Search Results (17)

Due to its high heat transfer property, microchannel heat sink has been widely applied in thermal management, microelectronic cooling and energy conversion. To develop a microchannel heat sink featuring low pressure drop ΔP and a high heat transfer property, a V-shaped wavy microchannel (VWM) is designed and CFD simulation is carried out. Subsequently, the influences of wave amplitude A, wave length λ and inlet velocity u on the Nusselt number Nu_ave, the Dean Vortexes and ΔP are studied. Furthermore, based on the performance evaluation criteria (PEC), the optimal parameters of A, λ and u are chosen. Next, the influence of microchannel number N is studied at the same pump power. Eventually, the optimal VWM heat sink is compared with the V-shaped straight microchannel (VSM) heat sink and the rectangular-shaped straight microchannel (RSM) heat sink. The results show that many Dean Vortexes periodically emerge in the V-shaped wavy microchannel, particularly at the wave peak and valley. These Dean Vortexes are capable of thinning the thermal boundary layer, which significantly strengthens heat transfer. As A and u increase while λ decreases, the area, number and severity of the Dean Vortexes increase, and thus both Nu_ave and ΔP also increase. In the present study, the PEC first increases and then decreases, reaching its maximum value when A = 0.3 mm, λ = 5 m and u = 1.0 m/s. At the same pump power, both the heat transfer area and the total Dean Vortex number increase with the increase in N, leading to a decrease in the thermal resistance R and the maximum temperature T_max. Compared to the VSM and RSM heat sinks, the optimal VWM heat sink decreases T_max by 29.93 K and 38.03 K, decreases R by 50.46% and 56.68%, increases h_ave by 156.42% and 155.43% and increases PEC by 137% and 130.78%, respectively. Full article

To enhance passive mixing in microchannels, T-shaped double-spiral and serpentine microchannels with identical curvature radii were designed and numerically analyzed across a Reynolds number (Re) range of 1 to 300. The double-spiral microchannel exhibited superior mixing performance at Re ≤ 200, which is primarily attributed to the efficient utilization of Dean vortices. In contrast, the serpentine microchannel showed better performance at Re ≥ 250, benefiting from the early formation of four-vortex structures induced by periodic curvature reversals. To further enhance the performance of the serpentine microchannel at low Re, groove structures with varying orientation angles were incorporated. The introduction of the groove structures generated lateral secondary flows that not only increased flow disturbances but also disrupted the symmetry of the Dean vortices. Among these configurations, Structure 2, with a 45° angle between the groove direction and centrifugal force, exhibited the most pronounced enhancement in vortex intensity, as the secondary flows induced by the grooves synergistically interacted with the Dean vortices. This configuration resulted in the highest mixing enhancement (>50%). This study provides valuable insights into geometry-driven mixing mechanisms and offers design guidelines for high-efficiency micromixers across a wide range of Re. Full article

The field of hydrodynamics, specifically microfluidics, is currently undergoing rapid development, with significant progress being made in the creation of new devices and technologies that outperform their macroscopic counterparts. Concurrently, determining the parameters of a non-Newtonian fluid is becoming an important task in many areas of industry and production, particularly in the oil industry. Both the drilling fluids (needed to create wells) and the polymer-based displacers and surfactants (needed to extract oil) have non-Newtonian properties. This paper presents a method for determining the indices of consistency and flow behaviour of the non-Newtonian fluid (power-law model) based on the analysis of secondary Dean vortices generated in a curved channel. This phenomenon is conveniently described using the recirculation angle. The structure of the flow of non-Newtonian fluids in a U-shaped micromixer has been studied. The dependence of the recirculation angle on the fluid flow rate was obtained for different fluid parameters. A universal correlation was proposed to describe the dependence of the inverse Dean number on the recirculation angle of the flow. The consistency and flow behaviour indices of the power-law model of non-Newtonian fluids found using the above correlation can be measured in the experiments. Full article

