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Keywords = Kirschner wire

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17 pages, 362 KB  
Review
The Role of Kirschner Wires in Foot and Ankle Surgery: A Comprehensive Review and Practical Appraisal of Applications, Benefits, and Challenges
by Alberto Arceri, Antonio Mazzotti, Simone Ottavio Zielli, Laura Langone, Federico Sgubbi, Gianmarco Di Paola, Giuseppe D’Antonio and Cesare Faldini
Medicina 2025, 61(10), 1836; https://doi.org/10.3390/medicina61101836 - 14 Oct 2025
Viewed by 752
Abstract
Kirschner wires (K-wires) have remained an integral part of orthopedic surgery for decades, particularly in the management of foot and ankle pathologies. This review examines the role of K-wires by analyzing the applications in fracture fixation and deformity correction, highlighting advantages such as [...] Read more.
Kirschner wires (K-wires) have remained an integral part of orthopedic surgery for decades, particularly in the management of foot and ankle pathologies. This review examines the role of K-wires by analyzing the applications in fracture fixation and deformity correction, highlighting advantages such as cost-effectiveness and minimal soft-tissue disruption, while acknowledging limitations including lower torsional stability compared with rigid fixation and the risk of pin-tract infection. The purpose was to provide a comprehensive perspective on the clinical applications, advantages, and limitations of K-wires in contemporary surgical practice, with a focus on the most recent evidence from clinical studies. Full article
(This article belongs to the Section Orthopedics)
14 pages, 2440 KB  
Article
Clinical and Radiographic Outcomes of ESIN, Plate, and K-Wire Fixation in Pediatric Tibial DDMJ Fractures: A Retrospective Comparative Study
by Nevzat Gönder, Çağrı Karabulut, Musa Alperen Bilgin, İbrahim Halil Demir, Ramazan Parıldar, Beytullah Unat and İbrahim Halil Rızvanoğlu
Children 2025, 12(10), 1345; https://doi.org/10.3390/children12101345 - 7 Oct 2025
Viewed by 428
Abstract
Background: Tibial distal diaphyseal–metaphyseal junction (DDMJ) fractures are rare in children and pose therapeutic challenges due to their morphology and risk of displacement. This study compared the clinical, radiological, and economic outcomes of elastic stable intramedullary nailing (ESIN), plate fixation, and Kirschner wire [...] Read more.
Background: Tibial distal diaphyseal–metaphyseal junction (DDMJ) fractures are rare in children and pose therapeutic challenges due to their morphology and risk of displacement. This study compared the clinical, radiological, and economic outcomes of elastic stable intramedullary nailing (ESIN), plate fixation, and Kirschner wire (K-wire) fixation. Methods: A retrospective review was conducted on 64 patients (6–15 years) treated between 2014 and 2023. Patients were grouped according to fixation method. Demographic, operative, radiographic, functional (AOFAS), complication, and cost data were analyzed. Results: The K-wire group, plate group, and ESIN group consisted of 27, 19, and 18 patients, respectively. The mean follow-up duration was 18.03 ± 6.87 months. Of the patients, 38 were male and 26 were female. Concomitant fibula fractures were present in 43 patients and were not present in 21 patients. AOFAS scores were highest in the plate group at the 4th month, while they were similar in all groups in the subsequent follow-ups. The costliest method was plate (2517.64 ± 104.83 $) (p = 0.001). Conclusions: All three fixation methods provided satisfactory long-term outcomes. Plate fixation offers faster early recovery but at higher cost and risk of soft-tissue complications; ESIN balances stability and invasiveness; K-wire is economical but less stable. Treatment choice should be individualized according to fracture pattern, patient factors, and resource availability. Full article
(This article belongs to the Special Issue Pediatric Orthopedic Injuries: Diagnosis and Treatment)
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11 pages, 211 KB  
Article
Open Fractures on the Field: Two Decades of Pediatric Sports Injuries in a Level 1 Trauma Cohort
by Britta Chocholka, Lara Marie Bogensperger, Iryna Yegorova, Vanessa Groß, Manuela Jaindl, Bikash Parajuli, Sanika Rapole, Thomas Manfred Tiefenboeck and Stephan Payr
J. Clin. Med. 2025, 14(18), 6667; https://doi.org/10.3390/jcm14186667 - 22 Sep 2025
Viewed by 542
Abstract
Background: Open fractures in pediatric patients are uncommon but clinically relevant, often resulting from high-energy trauma or sports-related incidents. This study analyzes the demographic patterns, types of sports, injury mechanisms, treatment strategies, and outcomes in children and adolescents with sports-related open fractures. [...] Read more.
