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23 pages, 3580 KiB  
Article
Distributed Collaborative Data Processing Framework for Unmanned Platforms Based on Federated Edge Intelligence
by Siyang Liu, Nanliang Shan, Xianqiang Bao and Xinghua Xu
Sensors 2025, 25(15), 4752; https://doi.org/10.3390/s25154752 (registering DOI) - 1 Aug 2025
Abstract
Unmanned platforms such as unmanned aerial vehicles, unmanned ground vehicles, and autonomous underwater vehicles often face challenges of data, device, and model heterogeneity when performing collaborative data processing tasks. Existing research does not simultaneously address issues from these three aspects. To address this [...] Read more.
Unmanned platforms such as unmanned aerial vehicles, unmanned ground vehicles, and autonomous underwater vehicles often face challenges of data, device, and model heterogeneity when performing collaborative data processing tasks. Existing research does not simultaneously address issues from these three aspects. To address this issue, this study designs an unmanned platform cluster architecture inspired by the cloud-edge-end model. This architecture integrates federated learning for privacy protection, leverages the advantages of distributed model training, and utilizes edge computing’s near-source data processing capabilities. Additionally, this paper proposes a federated edge intelligence method (DSIA-FEI), which comprises two key components. Based on traditional federated learning, a data sharing mechanism is introduced, in which data is extracted from edge-side platforms and placed into a data sharing platform to form a public dataset. At the beginning of model training, random sampling is conducted from the public dataset and distributed to each unmanned platform, so as to mitigate the impact of data distribution heterogeneity and class imbalance during collaborative data processing in unmanned platforms. Moreover, an intelligent model aggregation strategy based on similarity measurement and loss gradient is developed. This strategy maps heterogeneous model parameters to a unified space via hierarchical parameter alignment, and evaluates the similarity between local and global models of edge devices in real-time, along with the loss gradient, to select the optimal model for global aggregation, reducing the influence of device and model heterogeneity on cooperative learning of unmanned platform swarms. This study carried out extensive validation on multiple datasets, and the experimental results showed that the accuracy of the DSIA-FEI proposed in this paper reaches 0.91, 0.91, 0.88, and 0.87 on the FEMNIST, FEAIR, EuroSAT, and RSSCN7 datasets, respectively, which is more than 10% higher than the baseline method. In addition, the number of communication rounds is reduced by more than 40%, which is better than the existing mainstream methods, and the effectiveness of the proposed method is verified. Full article
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12 pages, 229 KiB  
Article
Difficulties of Difference
by Rachel Cecília de Oliveira
Arts 2025, 14(4), 79; https://doi.org/10.3390/arts14040079 - 21 Jul 2025
Viewed by 217
Abstract
This article examines the persistent conceptual and structural obstacles that pluralism faces within the Euro-United-Statesian art system, particularly in the fields of criticism, art history, and aesthetics. The study situates its inquiry within broader debates around the politics of difference and the decolonization [...] Read more.
This article examines the persistent conceptual and structural obstacles that pluralism faces within the Euro-United-Statesian art system, particularly in the fields of criticism, art history, and aesthetics. The study situates its inquiry within broader debates around the politics of difference and the decolonization of knowledge, aiming to understand how theoretical frameworks historically incorporated plurality in ways that ultimately neutralize its disruptive potential. Methodologically, the article combines philosophical analysis with a critical rereading of canonical texts by figures such as Clement Greenberg and Arthur Danto, juxtaposed with insights from Indigenous, Black, and decolonial thinkers. The findings suggest that pluralism, while rhetorically embraced, is frequently rendered compatible with a teleological and universalizing narrative that privileges Western aesthetic trajectories. As a result, forms of difference are tolerated only insofar as they can be translated into hegemonic terms. The article concludes by advocating for critical practices that sustain rather than resolve difference, calling for frameworks capable of embracing dissonance, incommensurability, and multiple ontologies without collapsing them into sameness. In doing so, it repositions the contemporary struggle over meaning in art not as a problem to be overcome, but as a necessary symptom of epistemic plurality. Full article
(This article belongs to the Section Visual Arts)
15 pages, 271 KiB  
Review
Modic Changes as Biomarkers for Treatment of Chronic Low Back Pain
by Jeffrey Zhang, Emily Bellow, Jennifer Bae, Derek Johnson, Sandi Bajrami, Andrew Torpey and William Caldwell
Biomedicines 2025, 13(7), 1697; https://doi.org/10.3390/biomedicines13071697 - 11 Jul 2025
Viewed by 660
Abstract
Background: Chronic low back pain (CLBP) is the leading cause of disability both within the United States and globally. However, reliable diagnosis and treatment remains limited due to a lack of objective and image-based biomarkers. Modic changes (MCs) are visible vertebral endplate and [...] Read more.