Extensive research has been conducted on the performance of pump turbines, particularly focused on understanding the generation mechanism of S-shaped characteristics. However, there has been a lack of research on unsteady flow characteristics in hump characteristics with small guide vane openings. This study focuses on the hump characteristics of a pump turbine in pump mode. The unsteady numerical simulation method is used along with experimental testing to examine the internal flow characteristics and induced pressure fluctuations under pump operating conditions. The results indicate that flow separation occurs in the impeller when the flow rate decreases to the valley operating condition, and recirculation flow occurs near the impeller inlet at the partial flow rate. Moreover, the unstable flow on the positive slope exhibits a low-frequency characteristic of 0.15f_n. The pressure fluctuation from the hub to shroud areas of the guide vane region diminishes sequentially. Notably, distinct vortex structures emerge at the draft tube cone section under the valley operating condition. These structures extend toward the elbow section of the draft tube as the flow rate decreases. This phenomenon generates low-frequency pressure fluctuation originating from the primary frequency of the vortex and dean vortex on the surface, located at 0.4 D of the draft tube under conditions of low flow rate. Full article

Vortex generators and pin fins are conventionally used to deliver fluid mixing and improved convective heat transfer. The increased pressure loss following a fractional increase in heat transfer, as well as the complex manufacturing design, leave room for improvement. The present work proposes a novel diverging–converging base corrugation model coupled with vortex generation using simple geometrical modifications across rectangular microchannels to ensure a superior performance. The Nusselt number, friction factor, and flow phenomenon were numerically studied across a Reynolds number range of 50–1000. The optimum cross-section of the microchannel-generating vortices was determined after thorough study, and base corrugation was further added to improve heat transfer. For the vortex–corrugation modeling, the heat transfer enhancement was verified in two optimized cases: (1) curved corrugated model, (2) interacting corrugated model. In the first case, an optimized curve generating Dean vortices was coupled with base corrugation. An overall increase in the Nusselt number of up to 32.69% and the thermal performance of “1.285 TPF” were observed at a high Reynolds number. The interacting channels with connecting bridges of varying width were found to generate vortices in the counter-flow configuration. The thermal performance of “1.25 TPF” was almost identical to the curved corrugated model; however, a major decrease in pressure, with a loss of 26.88%, was observed for this configuration. Full article

A novel passive micromixer based on multiple baffles and a submergence scheme was designed, and its mixing performance was simulated over a wide range of Reynolds numbers ranging from 0.1 to 80. The degree of mixing (DOM) at the outlet and the pressure drop between the inlets and outlet were used to assess the mixing performance of the present micromixer. The mixing performance of the present micromixer showed a significant enhancement over a wide range of Reynolds numbers (0.1 ≤ Re ≤ 80). The DOM was further enhanced by using a specific submergence scheme. At low Reynolds numbers (Re < 5), submergence scheme Sub24 produced the highest DOM, approximately 0.57, which was 1.38 times higher than the case with no submergence. This enhancement was due to the fluid flowing from or toward the submerged space, creating strong upward or downward flow at the cross-section. At high Reynolds numbers (Re > 10), the DOM of Sub1234 became the highest, reaching approximately 0.93 for Re = 20, which was 2.75 times higher than the case with no submergence. This enhancement was caused by a large vortex formed across the whole cross-section, causing vigorous mixing between the two fluids. The large vortex dragged the interface between the two fluids along the vortex perimeter, elongating the interface. The amount of submergence was optimized in terms of DOM, and it was independent of the number of mixing units. The optimum submergence values were 90 μm for Sub24 and Re = 1, 100 μm for Sub234 and Re = 5, and 70 μm for Sub1234 and Re = 20. Full article

