Search Results (609)

Objective: Visceral leishmaniasis (VL), a Neglected Tropical Disease caused by Leishmania donovani, remains insufficiently addressed by current therapies due to high toxicity, poor efficacy, and immunosuppressive complications. This study aimed to identify and characterize repurposed drugs that simultaneously target parasite-encoded and host-associated mechanisms essential for VL pathogenesis. Methods: Two complementary in silico drug repurposing strategies were employed. The first method utilized electron–ion interaction potential (EIIP) screening followed by molecular docking and molecular dynamics (MD) simulations targeting two L. donovani proteins: Rab5a and pteridine reductase 1 (PTR1). The second approach employed network-based drug repurposing using the Drugst.One platform, prioritizing candidates via STAT3-associated gene networks. Predicted drug–target complexes were validated by 100 ns MD simulations, and pharmacokinetic parameters were assessed via ADMET profiling using QikProp v7.0 and SwissADME web server. Results: Entecavir and valganciclovir showed strong binding to Rab5a and PTR1, respectively, with Glide Scores of −9.36 and −9.10 kcal/mol, and corresponding MM-GBSA ΔG_bind values of −14.00 and −13.25 kcal/mol, confirming their stable interactions and repurposing potential. Network-based analysis identified nifuroxazide as the top candidate targeting the host JAK2/TYK2–STAT3 axis, with high stability confirmed in MD simulations. Nifuroxazide also displayed the most favorable ADMET profile, including oral bioavailability, membrane permeability, and absence of PAINS alerts. Conclusions: This study highlights the potential of guanine analogs such as entecavir and valganciclovir, and the nitrofuran derivative nifuroxazide, as promising multi-target drug repurposing candidates for VL. Their mechanisms support a dual strategy targeting both parasite biology and host immunoregulation, warranting further preclinical investigation. Full article

To meet the requirements of the high spatiotemporal three-dimensional (3D) airflow field within the glide path corridor during carrier-based aircraft/unmanned aerial vehicles (UAVs) landings, this paper proposes a prediction method for high spatiotemporal resolution 3D ship airwake along the glide path by integrating computational fluid dynamics (CFD), backpropagation (BP) neural network, and Doppler wind lidar (DWL). Firstly, taking the conceptual design aircraft carrier model as the research object, CFD numerical simulations of the ship airwake within the glide path region are carried out using the Poly-Hexcore grid and the detached eddy simulation (DES)/the Reynolds-averaged Navier–Stokes (RANS) turbulence models. Then, using the high spatial resolution ship airwake along the glide path obtained from steady RANS computations under different inflow conditions as a sample dataset, the BP neural network prediction models were trained and optimized. Along the ideal glide path within 200 m behind the stern, the correlation coefficients between the predicted results of the BP neural network and the headwind, crosswind, and vertical wind of the testing samples exceeded 0.95, 0.91, and 0.82, respectively. Finally, using the inflow speed and direction with high temporal resolution from the bow direction obtained by the shipborne DWL as input, the BP prediction models can achieve accurate prediction of the 3D ship airwake along the glide path with high spatiotemporal resolution (3 m, 3 Hz). Full article

Spontaneous quadriceps tendon rupture is a very rare occurrence, notably for bilateral simultaneous ruptures. Its occurrence is commonly linked to an underlying condition that may weaken the tendons leading to rupture. We report the case of a 68-year-old Caucasian male afflicted with long-term gout who presented a bilateral simultaneous quadriceps tendon rupture (BSQTR). We showcase the clinical presentation, the surgical intervention, rehabilitation program, dynamic sonographic monitoring, and home-based rehabilitation techniques of this injury, which aimed to improve activities of daily living (ADL) and quality of life (QoL). The patient was included in a 9-week post-surgical rehabilitation program and a home-based rehabilitation program with subsequent pain management and gait reacquisition. The outcome measures included right and left knee active range of motion (AROM), pain intensity measured on Visual Analogue Scale (VAS), functioning measured through ADL score, and gait assessment on Functional Ambulation Categories (FAC). All endpoints were measured at different time points, scoring significant improvement at discharge compared to baseline (e.g., AROM increased from 0 degrees to 95 degrees, while VAS decreased from 7 to 1, ADL score increased from 6 to 10, and FAC increased from 1 to 5). Moreover, some of these outcomes continued to improve after discharge, and the effects of home-based rehabilitation program and a single hip joint manipulation were assessed at 6-month follow-up. Musculoskeletal ultrasound findings showed mature tendon structure, consistent dynamic glide, and no scarring. Full article