Background: Chronic low back pain (CLBP) is the leading cause of disability both within the United States and globally. However, reliable diagnosis and treatment remains limited due to a lack of objective and image-based biomarkers. Modic changes (MCs) are visible vertebral endplate and bone marrow changes in signal intensity seen on MRI. MCs have emerged as promising correlates with degenerative disc disease and CLBP. Methods: This is a non-systematic literature review. Results: This review synthesizes current evidence on the classification, pathophysiology, and imaging of MCs, with a particular focus on their associations with patient-reported outcomes, including pain (Visual Analog Scale), functional status (Oswestry disability index and Roland-Morris Disability Questionnaire), and health-related quality of life (Short Form-36 and EuroQol 5-Dimension 5 Level). MC type 1 and 2 show significant correlations with symptom severity and predict positive response to basi-vertebral nerve (BVN) ablation, a minimally invasive intervention inhibiting the nerves’ ability to transmit pain signals. Conclusions: Across multiple trials, BVN ablation has shown significant sustained improvements in patient-reported outcomes among patients with MC, reinforcing their role as both a diagnostic and therapeutic biomarker. Full article
(This article belongs to the Special Issue Biomarkers in Pain)
12 pages, 1253 KiB  
Article
The Feasibility of a Music Therapy Respiratory Telehealth Protocol on Long COVID Respiratory Symptoms
by Jingwen Zhang, Joanne V. Loewy, Lisa Spielman, Zijian Chen and Jonathan M. Raskin
COVID 2025, 5(7), 107; https://doi.org/10.3390/covid5070107 - 10 Jul 2025
Viewed by 1459
Abstract
Objective: This study aims to investigate the feasibility of an online music therapy protocol for individuals previously diagnosed with COVID-19, focusing on their perceptions of their respiratory symptoms and the intervention’s impact on psychosocial measures. Methods: A within-subject experimental design was applied to [...] Read more.
Objective: This study aims to investigate the feasibility of an online music therapy protocol for individuals previously diagnosed with COVID-19, focusing on their perceptions of their respiratory symptoms and the intervention’s impact on psychosocial measures. Methods: A within-subject experimental design was applied to examine an eight-week weekly online music therapy protocol, including singing, wind instrument playing, and music visualizations. All self-report data were collected bi-weekly throughout the 16-weeks study period, including baseline and post-tests. The measures for respiratory symptoms included the Medical Research Council’s Dyspnea Scale (MRC Dyspnea), Chronic Respiratory Questionnaire-Mastery Scores (CRQ Mastery), and Visual Analogue Scale for breathlessness. The measures for the secondary psychosocial outcomes were the Beck Depression Inventory-Short Form, the Generalized Anxiety Disorder 7-item, the Hospital Anxiety and Depression Scale, the Fatigue Severity Scale, the Epworth Sleepiness Scale, the EuroQol 5-Dimension 5-Level, and the Connor-Davidson Resilience Scale. Results: Twenty-four participants were enrolled. The participants perceived a reduction in respiratory symptoms, and shortness of breath (MRC Dyspnea). Planned comparisons showed significant decreases in MRC from baseline to post-treatment (p = 0.008). The mixed-effects model, including pre-baseline and post-treatment, was significant (p < 0.001). Significant changes in Breathing VAS were consistent with improvements in MRC Dyspnea, showing a significant baseline-to-post difference (p = 0.01). The CRQ Mastery showed significant improvements from baseline to Week 12 (p < 0.001). No significant changes were observed in other secondary measures. Conclusions: Our preliminary findings suggest that this protocol is feasible, and as a result, may help individuals previously diagnosed with COVID-19 to cope with lasting respiratory symptoms and improve their perception of shortness of breath. Live music-making, including playing accessible wind instruments and singing, may contribute to an increase sense of control over breathing. As this was a feasibility study, we conducted multiple uncorrected statistical comparisons to explore potential effects. While this approach may increase the risk of Type I error, the findings are intended to inform hypotheses for future confirmatory studies rather than to draw definitive conclusions. Full article
(This article belongs to the Section Long COVID and Post-Acute Sequelae)
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17 pages, 1952 KiB  
Article
Feasibility and Safety of Early Cardiac Rehabilitation Using Remote Electrocardiogram Monitoring in Patients with Cardiac Surgery: A Pilot Study
by Yeon Mi Kim, Bo Ryun Kim, Sung Bom Pyun, Jae Seung Jung, Hee Jung Kim and Ho Sung Son
J. Clin. Med. 2025, 14(14), 4887; https://doi.org/10.3390/jcm14144887 - 10 Jul 2025
Viewed by 383
Abstract
Purpose: We aimed to evaluate the safety and feasibility of a remote electrocardiogram (ECG) monitoring-based cardiac rehabilitation (CR) program during an early postoperative period in patients who underwent cardiac surgery. Methods: Five days after cardiac surgery, patients were referred to a [...] Read more.
