Search Results (9)

Congenital hepatic fibrosis/Autosomal recessive polycystic kidney disease (CHF/ARPKD) is an inherited neonatal disease induced by mutations in the PKHD1 gene and characterized by cysts and robust pericystic fibrosis in the liver and kidneys. The PCK rat is an excellent animal model that carries a Pkhd1 mutation and exhibits similar pathophysiology. We performed RNA-Seq analysis on liver samples from PCK rats over a time course of postnatal day (PND) 15, 20, 30, and 90 using age-matched Sprague Dawley (SD) rats as controls to characterize molecular mechanisms of CHF/ARPKD pathogenesis. A comprehensive gene expression analysis identified 1298 differentially expressed genes (DEGs) between PCK and SD rats. The genes overexpressed in the PCK rats at PND30 and 90 were involved cell migration (e.g., Lamc2, Tgfb2, and Plet1), cell adhesion (e.g., Spp1, Adgrg1, and Cd44), and wound healing (e.g., Plat, Celsr1, Tpm1). Connective tissue growth factor (Ctgf) and platelet-derived growth factor (Pdgfb), two genes associated with fibrosis, were upregulated in PCK rats at all time points. Genes associated with MHC class I molecules (e.g., RT1-A2) or involved in ribosome assembly (e.g., Pes1) were significantly downregulated in PCK rats. Upstream regulator analysis showed activation of proteins involved tissue growth (MTPN) inflammation (STAT family members), chromatin remodeling (BRG1), reduction in fibrosis (SMAD7), and inhibition of proteins involved in hepatic differentiation (HNF4α). Immunofluorescence staining revealed that cyst wall epithelium cells also express hepatic progenitor cell markers. The increase in mRNAs of four top upregulated genes, including Reg3b, Aoc1, Tm4sf20, and Cdx2, was confirmed at the protein level using immunohistochemistry. In conclusion, these studies indicate that a combination of increased inflammation, cell migration, wound healing, decreased antifibrotic gene expression, and inhibition of hepatic function are the major underlying pathogenic mechanisms in CHF/ARPKD. Full article

Fibre breaks govern the strength of unidirectional composite materials under tension. The progressive development of fibre breaks is studied using in situ X-ray computed tomography, especially with synchrotron radiation. However, even with synchrotron radiation, the resolution of the time-resolved in situ images is not sufficient for a fully automated analysis of continuous mechanical deformations. We therefore investigate the possibility of increasing the quality of low-resolution in situ scans by means of super-resolution (SR) using 3D deep learning techniques, thus facilitating the subsequent fibre break identification. We trained generative neural networks (GAN) on datasets of high—(0.3 μm) and low-resolution (1.6 μm) statically acquired images. These networks were then applied to a low-resolution (1.1 μm) noisy image of a continuously loaded specimen. The statistical parameters of the fibre breaks used for the comparison are the number of individual breaks and the number of 2-plets and 3-plets per specimen volume. The fully automated process achieves an average accuracy of 82% of manually identified fibre breaks, while the semi-automated one reaches 92%. The developed approach allows the use of faster, low-resolution in situ tomography without losing the quality of the identified physical parameters. Full article

In a consistent quantum theory known as “non-Hermitian interaction picture” (NIP), the standard quantum Coriolis operator $\mathsf{\Sigma }\left(t\right)$ emerges whenever the observables of a unitary system are given in their quasi-Hermitian and non-stationary rather than “usual” representations. With $\mathsf{\Sigma }\left(t\right)$ needed, in NIP, in both the Schrödinger-like and Heisenberg-like dynamical evolution equations we show that another, amended and potentially simplified theory can be based on an auxiliary $N-$term factorization of the Dyson’s Hermitization map $\mathsf{\Omega }\left(t\right)$. The knowledge of this factorization is shown to lead to a multiplet of alternative eligible Coriolis forces ${\mathsf{\Sigma }}_n\left(t\right)$ with $n=0,1,\dots ,N$. The related formulae for the measurable predictions constitute a new formalism refered to as “factorization-based non-Hermitian interaction picture” (FNIP). The conventional NIP formalism (where $N=1$) becomes complemented by an $(N-1)$-plet of its innovative “hybrid” alternatives. Some of the respective ad hoc adaptations of observables may result in an optimal representation of quantum dynamics. Full article

For the displaced harmonic double-well oscillator, the existence of exact polynomial bound states at certain displacements $d$ is revealed. The N-plets of these quasi-exactly solvable (QES) states are constructed in closed form. For non-QES states, the Schrödinger equation can still be considered “non-polynomially exactly solvable” (NES) because the exact left and right parts of the wave function (proportional to confluent hypergeometric function) just have to be matched in the origin. Full article

Grand unified theories (GUTs) may result in the $E_6$-inspired composite Higgs model (E${}_6$CHM) at low energies, almost stabilizing the electroweak scale. We consider an orbifold GUT in 6 dimensions in which the $E_6$-gauge group is broken to the gauge symmetry of the standard model (SM) while different multiplets of the SM fermions come from different 27-plets. The strongly coupled sector of the E${}_6$CHM is confined on the brane where $E_6$ is broken down to its $SU(6)$ subgroup. Near the scale of $f\gtrsim 5\mathrm{TeV}$, this approximate $SU(6)$ symmetry is expected to be further broken down to its $SU(5)$ subgroup, which contains the SM-gauge group. Such a breakdown leads to a set of pseudo-Nambu–Goldstone bosons (pNGBs) that includes an SM-like Higgs doublet. The approximate gauge coupling unification in the E${}_6$CHM takes place at high energies when the right-handed top quark is a composite fermion. To ensure anomaly cancellation, the weakly coupled sector of this model contains extra exotic matter beyond the SM. We discuss the mechanism of the generation of matter–antimatter asymmetry within the variant of the E${}_6$CHM in which the baryon number and CP invariance are violated. Full article

