Search Results (122)

The film Black Panther (2018) has been the subject of extensive discussion, particularly within the context of representational politics in contemporary Hollywood cinema. This critical scoping review maps how academic literature interprets the film‘s treatment of colonial, racial, cultural, gender, and disability-related stereotypes and examines how these interpretations are shaped by epistemic context. A systematic search and screening process yielded 52 publications from 2018 to 2024 that were analyzed with qualitative content analysis and descriptive mapping. The review indicates that scholarly response to the film is defined by structured ambivalence. While scholarship predominantly frames Black Panther as challenging colonial and racial stereotypes, it also points to inconsistent representations and reinforced stereotyping, particularly with regard to cultural homogenization, exceptionalism, and patriarchal governance. Interpretive stances vary systematically across epistemic positions. Scholarship based in Africa emphasizes counter-stereotypical readings, whereas scholarship from the United States, accounting for half of the reviewed contributions, displays greater interpretive diversity, including more critical and ambivalent positions. These findings suggest that Black Panther does not function as a counter-stereotypical text. Rather, it is a site where representational politics in global blockbuster cinema, industry constraints, and epistemic authority intersect, extending the soft-power dynamics of the Marvel Cinematic Universe into academic knowledge production. Full article

The present qualitative study explored perspectives from youth, caregivers, and community partners who lived in or worked with organizations that served two low-income, urban communities exposed to disproportionate rates of firearm violence. The purpose of the study was to (a) identify changes that community members and community partners would like to see in terms of safety, (b) compare the similarities and differences in responses across the three participant groups. Youth (n = 11), caregivers (n = 20), and community partners (n = 41) participated in semi-structured interviews as part of a larger study evaluating community strategies to reduce community-levels of youth violence. Perspectives on changes related to safety were represented across four themes: (1) Changes to policing, (2) Increasing safety, (3) More opportunities for youth and family programs and activities, (4) Structural and resource investments in communities. Overall, qualitative findings offered a context-specific picture of desired areas for change to improve community safety. The results contribute to a framework for community mobilization and have implications for the development of comprehensive community violence prevention initiatives. Full article

Background/Objectives: Pancreatic ductal adenocarcinoma is an aggressive malignancy with poor long-term survival. While surgical resection followed by adjuvant chemotherapy remains the standard of care for resectable disease, a substantial proportion of patients fail to receive postoperative therapy. Neoadjuvant treatment has emerged as an alternative strategy aimed at improving delivery of systemic therapy, increasing margin-negative resections, and better assessing tumor biology. This review summarizes major clinical trials evaluating neoadjuvant approaches in resectable and borderline resectable pancreatic cancer. Methods: A narrative review of published randomized and phase II–III clinical trials was performed, focusing on studies comparing neoadjuvant therapy with upfront surgery, trials comparing different neoadjuvant chemotherapy regimens, and studies evaluating the addition of neoadjuvant radiation therapy. Ongoing phase III trials were also reviewed. Results: Multiple trials demonstrated improved rates of chemotherapy delivery and higher R0 resection rates with neoadjuvant therapy. Some studies showed survival benefits (mOS ranging from 15.7 to 37 months), particularly in borderline resectable disease. While others failed to demonstrate an overall survival advantage compared with upfront surgery, especially in resectable disease. Trials comparing different neoadjuvant regimens and those evaluating the addition of radiation have yielded largely comparable outcomes, highlighting variability in treatment response and study design. Conclusions: Current evidence supports the feasibility and safety of neoadjuvant therapy in localized pancreatic cancer; however, survival benefits remain inconsistent, especially in resectable disease. Results underscore the need for well-powered randomized trials especially in Western populations, improved patient selection, and biologic stratification to better define the optimal role of neoadjuvant therapy. Full article

This article sets out an assertion that a mass art project can make a virtue of ‘network extension’ through an Instagram account, to build creative community, new connections, and physical artwork outcomes. We Are Making A Film About Mark Fisher is an example of a ‘manifested artwork’, where Fisher’s ideas on capitalism and community are explored through electronic media. We have taken the work of critical theorist, Mark Fisher, and subjected it to a process of détournement, alluding to the work of Guy de Bord and The Situationists. The thing in itself—Fisher’s processed ideas—are reprocessed and held up against the posthumous period between 2017 and now, since he died. The assertion in the work is that while the tools are circumscribed by a set of ‘standards’ and ‘production processes’, this does not delimit them from being employed towards the evolution of embodied and shared actions that develop a counter-narrative or something that eschews the methods of Hollywood or broadcast television documentaries. We just have to learn ways to do this. ‘Decapitalising’ a process, working with human agency and good will, turns the platform of Instagram into a tool of empowerment—reappropriating the algorithm and capturing the collective back from the closed corporate system of control. We see that a form of value is pulled back out of the machinic effects of a proprietary platform. Full article

