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31 Results Found

  • Review
  • Open Access
13 Citations
12,325 Views
16 Pages

18 September 2019

Peyronie’s disease is a condition that causes abnormal healing of the tunica albuginea, causing penile curvature. It is difficult to treat and its management is continuing to evolve. Proposed non-surgical treatments have included oral, topical,...

  • Review
  • Open Access
5 Citations
4,673 Views
21 Pages

Elastography is a noninvasive method that utilizes ultrasound imaging to assess the elasticity and stiffness of soft tissue. Peyronie’s disease (PD) is a chronic inflammatory condition that affects the male penis, causing the formation of fibro...

  • Article
  • Open Access
1,054 Views
16 Pages

Measurement of Oxidative Stress Index in 102 Patients with Peyronie’s Disease

  • Gianni Paulis,
  • Andrea Paulis,
  • Giovanni De Giorgio and
  • Salvatore Quattrocchi

Background: Peyronie’s disease (PD) is a chronic inflammatory condition that affects the penile albuginea. Oxidative stress (OS) plays a crucial role in the development of the disease, prompting us to investigate OS levels at the site of the di...

  • Review
  • Open Access
1 Citations
12,207 Views
8 Pages

1 June 2023

Peyronie’s disease is a condition characterized by the formation of fibrous plaques in the tunica albuginea, which can cause pain, curvature, and erectile dysfunction. Preclinical studies have demonstrated the potential benefits of hyaluronic a...

  • Review
  • Open Access
16 Citations
5,878 Views
29 Pages

Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease

  • Yozo Mitsui,
  • Fumito Yamabe,
  • Shunsuke Hori,
  • Masato Uetani,
  • Hideyuki Kobayashi,
  • Koichi Nagao and
  • Koichi Nakajima

Peyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality...

  • Review
  • Open Access
12 Citations
5,057 Views
16 Pages

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

  • Yasuyoshi Miyata,
  • Tomohiro Matsuo,
  • Yuichiro Nakamura,
  • Kensuke Mitsunari,
  • Kojiro Ohba and
  • Hideki Sakai

10 November 2021

Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients...

  • Review
  • Open Access
17 Citations
8,338 Views
20 Pages

15 December 2022

Background: Peyronie’s disease (PD) is a chronic inflammatory condition affecting adult males, involving the tunica albuginea of the corpora cavernosa of the penis. PD is frequently associated with penile pain, erectile dysfunction, and a secondary a...

  • Case Report
  • Open Access
5 Citations
23,866 Views
14 Pages

9 December 2022

Peyronie’s disease (PD) is a fibrotic disorder of the penile tunica albuginea. To date, only a few cases of recovery from PD following medical treatment have been reported in the literature. In this article, we describe three new cases of PD wh...

  • Article
  • Open Access
5 Citations
6,677 Views
20 Pages

Peyronie’s disease (PD) affects the penile albuginea, resulting in penile deformity, pain, erectile dysfunction (ED), and an anxious–depressive state. PD diagnosis involves a thorough medical history, penile palpation, documentation of th...

  • Review
  • Open Access
2 Citations
8,237 Views
17 Pages

12 February 2025

Peyronie’s disease (PD) is a chronic disease characterized by the development of fibrous tissue in the tunica albuginea of the penile corpora cavernosa that causes penile deformity. The precise cause of PD is not completely understood, but it i...

  • Article
  • Open Access
3 Citations
3,065 Views
15 Pages

15 January 2024

Peyronie’s disease (PD) is a chronic inflammatory disease affecting the penile albuginea. Oxidative stress (OS) is important for the development of the disease; therefore, it seemed interesting to us to directly measure OS at both the site of t...

  • Interesting Images
  • Open Access
1 Citations
2,138 Views
4 Pages

A 70-year-old man with high-risk prostate cancer (PCa) received radiation therapy and androgen deprivation therapy (ADT). The patient developed penile tenderness, compatible with Peyronie’s disease upon physical examination. An ultrasound revea...