Pipeline end termination (PLET) installation is an essential part of offshore pipe-laying operation. Pipe-laying operations are sensitive to pipe-laying barge motion and marine environmental conditions. Monitoring the field environment can provide a reasonable basis for planning pipe-laying. Therefore, the measurement and analysis of sea wave motion is helpful for the control and operational safety of the pipeline and vessels. In this study, an environmental monitoring system was established to measure wave motion during PLET operation. Fourier transforms were used to process images that were acquired by ultra-high-frequency X-band marine radar to extract wave parameters. The resulting wave spectra, as measured each minute, were used to simulate real-time wave data and calculate wave characteristics and regressed wave frequency and direction spectrum throughout the PLET operation. The regressed frequency, spectral density, and direction spectra were compared with the theoretical spectra to evaluate their similarity and find the most similar spreading function in the operational area (the South China Sea). Gaussian fitting of real-time wave data was tested while using a classical method. The marginal distribution and joint density of the wave characteristics were estimated and then compared with theoretical distributions to find the most suitable model for improving marine environmental forecasting. Full article

The QCD Lagrangian is based on quark and gluonic fields—not squarks nor gluinos. However, one can show that its hadronic eigensolutions conform to a representation of superconformal algebra, reflecting the underlying conformal symmetry of chiral QCD. The eigensolutions of superconformal algebra provide a unified Regge spectroscopy of meson, baryon, and tetraquarks of the same parity and twist as equal-mass members of the same 4-plet representation with a universal Regge slope. The predictions from light-front holography and superconformal algebra can also be extended to mesons, baryons, and tetraquarks with strange, charm and bottom quarks. The pion $q\overline{q}$ eigenstate has zero mass for $m_q=0.$ A key tool is the remarkable observation of de Alfaro, Fubini, and Furlan (dAFF) which shows how a mass scale can appear in the Hamiltonian and the equations of motion while retaining the conformal symmetry of the action. When one applies the dAFF procedure to chiral QCD, a mass scale $\kappa$ appears which determines universal Regge slopes, hadron masses in the absence of the Higgs coupling. One also predicts the form of the nonperturbative QCD running coupling: ${\alpha }_s\left(Q^2\right)\propto e^{-Q^2/4{\kappa }^2}$ , in agreement with the effective charge determined from measurements of the Bjorken sum rule. One also obtains viable predictions for spacelike and timelike hadronic form factors, structure functions, distribution amplitudes, and transverse momentum distributions. The combination of conformal symmetry, light-front dynamics, its holographic mapping to AdS ${}_5$ space, and the dAFF procedure thus provide new insights, not only into the physics underlying color confinement, but also the nonperturbative QCD coupling and the QCD mass scale. Full article

Single-track Gray codes (STGCs) is a type of absolute position coding method for novel angular sensors, because it has single-track property over traditional Gray codes and mono-difference over linear feedback shift register codes. However, given that the coding theory of STGCs is incomplete, STGC construction is still a challenging task even though it has been defined for more than 20 years. Published coding theories and results on STGCs are about two types of STGC, namely, necklace and self-dual necklace ordering, which are collectively called as k-spaced head STGCs. To find a new code, three constraints on generating sequences are proposed to accelerate the searching algorithm, and the complete searching result of length-6 STGCs is initially obtained. Among the entire 132 length-6 STGCs, two novel types of STGCs with non-k-spaced heads are found, and the basic structures of these codes with the general length n are proposed and defined as twin-necklace and triplet-necklace ordering STGCs. Furthermore, d-plet-necklace ordering STGC, which unifies all the known STGCs by changing the value of d, is also defined. Finally, a single-track absolute encoder prototype is designed to prove that STGCs are as convenient as the traditional position coding methods. Full article

The placenta expressed transcript 1 (PLET1) gene, which is expressed in placentas of pigs and mice, has been found to have a potential role in trophoblast cell fate decision in mice. Results of this study showed that the porcine PLET1 mRNA and protein were expressed exclusively in trophoblast cells on Days 15, 26, 50, and 95 of gestation (gestation length in the pig is 114 days), indicating that the PLET1 could be a useful marker for porcine trophoblast cells. Additionally, PLET1 protein was found to be redistributed from cytoplasm to the apical side of trophoblast cells as gestation progresses, which suggests a role of PLET1 in the establishment of a stable trophoblast and endometrial epithelial layers. In addition, two transcripts that differ in the 3′ UTR length but encode identical protein were identified to be generated by the alternative cleavage and polyadenylation (APA), and the expression of PLET1-L transcript was significantly upregulated in porcine placentas as gestation progresses. Furthermore, we demonstrated the interaction between the miR-365-3p and PLET1 gene using luciferase assay system. Our findings imply an important role of PLET1 in the placental development in pigs. Full article