Background/Objectives: Pain is a common symptom for hospitalised older adults. Pain is not always adequately assessed, which can lead to inadequate pain management and adverse patient outcomes. Thus, new technology-driven pain assessment tools have been developed; however, little is known about patients’ and families’ experiences of nurses using them in acute care. This study aimed to explore the perspectives of older adult inpatients and their families’ regarding nurses’ use of the digital technology-driven pain assessment application PainChek^® Universal. Methods: A survey was undertaken as part of a stakeholder evaluation of a randomised control trial exploring the effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults. The PainChek^® Universal application was implemented on two medical wards of an acute private hospital in Western Australia as part of a larger single-centre, prospective, non-blinded, cluster-randomised control trial. This stakeholder evaluation invited older adult inpatients and their family members to participate in a survey about nurses’ use of the PainChek^® Universal application for pain assessment. Results: A total of 96 inpatients and 27 family members completed the survey. Thirteen patients and nine family members provided additional feedback. Over 90% of patients and family members agreed that the use of the PainChek^® Universal application was a positive addition to pain assessments, rendered no concerns, and helped nurses complete pain assessments. A total of 84% of patients and 87% of family members felt PainChek^® Universal provided a more accurate pain assessment. Survey feedback related to PainChek^® Universal application use, integration of technology, and need for further education. Conclusions: The findings suggest that older adults and their families recognised the benefits of nurses using a digital application for pain assessments. Technology integration in healthcare must be accompanied by patient and family education. Full article

Self-efficacy beliefs and mindset influence student success, impacting how a learner experiences and responds to learning situations and setbacks. Accordingly, mindset interventions, are successful at increasing student performance with particular efficacy with historically underserved students such as those attending HBCUs. This paper studies a classroom-based mindset intervention that was implemented with the goal of increasing learning and achievement through improving the students’ cognitive disposition. The intervention, implemented at a mid-Atlantic minority serving institution of higher education, involved the creation of a custom-designed three-tool self-assessment developed to engender students’ critical reflection. The scales in question measured self-efficacy, growth mindset, and mastery goal orientation. This paper presents the results of reliability testing via Cronbach’s alpha and inter-item covariance. According to the findings, all three tools showed strong (good to excellent) reliability with acceptable positive covariance indicating that they are capable of serving as appropriate instruments for further adoption, usage, and analysis. It is the goal that this paper contributes to the body of literature on mindset interventions encouraging more individuals working with traditionally underserved learners to consider exploring efforts to increase students’ positive mindsets. Full article

Research Subject: Primary and secondary immunodeficiencies represent a growing clinical and public health challenge due to increased susceptibility to infections, impaired immune regulation, chronic inflammation, and disturbances in redox homeostasis. The pathophysiology of these disorders involves dysfunction of innate and adaptive immunity, altered cytokine production, oxidative stress, and reduced activity of antioxidant defense mechanisms. In recent years, attention has increasingly focused on the role of oxidative imbalance and chronic inflammation in weakening immune function. Ozone therapy, when used at controlled low doses, induces a hormetic response that triggers adaptive antioxidant pathways, modulates cytokine profiles, and enhances the activity of immune cells. Due to these properties, ozone has emerged as a potential adjunctive therapy aimed at restoring immune homeostasis and improving clinical outcomes in patients with immune disorders. Aim of Study: The aim of this review is to discuss the role of oxidative stress and immune dysregulation in the pathogenesis of immunodeficiencies and to provide an updated overview of current evidence regarding the therapeutic potential of ozone therapy. This article summarizes molecular mechanisms, biochemical effects, and clinical findings related to ozone-based interventions, with particular emphasis on cytokine modulation, redox balance, macrophage function, regulatory T cells (Treg), and NK cell activity. Materials and Methods: This review is based on scientific data retrieved from PubMed, Scopus, and Google Scholar. Included sources comprise randomized clinical trials, observational studies, meta-analyses, mechanistic studies, and review articles published between 1996 and 2025. Keywords used during the literature search included: “ozone therapy”, “immunomodulation”, “oxidative stress”, “inborn errors of immunity”, “secondary immunodeficiency”, “Treg cells”, “redox homeostasis”. Results: Analysis of current studies shows that controlled low-dose ozone (typically 10–40 µg/mL) activates the Nrf2/ARE antioxidant pathway, increases enzymatic defense (SOD, catalase, GPx), and reduces levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. Clinical trials report improved lymphocyte profiles, enhanced macrophage phagocytic function, increased Treg activity, and reinforced NK cell responses. Patients receiving ozone therapy demonstrate reductions in inflammatory markers (CRP, IL-6, D-dimer), improved redox balance, decreased infection frequency, and better overall immune performance. The therapy is generally well tolerated when administered within established safety guidelines. Conclusions: Available evidence indicates that ozone therapy may serve as a valuable adjunct in the management of immunodeficiencies by modulating immune responses, reducing oxidative stress, and restoring homeostatic balance. Although current clinical outcomes are promising, further multicenter randomized trials are needed to standardize dosing protocols, assess long-term effectiveness, and confirm safety. Full article