Background: Open fractures in pediatric patients are uncommon but clinically relevant, often resulting from high-energy trauma or sports-related incidents. This study analyzes the demographic patterns, types of sports, injury mechanisms, treatment strategies, and outcomes in children and adolescents with sports-related open fractures. Methods: In this retrospective study, 74 pediatric patients with sports-related open fractures treated at a level 1 trauma center between 2002 and 2023 were documented. Parameters such as age, sex, fracture location, sport type, treatment modality, complications, and outcomes were evaluated. Results: The cohort included 74 patients, with a mean age of 13 ± 3.6 years. Open fractures of the upper extremity were most common (seen in 34 patients). Moreover, 10 open craniofacial and 27 open nasal fractures represented 50.0% of injuries, mainly in male athletes involved in contact sports. Soccer was the leading injury-related sport (n = 14; 18.9%). Surgical treatment was required in 28 patients (37.8%), most frequently using elastic stable intramedullary nailing, Kirschner wire fixation in the upper extremities or nasal bone reduction. Antibiotics were administered in 46 patients (62.2%), with a mean documented duration of 2.7 ± 3.1 days. An excellent outcome was documented in 95%. Conclusions: Sports-related open fractures in children primarily affect male adolescents in contact sports and involve the upper extremities and facial region. Conservative management is effective in stable, non-displaced and low-grade injuries. Surgical treatment is frequently indicated in open forearm fractures. The implementation of a structured trauma care protocol, incorporating early debridement, definitive treatment, and antibiotics, has been demonstrated to yield a safe and effective treatment outcome with a favorable prognosis for sports-related open fractures in children. Full article
(This article belongs to the Special Issue Advancing Pediatric Sports Medicine: Insights and Innovations)
13 pages, 3483 KB  
Article
The “Double-Row Shoelace” Capsulodesis: A Novel Technique for the Repair and Reconstruction of the Scapholunate Ligament of the Wrist
by Adriano Cannella, Rocco De Vitis, Arturo Militerno, Giuseppe Taccardo, Vitale Cilli, Lorenzo Rocchi, Giulia Maria Sassara and Marco Passiatore
Surgeries 2025, 6(3), 57; https://doi.org/10.3390/surgeries6030057 - 16 Jul 2025
Viewed by 626
Abstract
Introduction: The scapholunate interosseus ligament (SLIL) is critical for wrist stability, with injuries causing carpal instability and potential scapholunate advanced collapse (SLAC). This technical note presents a novel ligament-sparing surgical technique for treating SLIL tears ranging from grade 2 to 4 of the [...] Read more.
Introduction: The scapholunate interosseus ligament (SLIL) is critical for wrist stability, with injuries causing carpal instability and potential scapholunate advanced collapse (SLAC). This technical note presents a novel ligament-sparing surgical technique for treating SLIL tears ranging from grade 2 to 4 of the Garcia-Elias classification. Materials and Methods: A retrospective study was performed on ten patients treated with this novel technique. The technique involves a dorsal approach to the wrist through a 5–7 cm incision ulnar to Lister’s tubercle. After exposing the scapholunate joint, reduction is performed using Kirschner wires (K-wires) as joysticks, followed by stabilisation with three K-wires through the scapholunate, scapho-capitate, and radio-lunate joints. Two 2.3 mm suture anchors with double sutures are placed where the reduction K-wires were removed. One pair of sutures connects the anchors and any remaining SLIL tissue, while the second pair create a shoelace-like capsulodesis. Post-operative care includes staged K-wire removal at one and two months, with progressive rehabilitation before returning to weight-bearing activities at six months. Results: All patients improved in pain and function. The technique addresses SLIL injuries by restoring both coronal alignment through ligament repair and sagittal alignment via dorsal capsulodesis. The use of suture anchors and direct repair preserves the native tissue while reinforcing the dorsal capsule–scapholunate septum complex, avoiding the need for tendon grafts or extensive bone tunnelling. Conclusions: This ligament-sparing technique offers several advantages, including absence of donor site morbidity, minimal damage to carpal cartilage and vascularity, and preservation of surgical options should revision be necessary. The procedure effectively addresses both components of scapholunate instability while maintaining a relatively straightforward surgical approach. Full article
(This article belongs to the Section Hand Surgery and Research)
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29 pages, 9634 KB  
Article
Finite Element Analysis and Simulation of 316L Stainless Steel and Titanium Alloy for Orthopedic Hip and Knee Prosthetics
by Omolayo M. Ikumapayi, Oluyemi O. Bankole, Abiodun Bayode, Peter Onu and Tin T. Ting
Prosthesis 2025, 7(3), 64; https://doi.org/10.3390/prosthesis7030064 - 11 Jun 2025
Cited by 1 | Viewed by 2416
Abstract
Background: Ferrous metals are used extensively in the manufacturing of plates, pins, Kirschner wires (K-wires), and screws, and in the performance of partial and total joint replacement surgeries for the shoulder, elbow, and wrist joints. The primary surgical procedures commonly performed are hip [...] Read more.
