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14 pages, 1840 KiB  
Article
Volatilomic Fingerprint of Tomatoes by HS-SPME/GC-MS as a Suitable Analytical Platform for Authenticity Assessment Purposes
by Gonçalo Jasmins, Tânia Azevedo, José S. Câmara and Rosa Perestrelo
Separations 2025, 12(8), 188; https://doi.org/10.3390/separations12080188 - 22 Jul 2025
Viewed by 165
Abstract
Tomatoes are globally esteemed not only for their nutritional value but also for their complex and appealing aroma, a key determinant of consumer preference. The present study aimed to comprehensively characterise the volatilomic fingerprints of three tomato species—Solanum lycopersicum L., S. lycopersicum [...] Read more.
Tomatoes are globally esteemed not only for their nutritional value but also for their complex and appealing aroma, a key determinant of consumer preference. The present study aimed to comprehensively characterise the volatilomic fingerprints of three tomato species—Solanum lycopersicum L., S. lycopersicum var. cerasiforme, and S. betaceum—encompassing six distinct varieties, through the application of headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME/GC-MS). A total of 55 volatile organic compounds (VOCs) spanning multiple chemical classes were identified, of which only 28 were ubiquitously present across all varieties examined. Carbonyl compounds constituted the predominant chemical family, with hexanal and (E)-2-hexenal emerging as putative key contributors to the characteristic green and fresh olfactory notes. Notably, esters were found to dominate the unique volatile fingerprint of cherry tomatoes, particularly methyl 2-hydroxybenzoate, while Kumato and Roma varieties exhibited elevated levels of furanic compounds. Multivariate statistical analyses, including principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), demonstrated clear varietal discrimination and identified potential aroma-associated biomarkers such as phenylethyl alcohol, 3-methyl-1-butanol, hexanal, (E)-2-octenal, (E)-2-nonenal, and heptanal. Collectively, these findings underscore the utility of volatilomic fingerprint as a robust tool for varietal identification and quality control within the food industry. Full article
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11 pages, 239 KiB  
Article
Examining Romosozumab Adherence and Side Effects in Osteoporotic Patients After Surgical Fracture Fixation: A Comparative, Descriptive, and Hypothesis-Generating Study with Non-Fractured Controls
by Amarildo Smakaj, Umberto Tarantino, Riccardo Iundusi, Angela Chiavoghilefu, Lorenzo Abbondante, Chiara Salvati, Chiara Greggi and Elena Gasbarra
Diseases 2025, 13(5), 148; https://doi.org/10.3390/diseases13050148 - 11 May 2025
Viewed by 588
Abstract
Objectives: The study aims to evaluate adherence to Romosozumab treatment in osteoporotic patients after surgical fracture fixation and compare side effects with non-fractured controls on the same therapy. Methods: This retrospective case–control study was conducted at the Orthopaedic Department of Policlinico Universitario di [...] Read more.
Objectives: The study aims to evaluate adherence to Romosozumab treatment in osteoporotic patients after surgical fracture fixation and compare side effects with non-fractured controls on the same therapy. Methods: This retrospective case–control study was conducted at the Orthopaedic Department of Policlinico Universitario di Roma “Tor Vergata”, following the principles of the Declaration of Helsinki. It included postmenopausal women aged over 60, with the case group receiving Romosozumab after fracture fixation, and the control group consisting of women on Romosozumab therapy without fracture fixation. Exclusion criteria included psychiatric conditions, contraindications to Romosozumab, high-energy trauma, or other bone metabolism disorders. Data on fractures, surgeries, FRAX (Fracture Risk Assessment Tool) scores, BMD (Bone Mineral Densit) values, and follow-up details were collected. Side effects, including nasopharyngitis and severe events like hypocalcemia, stroke, and myocardial infarction, were recorded. Adherence was assessed via pharmacy records and patient interviews during routine clinical follow-up visits. Statistical