Purpose: We aimed to evaluate the safety and feasibility of a remote electrocardiogram (ECG) monitoring-based cardiac rehabilitation (CR) program during an early postoperative period in patients who underwent cardiac surgery. Methods: Five days after cardiac surgery, patients were referred to a CR department and participated in a low-intensity inpatient CR program while wearing an ECG monitoring device. Prior to discharge, the patients underwent a cardiopulmonary exercise test (CPET) and squat endurance test to determine the suitable intensity and target heart rate (HR) for home-based CR (HBCR). During 2 weeks of the HBCR period after discharge, patients participated in aerobic and resistance exercises. Electrocardiogram data were transmitted to a cloud, where researchers closely monitored them through a website and provided feedback to the patients via telephone calls. Grip strength (GS), 6 min walk distance (6 MWD), EuroQol-5 dimension (EQ-5D), short-form 36-item health survey (SF-36), and Korean Activity Scale/Index (KASI) were measured at three different time points: 5 d post-surgery (T1), pre-discharge (T2), and 2 weeks after discharge (T3). Squat endurance tests and CPET were performed only at T2 and T3. Result: Sixteen patients completed the study, seven (44%) of whom underwent coronary artery bypass graft surgery (CABG). During the study period between T2 and T3, peak VO2 improved from 12.39 ± 0.57 to 17.93 ± 1.25 mL/kg/min (p < 0.01). The squat endurance test improved from 16.69 ± 2.31 to 21.81 ± 2.31 (p < 0.01). In a comparison of values of time points between T1 and T3, the GS improved from 28.30 ± 1.66 to 30.40 ± 1.70 kg (p = 0.02) and 6 MWD increased from 249.33 ± 20.92 to 387.02 ± 22.77 m (p < 0.01). The EQ-5D and SF-36 improved from 0.59 ± 0.03 to 0.82 ± 0.03 (p < 0.01) and from 83.99 ± 3.40 to 122.82 ± 6.06 (p < 0.01), and KASI improved from 5.44 ± 0.58 to 26.11 ± 2.70 (p < 0.01). In a subgroup analysis, the CABG group demonstrated a greater increase in 6 MWD (102.29 m, p < 0.01) than the non-CABG group. At the end of the study, 75% of the patients expressed satisfaction with the early CR program guided by remote ECG monitoring. Conclusions: Our findings suggest that early remote ECG monitoring-based CR programs are safe and feasible for patients who have undergone cardiac surgery. Additionally, the program improved aerobic capacity, functional status, and quality of life. Full article
(This article belongs to the Section Cardiology)
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23 pages, 1585 KiB  
Article
Safe Haven for Bitcoin: Digital and Physical Gold or Currencies?
by Halilibrahim Gökgöz, Aamir Aijaz Syed, Hind Alnafisah and Ahmed Jeribi
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 171; https://doi.org/10.3390/jtaer20030171 - 5 Jul 2025
Viewed by 1023
Abstract
The recent economic turmoil and the increasing volatility of bitcoins have necessitated the need for exploring safe-haven assets for bitcoins. In this quest, the present study aims to investigate the safe haven for bitcoins by examining the dynamic relationship between bitcoins, gold, foreign [...] Read more.