A passive micromixer combined with two different mixing units was designed by submerging planar structures, and its mixing performance was simulated over a wider range of the Reynolds numbers from 0.1 to 80. The two submerged structures are a Norman window and rectangular baffles. The mixing performance was evaluated in terms of the degree of mixing (DOM) at the outlet and the required pressure load between inlet and outlet. The amount of submergence was varied from 30 μm to 70 μm, corresponding to 25% to 58% of the micromixer depth. The enhancement of mixing performance is noticeable over a wide range of the Reynolds numbers. When the Reynolds number is 10, the DOM is improved by 182% from that of no submergence case, and the required pressure load is reduced by 44%. The amount of submergence is shown to be optimized in terms of the DOM, and the optimum value is about 40 μm. This corresponds to a third of the micromixer depth. The effects of the submerged structure are most significant in the mixing regime of convection dominance from Re = 5 to 80. In a circular passage along the Norman window, one of the two Dean vortices burst into the submerged space, promoting mixing in the cross-flow direction. The submerged baffles in the semi-circular mixing units generate a vortex behind the baffles that contributes to the mixing enhancement as well as reducing the required pressure load. Full article

The aim of present study was to develop radiolabeled NPs to overcome the limitations of fluorescence with theranostic potential. Synthesis of PLGA-NPs loaded with technetium-99m was based on a Dean-Vortex-Bifurcation Mixer (DVBM) using an innovative microfluidic technique with high batch-to-batch reproducibility and tailored-made size of NPs. Eighteen different formulations were tested and characterized for particle size, zeta potential, polydispersity index, labeling efficiency, and in vitro stability. Overall, physical characterization by dynamic light scattering (DLS) showed an increase in particle size after radiolabeling probably due to the incorporation of the isotope into the PLGA-NPs shell. NPs of 60 nm (obtained by 5:1 PVA:PLGA ratio and 15 mL/min TFR with ^99mTc included in PVA) had high labeling efficiency (94.20 ± 5.83%) and >80% stability after 24 h and showed optimal biodistribution in BALB/c mice. In conclusion, we confirmed the possibility of radiolabeling NPs with ^99mTc using the microfluidics and provide best formulation for tumor targeting studies. Full article

Due to the existence of a Dean vortex in a U-tube, the flow and heat transfer process of supercritical methane is complex, and its thermophysical property are greatly influenced by different factors. Based on computational fluid dynamics theory, the numerical simulation of the turbulent flow and heat transfer characteristics of supercritical methane in a U-tube with an inner diameter of 10 mm and a radius of curvature of 27 mm carried out by using the finite volume method. On the basis of verifying the reliability of the model, the influences of inlet mass flux (G), heat flux on the tube wall boundary (q), pressure on the outlet (P), and gravity acceleration factors (g) on heat transfer characteristics were analyzed. The calculation results show that the sensitivity of the effects of G, q, P, and g on the heat transfer coefficient is, from large to small, in the order of P, G, g, and q. Compared with a horizontal straight tube, a U-tube can significantly improve heat transfer in the elbow part, but the presence of the elbow reduces heat transfer in the subsequent straight pipe section. The research in this paper has significance as a reference for the construction of the LNG gasification process. Full article

Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features. We propose an extensive review of mechanisms of passive self-separation technologies and enumerate some experimental details and devices to exploit these effects. The performances, limitations and challenges of these technologies and devices are also compared and discussed. Full article

Inertial microfluidics enables fluid and particle manipulation for biomedical and clinical applications. Herein, we developed a simple semicircular microchannel with an ultra-low aspect ratio to interrogate the unique formations of the helical vortex and Dean vortex by introducing order micro-obstacles. The purposeful and powerful regulation of dimensional confinement in the microchannel achieved significantly improved fluid mixing effects and fluid and particle manipulation in a high-throughput, highly efficient and easy-to-use way. Together, the results offer insights into the geometry-induced multi-vortex mechanism, which may contribute to simple, passive, continuous operations for biochemical and clinical applications, such as the detection and isolation of circulating tumor cells for cancer diagnostics. Full article