analysis was performed using descriptive statistics, t-tests, and chi-square tests. Results: The study included 25 patients, with 12 in the surgical group and 13 in the conservative treatment group. The surgical group had a mean age of 67.3 years and a follow-up of 374 days, while the conservative group had a mean age of 76.4 years and a follow-up of 287 days. The surgical group underwent various fracture treatments, including femoral, humeral, and distal radius fractures, while the conservative group was treated with immobilization. There were no significant differences in FRAX scores or BMD values between the two groups. Vitamin D levels increased significantly in both groups after supplementation, but parathyroid hormone levels showed no difference. No new fractures occurred, and surgical patients had no delayed union or nonunion, though two had superficial wound infections. Conclusions: Both groups adhered well to Romosozumab therapy, with no severe side effects; minor side effects included myalgia in the surgical group and shoulder arthralgia in the conservative group. Romosozumab is well-tolerated and adherent in osteoporotic patients after osteosynthesis surgery, with adverse events similar to non-fractured individuals. While the study design is appropriate, multicenter trials would improve the sample size and allow for subgroup analysis based on fracture type and demographics. Full article
17 pages, 2796 KiB  
Article
Diagnostic Utility of Metalloproteinases from Collagenase Group (MMP-1, MMP-8 and MMP-13) in Biochemical Diagnosis of Ovarian Carcinoma
by Aleksandra Kicman, Ewa Gacuta, Rafał Marecki, Michał Stanisław Kicman, Monika Kulesza, Ewa Klank-Sokołowska, Paweł Knapp, Marek Niczyporuk, Maciej Szmitkowski and Sławomir Ławicki
Cancers 2024, 16(23), 3969; https://doi.org/10.3390/cancers16233969 - 26 Nov 2024
Cited by 2 | Viewed by 1047
Abstract
Background: Ovarian carcinoma (OC) has an unfavorable prognosis due to lack of screening and an asymptomatic course. New diagnostic methods are being sought to enable earlier diagnosis of this condition. The purpose of this study was to determine the diagnostic utility of collagenases [...] Read more.
Background: Ovarian carcinoma (OC) has an unfavorable prognosis due to lack of screening and an asymptomatic course. New diagnostic methods are being sought to enable earlier diagnosis of this condition. The purpose of this study was to determine the diagnostic utility of collagenases (MMP-1, MMP-8 and MMP-13) in the diagnosis of OC compared to HE4 and CA125 and the ROMA. Methods: The study group consisted of 120 patients with OC, the control group: 70 patients with benign ovarian lesions (BLs) and 50 healthy women (HS). MMP-1, MMP-8 and MMP-13 were determined by ELISA and HE4 and CA125 by CMIA. Results: OC patients had higher levels of MMP-1 and MMP-13 compared to the BL and HS groups. MMP-1 (SE: 81.66%; SP: 94%; PPV: 97.02%; NPV: 68.11%; AUC: 0.9625) and MMP-13 (SE: 77.50%; SP: 94%; PPV: 96.875%; NPV: 63.51%; AUC: 0.917) showed similar or higher diagnostic values to routine markers (HE4: SE:85%; SP: 92%; PPV: 96.22%; NPV: 71.875%; AUC: 0.943; CA125: SE: 80%; SP: 98%; PPV: 98.96%; NPV: 67.12%; AUC: 0.909) and the ROMA (SE: 90.83%; SP: 94%; PPV: 97.32%; NPV: 81.03%; AUC: 0.955). Performing combined analyses of individual MMPs and MMPs with ROMA was associated with further increases in diagnostic parameters. Conclusions: MMP-1 and MMP-13 have shown preliminary potential as diagnostic markers and auxiliary markers to ROMA in biochemical diagnosis of OC. Full article
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15 pages, 3030 KiB  
Article
Solar Wind Turbulence and Complexity Probed with Rank-Ordered Multifractal Analysis (ROMA)
by Marius Echim, Costel Munteanu, Gabriel Voitcu and Eliza Teodorescu
Entropy 2024, 26(11), 929; https://doi.org/10.3390/e26110929 - 30 Oct 2024
Viewed by 883
Abstract
The Rank-Ordered Multifractal Analysis (ROMA) is a tool designed to characterize scale (in)variance and multifractality based on rank ordering the fluctuations in “groups” characterized by the same mono-fractal behavior (Hurst exponent). A range-limited structure-function analysis provides the mono-fractal index for each rank-ordered range [...] Read more.