The recent economic turmoil and the increasing volatility of bitcoins have necessitated the need for exploring safe-haven assets for bitcoins. In this quest, the present study aims to investigate the safe haven for bitcoins by examining the dynamic relationship between bitcoins, gold, foreign exchange, and stablecoins. This is achieved by calculating hedge ratios and portfolio weight ratios for various asset classes, by employing adaptive-based techniques such as generalized orthogonal generalized autoregressive conditional heteroscedasticity, corrected dynamic conditional correlation, corrected asymmetric dynamic conditional correlation, and asymmetric dynamic conditional correlation under various market and time-varying conditions. The empirical estimate reveals that all the selected asset classes are effective risk diversifiers for bitcoins. However, among all the asset classes, as per the hedge and portfolio weight ratio, Japanese yen, stablecoin for Japanese yen and Great Britain Pound, and Crypto Holding Frank Token (lowest-cost hedging strategies) are the most effective risk diversifiers when compared with bitcoins. Moreover, while considering external economic shocks, the empirical estimate posits that stablecoins are more stable risk diversifiers compared to the asset class they represent. Furthermore, in terms of the bivariate portfolio analysis formed with bitcoin, this study concludes that the weight of bitcoin is more stable when combined with gold, tether gold, Euro, Great Britain Pound, Swiss franc, and Japanese Yen. Thus, these assets are attractive for long-term investment strategies. This study provides investors and policymakers with significant insight into understanding safe-haven assets for bitcoin’s volatility and constructing a flexible portfolio that is dependent on the investment timeline and the prevailing market conditions. Full article
(This article belongs to the Special Issue Blockchain Business Applications and the Metaverse)
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13 pages, 223 KiB  
Article
Safety Profile of Antipsychotics as Predictors of the Quality of Life in Patients with Schizophrenia—An Inpatient Welfare Institution-Based Cross-Sectional Study
by Aleksandra D. Petrovic, Ana M. Barjaktarevic, Olivera Z. Kostic, Sara S. Mijailovic, Slobodan M. Jankovic, Marija V. Andjelkovic, Marijana S. Stanojevic Pirkovic, Katarina D. Parezanovic Ilic, Vladimir S. Janjic, Jana Mojsilovic, Jana Arsenijevic, Danijela B. Jovanovic, Sanja Knezevic, Nevena Folic, Milovan Stevic, Dejana Ruzic Zecevic, Nemanja Z. Petrovic and Marina J. Kostic
Pharmaceuticals 2025, 18(6), 777; https://doi.org/10.3390/ph18060777 - 23 May 2025
Viewed by 592
Abstract
Background/Objectives: Adverse effects of antipsychotics represent a significant limiting factor in achieving favorable therapeutic outcomes in the treatment of schizophrenia, and may contribute to a diminished quality of life among affected individuals. The primary objective of this study was to identify and [...] Read more.
Background/Objectives: Adverse effects of antipsychotics represent a significant limiting factor in achieving favorable therapeutic outcomes in the treatment of schizophrenia, and may contribute to a diminished quality of life among affected individuals. The primary objective of this study was to identify and evaluate the adverse effects of antipsychotics in patients diagnosed with schizophrenia who were treated at the social welfare institution, as well as to analyze the impact of these adverse effects on patients’ overall quality of life. Methods: A clinical, observational cross-sectional study was conducted, involving a sample of 278 patients diagnosed with schizophrenia. The patients were assessed in terms of their sociodemographic and clinical characteristics. Adverse effects of antipsychotics were evaluated using The Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale, while quality of life was assessed in the previous study. Results: The average number of adverse effects per patient with schizophrenia was 3.56 for psychiatric, 1.18 for neurological, 2.62 for autonomic, and 7.12 for other side effects. The average UKU score was 17.22 ± 11.04, with significant differences based on accommodation, antipsychotic type, and dosing regimen. UKU scores were negatively correlated with the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) index, Visual Analog Scale (VAS) score, the Quality-of-Life Enjoyment and Satisfaction Questionnaire—Short Form (Q-LES-Q-SF) score, and the scores of physical and psychological domains of the World Health Organization Quality-of-Life Scale (WHOQOL-BREF). Conclusions: The findings of this study suggest that the presence of antipsychotic-related adverse effects is a significant determinant that can negatively influence the quality of life in patients with schizophrenia. These results underscore the importance of an individualized approach when determining pharmacological treatment strategies in the management of schizophrenia. Full article
(This article belongs to the Section Pharmacology)
14 pages, 229 KiB  
Article
The Presence and Role of Ancestors in Indigenous Cultures, Euro-American Cultures, and Democratic Intergenerational Dialogue
by Mark S. Cladis
Religions 2025, 16(5), 649; https://doi.org/10.3390/rel16050649 - 20 May 2025
Viewed by 487
Abstract
What does it mean for a culture to include, or exclude, ancestors as active members? How do Indigenous cultures and traditions cast light on the role of ancestors? Those are the central questions in this article. It begins by offering a general account [...] Read more.