Background: Left atrial appendage occlusion (LAAO) is a valuable alternative to long-term anticoagulation in patients with atrial fibrillation (AF) and a high bleeding risk. However, effective vascular closure following large-bore venous access remains a clinical challenge, particularly in patients with multiple comorbidities. This study compares two venous closure techniques—Z-sutures and the suture-mediated ProGlide™ device—regarding their safety and efficacy in patients undergoing LAAO. Methods: We conducted a single-center observational study including 163 patients treated with LAAO between 2021 and 2024. Closure was achieved via a Z-suture (n = 126) or the ProGlide™ (n = 37) based on operator preference. The primary endpoint was clinically relevant bleeding (BARC ≥ 2). The secondary endpoints included 30-day mortality and hospital stay duration. Results: The Z-suture group included older and more comorbid patients. Despite these differences, the bleeding rates were comparable between groups. Clinically relevant bleeding was infrequent (Z-suture: 12.6%; ProGlide™: 13.5%). No 30-day deaths occurred in either group, and their hospital stay durations were similar. Conclusions: Both the Z-suture and ProGlide™ techniques demonstrated comparable safety and efficacy. Due to their simplicity and potential cost advantage, Z-sutures may be a practical alternative in routine care for high-risk patients. Full article

The development of alternative energy is crucial to realizing the goals of the Paris Agreement. Hydrogen is a key energy carrier, and ammonia is considered its practical storage medium due to its high H₂ content and efficient storage and transportation. However, efficient NH₃ decomposition methods are needed to recover stored hydrogen. Plasma-assisted decomposition offers a potential solution, but high energy consumption, mainly due to inefficient power supply systems, remains a challenge. This study examines the impact of varying the driving frequency of a gliding discharge plasma system on ammonia decomposition, comparing low-frequency 50 Hz and high-frequency 20 kHz power supplies. Results show that high-frequency plasma enhances electron density and energy distribution, increasing the amount of vibrationally excited nitrogen molecules. This improves catalyst activation, leading to higher ammonia conversion and hydrogen production. Compared to the thyristor-powered system, the high-frequency system increased ammonia decomposition productivity by 30% and reduced energy consumption by 36% using a coprecipitated catalyst. These findings emphasize the importance of a plasma generator optimizing plasma-assisted ammonia decomposition and improving efficiency in hydrogen production. Full article

The dry conversion of CO₂ into CO and O₂ provides an attractive path for CO₂ utilization which allows for the use of the CO produced for the synthesis of valuable hydrocarbons. In the following work, the CO₂ conversion is driven by an arc discharge at atmospheric pressure, producing hot plasma. This study presents a series of experiments aiming to optimize the process. The results obtained include the energy efficiency and the conversion rate of the process, as well as the electrical parameters of the discharge (current and voltage signals). In addition, optical emission spectroscopy diagnostics based on an analysis of C₂’s Swan bands are used to determine the gas temperature in the discharge. The data is analyzed according to several aspects—an analysis of the arc’s motion based on the electrical signals; an analysis of the effect of the gas flow and the discharge current on the discharge performance for CO₂ conversion; and an analysis of the vibrational and rotational temperatures of the arc channel. The results show significant improvements over previous studies. Relatively high gas conversion and energy efficiency are achieved due to the arc acceleration caused by the Lorentz force. The rotational (gas) temperatures are in the order of 5500–6000 K. Full article