The Rank-Ordered Multifractal Analysis (ROMA) is a tool designed to characterize scale (in)variance and multifractality based on rank ordering the fluctuations in “groups” characterized by the same mono-fractal behavior (Hurst exponent). A range-limited structure-function analysis provides the mono-fractal index for each rank-ordered range of fluctuations. We discuss here two examples of multi-scale solar wind turbulence and complexity where ROMA is applied on the following: (a) data collected by Ulysses spacecraft in the fast solar wind, outside the ecliptic, between 25 and 31 January 2007, at roughly 2.5 Astronomical Units (AU) from the Sun, in the Southern heliosphere, at latitudes between −76.5 and −77.3 degrees, and (b) slow solar wind data collected in the ecliptic plane by Venus Express spacecraft, at 0.72 AU, on 28 January 2007. The ROMA spectrum of fast solar wind derived from ULYSSES data shows a scale-dependent structure of fluctuations: (1) at the smallest/kinetic range of scales (800 to 3200 km), persistent fluctuations are dominant, and (2) at the inertial range of scales (104 to 2 × 105 km), anti-persistent fluctuations are dominant, but less clearly developed and possibly indicative for the development of instabilities with cross-over behavior. The ROMA spectrum of the slow solar wind derived from Venus Express data, suggests a different structure of turbulence: (1) fully developed multifractal turbulence across scales between 5 × 104 and 4 × 105 km, with the Hurst index changing from anti-persistent to persistent values for the larger amplitude magnetic fluctuations; (2) at the smallest scales (400 to 6400 km), fluctuations are mainly anti-persistent, and the ROMA spectrum indicates a tendency towards mono-fractal behavior. Full article
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16 pages, 760 KiB  
Article
Clinical and Metabolic Particularities of a Roma Population with Diabetes—Considering Ethnic Disparities in Approaching Healthcare Management
by Andrada Cosoreanu, Emilia Rusu, Florin Rusu, Silviu Stanciu, Ioana Ungureanu, Marius Donici, Alexandra Visinescu, Georgiana Enache and Gabriela Radulian
Biomedicines 2024, 12(7), 1422; https://doi.org/10.3390/biomedicines12071422 - 26 Jun 2024
Cited by 1 | Viewed by 2309
Abstract
The Roma population is Europe’s largest ethnic minority, yet data on the prevalence of non-communicable diseases remain scarce in medical literature. This study aimed to compare the clinical and metabolic particularities of a Roma population with diabetes with a group of non-Roma. We [...] Read more.
The Roma population is Europe’s largest ethnic minority, yet data on the prevalence of non-communicable diseases remain scarce in medical literature. This study aimed to compare the clinical and metabolic particularities of a Roma population with diabetes with a group of non-Roma. We conducted an observational, transversal study and evaluated 808 adult patients with diabetes mellitus, from a tertiary diabetes care hospital. The prevalence of metabolic syndrome was high among both groups, 94.3% in the Roma patients and 89.1% in the non-Roma. A slightly higher mean value of the triglyceride–glucose (TyG) index was observed among the Roma group (10.07 ± 0.71 versus 9.71 ± 0.82). Among the non-Roma, variables that were significantly associated with the TyG index were glycated hemoglobin (HbA1c), total cholesterol (TC), high density lipoprotein–cholesterol (HDL-c), and low-density lipoprotein-cholesterol (LDL-c), while among the Roma, HbA1c and HDL-c were correlated with this index. There were no differences concerning myocardial infarction; however, the number of patients with a history of stroke was 2.1 times higher in the Roma group compared to the non-Roma group. The prevalence of cardiovascular risk factors, cardiovascular disease, and microvascular complications among the study’s Roma population are quite significant, underscoring the importance of ethnic disparities in approaching healthcare management strategies. Full article
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21 pages, 2118 KiB  
Article
Diagnostic Utility of Selected Matrix Metalloproteinases (MMP-2, MMP-3, MMP-11, MMP-26), HE4, CA125 and ROMA Algorithm in Diagnosis of Ovarian Cancer
by Aleksandra Kicman, Ewa Gacuta, Monika Kulesza, Ewa Grażyna Będkowska, Rafał Marecki, Ewa Klank-Sokołowska, Paweł Knapp, Marek Niczyporuk and Sławomir Ławicki
Int. J. Mol. Sci. 2024, 25(11), 6265; https://doi.org/10.3390/ijms25116265 - 6 Jun 2024
Cited by 4 | Viewed by 1903
Abstract
Ovarian cancer (OC) has an unfavorable prognosis. Due to the lack of effective screening tests, new diagnostic methods are being sought to detect OC earlier. The aim of this study was to evaluate the concentration and diagnostic utility of selected matrix metalloproteinases (MMPs) [...] Read more.