Background: Ferrous metals are used extensively in the manufacturing of plates, pins, Kirschner wires (K-wires), and screws, and in the performance of partial and total joint replacement surgeries for the shoulder, elbow, and wrist joints. The primary surgical procedures commonly performed are hip and knee replacement surgeries. Metals possess a combination of high modulus, yield point, and ductility, rendering them well suited for load-bearing applications, as they can withstand significant loads without experiencing substantial deformations or permanent alterations in their dimensions. Application of metals and alloys is of prime importance in orthopedics as they lead the way to overcoming many issues encountered in implant use. In some instances, pure metals are used, but alloys consisting of two or more elements typically exhibit greater material characteristics, including corrosion resistance as well as toughness. The first item to address when selecting a metallic implant material is its biocompatibility. In this regard, three classes of materials are also commonly known as biomedical metals—316L stainless steel, pure titanium, and titanium alloys. Objective: The aim of this work is to create a model describing the material behavior and then simulate the metals under a load of 2300 N, which is equivalent to plastic loading. Methods: Under ten different case studies, a sub-routine was developed to combine the material characteristics of titanium and 316L stainless steel with the software. Results: The outcomes of the research were then investigated. A femur model was created using ANSYS software, and two materials, stainless steel and titanium, were used. The model was then exposed to a force of 2300 N. Full article
(This article belongs to the Special Issue State of Art in Hip, Knee and Shoulder Replacement (Volume 2))
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13 pages, 1552 KB  
Article
Surgical Treatment of Distal Radius Fractures Using Minimally Invasive Plate Osteosynthesis or Open Reduction and Internal Fixation: A Five-Year Comparative Follow-Up Study
by Giuseppe Rovere, Pierfrancesco Pirri, Gianmarco Murgante, Vincenzo De Luna, Aurelio Testa, Giovanna Fidone, Francesco Liuzza, Pasquale Farsetti and Fernando De Maio
Appl. Sci. 2025, 15(11), 6235; https://doi.org/10.3390/app15116235 - 1 Jun 2025
Viewed by 2299
Abstract
Distal radius fractures (DRFs) constitute one of the most prevalent injuries in adults. This study compares the clinical and radiological outcomes of intra- and extra-articular DRFs treated with percutaneous Kirschner wires (PKW) or volar locking plates (VLP). Materials and Methods: A retrospective analysis [...] Read more.