Rhizopus stolonifer causes soft rot disease in strawberry and is considered one of the most destructive pathogens affecting strawberries worldwide. This study investigated the efficacy of three atmospheric non-thermal plasmas (NTPs) consisting of gliding arc (GA), Tesla coil (TC) and dielectric barrier discharge (DBD) for controlling R. stolonifer infection. Fungal mycelial discs were exposed to these plasmas for 10, 15 or 20 min, whereas conidial suspensions were treated for 1, 3, 5 or 7 min. Morphological alterations following non-thermal plasma exposure were studied using scanning electron microscopy (SEM). Exposure to GA and DBD plasmas for 20 min completely inhibited mycelial growth. SEM analysis revealed significant structural damage to the mycelium, sporangia and sporangiospores of treated samples compared to untreated controls. Complete inhibition of sporangiospore germination was achieved with treatments for at least 3 min for all NTPs. Pathogenicity assays on strawberry fruit showed that 15 min exposure to any of the tested NTPs completely prevented the development of soft rot disease. Importantly, NTP treatments did not adversely affect the external or internal characteristics of treated strawberries. These findings suggest that atmospheric non-thermal plasmas offer an effective approach for controlling R. stolonifer infection in strawberries, potentially providing a non-chemical alternative for post-harvest disease management. Full article

Pulse and Glide (PnG), as a fuel-saving technique, has primarily been applied to manual transmission vehicles. So, its effectiveness when integrated with a novel vehicle type like connected and automated vehicles (CAVs) remains largely unexplored. On the other hand, CAVs have evidently received less attention regarding energy conservation, and their prominent perception capabilities clearly exhibit individual variations. In light of this, this study investigates the impacts of PnG combined with CAVs on energy conservation and safety within the emerging mixed traffic flow composed of CAVs with varying sensing accuracies. The results indicate the following: (i) compared to the traditional driving modes, the PnG can achieve a maximum fuel-saving rate of 39.53% at Fuel Consumption with Idle (FCI), reducing conflicts by approximately 30% on average; (ii) CAVs, equipped with sensors boasting a greater detection range, markedly enhance safety during vehicle operation and contribute to a more uniform distribution of individual fuel consumption; (iii) PnG modes with moderate acceleration, such as 1–2 m/s², can achieve excellent fuel consumption while ensuring safety and may even slightly enhance the operational efficiency of the intersection. The findings could provide a theoretical reference for the transition of transportation systems toward sustainability. Full article

Background/Objectives: Intramedullary headless compression screw (IMHCS) fixation has emerged as a minimally invasive and biomechanically robust method for treating metacarpal and proximal phalangeal fractures. While the clinical outcomes are generally favorable, the impact of anatomical fracture reduction on postoperative function has not been systematically examined. Methods: We retrospectively analyzed 69 patients (41 metacarpal, 28 proximal phalanx) treated with IMHCSs between June 2020 and March 2025. Fractures were classified radiographically as reduced or non-reduced. Functional outcomes were assessed using the Total Active Motion (TAM) scoring system. The association between the reduction quality and TAM outcome was analyzed separately for metacarpal and proximal phalangeal fractures using the Fisher–Freeman–Halton exact test. Results: All fractures achieved radiographic union. In the metacarpal fractures, 90% of the patients attained good-to-excellent TAM scores, with no statistically significant association between the reduction quality and functional outcome (p = 0.1303). In contrast, for the proximal phalangeal fractures, anatomical reduction was significantly associated with superior TAM outcomes (p = 0.0014; Cohen’s w = 0.802). The postoperative radiographs in this group revealed smooth dorsal cortical alignment in the patients with good outcomes, suggesting preserved tendon gliding surfaces. Conclusions: Anatomical fracture reduction significantly predicts postoperative function in proximal phalangeal fractures treated with IMHCSs. In contrast, metacarpal fractures appear more tolerant of minor malalignment. These findings underscore the importance of achieving cortical continuity in phalangeal fractures to optimize digital biomechanics. A minimal open approach should be considered to ensure proper alignment during IMHCS fixation. Full article