Ovarian cancer (OC) has an unfavorable prognosis. Due to the lack of effective screening tests, new diagnostic methods are being sought to detect OC earlier. The aim of this study was to evaluate the concentration and diagnostic utility of selected matrix metalloproteinases (MMPs) as OC markers in comparison with HE4, CA125 and the ROMA algorithm. The study group consisted of 120 patients with OC; the comparison group consisted of 70 patients with benign lesions and 50 healthy women. MMPs were determined via the ELISA method, HE4 and CA125 by CMIA. Patients with OC had elevated levels of MMP-3 and MMP-11, similar to HE4, CA125 and ROMA values. The highest SE, SP, NPV and PPV values were found for MMP-26, CA125 and ROMA in OC patients. Performing combined analyses of ROMA with selected MMPs increased the values of diagnostic parameters. The topmost diagnostic power of the test was obtained for MMP-26, CA125, HE4 and ROMA and performing combined analyses of MMPs and ROMA enhanced the diagnostic power of the test. The obtained results indicate that the tested MMPs do not show potential as stand-alone OC biomarkers, but can be considered as additional tests to raise the diagnostic utility of the ROMA algorithm. Full article
(This article belongs to the Special Issue Molecular Advances in Ovarian Cancer)
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16 pages, 279 KiB  
Article
Understanding the Impact of COVID-19 on Roma Vulnerable Communities in Western Romania: Insights and Predictive Factors from a Retrospective Study
by Ionut Dragos Capraru, Catalin Marian, Dan Dumitru Vulcanescu, Sonia Tanasescu, Tiberiu Liviu Dragomir, Teodora Daniela Marti, Casiana Boru, Cecilia Roberta Avram, Monica Susan and Cristian Sebastian Vlad
Viruses 2024, 16(3), 435; https://doi.org/10.3390/v16030435 - 12 Mar 2024
Cited by 4 | Viewed by 1961
Abstract
Background: The COVID-19 pandemic disproportionately affected vulnerable populations like Roma patients in Western Romania due to marginalization and limited healthcare access. Methods: A retrospective study analyzed COVID-19 cases between March 2020 and August 2022 using data from the Directorate of Public Health in [...] Read more.
Background: The COVID-19 pandemic disproportionately affected vulnerable populations like Roma patients in Western Romania due to marginalization and limited healthcare access. Methods: A retrospective study analyzed COVID-19 cases between March 2020 and August 2022 using data from the Directorate of Public Health in Timis county. Demographic, epidemiological, clinical, and laboratory data were assessed, along with risk factors and biomarkers for ICU admission and mortality prediction. The following biomarkers were assessed: C-reactive protein (CRP), ferritin (FER), IL-6, D-dimers, lactate dehydrogenase (LDH), high density lipoprotein cholesterol (HDL), and 25-OH vitamin D (25-OHD). Results: In comparison with the general population (GP), Roma patients were more overweight (p = 0.0292), came from rural areas (p = 0.0001), could not recall transmission source (p = 0.0215), were admitted to the intensive care unit (ICU, p = 0.0399) more frequently, had worse symptomatology (p = 0.0490), showed more elevated levels of CRP (p = 0.0245) and IL-6 (p < 0.0001) and lower levels of HDL (p = 0.0008) and 25-OHD (p = 0.0299). A stronger, significant correlation was observed between CRP and severity (rho = 0.791 vs. 0.433 in GP), and an inverse stronger significant one was observed between HDL and severity (rho = −0.850 vs. −0.734 in GP) in the Roma patients. The male sex continues to be an important risk factor for ICU admission (OR = 2.379) and death (OR = 1.975), while heavy smoking was more important in relation to ICU admission (OR = 1.768). Although the Roma ethnicity was 1.454 times more at risk of ICU admission than the GP, this did not prove statistically significant (p = 0.0751). CRP was the most important predictive factor in regards to admission to the ICU for both Roma (OR = 1.381) and the GP (OR = 1.110) and in regards to death (OR = 1.154 for Roma, OR = 1.104 for GP). A protective effect of normal values of HDL and 25-OHD was observed in the GP for both ICU admission (OR = 0.947, 0.853, respectively) and death (OR = 0.920, 0.921, respectively), while for the Roma group, normal 25-OHD values were only considered protective in regards to death (OR = 0.703). Cutoff values for ICU admission were 28.98 mg/L for Roma and 29.03 mg/L for GP patients, with high specificity for both groups (over 95). Conclusions: Higher rates of ICU admissions, severe symptomatology, and distinct laboratory biomarker profiles among Roma patients emphasize the critical importance of personalized care strategies and targeted interventions to mitigate the disproportionate burden of COVID-19 on vulnerable communities. CRP values at admission have had a clear impact as a risk assessment biomarker for Roma patients, while the significance of IL-6, HDL, and 25-OHD should also not be overlooked in these patients. Full article
(This article belongs to the Special Issue Viral Sepsis: Pathogenesis, Diagnostics and Therapeutics)
13 pages, 698 KiB  
Article
Water Quality and Associated Human Health Risk Assessment Related to Some Ions and Trace Elements in a Series of Rural Roma Communities in Transylvania, Romania
by Călina Creța, Cristina Horga, Mariana Vlad, Vlad-Alexandru Pănescu, Victor Bocoș-Bințințan, Maria-Virginia Coman, Mihaela Cătălina Herghelegiu, Vidar Berg, Jan Ludvig Lyche and Mihail Simion Beldean-Galea
Foods 2024, 13(3), 496; https://doi.org/10.3390/foods13030496 - 4 Feb 2024
Cited by 3 | Viewed by 1700
Abstract
This research aims to assess the content of some ions and trace elements in water sources in 24 rural Roma communities in Transylvania in order to assess the human health risk associated with exposure to such elements and ions. To this end, eight [...] Read more.
