J. Mar. Sci. Eng. 2024, 12(11), 2008; https://doi.org/10.3390/jmse12112008 - 7 Nov 2024
Cited by 2 | Viewed by 1463
Abstract
Artificial island construction is a multifaceted engineering endeavor that demands precise scheduling to optimize resource allocation, control costs, ensure safety, and minimize environmental impact within dynamic marine environments. This study introduces a comprehensive multi-objective optimization model that integrates critical factors such as resource [...] Read more.
Artificial island construction is a multifaceted engineering endeavor that demands precise scheduling to optimize resource allocation, control costs, ensure safety, and minimize environmental impact within dynamic marine environments. This study introduces a comprehensive multi-objective optimization model that integrates critical factors such as resource limitations, task dependencies, environmental variability, safety risks, and regulatory compliance. To effectively address the complexities of this model, we develop and employ the Multi-Objective Adaptive Cooperative Evolutionary Marine Genetic Algorithm (MACEMGA). MACEMGA combines cooperative coevolution, adaptive dynamic weighting, dynamic penalty functions, and advanced genetic operators to navigate the solution space efficiently and identify Pareto optimal schedules. Through extensive computational experiments using data from the Dalian Bay Cross-Sea Traffic Engineering project, MACEMGA is benchmarked against algorithms such as NSGA-II, SPEA2, and MOEA/D. The results demonstrate that MACEMGA achieves a reduction in construction time from 32.8 to 23.5 months and cost savings from CNY 4105.3 million to CNY 3650.0 million while maintaining high-quality outcomes and compliance with environmental standards. Additionally, MACEMGA shows improvements in hypervolume by up to 15% over existing methods and a Convergence Rate that is 8% faster than MOEA/D. Full article
(This article belongs to the Special Issue Advances in Recent Marine Engineering Technology)
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21 pages, 1474 KB  
Article
A Multi-Objective Optimization of Neural Networks for Predicting the Physical Properties of Textile Polymer Composite Materials
by Ivan Malashin, Vadim Tynchenko, Andrei Gantimurov, Vladimir Nelyub and Aleksei Borodulin
Polymers 2024, 16(12), 1752; https://doi.org/10.3390/polym16121752 - 20 Jun 2024
Cited by 10 | Viewed by 3047
Abstract
This paper explores the application of multi-objective optimization techniques, including MOPSO, NSGA II, and SPEA2, to optimize the hyperparameters of artificial neural networks (ANNs) and support vector machines (SVMs) for predicting the physical properties of textile polymer composite materials (TPCMs). The optimization process [...] Read more.
This paper explores the application of multi-objective optimization techniques, including MOPSO, NSGA II, and SPEA2, to optimize the hyperparameters of artificial neural networks (ANNs) and support vector machines (SVMs) for predicting the physical properties of textile polymer composite materials (TPCMs). The optimization process utilizes data on the physical characteristics of the constituent fibers and fabrics used to manufacture these composites. By employing optimization algorithms, we aim to enhance the predictive accuracy of the ANN and SVM models, thereby facilitating the design and development of high-performance textile polymer composites. The effectiveness of the proposed approach is demonstrated through comparative analyses and validation experiments, highlighting its potential for optimizing complex material systems. Full article
(This article belongs to the Special Issue Scientific Machine Learning for Polymeric Materials)
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22 pages, 1289 KB  
Article
An Improved Discrete Bat Algorithm for Multi-Objective Partial Parallel Disassembly Line Balancing Problem
by Qi Zhang, Yang Xing, Man Yao, Jiacun Wang, Xiwang Guo, Shujin Qin, Liang Qi and Fuguang Huang
Mathematics 2024, 12(5), 703; https://doi.org/10.3390/math12050703 - 28 Feb 2024
Cited by 6 | Viewed by 1839
Abstract
Product disassembly is an effective means of waste recycling and reutilization that has received much attention recently. In terms of disassembly efficiency, the number of disassembly skills possessed by workers plays a crucial role in improving disassembly efficiency. Therefore, in order to effectively [...] Read more.