  • Article
  • Open Access

Intralesional Platelet-Rich Plasma for Treating Chronic Peyronie’s Disease: A Single-Center Retrospective Cohort Study

  • Luigi Pucci,
  • Celeste Manfredi,
  • Catello Sansone,
  • Simone Tammaro,
  • Giorgio Stanziola,
  • Nunzio Langella,
  • Giuseppe Dachille,
  • Davide Arcaniolo,
  • Marco De Sio and
  • Maurizio Carrino

21 January 2026

Background and Objectives: Peyronie’s disease (PD) is a chronic fibrotic disorder of the tunica albuginea causing penile deformity and sexual dysfunction. Platelet-rich plasma (PRP) has been proposed as a regenerative therapy with potential dis...

  • Case Report
  • Open Access
10 Citations
28,803 Views
13 Pages

26 August 2022

Peyronie’s disease (PD) is a fibrotic disorder of the tunica albuginea of the penis. Conservative medical therapy includes oral and/or injective active substances. Until now, only two PD patients who recovered after medical treatment are descri...

  • Article
  • Open Access
1 Citations
7,712 Views
9 Pages

The Use of Vacuum Devices as Adjuvant Therapy before and after Penile Curvature Surgery in Patients Affected by La Peyronie’s Disease: Results from a Comparative Study

  • Tommaso Cai,
  • Marco Capece,
  • Carlo Ceruti,
  • Daniele Tiscione,
  • Marco Puglisi,
  • Paolo Verze,
  • Paolo Gontero and
  • Alessandro Palmieri

17 October 2023

Background: Peyronie’s disease (PD) represents a challenging urological disease, due to not optimal post-operative surgical outcomes. We aim to retrospectively evaluate if vacuum erection device (VED) treatment before penile curvature surgery i...

  • Article
  • Open Access
1 Citations
5,624 Views
8 Pages

Use of Li-ESWT, Tadalafil, and a Vacuum Device to Preserve Erectile Function in Subjects Affected by Peyronie’s Disease and Undergoing Grafting Surgery

  • Francesco Trama,
  • Antonio Ruffo,
  • Ester Illiano,
  • Giuseppe Romeo,
  • Filippo Riccardo,
  • Marco Sarcinella,
  • Felice Crocetto,
  • Elisabetta Costantini and
  • Fabrizio Iacono

13 August 2021

Background: Peyronie’s disease (PD) is a little-known disease characterized by pain during erections, the presence of penile curvature, and consequent psychological disorders. In addition, concomitant erectile dysfunction may be present. The treatmen...

  • Article
  • Open Access
3 Citations
15,223 Views
9 Pages

13 September 2024

Background: The purpose of this study is to examine the combination of the mechanical effects of penile therapy with vacuum erection devices (VEDs) plus PDE5i, which improve clinical outcomes after extracorporeal shockwave therapy (ESWT) in men affec...

  • Article
  • Open Access
10 Citations
3,136 Views
9 Pages

Negative Self-Perception and Self-Attitude of Sexuality Is a Risk Factor for Patient Dissatisfaction Following Penile Surgery with Small Intestinal Submucosa Grafting for the Treatment of Severe Peyronie’s Disease

  • Armin Soave,
  • Sebastian Laurich,
  • Roland Dahlem,
  • Malte W. Vetterlein,
  • Oliver Engel,
  • Timo O. Nieder,
  • Peer Briken,
  • Michael Rink,
  • Margit Fisch and
  • Philip Reiss

28 July 2019

Objective: To assess patient satisfaction with surgical outcome, body related self-perceptions, self-attitudes of sexuality, and health related quality of life after penile surgery with small intestinal submucosa (SIS) grafting for the treatment of s...

