Search Results (1,451)

Rare-earth-doped upconversion nanoparticles (UCNPs) exhibit upconversion luminescence upon excitation with infrared light and have been extensively utilized in the field of biosensing. In this study, a UCNPs-based biosensor with porous silicon (PSi) as the substrate was developed for the first time, enabling the detection of target DNA molecule concentration. First, a PSi substrate was prepared via electrochemical etching and subsequently functionalized to enable target DNA molecules to immobilize onto the inner walls of the PSi substrate’s pores. Then, UCNPs-labeled probe DNA molecules hybridized with the target DNA molecules, enabling indirect attachment of UCNPs to the inner walls of the PSi substrate. Subsequently, the sample surface is irradiated with a 980 nm laser. Upconversion fluorescence images of the sample, both before and after the biological reaction, are captured using an image acquisition device. Image processing software is employed to calculate the average change in grayscale values, enabling the determination of the molecular concentration of target DNA. The limit of detection (LOD) of this method for target DNA molecular concentration is 86 pM, demonstrating that it enables low-cost, highly sensitive, rapid, and convenient biological detection of target DNA molecules. Full article

This study aims to model and optimize the process parameters influencing the efficiency and yield of oil extraction from Mongolian sea buckthorn seeds using supercritical carbon dioxide (CO₂). The experiments were planned using response surface methodology (RSM) based on a central composite rotatable design (CCRD) to evaluate the effects of extraction pressure, temperature, and time, while maintaining a constant solvent flow rate of 2.0 L/min to balance extraction efficiency and selectivity. Following data refinement and outlier exclusion, the developed second-order polynomial model exhibited excellent accuracy with a coefficient of determination R² of 0.9375. Among the parameters studied, pressure was identified as the most critical factor affecting oil yield. Furthermore, significant interaction effects were observed, particularly between extraction time and the other variables, pressure–time (A * C) and temperature–time (B * C), indicating the time-dependent nature of mass transfer. The predicted optimal conditions for maximum yield were determined to be 5075 psi, 70 °C, and an extraction time of 10 h. Validation experiments under these conditions resulted in an oil yield of 800 g, confirming the reliability of the model. These findings demonstrate the feasibility of optimizing supercritical CO₂ extraction for the industrial-scale production of high-quality functional oils and nutraceuticals. Full article

With the integration of high-penetration power electronics, the dynamic characteristics of modern power systems are jointly dominated by synchronous generators (SGs) and virtual synchronous machines (VSMs). However, the accuracy of these system parameters cannot always be guaranteed in real-world scenarios. To tackle this issue, we propose a robust parameter identification and correction framework based on trajectory sensitivity analysis and Pareto smoothed importance sampling (PSIS). First, to identify the sources of dynamic anomalies, we employ trajectory sensitivity analysis to quantify the impact of parameter variations and screen out key parameters for targeted identification. Subsequently, to utilize the readily available ambient measurements, we incorporate successive variational mode decomposition (SVMD). This method adaptively extracts the dominant variation modes, thereby recovering high-quality data for the identification process. Finally, to circumvent the weight degradation problem inherent in traditional particle filters, we propose a cost-effective PSIS algorithm to obtain the robust posterior distribution of modern system parameters. Simulation results demonstrate the excellent performance of the proposed method. It can not only precisely estimate the key parameters of both SGs and VSMs but also realize the automatic correction of dynamic models under complex operating scenarios. Full article