This research aims to assess the content of some ions and trace elements in water sources in 24 rural Roma communities in Transylvania in order to assess the human health risk associated with exposure to such elements and ions. To this end, eight ions (F, Cl, Br, NO2, NO3, SO42−, PO43−, NH4+) and ten trace elements (Cr, Ni, As, Pb, Cd, Mn, Cu, Zn, Fe, and Hg) were determined in 71 water samples by ion chromatography coupled with a conductivity detector for ions and atomic absorption spectrophotometry for all trace elements. General parameters were also determined. Non-conformity (as number of samples), according to the EU Drinking Water Directive, was observed as follows: pH (7), EC (7), hardness (1), oxidizability (15), Cl (4), NO3 (30), SO42− (6), Fe (16), Mn (14), As (3), and Ni (1 sample). The incidence of ions was Cl (71), SO42− (70), F (67), NO3 (65), NH4+ (21), Br (10), PO43−, and NO2 (1 sample) and for trace elements, Mn (59), Fe (50), As (38), Ni (32), Cu (29), Zn (28), Cd (12), Cr (11), and Pb (3 samples). Hg was not detected. Non-carcinogenic (HI) values exceeded one for As in 13 Roma communities, with higher values for children than for adults. For NO3, the HI values were >1 in 12 for adults and 14 communities for children. The carcinogenic risk (CR) for As through ingestion ranged from 0.795 to 3.50 × 10−4 for adults and from 1.215 to 5.30 × 10−4 for children. CR by dermal contact was in the range of ×10−6 both for adults and children. Full article
(This article belongs to the Special Issue Assessment of Food Toxicology, Diet and Nutrition)
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13 pages, 452 KiB  
Article
Association of HDL Subfraction Profile with the Progression of Insulin Resistance
by Peter Piko, Tibor Jenei, Zsigmond Kosa, Janos Sandor, Nora Kovacs, Ildiko Seres, Gyorgy Paragh and Roza Adany
Int. J. Mol. Sci. 2023, 24(17), 13563; https://doi.org/10.3390/ijms241713563 - 1 Sep 2023
Cited by 7 | Viewed by 2064
Abstract
Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of [...] Read more.
Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of the present study was to investigate the association between HDL and its subfraction profile and the progression of IR, as assessed by the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The HDL subfractions were separated using the Lipoprint system, which identifies ten subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 individuals without IR and 137 with IR from the Hungarian general and Roma populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant negative association with the progression and existence of IR. Among them, HDL-2 (B = −40.37, p = 2.08 × 10−11) and HDL-L (B = −14.85, p = 9.52 × 10−10) showed the strongest correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 × 10−7), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 × 10−6). This study demonstrates that the HDL subfraction profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose and insulin metabolism. Full article
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18 pages, 282 KiB  
Article
Personality Development and Behavior in Adolescence: Characteristics and Dimensions
by Valentina Milenkova and Albena Nakova
Societies 2023, 13(6), 148; https://doi.org/10.3390/soc13060148 - 19 Jun 2023
Cited by 3 | Viewed by 10422
Abstract
This article aims to present the specifics and characteristics of personality development during adolescence in light of the family’s influence on the adolescent’s self-esteem, self-perception, and behavior. Self-concept holds a particular importance in an individual’s psychological and social development and expression. Self-concept contributes [...] Read more.