What does it mean for a culture to include, or exclude, ancestors as active members? How do Indigenous cultures and traditions cast light on the role of ancestors? Those are the central questions in this article. It begins by offering a general account of the role of ancestors in Indigenous cultures and traditions. These general comments contextualize specific engagement with the work of the novelist and essayist Leslie Marmon Silko (a Laguna Pueblo author) and also with the philosopher Kyle Whyte (a Potawatomi author). Having acquired from Silko and Whyte a sense for the active, intergenerational role played by ancestors in Indigenous cultures, the article then addresses the place of ancestors in Euro-American cultures and traditions, noting that due to particular forms of Christianity and secularism, Euro-American scholars and popular culture more generally tend to discount the role of ancestors. Yet, the work of Silko and others lend sight to see traces of ancestors in Euro-American cultures. Finally, the article returns to the question: What difference might it make to include or exclude ancestors in Euro-American communities and democracy? The approach in this article is transdisciplinary, drawing from the fields of religious studies (specifically its subfield, philosophy of religion and ethics), Indigenous studies, anthropology, political theory, and literary criticism. Full article
24 pages, 1674 KiB  
Article
On the Weak Impact of Base Money on Broad Money in the Context of Unconventional Monetary Policy: Euro Area 2008–2024
by Carlos Pateiro-Rodríguez, Federico Martín-Bermúdez, Esther Barros-Campello and Carlos Pateiro-López
Economies 2025, 13(5), 130; https://doi.org/10.3390/economies13050130 - 12 May 2025
Cited by 1 | Viewed by 1002
Abstract
In its response to the economic and financial crises of 2008, the sovereign debt and euro crisis of 2010–2015, and the COVID-19 pandemic of 2020–2023, the European Central Bank (ECB) implemented an unconventional monetary policy aimed at providing liquidity for more than a [...] Read more.
In its response to the economic and financial crises of 2008, the sovereign debt and euro crisis of 2010–2015, and the COVID-19 pandemic of 2020–2023, the European Central Bank (ECB) implemented an unconventional monetary policy aimed at providing liquidity for more than a decade, through a complex set of tools and operations that make up the so-called quantitative easing. The results of all of them are being analyzed from different perspectives. This paper studies the relationship between a large base money, characterized by a voluminous concentration of liquidity in the form of excess reserves, and broad money (the broad M3 aggregate). Our econometric work shows a low elasticity of broad money with respect to base money, concluding the existence of a weak relationship between both monetary magnitudes, with a sharp decline in the money multiplier. The demand for money has remained stable relative to its determining variables, interest rates and income. At the same time, some practices related to the handling of excess liquidity by European banks through deposit facilities deserve consideration. We propose strict control by the monetary authority over the nature and origin of the funds that constitute the excess liquidity derived from the ECB’s unconventional operations, and over its management. Full article
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15 pages, 7306 KiB  
Article
Ecclesiastical Adaptation and Reformation: The Evolution of Dutch Reformed Urban Church Architecture in Sri Lanka (1658–1796)
by Sagara Jayasinghe
Religions 2025, 16(4), 529; https://doi.org/10.3390/rel16040529 - 18 Apr 2025
Viewed by 754
Abstract
Sri Lanka, then known as Ceylon, was ruled by three Euro-Christian colonisers for over 450 years. Alongside their pursuit of trade and wealth, these colonial powers—the Portuguese (1505–1658), Dutch (1658–1796), and British (1796–1948)—sought to establish their distinct forms of Christianity: Catholicism by the [...] Read more.