Background: Administrative data help managers monitor and manage health care enrollees’ health. Of the few available administrative measures of psychiatric illness severity, however, most either commingle sociodemographics and medical comorbidities or lack ordinal properties. Objective: To assess construct, concurrent, and predictive validity of a novel, 6-item, administrative measure of psychiatric severity, the Manifestations of Psychiatric Severity Index (MoPSI). Methods: A panel study of 960 gender-stratified, nationally representative, post-9/11 US Veterans with pending disability claims for posttraumatic stress disorder (PTSD). MoPSI scoring was based on the joint probability density (JPD) method and a JPD linear approximation. Results: The JPD MoPSI score and its linear approximated score had a correlation of 0.999. Relative to their counterparts, unmarried Veterans, Veterans with low income, and Veterans with serious mental illness or PTSD had higher MoPSI scores (Ps: <0.0001–0.03). Higher MoPSI scores predicted cigarette and street drug use and PTSD and depression/anxiety symptoms six months later, and disability award approximately 1 year later (Ps: 0.01–0.02). Conclusions: In this sample, the MoPSI had evidence of construct, concurrent, and predictive validity. Full article

To enhance the wide-temperature-range magnetocaloric performance of (Mn,Fe)₂(P,Si) alloys, the effects of Mg-Co co-doping on their structural and magnetocaloric properties were systematically investigated. Mn_1.05−yCo_yFe_0.9P_0.5Si_0.48Mg_0.02 alloys were prepared by the arc melting method. The results show that Mg-Co co-doping can tune the lattice parameters and ferromagnetic coupling between Mn and Fe atoms. The Mn_1.03Co_0.02Fe_0.9P_0.5Si_0.48Mg_0.02 alloy exhibited an effective refrigeration capacity of 425.4 J·kg⁻¹ and an effective working temperature span of 52 K. During the temperature-induced ferromagnetic transition, coupling between the magnetic moment of Fe-Si layers and the crystal lattice drives a magnetoelastic transition, leading to a giant magnetocaloric effect. The Mg-Co co-doping strategy effectively tunes the crystal structure and local electron density distribution of the Fe-Si layer, thereby influencing the total magnetic moment and magnetothermal properties of the alloys. Full article

Enhanced Geothermal Systems (EGS) extend geothermal energy beyond conventional hydrothermal resources but face challenges in creating sustainable heat exchangers in low-permeability formations. This review synthesizes achievements from the Utah Frontier Observatory for Research in Geothermal Energy (FORGE), a field laboratory advancing EGS readiness in 175–230 °C granitic basement. From 2017 to 2025, drilling, multi-stage hydraulic stimulation, and monitoring established feasibility and operating parameters for engineered reservoirs. Hydraulic connectivity was created between highly deviated wells with ~300 ft vertical separation via hydraulic and natural fracture networks, validated by sustained circulation tests achieving 10 bpm injection at 2–3 km depth. Advanced monitoring (DAS, DTS, and microseismic arrays) delivered fracture propagation diagnostics with ~1 m spatial resolution and temporal sampling up to 10 kHz. A data infrastructure of 300+ datasets (>133 TB) supports reproducible ML. Geomechanical analyses showed minimum horizontal stress gradients of 0.74–0.78 psi/ft and N–S to NNE–SSW fractures aligned with maximum horizontal stress. Near-wellbore tortuosity, driving treating pressures to 10,000 psi, underscores completion design optimization, improved proppant transport in high-temperature conditions, and coupled thermos-hydro-mechanical models for long-term prediction, supported by AI platforms including an offline Small Language Model trained on Utah FORGE datasets. Full article

This paper demonstrates the results of constructive technological research on the development of a catalyst with a Ni/PSi@Pt structure. This catalyst eliminates the use of gold in the structure of μ-FC electrodes. This work uses the main technological solutions for the formation of a gold-containing “core–shell” structure on the inner surface of pores. Comparative data on the results of assessing the durability of porous silicon electrodes with both Pt catalysts and composite catalysts of the Pt/In₂O₃, Pt/SnO₂, Pt/Au and Pt/Ni types are also presented. Full article