Product disassembly is an effective means of waste recycling and reutilization that has received much attention recently. In terms of disassembly efficiency, the number of disassembly skills possessed by workers plays a crucial role in improving disassembly efficiency. Therefore, in order to effectively and reasonably disassemble discarded products, this paper proposes a partial parallel disassembly line balancing problem (PP-DLBP) that takes into account the number of worker skills. In this paper, the disassembly tasks and the disassembly relationships between components are described using AND–OR graphs. In this paper, a multi-objective optimization model is established aiming to maximize the net profit of disassembly and minimize the number of skills for the workers. Based on the bat algorithm (BA), we propose an improved discrete bat algorithm (IDBA), which involves designing adaptive composite optimization operators to replace the original continuous formula expressions and applying them to solve the PP-DLBP. To demonstrate the advantages of IDBA, we compares it with NSGA-II, NSGA-III, SPEA-II, ESPEA, and MOEA/D. Experimental results show that IDBA outperforms the other five algorithms in real disassembly cases and exhibits high efficiency. Full article
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20 pages, 4366 KB  
Article
Application of Strength Pareto Evolutionary Algorithm II in Multi-Objective Water Supply Optimization Model Design for Mountainous Complex Terrain
by Yihong Guan, Yangyang Chu, Mou Lv, Shuyan Li, Hang Li, Shen Dong and Yanbo Su
Sustainability 2023, 15(15), 12091; https://doi.org/10.3390/su151512091 - 7 Aug 2023
Cited by 8 | Viewed by 2027
Abstract
Water distribution networks (WDN) model optimization is an important part of smart water systems to achieve optimal strategies. WDN optimization focuses on the nonlinearity of the discharge head loss equation, the availability of discrete properties of pipe sizes, and the conservation of constraints. [...] Read more.
Water distribution networks (WDN) model optimization is an important part of smart water systems to achieve optimal strategies. WDN optimization focuses on the nonlinearity of the discharge head loss equation, the availability of discrete properties of pipe sizes, and the conservation of constraints. Multi-objective evolutionary algorithms (MOEAs) have been proposed and successfully applied in the field of WDN design optimization. Previous studies have focused on comparing the optimization effects of algorithms in water distribution networks, ignoring the problems of unbalanced pressure distribution and water hammer at the nodes of the pipe network caused by the complex terrain in mountainous areas. In this paper, a multi-objective water supply optimization model that integrated cost, reliability, and water quality was established for a mountainous WDN in real engineering. The method of traversing the nodes to solve the water age was introduced to find a more scientific and practical water age solution model, with setting the weight function to evaluate the water age of the water supply model comprehensively. Strength Pareto Evolutionary Algorithm II (SPEA-II) and Non-dominated Sorting Genetic Algorithm II (NSGA-II) were adopted to optimize the WDN design model in the mountainous complex terrain. The significance levels of the number of Pareto solutions (NOPS) and running time are 0.029 and 0.001, respectively, indicating that the two algorithms have significant differences. Compared to NSGA-II, SPEA-II has a better convergence rate and running time in multi-objective water supply optimization design. The solution set distribution of SPEA-II is more concentrated than that of NSGA-II, also the numerical value is better. The number of SPEA-II optimization schemes is larger and the scheme is more effective. Among them, the Pareto solution set of SPEA-II can obtain more desirable optimization results on cost, reliability index (RI) and water age. In summary, the study provides valuable information for decision makers in WDN with complex terrain. Full article
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21 pages, 2417 KB  
Article
Software Product Line Maintenance Using Multi-Objective Optimization Techniques
by Muhammad Abid Jamil, Mohamed K. Nour, Saud S. Alotaibi, Mohammad Jabed Hussain, Syed Mutiullah Hussaini and Atif Naseer
Appl. Sci. 2023, 13(15), 9010; https://doi.org/10.3390/app13159010 - 6 Aug 2023
Cited by 7 | Viewed by 2179
Abstract
Currently, software development is more associated with families of configurable software than the single implementation of a product. Due to the numerous possible combinations in a software product line, testing these families of software product lines (SPLs) is a difficult undertaking. Moreover, the [...] Read more.
Currently, software development is more associated with families of configurable software than the single implementation of a product. Due to the numerous possible combinations in a software product line, testing these families of software product lines (SPLs) is a difficult undertaking. Moreover, the presence of optional features makes the testing of SPLs impractical. Several features are presented in SPLs, but due to the environment’s time and financial constraints, these features are rendered unfeasible. Thus, testing subsets of configured products is one approach to solving this issue. To reduce the testing effort and obtain better results, alternative methods for testing SPLs are required, such as the combinatorial interaction testing (CIT) technique. Unfortunately, the CIT method produces unscalable solutions for large SPLs with excessive constraints. The CIT method costs more because of feature combinations. The optimization of the various conflicting testing objectives, such as reducing the cost and configuration number, should also be considered. In this article, we proposed a search-based software engineering solution using multi-objective evolutionary algorithms (MOEAs). In particular, the research was applied to different types of MOEA method: the Indicator-Based Evolutionary Algorithm (IBEA), Multi-objective Evolutionary Algorithm based on Decomposition (MOEA/D), Non-dominant Sorting Genetic Algorithm II (NSGAII), NSGAIII, and Strength Pareto Evolutionary Algorithm 2 (SPEA2). The results of the algorithms were examined in the context of distinct objectives and two quality indicators. The results revealed how the feature model attributes, implementation context, and number of objectives affected the performances of the algorithms. Full article
(This article belongs to the Collection Software Engineering: Computer Science and System)
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17 pages, 3388 KB  
Article
Novel SPEA Superantigen Peptide Agonists and Peptide Agonist-TGFαL3 Conjugate. In Vitro Study of Their Growth-Inhibitory Effects for Targeted Cancer Immunotherapy
by Sara S. Bashraheel and Sayed K. Goda
Int. J. Mol. Sci. 2023, 24(13), 10507; https://doi.org/10.3390/ijms241310507 - 22 Jun 2023
Cited by 1 | Viewed by 2927
Abstract
Bacterial superantigens (SAgs) are effective T-cell stimulatory molecules that lead to massive cytokine production. Superantigens crosslink between MHC class II molecules on the Antigen Presenting Cells (APC) and TCR on T-cells. This enables them to activate up to 20% of resting T cells, [...] Read more.