Distal radius fractures (DRFs) constitute one of the most prevalent injuries in adults. This study compares the clinical and radiological outcomes of intra- and extra-articular DRFs treated with percutaneous Kirschner wires (PKW) or volar locking plates (VLP). Materials and Methods: A retrospective analysis was conducted on 42 patients (aged 18 to 85) treated between 2017 and 2019 with a minimum follow-up of five years. Outcomes were assessed using radiographic parameters and validated clinical scoring systems such as Disabilities of the Arm, Shoulder, and Hand (DASH), Patient-Rated Wrist Evaluation (PRWE), and Mayo Wrist Score (MAYO). Results: Clinical outcomes were better in the VLP group but not statistically significant (p > 0.05). For extra-articular fractures, DASH were 1.5 (VLP) vs. 6.4 (PKW) (p = 0.5007), PRWE were 1.3 (VLP) vs. 2.9 (PKW) (p = 0.4049), and MAYO were 95 (VLP) vs. 86.1 (PKW) (p = 0.2406). For intra-articular fractures, DASH were 6.6 (VLP) vs. 19.7 (PKW) (p = 0.0981), PRWE 12.9 (VLP) vs. 21.1 (PKW) (p = 0.3661), and MAYO 78.9 (VLP) vs. 72.2 (PKW) (p = 0.4503). Conclusions: PKW and VLP showed satisfactory long-term outcomes. VLP fixation allowed better short-term recovery and anatomical restoration, but long-term functional outcomes were comparable. Full article
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6 pages, 732 KB  
Article
In Silico Comparison of Two Kirschner Wire Arrangements for Stabilization of Femoral Capital Physeal Fractures
by Logan M. Scheuermann, Daniel D. Lewis and Richard B. Evans
Vet. Sci. 2025, 12(5), 422; https://doi.org/10.3390/vetsci12050422 - 29 Apr 2025
Viewed by 587
Abstract
Despite advancements in surgical techniques, including the utilization of intra-operative fluoroscopy and custom surgical guides, intra-articular implant placement during the pinning of capital physeal fractures can occur and may result in catastrophic complications. Our objective in this study was to compare the epiphyseal [...] Read more.
Despite advancements in surgical techniques, including the utilization of intra-operative fluoroscopy and custom surgical guides, intra-articular implant placement during the pinning of capital physeal fractures can occur and may result in catastrophic complications. Our objective in this study was to compare the epiphyseal purchase afforded by a linear and triangular pattern of Kirschner wires for stabilizing femoral capital physeal fractures. Archived pelvic limb computed tomography scans of 16 skeletally immature dogs were obtained, from which virtual femoral models were created. Separate linear and triangular arrangements of three virtual 1.6 mm Kirschner wires were centered on the thickest region of the proximal epiphysis. The length of each Kirschner wire implanted within the proximal femoral epiphysis was measured. Kirschner wire placement in triangular and linear patterns resulted in a mean epiphyseal purchase for each wire of 8.4 mm and 8.0 mm, respectively. The cumulative Kirschner wire purchase was greater with the triangular pattern (p = 0.004). The mean difference in the cumulative wire purchase was 1.3 mm. The use of a triangular Kirschner wire pattern resulted in greater implant purchase within the epiphysis compared to the linear pattern. The triangular Kirschner wire pattern may reduce the risk of intra-articular implant placement by more closely centering the wires within the thickest region of the epiphysis. Full article
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14 pages, 1598 KB  
Review
Modern Treatment of Supracondylar Humeral Fractures in Children
by Adrian Surd, Rodica Muresan, Carmen Iulia Ciongradi, Lucia Maria Sur, Lucia Raluca Ardelean, Lia Oxana Usatiuc, Kriszta Snakovszki, Camelia Munteanu and Ioan Sârbu
Children 2025, 12(5), 556; https://doi.org/10.3390/children12050556 - 25 Apr 2025
Cited by 2 | Viewed by 3491
Abstract
Supracondylar humeral fractures are the most common type of elbow fractures in children. The treatment methods vary depending on the type of fracture (Gartland classification), which can be conservative or surgical. There is no clear consensus or guidelines to dictate the treatment of [...] Read more.