This article aims to present the specifics and characteristics of personality development during adolescence in light of the family’s influence on the adolescent’s self-esteem, self-perception, and behavior. Self-concept holds a particular importance in an individual’s psychological and social development and expression. Self-concept contributes to an individual’s communication, personal confidence, and independence. The objectives of the article are as follows: to trace some basic aspects of the influence of family on personality and its formation; to present concrete empirical dimensions of the Self-concept of students in a Bulgarian environment as well as their relationships with their parents; to show whether there are differences among the main ethnic groups in terms of their Self-concept and parental influence. The empirical analysis of the article is based on research conducted with secondary school students in 2018 within the framework of the “Modern Bulgarian Education: Status and Deficits” project, of which there were 130 Bulgarian, 70 Turk, and 70 Roma students aged 14–16 and of both sexes. The students were randomly selected from several Bulgarian secondary schools. To establish Self-images and the formation of various qualities, we used a method highlighting the types of personality tests used to register Self-concept profiles, including various personal qualities in different areas of personality expression. Students rate the qualities as real and as their desire to possess them on a five-degree scale from “1”—I do not possess at all to “5”—I completely possess the corresponding quality. The survey results showed that young people to a large extent tend to strive for the construction of their Self-image as open to sociability, contacts, and communication to attain affirmation among peers and autonomy. The article also analyzes assessments of parents’ involvement in children’s lives as well as the importance of family as a value. The main conclusion of the article is that upbringing in the family is key to the development of a child’s Self-concept and success, the value structure and emotional state, as well as overall personal activity. Full article
(This article belongs to the Special Issue Family and Social Environment on Shaping Juvenile Growth)
29 pages, 11542 KiB  
Article
Ethnicities in Post-Communist Romania: Spatial Dynamics, Fractionalisation, and Polarisation at the NUTS-3 Level
by Marina-Alexandra Rotaru, Remus Creţan and Ana-Neli Ianăş
Land 2023, 12(6), 1133; https://doi.org/10.3390/land12061133 - 26 May 2023
Cited by 14 | Viewed by 7243
Abstract
Scholars have shown a special interest in discovering and studying the role of ethnic diversity and spatiality at the country and region levels. This study contributes to the theoretical debate on the spatial dynamics of ethnicities, with the aim of (1) determining the [...] Read more.
Scholars have shown a special interest in discovering and studying the role of ethnic diversity and spatiality at the country and region levels. This study contributes to the theoretical debate on the spatial dynamics of ethnicities, with the aim of (1) determining the evolution of ethnic dynamics in post-communist Romania and (2) applying ethnic fractionalisation and polarisation indices. The study uses a mixed methods approach based on a descriptive statistics analysis and applies the fractionalisation and polarisation indices to Romania’s NUTS-3 (i.e., county) level. The findings suggest that the ethnic spatial dynamics in post-communist Romania have shown a decrease in all ethnicities due to migration and low birth rates, with the exception of the Roma ethnicity, for whom the trend is increasing. Additionally, polarisation and fractionalisation indices have different evolutionary manifestations depending on the dynamics of the ethnic groups present in certain geographical areas. Although neither of the two analysed indices has witnessed profound change at the spatial level, these small changes in spatial and short-term ethnic diversity can help us advance knowledge about co-existence in ethnically diverse societies. Higher values of the two indices are obvious in several counties where ethnic Hungarians cohabitate with Romanians and other ethnicities. This discovery can inform policy-makers to implement more policies for the further peaceful co-existence of Hungarians, Romanians, and other ethnic groups in Transylvania and other western counties in Romania. Furthermore, as the population growth trend for the Roma ethnicity is upward, Romania has to implement proper policies and build better government infrastructure to counter social inequality against the Roma people. This will help curb potential conflicts between the Roma and other ethnic groups at the local level. Finally, as most ethnicities decreased in number in post-communist times, further attention needs to be paid to the erosion of ethnic diversity in Romania because this could have a negative impact on economic development, social trust, and democracy. Full article
(This article belongs to the Topic Sustainability in Heritage and Urban Planning)
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18 pages, 25875 KiB  
Article
From Digital Restitution to Structural Analysis of a Historical Adobe Building: The Escuela José Mariano Méndez in El Salvador
by Silvia Santini, Marco Canciani, Vittoria Borghese, Valerio Sabbatini and Claudio Sebastiani
Heritage 2023, 6(5), 4362-4379; https://doi.org/10.3390/heritage6050231 - 16 May 2023
Cited by 6 | Viewed by 2036
Abstract
Nowadays, the research in the fields of conservation and restoration is focusing on recording large amounts of data and information in order to obtain highly accurate surveys that include most details of constructions. Documenting and surveying are fundamental activities in achieving the successful [...] Read more.