Parental stress is a critical yet understudied dimension of childhood total blindness, a condition that imposes substantial developmental, emotional, and functional challenges on families. This cross-sectional study assessed parenting stress, maternal health symptoms, and children’s functional vision-related quality of life in 81 mothers of children aged 0 to 12 years with total congenital blindness. Parenting stress was assessed in the full sample using the Parenting Stress Index–Fourth Edition (PSI-4). Children’s functional vision-related quality of life was evaluated in age-specific subsamples using the Quality of Family Vision Impact (QFVI-3 for children aged 0–3 years and QFVI-7 for children aged 3–7 years). All participants also completed a sociodemographic and maternal health survey. Total Parent Stress showed moderately elevated percentile scores (mean ≈ 67), with the highest PSI-4 subdomains in Adaptability, Depression, and Health. Approximately 21% of mothers scored within the clinical range for high stress. Maternal symptoms including sadness, insomnia, headaches, forgetfulness, and musculoskeletal pain were significant (all p < 0.01). QFVI global scores indicated moderate impairments in functional vision-related quality of life across age groups. Life Stress demonstrated a small-to-moderate negative correlation with QFVI-7, suggesting that cumulative environmental stressors may adversely affect children’s functional outcomes. Several factors were associated with more favorable outcomes. Among children under three years of age, maternal engagement in physical activity was associated with higher QFVI scores, whereas among children aged 3–7 years, school attendance was associated with higher functional vision-related quality of life scores. In contrast, sociodemographic disadvantage, limited access to educational adaptations, and reduced maternal participation in work or leisure activities were associated with higher levels of parental stress. These findings highlight the importance of multidisciplinary, family-centered care incorporating psychosocial assessment, early stimulation, orientation and mobility support, and maternal mental health interventions in pediatric ophthalmology. Full article

Background: Attention Deficit Hyperactivity Disorder (ADHD) is associated with executive function deficits—such as planning, organization, and prospective memory—that impair autonomy and daily functioning, increase family stress, and create challenges in educational contexts. These consequences underscore the need for accessible and ecologically valid interventions addressing the cognitive, familial, and educational dimensions. Traditional approaches often lack ecological validity, and pharmacological treatment shows a limited impact on functional cognition. Objectives: This protocol outlines a feasibility study of DiverAcción, a web-based telerehabilitation system designed to enhance functional cognition through interactive and gamified tasks integrated into a comprehensive healthcare programme. Methods: A quasi-experimental feasibility study before and after the study will recruit 30 participants aged 9 to 17 years with ADHD. The study comprises an initial face-to-face session for instructions and baseline assessment (T0), followed by twelve supervised online sessions over six weeks. Therapeutic support is provided via integrated chat, email, and two scheduled videoconference check-ins. Feasibility Outcomes: include recruitment, adherence, retention, usability (SUS), acceptability (TAM), satisfaction, user-friendly design, therapeutic alliance (WAI-I), and professionals’ attitudes toward technology (e-TAP-T). Exploratory Measures: include parental self-efficacy (BPSES), parenting stress (PSI-4-SF), ADHD symptomatology (SNAP-IV), executive functioning (BRIEF-2), time management (Time-S), emotional regulation (ERQ-CA), prospective memory (PRMQ-C), and health-related quality of life (KIDSCREEN-52). Analyses emphasize descriptive statistics for feasibility metrics (recruitment, adherence, retention, dropout and fidelity). Assessments are conducted post-intervention (T1) and at three-month follow-up (T2) and analyzed relative to baseline using repeated-measures ANOVA or Friedman tests, depending on data distribution. Conclusions: This feasibility protocol will provide preliminary evidence on the usability, acceptability, and implementation of DiverAcción. Findings will guide refinements and inform the design of a subsequent randomized controlled trial. Full article