Supracondylar humeral fractures are the most common type of elbow fractures in children. The treatment methods vary depending on the type of fracture (Gartland classification), which can be conservative or surgical. There is no clear consensus or guidelines to dictate the treatment of complicated supracondylar humeral fractures (Gartland types II and III). Gartland type II and III fractures are most frequently treated with closed reduction and percutaneous Kirchner-wire pinning or open reduction with K-wire pinning, depending on the degree of displacement and the orthopedic surgeon’s preference. Most studies recommend avoiding open reduction because of prolonged hospitalization and higher rates of complications. Orthopedic surgeons have different opinions regarding the Kirschner pin placement technique. Studies suggest that only lateral pinning is safe and effective, but medial and lateral pinning is proven to give more stability; there is always a risk of iatrogenic ulnar nerve damage during surgery. Modern treatment of supracondylar humeral fracture in children should focus on minimally invasive techniques and avoid open reduction, when possible, to ensure the best outcome for the patients. This scoping review’s purpose is to gather the available information on the topic in one place and to underline the lack of clear protocols. Full article
(This article belongs to the Special Issue Pediatric Orthopedic Injuries: Diagnosis and Treatment)
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20 pages, 786 KB  
Review
Applications and Effectiveness of 3D Printing in Various Ankle Surgeries: A Narrative Review
by Jeong-Jin Park, Jun Young Choi, Jung-Min Lee, Hyun-Gyu Seok and Chul Hyun Park
Life 2025, 15(3), 473; https://doi.org/10.3390/life15030473 - 15 Mar 2025
Cited by 1 | Viewed by 1516
Abstract
Background: Technological advancements have made three-dimensional printing prevalent in orthopedic surgery. It facilitates the production of customized implants and tailored patient instruments, enhancing surgical planning and results. This review focuses on the uses and effectiveness of patient-specific products manufactured using three-dimensional printing in [...] Read more.
Background: Technological advancements have made three-dimensional printing prevalent in orthopedic surgery. It facilitates the production of customized implants and tailored patient instruments, enhancing surgical planning and results. This review focuses on the uses and effectiveness of patient-specific products manufactured using three-dimensional printing in ankle surgery. Methods: A search of databases—PubMed, Embase, Cochrane Library, and Google Scholar—yielded 41 articles for review. Results: Total talus replacement offers a viable alternative to standard treatments like arthrodesis and total ankle arthroplasty. Custom implants and patient-specific instrumentation in total ankle arthroplasty procedures guarantee a tailored fit and accurate alignment. For arthrodesis, three-dimensional printing enables the production of cages, effectively solving issues associated with conventional bone grafts, such as poor bone quality, significant defects, and nonunion. Additionally, patient-specific instrumentation facilitates the swift and accurate placement of Kirschner wires at the correct sites. When performing supramalleolar osteotomy, patient-specific instrumentation leads to shorter operation times, reduced blood loss, and less radiation exposure. Conclusions: Three-dimensional printing is increasingly employed in ankle surgeries, and as technology advances, it is anticipated to become critical for addressing complex ankle issues. Full article
(This article belongs to the Section Medical Research)
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15 pages, 5071 KB  
Article
Comparative Biomechanical Analysis of Kirschner Wire Fixation in Dorsally Displaced Distal Radius Fractures
by Awad Dmour, Ștefan-Lucian Toma, Alin-Marian Cazac, Stefan Dragos Tirnovanu, Nicoleta Dima, Bianca-Ana Dmour, Dragos Cristian Popescu and Ovidiu Alexa
Life 2024, 14(12), 1684; https://doi.org/10.3390/life14121684 - 19 Dec 2024
Viewed by 2586
Abstract
Objective: This study aims to evaluate and compare the biomechanical performance of two Kirschner (K) wire configurations—the intra-focal and interfragmentary techniques—for the fixation of dorsally displaced distal radius fractures. The study also assesses the impact of K-wire diameter (1.6 mm vs. 2.0 mm) [...] Read more.