Bacterial superantigens (SAgs) are effective T-cell stimulatory molecules that lead to massive cytokine production. Superantigens crosslink between MHC class II molecules on the Antigen Presenting Cells (APC) and TCR on T-cells. This enables them to activate up to 20% of resting T cells, whilst conventional antigen presentation results in the activation of 0.001–0.0001% of the T cell population. These biological properties of superantigens make them attractive for use in immunotherapy. Previous studies have established the effectiveness of superantigens as therapeutic agents. This, however, was achieved with severe side effects due to the high lethality of the native toxins. Our study aims to produce superantigen-based peptides with minimum or no lethality for safer cancer treatment. In previous work, we designed and synthesized twenty overlapping SPEA-based peptides and successfully mapped regions in SPEA superantigen, causing a vasodilatory response. We screened 20 overlapping SPEA-based peptides designed and synthesized to cover the whole SPEA molecule for T-cell activation and tumor-killing ability. In addition, we designed and synthesized tumor-targeted superantigen-based peptides by fusion of TGFαL3 either from the N′ or C′ terminal of selected SPEA-based peptides with an eight-amino acid flexible linker in between. Our study identified parts of SPEA capable of stimulating human T-cells and producing different cytokines. We also demonstrated that the SPEA-based peptide conjugate binds specifically to cancer cells and can kill this cancer. Peptides induce T-cell activation, and tumor killing might pave the way for safer tumor-targeted superantigens (TTS). We proposed the combination of our new superantigen-based peptide conjugates with other immunotherapy techniques for effective and safer cancer treatment. Full article
(This article belongs to the Special Issue Cancer Treatment: New Drugs and Strategies)
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26 pages, 14733 KB  
Article
Performance of Six Metaheuristic Algorithms for Multi-Objective Optimization of Nonlinear Inelastic Steel Trusses
by Truong-Son Cao, Thi-Thanh-Thuy Nguyen, Van-Son Nguyen, Viet-Hung Truong and Huu-Hue Nguyen
Buildings 2023, 13(4), 868; https://doi.org/10.3390/buildings13040868 - 26 Mar 2023
Cited by 20 | Viewed by 3480
Abstract
This paper presents a multi-objective optimization of steel trusses using direct analysis. The total weight and the inter-story drift or displacements of the structure were two conflict objectives, while the constraints relating to strength and serviceability load combinations were evaluated using nonlinear inelastic [...] Read more.
This paper presents a multi-objective optimization of steel trusses using direct analysis. The total weight and the inter-story drift or displacements of the structure were two conflict objectives, while the constraints relating to strength and serviceability load combinations were evaluated using nonlinear inelastic and nonlinear elastic analyses, respectively. Six common metaheuristic algorithms such as nondominated sorting genetic algorithm-II (NSGA-II), NSGA-III, generalized differential evolution (GDE3), PSO-based MOO using crowding, mutation, and ε-dominance (OMOPSO), improving the strength Pareto evolutionary algorithm (SPEA2), and multi-objective evolutionary algorithm based on decomposition (MOEA/D) were applied to solve the developed MOO problem. Four truss structures were studied including a planar 10-bar truss, a spatial 72-bar truss, a planar 47-bar powerline truss, and a planar 113-bar truss bridge. The numerical results showed a nonlinear relationship and inverse proportion between the two objectives. Furthermore, all six algorithms were efficient at finding feasible optimal solutions. No algorithm outperformed the others, but NSGA-II and MOEA/D seemed to be better at both searching Pareto and anchor points. MOEA/D was also more stable and yields a better solution spread. OMOPSO was also good at solution spread, but its stability was worse than MOEA/D. NSGA-III was less efficient at finding anchor points, although it can effectively search for Pareto points. Full article
(This article belongs to the Special Issue Machine Learning Applications in Sustainable Buildings)
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