Background/Objectives: Proinsulin, the precursor to insulin, has limited activity on the insulin receptor. Proinsulin levels increase with increasing insulin resistance in type 2 diabetes due to incomplete processing by the β-cell. To assess whether the development of peptides that could convert circulating proinsulin to insulin in the blood would provide therapeutic value, we used a quantitative systems pharmacology (QSP) model of glucose homeostasis. In silico hypothesis testing such as this is an example of how modeling can inform decisions in drug discovery. Methods: In silico hypothesis testing involved (1) the addition and qualification of proinsulin biology into a preexisting QSP model, (2) the creation and validation of virtual patients (VPs) for subpopulations of type 2 diabetics based on phenotypic traits, and (3) the simulation of clinical trials evaluating the therapeutic value of the conversion of circulating proinsulin to insulin in the VPs created. Results: Proinsulin conversion led to a ~0.2% reduction in HbA1c in VPs at varying stages of diabetes, a decrease that does not hold meaningful therapeutic value. The lack of significant impact on HbA1c was likely a result of the surprisingly small effect on plasma insulin levels from proinsulin, which has a significantly slower secretion and clearance rate. Although patients with higher proinsulin/insulin ratios showed the largest reductions, clinically significant ≥ 0.5% reduction in HbA1c required ratios of proinsulin/insulin above the reported physiological range. Conclusions: This effort demonstrates how in silico hypothesis testing using QSP modeling can provide insights on the probability of success of novel interventions with minimal time and resources. These efficiencies are a means of overcoming the pressures on the pharmaceutical industry to do more with less in providing therapies that improve the lives of patients. Full article

This article brackets the sociology of music and urban arts by exploring how independent musicians derive creative meaning and connections within the musically diverse place of West Hollywood, CA (WeHo), and describes the existing municipal conditions that enable professional musicians to experience their career trajectories as authentic to their selves. Findings from in-depth interviews and ethnographic observations with 23 local, professional musicians emphasize (i) the artists’ authentic expression through innate musicality and live performances; (ii) feelings of acceptance and validation from connections to culturally hybrid audiences; and (iii) appreciation for the city’s diverse musical stages with storied histories. In further analyses, original insights are generated into how musicians continue influencing WeHo’s cosmopolitanism through their cultural omnivore attitudes and postmaterialist lifestyles. I conclude that the interconnectedness between these independent musicians and the structure of West Hollywood coevolves moral capital, contributing to a more legitimate and musically equitable urban space for artists to be recognized. Full article

Invasive fish species are a major driver of freshwater native fish biodiversity loss and their spread and impacts on the native fish are expected to increase within the current freshwater salinization and global warming crisis. In the current study, the upper thermal and salinity tolerance of the geographically range-restricted, threatened killifish Valencia robertae and its alien competitor, the globally invasive Eastern mosquitofish Gambusia holbrooki are compared in an experimental setting. Fish were exposed, after acclimation, to a continuous, dynamic temperature or salinity increase until predefined sub-lethal end points (loss of equilibrium and/or loss of buoyancy). The critical thermal and salinity maxima (CTMax and CSMax) were then calculated as the arithmetic mean of the combined thermal or salinity points at which the endpoint was attained. Finally, thermal and salinity safety margins for the two species were also calculated using abiotic data. Mosquitofish (females and males pooled) showed an average CΤmax of 35.85 °C and the killifish 36.27 °C (sexes pooled). Mosquitofish (male) showed an average CSmax of 40.25‰ and (male) killifish 42.64‰ (sexes also pooled). Killifish safety margins are much higher than those of the mosquitofish. Future impacts of global warming and salinisation on these species and on their interactions under current climate change scenarios are discussed. Full article