  • Review
  • Open Access
11 Citations
36,151 Views
11 Pages

The Application of Hyaluronic Acid Injections in Functional and Aesthetic Andrology: A Narrative Review

  • Nicolò Schifano,
  • Paolo Capogrosso,
  • Gabriele Antonini,
  • Sara Baldini,
  • Fabrizio Scroppo,
  • Andrea Salonia,
  • Nicola Zerbinati and
  • Federico Dehò

1 February 2023

Hyaluronic acid (HA) is a glycosaminoglycan widely utilised in different fields of medicine. We aimed to provide a comprehensive overview of the scientific evidence on the use of HA in andrology. A review of the literature to identify pertinent studi...

  • Review
  • Open Access
636 Views
21 Pages

Male Infertility: A Comprehensive Review of Urological Causes and Contemporary Management

  • Biagio Barone,
  • Ugo Amicuzi,
  • Simone Tammaro,
  • Michelangelo Olivetta,
  • Marco Stizzo,
  • Michele Musone,
  • Luigi Napolitano,
  • Luigi De Luca,
  • Pasquale Reccia and
  • Felice Crocetto
  • + 16 authors

5 January 2026

Male infertility is a prevalent global health issue, with urological disorders representing some of the most common and correctable causes. Key conditions such as varicocele, obstructive azoospermia, erectile dysfunction and Peyronie’s disease...

  • Review
  • Open Access
5 Citations
5,022 Views
18 Pages

The Immunological Microenvironment and the Emerging Role of Stem Cells Therapy in Peyronie’s Disease: A Systematic Narrative Review

  • Che-Hsueh Yang,
  • Dian-Yu Lin,
  • Yi-Sheng Lin,
  • Chao-Yu Hsu,
  • Min-Che Tung,
  • Kok-Tong Tan and
  • Yen-Chuan Ou

Current literature has indicated that Peyronie’s disease (PD) could be initiated by microtrauma and the subsequent inflammation episodes that follow. PD could be sorted into acute or chronic status, and it can differ when selecting the clinical...

  • Review
  • Open Access
1,398 Views
25 Pages

MRI of the Scrotum and Penis: Current Applications and Clinical Relevance

  • Bartosz Regent,
  • Karolina Nowak,
  • Katarzyna Skrobisz,
  • Marcin Matuszewski and
  • Michał Studniarek

9 December 2025

Background: Magnetic resonance imaging (MRI) plays an increasingly important role in the evaluation of scrotal and penile disorders, complementing ultrasonography in cases where findings are equivocal or complex. With its superior soft-tissue contras...

  • Systematic Review
  • Open Access
4,288 Views
15 Pages

Buccal Mucosa Graft in Urological Surgery: A State-of-the-Art Review and Expert Opinion

  • Simone Botti,
  • Tommaso Ceccato,
  • Marco Cassaro,
  • Giangiacomo Sanna,
  • Lorenzo Trevisiol and
  • Tommaso Cai

8 August 2025

Background/Objectives: Buccal mucosa graft (BMG) is increasingly utilized in reconstructive urological surgeries due to its versatility, robust integration, histological characteristics and low morbidity at the donor site. Initially employed in ureth...

  • Article
  • Open Access
4 Citations
4,748 Views
8 Pages

Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction

  • Ercan Ogreden,
  • Ural Oğuz,
  • Erhan Demirelli,
  • Alptekin Tosun and
  • Orhan Yalçın

26 March 2018

The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients w...

  • Commentary
  • Open Access
1,511 Views
2 Pages

17 February 2024

Highlighting the restricted access to andrology medical devices in Arab Muslim countries, where unjust associations with sexual instruments lead to prohibitions, this commentary underscores the challenges in providing appropriate medical care for and...