Objective: This study aims to evaluate and compare the biomechanical performance of two Kirschner (K) wire configurations—the intra-focal and interfragmentary techniques—for the fixation of dorsally displaced distal radius fractures. The study also assesses the impact of K-wire diameter (1.6 mm vs. 2.0 mm) on mechanical stability. Methods: Sixty fresh turkey tarsometatarsus bones were selected and divided into four groups based on the K-wire configuration and diameter used. Fractures were created at standardized locations, and each bone was stabilized using either the intra-focal also known as modified Kapandji (Ka) or interfragmentary technique. Mechanical testing, including axial compression and flexion tests, was performed to assess the biomechanical stability of each configuration. Results: The interfragmentary configuration consistently demonstrated superior biomechanical performance compared to the intra-focal technique. Specifically, the use of 2.0 mm K-wires resulted in significantly higher axial stiffness (13.28 MPa) and load at break (3070 N) compared to the 1.5 mm wires. Confidence intervals further supported the robustness of these findings. The interfragmentary technique, especially with thicker K-wires, provided greater load-bearing capacity and stiffness. Conclusion: The interfragmentary technique with 2.0 mm K-wires offers superior mechanical stability compared to the intra-focal technique, making it the preferred choice for stabilizing comminuted extra-articular distal radius fractures. These findings suggest that adopting this technique may reduce the risk of postoperative complications such as fracture displacement or malunion. Further research involving osteoporotic bone models and clinical trials is recommended to validate these findings in real-world settings. Full article
(This article belongs to the Section Medical Research)
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9 pages, 1143 KB  
Article
Treatment Outcome of 2nd to 5th Metacarpal Fractures: Kirschner Wires Versus Intramedullary Screws
by Melissa Walde, Dirk Johannes Schaefer and Alexandre Kaempfen
J. Clin. Med. 2024, 13(24), 7626; https://doi.org/10.3390/jcm13247626 - 14 Dec 2024
Cited by 2 | Viewed by 3672
Abstract
Background/Objectives: Most metacarpal fractures are isolated, simple, closed, and stable fractures and located distally. They are often caused by accidental falls, strikes by humans, by objects or traffic accidents. The majority can be treated conservatively. When unstable, angulated, malrotated or shortened, a [...] Read more.
Background/Objectives: Most metacarpal fractures are isolated, simple, closed, and stable fractures and located distally. They are often caused by accidental falls, strikes by humans, by objects or traffic accidents. The majority can be treated conservatively. When unstable, angulated, malrotated or shortened, a surgical fixation of these frequent fractures is needed. To treat simple, spiral, distal or shaft fractures, intramedullary Kirschner wiring (KW) or intramedullary compression screws (ISs) are used. We wanted to compare the outcomes of those two treatments. Methods: In a retrospective study we analyzed the prospectively collected data of our hospital on the indication factors and outcome factors of selected patients with simple or spiral, distal or shaft metacarpal fractures of the second to fifth finger. Indication factors were sex, age, profession, hand dominance, comorbidities, metacarpal finger number, total active range of motion (TAM), rotation, soft tissue damage, localization, articular involvement, fracture type, dislocation and axial shortening. Outcome factors were TAM, rotation, splint time, return to work, bone healing and complications. Results: Out of 750 patients, 59 fractures could be included in this study, containing 34 in the KW Group and 25 in the IS Group. Only fracture localization and fracture type were significantly different in the two groups, with more shaft and spiral fractures in the IS Group. The primary outcome of TAM and rotation as well as the secondary outcome of splint time, return to work, bone healing and complication rates showed no significant difference. Only a difference in mean follow-up time was seen. Conclusions: Intramedullary screw fixation seems a valid alternative to KW fixation for certain fracture types regarding active range of motion and rotation after treatment, splint time, bone healing and return to work time. Only the tendency of an earlier return to work and a higher rate of full TAM after treatment was seen in favor of intramedullary screws. Full article
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10 pages, 791 KB  
Article
Revisiting Antibiotic-Impregnated Cement Spacer for Diabetic Osteomyelitis of the Foot
by Farouk Khury, Ihab Karkabi, Elias Mazzawi, Doron Norman, Eyal A. Melamed and Eli Peled
Antibiotics 2024, 13(12), 1153; https://doi.org/10.3390/antibiotics13121153 - 1 Dec 2024
Cited by 2 | Viewed by 1531
Abstract
Introduction: Despite the rising global awareness and improvement of socioeconomic and living standards, the prevalence of diabetic osteomyelitis (DOM) and its complications has been increasing rapidly. This study aims to investigate the long-term prognosis of DOM of the foot treated using antibiotic-impregnated cement [...] Read more.