Sri Lanka, then known as Ceylon, was ruled by three Euro-Christian colonisers for over 450 years. Alongside their pursuit of trade and wealth, these colonial powers—the Portuguese (1505–1658), Dutch (1658–1796), and British (1796–1948)—sought to establish their distinct forms of Christianity: Catholicism by the Portuguese, Reformation by the Dutch, and Anglicanism and other Protestant denominations by the British. The missionary strategies and religious policies of these European colonisers varied significantly. Unlike Catholicism, which closely aligned with the external rituals of local religions such as Buddhism and Hinduism, the Dutch Reformed religion emphasised Christian doctrine and biblical scripture, distinguishing itself in its liturgy, art, and architecture. This paper examines the origins and development of Dutch Reformed urban church architecture in Sri Lanka through archival, cartographical, and morphological research, complemented by an architectural survey of the surviving Dutch Reformed churches. The study reveals that the Dutch initially repurposed several Portuguese churches for Reformed worship, and later, they introduced the “Meeting House” typology, aligning with Reformed ecclesiastical and liturgical principles. Over time, this evolved into larger “Greek Cross Plan” churches, a trend that continued until the rise of Anglicanism. Full article
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20 pages, 6291 KiB  
Article
The Analysis of Exhaust Composition Serves as the Foundation of Sustainable Road Transport Development in the Context of Meeting Emission Standards
by Anna Kochanek, Józef Janczura, Sławomir Jurkowski, Tomasz Zacłona, Anna Gronba-Chyła and Paweł Kwaśnicki
Sustainability 2025, 17(8), 3420; https://doi.org/10.3390/su17083420 - 11 Apr 2025
Cited by 2 | Viewed by 2606
Abstract
The main objective of the research presented in this article was to analyze the composition of exhaust gases from passenger cars undergoing periodic inspections and to determine the influence of vehicle age, mileage and the applicable EURO emission standard on the level of [...] Read more.
The main objective of the research presented in this article was to analyze the composition of exhaust gases from passenger cars undergoing periodic inspections and to determine the influence of vehicle age, mileage and the applicable EURO emission standard on the level of emissions of individual components of exhaust gases and thus on the environment. The research was carried out at the District Vehicle Inspection Station in Nowy Sącz, using methods for analyzing the composition of exhaust gases and smoke opacity. The results obtained make it possible to assess whether exhaust emission diagnostics can form the basis for the implementation of a sustainable road transport policy. The study showed that older vehicles emit higher concentrations of carbon monoxide (CO) and hydrocarbons (HC), and diesel cars manufactured before 2010 are characterized by increased smoke opacity. A reliable analysis of the emissions performance of vehicles on the road enables more effective measures to be taken to reduce emissions and improve air quality through regulation, the introduction of clean traffic zones and raising environmental awareness among drivers. This is especially important in regions with specific geographical conditions, such as the Nowy Sącz district, where the terrain—Nowy Sącz is located in a basin surrounded by mountain ranges—favors the accumulation of pollutants and hinders the natural air circulation, leading to the long-term persistence of smog. Full article
(This article belongs to the Special Issue Control of Traffic-Related Emissions to Improve Air Quality)
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22 pages, 5880 KiB  
Article
A Floristic Survey of Wild Edible Plants in Tuscan Maremma, Italy
by Mario Pentassuglia, Tiziana Lombardi, Giovanni Bambi, Irene Ventura, Benedetta D’Ambrosio, Andrea Bertacchi and Laura Pistelli
Plants 2025, 14(6), 976; https://doi.org/10.3390/plants14060976 - 20 Mar 2025
Viewed by 861
Abstract
This study explores the floristic diversity of wild edible plants (WEPs) in the area surrounding Tirli, a small village in the Tuscan Maremma, Italy. Field surveys identified 128 vascular plant taxa across 46 families and 106 genera, with Asteraceae (26 taxa), Rosaceae (10 [...] Read more.