The field of inertial microfluidics has been significantly advanced in terms of application to fluid manipulation for biological analysis, materials synthesis, and chemical process control. Because of their superior benefits such as high-throughput, simplicity, and accurate manipulation, inertial microfluidics designs incorporating channel geometries generating Dean vortexes and helical vortexes have been studied extensively. However, existing technologies have not been studied by designing low-aspect-ratio microchannels to produce multi-vortexes. In this study, an inertial microfluidic device was developed, allowing the generation and regulation of the Dean vortex and helical vortex through the introduction of micro-obstacles in a semicircular microchannel with ultra-low aspect ratio. Multi-vortex formations in the vertical and horizontal planes of four dimension-confined curved channels were analyzed at different flow rates. Moreover, the regulation mechanisms of the multi-vortex were studied systematically by altering the micro-obstacle length and channel height. Through numerical simulation, the regulation of dimensional confinement in the microchannel is verified to induce the Dean vortex and helical vortex with different magnitudes and distributions. The results provide insights into the geometry-induced secondary flow mechanism, which can inspire simple and easily built planar 2D microchannel systems with low-aspect-ratio design with application in fluid manipulations for chemical engineering and bioengineering. Full article

A new cross-channel split-and-recombine (CC-SAR) micro-mixer was proposed, and its performance was demonstrated numerically. A numerical study was carried out over a wide range of volume flow rates from 3.1 μL/min to 826.8 μL/min. The corresponding Reynolds number ranges from 0.3 to 80. The present micro-mixer consists of four mixing units. Each mixing unit is constructed by combining one split-and-recombine (SAR) unit with a mixing cell. The mixing performance was analyzed in terms of the degree of mixing and relative mixing cost. All numerical results show that the present micro-mixer performs better than other micro-mixers based on SARs over a wide range of volume flow rate. The mixing enhancement is realized by a particular motion of vortex flow: the Dean vortex in the circular sub-channel and another vortex inside the mixing cell. The two vortex flows are generated on the different planes perpendicular to each other. They cause the two fluids to change their relative position as the fluids flow into the circular sub-channel of the SAR, eventually promoting violent mixing. High vorticity in the mixing cell elongates the flow interface between two fluids, and promotes mixing in the flow regime of molecular diffusion dominance. Full article

Inertial focusing conditions of fluorescent polystyrene spherical particles are studied at the pointwise level along their pathlines. This is accomplished by an algorithm that calculates a degree of spreading function of the particles’ trajectories taking streaklines images as raw data. Different confinement ratios of the particles and flow rates are studied and the results are presented in state diagrams showing the focusing degree of the particles in terms of their position within a curve of an asymmetric serpentine and the applied flow rate. In addition, together with numerical simulation results, we present empirical evidence that the preferred trajectories of inertially focused spheres are contained within Dean vortices’ centerlines. We speculate about the existence of a new force, never postulated before, to explain this fact. Full article

Inertial microfluidics has become a popular topic in microfluidics research for its good performance in particle manipulation and its advantages of simple structure, high throughput, and freedom from an external field. Compared with traditional microfluidic devices, the flow field in inertial microfluidics is between Stokes state and turbulence, whereas the flow is still regarded as laminar. However, many mechanical effects induced by the inertial effect are difficult to observe in traditional microfluidics, making particle motion analysis in inertial microfluidics more complicated. In recent years, the inertial migration effect in straight and curved channels has been explored theoretically and experimentally to realize on-chip manipulation with extensive applications from the ordinary manipulation of particles to biochemical analysis. In this review, the latest theoretical achievements and force analyses of inertial microfluidics and its development process are introduced, and its applications in circulating tumor cells, exosomes, DNA, and other biological particles are summarized. Finally, the future development of inertial microfluidics is discussed. Owing to its special advantages in particle manipulation, inertial microfluidics will play a more important role in integrated biochips and biomolecule analysis. Full article