Background: Orbital dermoid cysts are common benign lesions; however, deep-seated or recurrent lesions near the orbital apex pose major surgical challenges due to their proximity to critical neurovascular structures. Lateral orbitotomy remains the reference approach, but accurate osteotomies and stable reconstruction can be difficult to achieve using conventional techniques. This study reports our initial experience using a fully digital, hospital-based point-of-care (POC) workflow to enhance precision and safety in complex orbital dermoid cyst surgery. Methods: We present a case series of three patients with orbital dermoid cysts treated at a tertiary center (2024–2025) using a comprehensive digital workflow. Preoperative assessment included CT and/or MRI followed by virtual surgical planning (VSP) with orbit–tumor segmentation and 3D modeling. Cutting guides and patient-specific implants (PSIs) were manufactured in-house under a certified hospital-based POC protocol. Surgical strategies were tailored to each lesion and included piezoelectric osteotomy, intraoperative navigation, intraoperative CT, and structured-light scanning when indicated. Results: Complete en bloc resection was achieved in all cases without capsular rupture or optic nerve injury. Intraoperative CT confirmed complete lesion removal and accurate PSI positioning and fitting. Structured-light scanning enabled radiation-free postoperative monitoring when used. All patients preserved full ocular motility, visual acuity, and facial symmetry, with no complications or recurrences during follow-up. Conclusions: The integration of VSP, in-house POC manufacturing, and image-guided surgery within a lateral orbitotomy approach provides a reproducible and fully integrated workflow. This strategy appears to improve surgical precision and safety while supporting optimal long-term functional and aesthetic outcomes in challenging orbital dermoid cyst cases. Full article

E-scooters have become a widely adopted form of urban mobility, increasing the need to understand how vibration exposure affects comfort and safety. While most studies have examined the effects of speed, pavement roughness, and overall tire stiffness, none have evaluated how differing stiffness curves between the front and rear wheels influence rider comfort. This article uses real stiffness curves for rigid and inflatable tires at various pressures (30 psi, 60 psi, and rigid) to assess how front–rear stiffness asymmetry affects vibration transmission across speeds (10–20–30 km/h) and two roughness levels (low and high). The analysis, following the standard UNE-ISO 2631-1:2008 and supported by a multiple-regression model (adjusted R² = 93.84%, homoscedastic residuals), shows that speed and roughness dominate the comfort response (98.9%), while tire stiffness offers a secondary (1.1%) but useful tuning parameter, inducing comfort index variations exceeding 14% between front–rear pressure combinations under typical urban conditions (~20 km/h, low roughness). In this case, the most favorable configuration corresponds to inflatable tires with slightly higher front pressure (+2.9–4.35 psi), whereas solid tires consistently yield the poorest comfort. These findings underscore the role of front–rear stiffness management in improving ride quality and provide practical guidance for optimal inflation strategies in urban e-scooters. Full article

This study explores the viability of ultra-high-performance concrete (UHPC) as a structural material for compressed air storage (CAES) systems, combining comprehensive experimental testing and numerical simulations. Scaled (1:20) CAES tanks were designed and tested experimentally under controlled pressure conditions up to 4 MPa (580 psi), employing strain gauges to measure strains in steel cylinders both with and without UHPC confinement. Finite element models (FEMs) developed using ANSYS Workbench 2024 simulated experimental conditions, enabling detailed analysis of strain distribution and structural behavior. Experimental and numerical results agreed closely, with hoop strain relative errors between 0.9% (UHPC-confined) and 1.9% (unconfined), confirming the numerical model’s accuracy. Additionally, the study investigated the role of a rubber interface layer integrated between the steel and UHPC, revealing its effectiveness in mitigating localized stress concentrations and enhancing strain distribution. Failure analyses conducted using the von Mises criterion for steel and the Drucker–Prager criterion for UHPC confirmed adequate safety factors, validating the structural integrity under anticipated operational pressures. Principal stresses from numerical analyses were scaled to real-world operational pressures. These thorough results highlight that incorporating rubber enhances the system’s structural performance. Full article