Cystic fibrosis (CF) is an autosomal recessive genetic condition affecting nearly 1 in 4000 newborns. Early diagnosis and treatment have been shown to improve the care of individuals with CF, which is enhanced through newborn screening (NBS). The state of Florida has been performing CF NBS since 2007, and in 2022, Florida implemented enhanced next generation sequencing (NGS). The goal of this change was to identify individuals from under-represented racial and ethnic groups, who may have rare or de novo variants. NBS screening for CF involved a first tier with immunoreactive trypsinogen (IRT) ≥ 50 or the top 4% of daily specimens, whichever is lower, reflexing to a second tier. As of 2022, the second tier has evolved to an expanded sequence with an Agena 74-variant panel. Single variants would then reflex to the third tier utilizing NGS. NGS is able to confirm what is detected in second-tier testing, adding variants not included in the Agena panel, and refining the TG replications for Poly-T variants to determine pathogenicity of 5T results. When there is a variant of varying clinical consequence between the two databases, the most conservative classification is selected. Individuals with variants would then be referred to one of the contracted CF NBS referral centers for confirmatory sweat chloride testing (sweat). With implementation of NGS, referrals nearly tripled in 2022–2024, with 538 referrals in 2019; 485 in 2020; and 805 in 2021; followed by 1223 referrals made in 2022; 1146 in 2023; and 1294 in 2024. In 2022–2024, 71% of referrals to the contracted NBS CF referral centers were for single variant results, and no cases of CF were identified from these referrals. The number of CF cases remained about the same, ranging from 23 to 40 through the years 2019–2024. The number of CRMS/CFSPID cases, however, tripled going from 10 to 12 in 2019–2022 to over 100 in 2024. The reason for this change seems to be related to complex heterozygous genetic variants as opposed to abnormal sweat. Implementation of NGS for CF in Florida led to a significant increase in the identification of CFTR variants which affected all aspects of the NBS CF process, from an increased workload on the NBS laboratory and follow-up staff, to an increase in referrals to the NBS CF referral centers. The majority of referrals were for single-variant results, which meant the infants had a very low likelihood of having CF. It is recommended that when an algorithm involving NGS is utilized, one should verify that there are appropriate processes for sweat, including the manner in which single-variant CF results are handled, avoiding unnecessary healthcare utilization. Full article

Diversity, equity, and inclusion, most commonly known as DEI, serves as a framework for practices that promote the fair treatment and full participation of all members of a community. Culturally responsive teaching and critical pedagogy are commonly associated with DEI as part of the larger strategy to validate and inspire learners while improving their self-efficacy and ability to challenge oppressive systems. While DEI is becoming increasingly better known in higher education, Historically Black Colleges or Universities (HBCUs) are heralded in the literature as a model for this work. Nevertheless, there is relatively limited empirical research exploring facets of DEI and culturally responsive teaching on HBCU and other minority-serving institutions’ campuses. This paper examines the campus of an HBCU located in the Mid-Atlantic United States, with an institutional commitment to diversity, equity, and inclusion, via a comprehensive DEI climate study that included separate surveys of students and faculty/staff. More specifically, the study explored whether all community members consider the campus inclusive, whether all community members experience a culture of belonging, whether adequate resources and supports exist for all campus members to succeed, whether faculty exhibit culturally responsive teaching practices, and whether the perceptions of faculty and staff differ from those of students. The purpose of the study was to help address the gap in the DEI literature exploring the practices of minority-serving institutions. According to the results, participants found the University to be an inclusive place, expressing strong satisfaction with the campus climate and experience. Further, when the presence of culturally responsive teaching practices was explored, strong evidence was indicated. Possible areas for improvement include greater supports and resources for LGBTQIA+, Indigenous, and disabled community members. Full article

Background and Clinical Significance: Left ventricular hypoplasia is often repaired surgically in sequence to a Fontan circulation, which is a physiologic state that presents unique challenges during pregnancy. Although women with Fontan physiology can achieve successful pregnancy outcomes, they remain at elevated risk for cardiac, thrombotic, and obstetric complications. Case Presentation: We describe a 38-year-old woman with Fontan physiology and acquired von Willebrand syndrome (AVWS) who was admitted at 23 weeks gestation for preterm premature rupture of membranes. The patient had history of prior classical cesarean delivery and two previous miscarriages. Her pregnancy was further complicated by abnormal placental vasculature and uterine arteriovenous malformation. Given her bleeding diathesis, hematology advised against anticoagulation or antiplatelet therapy, and she ultimately underwent a successful low transverse cesarean delivery under general anesthesia at 24 weeks. Postpartum hemorrhage was managed with clotting factor replacement and supportive care. Conclusions: This case illustrates how AVWS may mitigate thrombotic risk in Fontan physiology and how early activation of a cardio-obstetrics team can enable tailored planning. As more patients with complex congenital heart disease reach reproductive age, multidisciplinary coordination, shared infrastructure, and individualized birth plans will be essential to achieving optimal maternal–fetal outcomes. Full article