Introduction: Despite the rising global awareness and improvement of socioeconomic and living standards, the prevalence of diabetic osteomyelitis (DOM) and its complications has been increasing rapidly. This study aims to investigate the long-term prognosis of DOM of the foot treated using antibiotic-impregnated cement spacer (ACS) and the contributing risk factors for reoperation. Methods and Materials: We retrospectively reviewed the data of 55 diabetic patients with Meggitt-Wagner Grade IIB wounds diagnosed with osteomyelitis of the foot, treated in our institution with excessive debridement, excision of the infected tissue, and implantation of antibiotic-impregnated cement spacer fixed with a Kirschner wire. Descriptive statistics, including patient demographics, were analyzed. Statistical analysis was performed using point-biserial correlation and a Chi-square test with Cramer’s V effect-size estimation to determine the relationship between reoperation and various parameters. Results: 55 patients (36 (65.45%) males and 19 (34.55%) females) with a median age of 64 (39–84) years were thoroughly analyzed throughout a median follow-up of 884 days (2–4671 days). Of the entire cohort, 29 (52.72%) patients achieved primary successful infection eradication without any further intervention, and 8 (14.54%) patients were successfully treated using a secondary procedure. More than half of the reoperated patients underwent the secondary intervention within less than a month after the primary ACS. When assessing correlation, age (r = 0.28, p = 0.04), gender (r = 0.31, p = 0.02), Staphylococcus aureus (r = −0.10, p = 0.04), and the use of gentamicin-only antibiotic cement spacer (r = 0.34, p = 0.01) demonstrated statistically significant correlation to reoperation. 89.18% of the patients who achieved infection eradication did not undergo cement removal. Conclusions: ACS has shown excellent results in eradicating bone infection with up to 7.23 years of follow-up, acting as a structural stabilizer, preventing soft tissue contractures, and delivering highly concentrated local antibiotic treatment both to soft tissue and bone. Regardless, specific factors should be thoroughly evaluated prior to surgery, as advancing age, gender, and the use of gentamicin-only antibiotics appear to be positively associated with a higher likelihood of reoperation. Conversely, infections caused by cultured Staphylococcus aureus seem to be inversely related to reoperation. Full article
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14 pages, 2103 KB  
Review
Management of Acute Lateral Humeral Condyle Fractures in Children
by Mónica Álvarez Muñoz, Juan Carlos García de la Blanca, Myriam Vidart Anchía, Rafael Martí Ciruelos, Sara Calvo Calvo and María Teresa Menéndez Crespo
Children 2024, 11(12), 1421; https://doi.org/10.3390/children11121421 - 25 Nov 2024
Viewed by 3131
Abstract
Pediatric elbow fractures are quite common, accounting for up to 34% of bone fractures in children. Among these, acute lateral humeral condyle (LHC) fractures represent up to 22%. The accurate diagnosis and early treatment of LHC fractures are crucial due to the potential [...] Read more.
Pediatric elbow fractures are quite common, accounting for up to 34% of bone fractures in children. Among these, acute lateral humeral condyle (LHC) fractures represent up to 22%. The accurate diagnosis and early treatment of LHC fractures are crucial due to the potential for abnormal growth and significant long-term impacts on joint motion. With the aim of enhancing the understanding of pediatric LHC fracture management among pediatric healthcare practitioners, we present a literature review combined with our technical recommendations based on our experience. Imaging through AP, lateral, and internal oblique X-rays remains the gold standard for diagnosis, although there is increasing focus on non-irradiating techniques, considering the skeletally immature nature of the patients. Several classification systems aid in fracture assessment, each varying in their simplicity, reproducibility, and inter- and intra-observer correlations. The treatment approaches for LHC fractures include conservative management with immobilization for minimally displaced fractures and surgical intervention for displaced fractures. The surgical options encompass closed and open reductions, using Kirschner wires or cannulated screws for fixation. While both methods show favorable outcomes, recent years have seen a growing interest in expanding the traditional indications for closed approaches. After a period of post-surgical immobilization of the limb, rehabilitation care is recommended to assist in the recovery of the range of motion. During the postoperative period, the most frequent complications are bony overgrowth, malunion, and infection, although with highly variable rates, which typically do not result in functional impairment if managed properly. Regular follow-up and monitoring are essential for optimal recovery and minimizing long-term complications. Full article
(This article belongs to the Special Issue Pediatric Trauma and Rehabilitation)
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13 pages, 1160 KB  
Article
Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model
by Jason Young, Mohammad Javad Shariyate, Prateek Misra, Shubham Laiwala, Ara Nazarian and Edward Kenneth Rodriguez
Viruses 2024, 16(11), 1800; https://doi.org/10.3390/v16111800 - 20 Nov 2024
Cited by 2 | Viewed by 1603
Abstract
Prosthetic joint infections (PJIs) are a serious complication of orthopedic surgery. Bacteriophage (phage) therapy shows promise as an adjunctive treatment but requires further study, particularly in its pharmacokinetics. Consequently, we performed a pharmacokinetic assessment of phage therapy for PJIs using a Staphylococcus epidermidis [...] Read more.