Global biodiversity losses continue despite intensive conservation efforts. Many mammal species are understudied due to their specialized ecological niches. One such species is the Philippine colugo (Cynocephalus volans), a nocturnal endemic species in the Philippines. In this study, we utilized Local Ecological Knowledge (LEK) to obtain baseline information on species knowledge, attitudes, population status, and threats. Between June and September 2023, we interviewed 471 residents across all villages in Anda, Bohol. The majority of local people recognized the species and had witnessed it in Anda, occasionally near households. Residents have limited knowledge of colugo diet and distribution, which they get primarily through word-of-mouth and personal experience. The species is perceived as neutral, but the willingness to conserve it is high. Although the Philippine colugo population seems to be present in several villages in Anda, one-fourth of the respondents believe it is declining. We identified hunting for consumption as the main threat to the colugo population in Anda, which, together with other threats, may corroborate this result. We recommend actively involving male farmers in colugo population monitoring and behavioral observations, as well as investigating the drivers and importance of colugo meat consumption among residents to design a proper conservation strategy. Full article

Hypersonic morphing vehicles (HMVs), renowned for their adaptive structural reconfiguration and cross-domain maneuverability, confront formidable reentry guidance challenges under multiple no-fly zones, stringent path constraints, and nonlinear dynamics exacerbated by morphing-induced aerodynamic uncertainties. To address these issues, this study proposes a hierarchical framework integrating an A-based energy-optimal waypoint planner, a deep deterministic policy gradient (DDPG)-driven morphing policy network, and a quasi-equilibrium glide condition (QEGC) guidance law with continuous sliding mode control. The A* algorithm generates heuristic trajectories circumventing no-fly zones, reducing the evaluation function by 6.2% compared to greedy methods, while DDPG optimizes sweep angles to minimize velocity loss and terminal errors (0.09 km position, 0.01 m/s velocity). The QEGC law ensures robust longitudinal-lateral tracking via smooth hyperbolic tangent switching. Simulations demonstrate generalization across diverse targets (terminal errors < 0.24 km) and robustness under Monte Carlo deviations (0.263 ± 0.184 km range, −12.7 ± 42.93 m/s velocity). This work bridges global trajectory planning with real-time morphing adaptation, advancing intelligent HMV control. Future research will extend this framework to ascent/dive phases and optimize its computational efficiency for onboard deployment. Full article

Background: Suprascapular neuropathy is a known cause of shoulder pain. Although neurodynamic techniques are widely used to treat peripheral neuropathies, the mechanical behavior of the suprascapular nerve in the shoulder region remains poorly understood. Objectives: This study aimed to analyze the mechanical behavior of the suprascapular nerve during a contralateral cervical glide and an infraspinatus muscle contraction. Methods: The study was conducted in two phases. First, nerve movement was analyzed in 12 cryopreserved cadaveric shoulders using anatomical dissection. Second, suprascapular nerve displacement was assessed in 34 shoulders from 17 healthy volunteers using ultrasound imaging. Results: In cadaveric dissections, the contralateral cervical glide produced a proximal nerve displacement of 1.85 mm at the suprascapular notch. In the ultrasound study, this maneuver resulted in horizontal and vertical displacements of 1.18 mm and 0.39 mm, respectively. In contrast, infraspinatus muscle contraction caused a distal displacement of 3.21 mm in the cadaveric study, and ultrasound imaging showed horizontal and vertical displacements of 1.34 mm and 0.75 mm, respectively. All reported displacements were statistically significant (p < 0.05). Conclusions: The findings of both phases of the study contribute to a better understanding of suprascapular nerve biomechanics and may inform clinical neurodynamic interventions. Full article