Nowadays, the research in the fields of conservation and restoration is focusing on recording large amounts of data and information in order to obtain highly accurate surveys that include most details of constructions. Documenting and surveying are fundamental activities in achieving the successful preservation of cultural heritage, but also in implementing efficient strengthening interventions of structures. The applications of methods and techniques that link the disciplines of geometrical surveys and structural analyses are still fragmented, and further research is necessary to fully transfer site information into structural models. In this article, the authors propose a methodology with which to link different restoration fields, with the aim of highlighting the strengths and weaknesses of the interoperability between surveys (carried out through detailed restitution from point clouds), heritage building information modeling (HBIM), and structural analyses to connect three different disciplines. The goal is to find a synthesis model that brings together historical and geometric characteristics, but also physical–mechanical properties, for a structural evaluation through a finite element model (FEM). The case study of the Escuela José Mariano Méndez is analyzed, an extremely damaged historical adobe building in Santa Ana, the second largest city of El Salvador; it is considered fundamental to the national economy, particularly after the “coffee boom” in the late 1800s. The site, located near the historic center, is also known as “Antigua Escuela de Artes y Oficios” and embodies the architectural traditions of the region, being built in adobe and stone. Roma Tre University and the Secretaría de Cultura de la Presidencia (SECULTURA) are partners in this research project to document and restore the historical and cultural value of this site. Full article
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14 pages, 585 KiB  
Article
Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations
by Péter Pikó, Éva Bácsné Bába, Zsigmond Kósa, János Sándor, Nóra Kovács, Zoltán Bács and Róza Ádány
Int. J. Mol. Sci. 2023, 24(5), 4566; https://doi.org/10.3390/ijms24054566 - 26 Feb 2023
Viewed by 2149
Abstract
Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are [...] Read more.
Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12–1.97; p = 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16–1.70; p < 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGSRoma: 2.19 ± SD: 0.99 vs. oPGSHG: 2.70 ± SD: 1.06; p < 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status. Full article
(This article belongs to the Special Issue Genetics of Health and Disease)
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15 pages, 3377 KiB  
Article
Performance of IOTA Simple Rules Risks, ADNEX Model, Subjective Assessment Compared to CA125 and HE4 with ROMA Algorithm in Discriminating between Benign, Borderline and Stage I Malignant Adnexal Lesions
by Artur Czekierdowski, Norbert Stachowicz, Agata Smolen, Tomasz Łoziński, Paweł Guzik and Tomasz Kluz
Diagnostics 2023, 13(5), 885; https://doi.org/10.3390/diagnostics13050885 - 25 Feb 2023
Cited by 12 | Viewed by 5265
Abstract
BACKGROUND: Borderline ovarian tumors (BOTs) and early clinical stage malignant adnexal masses can make sonographic diagnosis challenging, while the clinical utility of tumor markers, e.g., CA125 and HE4, or the ROMA algorithm, remains controversial in such cases. OBJECTIVE: To compare the IOTA group [...] Read more.