Prosthetic joint infections (PJIs) are a serious complication of orthopedic surgery. Bacteriophage (phage) therapy shows promise as an adjunctive treatment but requires further study, particularly in its pharmacokinetics. Consequently, we performed a pharmacokinetic assessment of phage therapy for PJIs using a Staphylococcus epidermidis Kirschner wire-based prosthesis rat model. We used 52 male Sprague–Dawley rats in four groups: negative controls (no phage, sterile implant), PJI controls (bacteria, no phage), sterile phage (phages given, sterile implant), and PJI (bacteria, phages given). The PJI groups were inoculated with ~106 CFU of S. epidermidis. The groups receiving phage were intra-articularly injected with ~108 PFU of vB_SepM_Alex five days post-implantation. The rats were euthanized between 30 min and 48 h post-injection. The measured phage concentrations between the PJI rats and the sterile controls in periarticular tissues were not significantly different. In a noncompartmental pharmacokinetic analysis, the estimated phage half-lives were under 6 h (combined: 3.73 [IQR, 1.45, 10.07]). The maximum phage concentrations were reached within 2 h after administration (combined: 0.75 [0.50, 1.75]). The estimated phage mean residence time was approximately three hours (combined: 3.04 [1.44, 4.19]). Our study provides a preliminary set of pharmacokinetic parameters that can inform future phage dosing studies and animal models of phage therapy for PJIs. Full article
(This article belongs to the Special Issue Phage-Bacteria Interplay in Health and Disease, Second Edition)
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13 pages, 2363 KB  
Article
Surgical Treatment of Periarticular Distal Radius Fracture in Elderly: A Systematic Review
by Gianluca Testa, Flora Maria Chiara Panvini, Marco Simone Vaccalluzzo, Andrea Giovanni Cristaudo, Marco Sapienza and Vito Pavone
Medicina 2024, 60(10), 1671; https://doi.org/10.3390/medicina60101671 - 11 Oct 2024
Cited by 2 | Viewed by 4340
Abstract
Background/Objectives: The treatment of periarticular distal radius fractures remains challenging. Different surgical treatment options have been proposed as alternatives to conservative treatment. This systematic review aims to compare the functional outcomes, radiological outcomes, and complications among volar locking plates (VLPs), Kirschner-wire fixations, [...] Read more.
Background/Objectives: The treatment of periarticular distal radius fractures remains challenging. Different surgical treatment options have been proposed as alternatives to conservative treatment. This systematic review aims to compare the functional outcomes, radiological outcomes, and complications among volar locking plates (VLPs), Kirschner-wire fixations, and external fixations (EFs) for distal radius fractures in patients aged 60 years and older. Methods: We conducted a comprehensive search of PubMed, Cochrane, and Science Direct databases assessing the effects of VLP, EF, and K-wire treatments for distal radius fractures in patients aged 60 years and over. The primary outcome was the evaluation of the range of motion (ROM) degrees after three surgical procedures, trying to assess the best treatment option. The secondary outcome included evaluation of the Disabilities of the Arm, Shoulder, and Hand (DASH) score, quick-DASH score, Patient-Rated Wrist Evaluation (PRWE) score, Visual Analog Scale (VAS) score, grip strength, radiographic assessment, and complications comparing VLPs, EFs and K-wires. Results: A total of 23 studies were included, comparing VLP, EF, and K-wire fixation. The overall population comprised 5618 patients, with 4690 females and 1015 males, of which 4468 patients were treated with VLP, 503 with EF, and 647 with K-wire. The most common complications among the VLP group were complex regional pain syndrome (7.5%) and carpal tunnel syndrome (6.8%); for the EF group, infections (9.8%) and carpal tunnel syndrome (6.8%); and for the K-wire group, carpal tunnel syndrome (7.5%) and infections (6.9%). Conclusions: VLP showed better clinical outcomes in the first few months after treatment. However, these differences decreased over time and became similar after one year. EF and K-wire fixations remain easier to manage during surgery. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Distal Radial Fractures—2nd Edition)
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