Webbed-foot gliding water entry is a characteristic water-landing strategy employed by swans and other large waterfowls, demonstrating exceptional low-impact loading and remarkable motion stability. These distinctive biomechanical features offer significant potential for informing the design of cross-medium vehicles’ (CMVs’) water-entry systems. To analyze the hydrodynamic mechanisms and flow characteristics during swan webbed-foot gliding entry, the three-dimensional bionic webbed-foot water-entry process was investigated through a computational fluid dynamics (CFD) method coupled with global motion mesh (GMM) technology, with a particular emphasis on elucidating the regulatory effects of entry parameters on dynamic performance. The results demonstrated that the gliding water-entry process can be divided into two distinct phases: stable skipping and surface gliding. During the stable skipping phase, the motion trajectory exhibits quasi-sinusoidal periodic fluctuations, accompanied by multiple water-impact events and significant load variations. In the surface-gliding phase, the kinetic energy of the bionic webbed foot progressively decreases while maintaining relatively stable load characteristics. Increasing the water-entry velocity will enhance impact loads while simultaneously increasing the skipping frequency and distance. Increasing the water-entry angle will primarily intensify the impact load magnitude while slightly reducing the skipping frequency and distance. An optimal pitch angle of 20° provides maximum glide-skip stability for the bio-inspired webbed foot, with angles exceeding 25° or below 15° leading to motion instability. This study on webbed-foot gliding entry behavior provided insights for developing novel bio-inspired entry strategies for cross-medium vehicles, while simultaneously advancing the optimization of impact-mitigation designs in gliding water-entry systems. Full article

This paper addresses the real-time trajectory generation problem for hypersonic glide vehicles (HGVs) during atmospheric entry, subject to complex constraints including aerothermal limits, actuator bounds, and no-fly zones (NFZs). To achieve efficient and reliable trajectory planning, a two-phase hp-adaptive sequential convex programming (SCP) framework is proposed. NFZ avoidance is reformulated as a soft objective to enhance feasibility under tight geometric constraints. In Phase I, a shrinking-trust-region strategy progressively tightens the soft trust-region radius by increasing the penalty weight, effectively suppressing linearization errors. A sensitivity-driven mesh refinement method then allocates collocation points based on their contribution to the objective function. Phase II applies residual-based refinement to reduce discretization errors. The resulting reference trajectory is tracked using a linear quadratic regulator (LQR) within a reference-trajectory-tracking guidance (RTTG) architecture. Simulation results demonstrate that the proposed method achieves convergence in only a few iterations, generating high-fidelity trajectories within 2–3 s. Compared to pseudospectral solvers, the method achieves over 12× computational speed-up while maintaining kilometer-level accuracy. Monte Carlo tests under uncertainties confirm a 100% success rate, with all constraints satisfied. These results validate the proposed method’s robustness, efficiency, and suitability for onboard real-time entry guidance in dynamic mission environments. Full article

Objectives: The aim of this study is to investigate how Adaptive Torque Control motion influences the shaping efficiency of Neolix EDMax (Neolix SAS, Évron, France) and its ability to reach working length with or without a pre-existing glide path. Methods: A total of 90 endo training blocks with an S-shape curvature were divided into three groups based on the kinematics and preparation phase: the control group, where the Neolix EDMax (Neolix SAS, Évron, France) was used for shaping after a glide path was established; the no glide path group, where the Neolix EDMax (Neolix SAS, Évron, France) was used for shaping without a glide path; and the Adaptive Torque Control group, where the Neolix EDMax (Neolix SAS, Évron, France) was used for shaping without a glide path but in an Adaptive Torque Control motion. The time for shaping, the instrument passes, and the ability to reach working length were recorded and analyzed using a one-way Anova and Tukey’s HSD post hoc test. Results: Establishing a glide path helped the shaping file to reach working length faster and in fewer passes when compared with the no glide path group, but the Adaptive Torque Control group was able to perform even better than the control group despite not having a pre-established glide path. Conclusions: The Adaptive Torque Control motion on continuous rotation instruments does impact their performance. Combining the efficiency of continuous rotation and the safety of reciprocation, this type of motion had a significant effect on the ability to shape the simulated root canal even in the presence of a double curvature and without a pre-established glide path. Full article