This study explores the floristic diversity of wild edible plants (WEPs) in the area surrounding Tirli, a small village in the Tuscan Maremma, Italy. Field surveys identified 128 vascular plant taxa across 46 families and 106 genera, with Asteraceae (26 taxa), Rosaceae (10 taxa), and Lamiaceae (8 taxa) being the most represented. The dominant life-forms are scapose Hemicryptophytes, scapose Therophytes, and rosulate Hemicryptophytes, with Euro-Mediterranean, Subcosmopolitan, and Steno-Mediterranean distributions prevailing. Statistical analyses revealed significant associations between life-forms and edible plant parts: scapose and rosulate Hemicryptophytes were linked to leaf use, scapose Therophytes to root use, and Phanerophytes to fruit use. The Asteraceae family exhibited exceptional versatility, being associated with various edible parts. Notably, the endemic species Centaurea nigrescens Willd. subsp. pinnatifida (Fiori) Dostál was recorded for the first time in the Tuscan Maremma, underscoring the area’s naturalistic value. Traditional culinary practices were linked to some edible plants, which were analyzed for bioactive compounds, including photosynthetic pigments, primary metabolites, secondary metabolites, and antioxidant activity. The results confirmed their biochemical richness and functional properties. This study emphasizes the ecological, nutritional, and cultural significance of Tirli’s wild edible flora, promoting biodiversity conservation, cultural heritage preservation, and sustainable food practices. Full article
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13 pages, 581 KiB  
Article
Radiographic and Clinical Comparison of Polyetheretherketone Versus 3D-Printed Titanium Cages in Lumbar Interbody Fusion—A Single Institution’s Experience
by Diang Liu, Julie L. Chan, Art Eleanore, Kristin DeCost, Justin Luk, Lissette C. Neukam, Tasneem Zaihra Rizvi, Zhibang Lin, Zoher Ghogawala, Subu N. Magge, Andrew Y. Yew and Robert G. Whitmore
J. Clin. Med. 2025, 14(6), 1813; https://doi.org/10.3390/jcm14061813 - 7 Mar 2025
Viewed by 1400
Abstract
Background/Objectives: Spinal fusion surgery is an accepted form of management for select patients who suffer from degenerative lumbar disease. The need for cost-effective durable techniques is paramount as our population ages. This study compares the radiographic and clinical outcomes of PEEK and 3D-printed [...] Read more.
Background/Objectives: Spinal fusion surgery is an accepted form of management for select patients who suffer from degenerative lumbar disease. The need for cost-effective durable techniques is paramount as our population ages. This study compares the radiographic and clinical outcomes of PEEK and 3D-printed titanium interbody cages. Methods: This study compared two cohorts which underwent either PEEK or 3D-printed titanium (3DPT) interbody fusion at a single institution between 2013 and 2022. The PEEK cohort was a retrospective analysis of a prospectively collected registry. The 3DPT data were prospectively collected. The inclusion criteria were adults >18 years who underwent 1 or 2 level lumbar interbody fusion for degenerative spine disease with at least 6 months follow-up. Patient demographics, radiographs, and PROMs were collected. The cohorts were compared using ANOVA for continuous variables and Fisher’s exact test for categorical variables, with significance set to 0.05. Results: The final study included 91 patients, 49 PEEK and 42 3DPT. The 3DPT patients were older (p = 0.047) with increased incidence of hypertension (p < 0.001). The 3DPT patients had less bone morphogenetic protein (BMP) usage (80.9% vs. 54.8%; p = 0.012), but more cellular allograft (p < 0.001). Fusion rate was high for both cohorts, with PEEK at 95.9% and 3DPT at 97.6%. There was no significant difference in reoperation rate. Both the PEEK and 3DPT cohorts demonstrated an improvement in the Oswestry Disability Index (ODI) and EuroQol 5 Dimension (EQ-5D) at 1 and 2 years compared to preoperative baseline. More patients in the 3DPT group met the MCID for EQ-5D at 1 and 2 years compared to PEEK; however, this was not significant (p = 0.350; p = 1.000). Conclusions: The 3DPT interbody provided comparable if not superior fusion properties to the PEEK interbody given the decreased use of BMP. Both cohorts demonstrated similar improvements in ODI and EQ-5D compared to preoperative baseline. These results suggest that 3DPT cages may be a cost-effective alternative in spinal fusion. Further studies utilizing a larger population with higher follow-up rates are indicated to determine the economic and clinical benefits of 3DPT compared to PEEK cages in lumbar fusion surgery. Full article
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17 pages, 2073 KiB  
Article
Dynamics of Glycemic Status and Glucose Metabolism Markers 12 Months After Coronary Artery Bypass Grafting and Their Relationship with the Annual Prognosis of Patients
by Alexey N. Sumin, Natalia A. Bezdenezhnykh, Ekaterina V. Belik, Yulia A. Dyleva, Andrey V. Bezdenezhnykh, Olga V. Gruzdeva and Olga L. Barbarash
J. Clin. Med. 2025, 14(2), 351; https://doi.org/10.3390/jcm14020351 - 8 Jan 2025
Viewed by 1043
Abstract
Background and Objectives: We aim to evaluate the dynamics of glycemic status and markers of carbohydrate metabolism 12 months after coronary artery bypass grafting (CABG) and their relationship with the one-year prognosis. Materials and Methods: The analysis of outcomes of 653 patients during [...] Read more.