  • Review
  • Open Access
4 Citations
12,323 Views
14 Pages

Ledderhose’s Disease: An Up-to-Date Review of a Rare Non-Malignant Disorder

  • Alexandru Tomac,
  • Alexandru Petru Ion,
  • Diana Roxana Opriș,
  • Eliza Mihaela Arbănași,
  • Claudiu Constantin Ciucanu,
  • Bogdan Corneliu Bandici,
  • Cătălin Mircea Coșarcă,
  • Diana Carina Covalcic and
  • Adrian Vasile Mureșan

28 September 2023

Plantar fibromatosis (or Ledderhose’s disease) is a rare benign condition, difficult to treat, defined by gradual-growing nodules in the central medial part of the plantar fascia, with the possibility of sclerosis and shrinkage of the entire fa...

  • Review
  • Open Access
6 Citations
4,464 Views
12 Pages

Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment

  • Harrina E. Rahardjo,
  • Viktoria Märker,
  • Dimitrios Tsikas,
  • Markus A. Kuczyk,
  • Stefan Ückert and
  • Andreas Bannowsky

19 July 2023

Fibrosis is a disease condition characterized by abnormalities of the extracellular matrix, such as accumulation of the transforming growth factor β, infiltration by myofibroblasts, deposition of collagen, and a generalized dysregulation of coll...

  • Case Report
  • Open Access
4 Citations
5,678 Views
10 Pages

Pain-Relieving Effects of Shockwave Therapy for Ledderhose Disease: An Ultrasound-Based Study of an Unusual Bilateral Case

  • Federica Fulceri,
  • Larisa Ryskalin,
  • Gabriele Morucci,
  • Francesco Busoni,
  • Paola Soldani and
  • Marco Gesi

24 January 2024

Ledderhose disease (LD, or plantar fibromatosis) is a rare, nodular, hyperproliferative condition affecting the plantar aponeurosis of the foot. At present, several conservative, non-surgical treatments have been documented, although with various deg...

  • Article
  • Open Access
4 Citations
2,600 Views
10 Pages

Voice Assistants as Consultants for Male Patients with Sexual Dysfunction: A Reliable Option?

  • Luigi Napolitano,
  • Biagio Barone,
  • Lorenzo Spirito,
  • Francesco Trama,
  • Savio Domenico Pandolfo,
  • Marco Capece,
  • Esther García-Rojo,
  • Esaú Fernández-Pascual,
  • Felice Crocetto and
  • Celeste Manfredi
  • + 3 authors

The aim of this study was to evaluate the ability of Google Assistant, Alexa, and Siri to recognize and answer questions about male sexual health. Each VA was tested on a smart speaker: Alexa on Amazon Echo Dot 4th Gen., Google Assistant on Google Ho...

  • Article
  • Open Access
4 Citations
3,288 Views
18 Pages

UVA-Degradable Collagenase Nanocapsules as a Potential Treatment for Fibrotic Diseases

  • Víctor M. Moreno,
  • Carolina Meroño,
  • Alejandro Baeza,
  • Alicia Usategui,
  • Pablo L. Ortiz-Romero,
  • José L. Pablos and
  • María Vallet-Regí

Peyronie and Dupuytren are pathologies characterized by the appearance of localized fibrotic lesions in an organ. These disorders originate from an excessive production of collagen in the tissue provoking dysfunction and functional limitations to the...

  • Article
  • Open Access
45 Citations
9,011 Views
13 Pages

Administration of Adipose Derived Mesenchymal Stem Cells and Platelet Lysate in Erectile Dysfunction: A Single Center Pilot Study

  • Vassilis Protogerou,
  • Efstathios Michalopoulos,
  • Panagiotis Mallis,
  • Ioanna Gontika,
  • Zetta Dimou,
  • Christos Liakouras,
  • Catherine Stavropoulos-Giokas,
  • Nikolaos Kostakopoulos,
  • Michael Chrisofos and
  • Charalampos Deliveliotis

Erectile dysfunction (ED) affects more than 30 million men; endothelial dysfunction plays a significant role in EDs pathogenesis. The aim of this study was to administer mesenchymal stem cells (MSC) derived from adipose tissue and platelet lysate (PL...