Background: Three-dimensional virtual surgical planning (Three-dimensional VSP) has become standard practice in the treatment of mandibular oral squamous cell carcinoma (OSCC) in the last decade. Dutch guidelines recommend a care pathway interval (CPI) of a maximum of 30 days, and a free bone margin of at least 5 mm. Fused MRI and CT data are used for accurate tumor delineation. Based on this data, a virtual surgical plan is created and transferred to the operating room using resection guides and patient-specific implants (PSIs). Long-term evaluation is needed to further optimize its clinical use. Objectives: This study evaluates adherence to bone margin and CPI guidelines in mandibular OSCC. Additionally, it assesses the accuracy of tumor resection and reconstruction using 3D-VSP and compares the complications of 3D-planned mandibular reconstruction using different kinds of osteosynthesis plates. Methods: All patients who underwent a segmental mandibulectomy between 2014 and 2024 at the University Medical Center Groningen were included. CPI, clinical outcomes, and complications were analyzed. The preoperative virtual plan was compared with the postoperative outcome to assess accuracy. Results: The median CPI was 34 days, and 93.7% of bone margins were tumor-free. Mean absolute resection deviation was 1.63 mm (±1.42). PSI reconstructions were significantly more accurate in intergonial distance and coronal angle compared to conventional plates. Plate-related complications were more common in non-bony reconstructions; PSI reconstructions showed significantly more plate exposure. Conclusions: 3D-VSP leads to high accuracy in resection and reconstruction and favorable bone margins. Shortening the CPI and reducing biological complications are essential to further improve oncological outcomes. Full article

Autism spectrum disorder (ASD) and intellectual disability (ID) frequently coexist and share heterogeneous cognitive manifestations, yet their specific performance patterns on Wechsler scales remain poorly systematized. This meta-analysis synthesized data from 31 studies using the WISC-IV, WISC-V, WAIS-III, and WAIS-IV to compare cognitive index profiles in individuals with ASD, ID and ASD+ID. Standardized mean differences (Hedges’ g) were calculated using random-effects models, adopting a normative reference of mean 100 and SD 15. Results showed a distinct profile for ASD, with greater impairments in the Processing Speed Index (PSI) and Working Memory Index (WMI), while the Vocabulary Comprehension Index (VCI), Perceptual/Fluid Reasoning Index (PRI/FRI), and Visual Processing Index (VPI) remained close to normative scores. In contrast, ID and ASD+ID exhibited generalized deficits across all indices, with the lowest scores in Full-Scale IQ (FSIQ) and broad effects above g = −2.5. No significant differences emerged between Wechsler versions or age-based test types. Heterogeneity was high in ASD and ID across outcomes, but negligible in ASD+ID due to reduced k. These findings reinforce that ASD presents a specific cognitive pattern, whereas ID and ASD+ID display diffuse impairment, and that Wechsler scales are consistent across versions for identifying these profiles. Full article

Background/Objectives: Children born small for gestational age (SGA) are at increased risk for impaired growth, metabolic disturbances, and neurodevelopmental difficulties. Although previous research has examined cognitive and behavioral outcomes in this population, findings remain inconsistent. Moreover, limited evidence is available regarding the potential effects of recombinant human growth hormone (rhGH) therapy on cognitive development. We aimed to assess cognitive performance, emotional–behavioral functioning, and neonatal predictors of neurocognitive outcomes in term SGA children compared with age- and sex-matched peers born appropriate for gestational age (AGA). We also explored potential differences in cognitive outcomes between rhGH-treated and untreated SGA children. Methods: A total of 18 term SGA children and 23 AGA controls underwent anthropometric measurements, biochemical evaluation, cognitive testing using the Wechsler Intelligence Scale for Children—Fourth Edition (WISC-IV), and behavioral assessment through the Child Behavior Checklist (CBCL). Birth weight, length, and head circumference were analyzed as potential predictors of cognitive performance. Results: SGA children demonstrated significantly lower Intelligence Quotient (IQ) scores than AGA peers, with marked weaknesses in Perceptual Reasoning index (PRI) and Processing Speed index (PSI), while Verbal Comprehension and Working Memory were preserved. They also exhibited higher internalizing behavioral symptoms, whereas externalizing behaviors did not differ between groups. Birth head circumference emerged as a strong predictor of PRI and a modest predictor of PSI. No associations were found between rhGH treatment parameters and cognitive outcomes. Larger longitudinal studies are needed to clarify how early growth restriction affects brain development and cognition and whether GH therapy influences these processes. Full article