Background and Objectives: We aim to evaluate the dynamics of glycemic status and markers of carbohydrate metabolism 12 months after coronary artery bypass grafting (CABG) and their relationship with the one-year prognosis. Materials and Methods: The analysis of outcomes of 653 patients during 1 year after coronary artery bypass grafting is presented. In those patients who visited the study center after 1 year, markers of carbohydrate metabolism (glucose, glycated hemoglobin, fructosamine, 1.5 anhydroglucitol) were assessed; in 371 of them, they were studied at three points—before surgery, before discharge from the hospital, and one year after surgery. The influence of these indicators on the incidence of cardiovascular events (death from any cause, myocardial infarction, stroke, repeat myocardial revascularization, surgical interventions on non-coronary arteries, amputations due to peripheral atherosclerosis, emergency hospitalizations due to cardiovascular disease, or combined endpoint [CEP]) was assessed during the year after CABG. Groups with (n = 59)/absence (n = 594) of the combined endpoint were formed and compared based on the dynamics of carbohydrate metabolism markers over the course of a year. Additionally, factors associated with the development of major adverse cardiovascular events (MACE) after CABG were assessed. Results: After 1 year, the number of patients with type 2 diabetes increased from 23.9% to 25.6% and prediabetes from 17.2% to 26.6% (p < 0.001). Among patients with diabetes mellitus, the following dynamics of carbohydrate metabolism markers were noted: a decrease in glucose levels in both groups (with or without CEP), glycated hemoglobin in the group without CEP, and fructosamine in the group with CEP. There were no differences in the intergroup comparison of all the described markers (glucose, fructosamine, glycated hemoglobin) and carbohydrate metabolism at all points. The following factors were associated with the development of MACE within a year after CABG: the presence of peripheral arterial disease, preoperative fibrinogen level, the risk of surgery according to the EuroSCORE scale, and off-pump CABG. Conclusions: In patients with diabetes mellitus one year after coronary artery bypass grafting, a decrease in glucose and glycated hemoglobin levels was noted. No differences in the dynamics of carbohydrate metabolism markers were found in the groups of patients with and without cardiovascular complications. The impact of glycated hemoglobin dynamics one year after CABG on long-term prognosis requires further research. Full article
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8 pages, 2395 KiB  
Brief Report
Can Quality of Life Tests Be Useful in Patients Affected by Alpha-1 Antitrypsin Deficiency?
by José María Hernández-Pérez, Hassan Khadour-Khadour, Gema Romero-Romero and Miguel Ángel García-Bello
J. Clin. Med. 2024, 13(24), 7711; https://doi.org/10.3390/jcm13247711 - 17 Dec 2024
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Abstract
Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that predisposes a person to certain diseases over their lifetime, mainly including lung disease (in the form of emphysema) and liver disease (liver cirrhosis). Quality of life questionnaires are instruments designed to quantify the deterioration [...] Read more.
Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that predisposes a person to certain diseases over their lifetime, mainly including lung disease (in the form of emphysema) and liver disease (liver cirrhosis). Quality of life questionnaires are instruments designed to quantify the deterioration of a patient’s health. Background/Objectives: This study aimed to assess whether certain quality of life tests that are routinely used in clinical practice can be useful for patients with AATD. Methods: A sample of AATD patients, with various genotypes, but with the common characteristic that they must have both altered alleles (Pi* ≠ M), participated in the study. Different quality of life tests were used, including the COPD Assessment Test (CAT), COPD and Asthma Sleep Impact Scale, the short form of the Short Form Health Survey, and EuroQol 5 dimensions, and were related to differing clinical and functional characteristics. Results: The sample was composed of 54 patients, and slightly more than half of the participants were women (57.4%), with a mean age of 51.5 ± 13.7. The main genotypes were Pi*SZ (43.4%) and Pi*ZZ (34%). In patients under 65 years of age (n = 47), those who were actively working could walk a greater distance in the walking test, namely, 573 m (511–629), compared to those who were not actively working, namely, 415.5 m (392–469; p < 0.001). Active non-workers had a worse CAT (13.6 ± 7.8 vs. 4.6 ± 4.3; p < 0.001). In total, 80% of non-working patients had exacerbations, but only 46. 9% of those who were active, although the association did not reach statistical significance (p = 0.068). Having a lower score in the physical component of SF-12 was related to suffering from lung disease (46.0 ± 11.4 vs. 38.4 ± 11.1 (p = 0.026)). Conclusions: Quality of life tests were able to detect differences and relate them to functional factors such as the distance covered in the walking test, being sensitive and specific in this regard. Full article
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