BACKGROUND: Borderline ovarian tumors (BOTs) and early clinical stage malignant adnexal masses can make sonographic diagnosis challenging, while the clinical utility of tumor markers, e.g., CA125 and HE4, or the ROMA algorithm, remains controversial in such cases. OBJECTIVE: To compare the IOTA group Simple Rules Risk (SRR), the ADNEX model and the subjective assessment (SA) with serum CA125, HE4 and the ROMA algorithm in the preoperative discrimination between benign tumors, BOTs and stage I malignant ovarian lesions (MOLs). METHODS: A multicenter retrospective study was conducted with lesions classified prospectively using subjective assessment and tumor markers with the ROMA. The SRR assessment and ADNEX risk estimation were applied retrospectively. The sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR−) were calculated for all tests. RESULTS: In total, 108 patients (the median age: 48 yrs, 44 postmenopausal) with 62 (79.6%) benign masses, 26 (24.1%) BOTs and 20 (18.5%) stage I MOLs were included. When comparing benign masses with combined BOTs and stage I MOLs, SA correctly identified 76% of benign masses, 69% of BOTs and 80% of stage I MOLs. Significant differences were found for the presence and size of the largest solid component (p = 0.0006), the number of papillary projections (p = 0.01), papillation contour (p = 0.008) and IOTA color score (p = 0.0009). The SRR and ADNEX models were characterized by the highest sensitivity (80% and 70%, respectively), whereas the highest specificity was found for SA (94%). The corresponding likelihood ratios were as follows: LR+ = 3.59 and LR− = 0.43 for the ADNEX; LR+ = 6.40 and LR− = 0.63 for SA and LR+ = 1.85 with LR− = 0.35 for the SRR. The sensitivity and specificity of the ROMA test were 50% and 85%, respectively, with LR+ = 3.44 and LR− = 0.58. Of all the tests, the ADNEX model had the highest diagnostic accuracy of 76%. CONCLUSIONS: This study demonstrates the limited value of diagnostics based on CA125 and HE4 serum tumor markers and the ROMA algorithm as independent modalities for the detection of BOTs and early stage adnexal malignant tumors in women. SA and IOTA methods based on ultrasound examination may present superior value over tumor marker assessment. Full article
(This article belongs to the Special Issue Diagnosis and Management of Ovarian Cancer)
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14 pages, 799 KiB  
Article
Laboratory Findings and Clinical Outcomes of ICU-admitted COVID-19 Patients: A Retrospective Assessment of Particularities Identified among Romanian Minorities
by Alexandra Mocanu, Voichita Elena Lazureanu, Ruxandra Laza, Adelina Raluca Marinescu, Talida Georgiana Cut, Suzana-Vasilica Sincaru, Adina Maria Marza, Irina-Maria Popescu, Lucian-Flavius Herlo, Andreea Nelson-Twakor, Mircea Rivis, Felix Bratosinand, Tamara Mirela Porosnicu and Alexandru Ovidiu Mederle
J. Pers. Med. 2023, 13(2), 195; https://doi.org/10.3390/jpm13020195 - 21 Jan 2023
Cited by 8 | Viewed by 2558
Abstract
The Roma population accounts for over 3% (approximately 10 to 15 million) of Romania’s permanent population, and it represents one of Europe’s most impoverished populations. Due to poverty and unemployment, Romania’s Roma minority may have diminished access to healthcare and preventive medicine. The [...] Read more.
The Roma population accounts for over 3% (approximately 10 to 15 million) of Romania’s permanent population, and it represents one of Europe’s most impoverished populations. Due to poverty and unemployment, Romania’s Roma minority may have diminished access to healthcare and preventive medicine. The limited existing evidence suggests that the European Roma group has been at a higher risk of becoming ill and dying during the pandemic owing to their lifestyle choices, socioeconomic circumstances, and genetic pathophysiological traits. As a result, the purpose of the present research was to investigate the link between the inflammatory markers implicated and the clinical progression of COVID-19 in Roma patients who were brought to the intensive care unit. We considered 71 Roma patients admitted to the ICU with SARS-CoV-2 infection and 213 controls from the general population with the same inclusion criteria. The body mass index of patients was statistically significantly higher among Roma patients, with more than 57% being overweight, compared with 40.7% in the control group. Frequent smoking was more prevalent in patients of Roma ethnicity admitted to the ICU and the number of comorbidities. We observed a significantly higher proportion of severe imaging features at admission in the group of cases, although this difference may have been associated with the higher prevalence of smoking in this group. The mean duration of hospitalization was longer by 1.8 days than the control group. Elevated ESR levels were observed in 54.0% of Roma patients at admission, compared with 38.9% in the control group. Similarly, 47.6% of them had elevated CRP levels. IL-6 increased significantly at the time of ICU admission, similarly to the significant rise in the CRP levels, compared with the general population. However, the proportion of intubated patients and mortality did not differ significantly. On multivariate analysis, the Roma ethnicity significantly influenced the CRP (β = 1.93, p-value = 0.020) and IL-6 (β = 1.85, p-value = 0.044). It is necessary to plan different healthcare strategies aimed at special populations, such as the Roma ethnicity, to prevent the reduced disparities presented in in this study. Full article
(This article belongs to the Special Issue Challenges in COVID-19 and Related Complications)
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