Search Results (15)

This article explores the role of discursive practices and epistemological obstacles in shaping educational knowledge and power dynamics within schools. Drawing on critical pedagogy and the works of McLaren, Foucault, Gramsci, and Bachelard, it examines how schools act as sites where hegemonic Discourses are either reproduced or resisted. Discourses, understood as integrated social practices encompassing language, actions, beliefs, and values, deeply influence how students form their social representations of the world. The article highlights the need for educators to challenge traditional curricular theories that prioritize technical knowledge, often presented as neutral, while masking underlying power relations. Through the analysis of Bachelard’s epistemological obstacles, such as simplification, generalization, and depersonalization, the article discusses how these barriers impede students’ ability to critically engage with complex social phenomena. Multiperspectivity is proposed as a key educational approach to foster critical thinking and empower students to challenge social injustices. The discussion calls for systemic educational reforms, emphasizing the importance of teacher training that encourages the identification and questioning of dominant ideologies. By adopting a critical, social justice-oriented pedagogy, educators can help students not only understand but also transform their social realities, promoting an equitable and democratic educational environment. Full article

Background/Objectives: Cancer patients often experience psychological and physical symptoms that can significantly impact their quality of life and treatment outcomes. Virtual reality (VR) has emerged as a promising complementary approach to standard cancer care. Due to the rapidly evolving nature of VR research in oncology, it seems essential to provide an overview of the current state of knowledge in this field. Therefore, this umbrella review aimed to synthesize evidence from all relevant systematic reviews and meta-analyses on VR-based interventions for improving psychological and physical well-being among cancer patients. Methods: A comprehensive search was conducted in four databases (Cochrane Database of Systematic Reviews, Medline, Web of Science, PsycInfo) from inception to August 2023. We included systematic reviews with or without meta-analyses that evaluated the effects of VR-based interventions on any health-related outcomes in cancer patients. The methodological quality of included reviews was assessed using the AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews) tool. Results: Eighteen individual systematic reviews including ten performed meta-analyses were included, with sample sizes ranging from 225 to 842 participants. VR-based interventions were categorized into three main types: distraction, rehabilitation, and education. The interventions varied significantly in terms of content, equipment, setting, and duration. The most frequent use of VR is one-off exposure in hospital settings to distract patients from anticancer treatment and painful procedures, with natural or game-based content. The mechanism most commonly proposed to explain the effectiveness of VR involves attentional redirection. Conclusions: This umbrella review suggests that VR-based interventions may be effective in improving psychological outcomes in cancer patients, particularly anxiety, pain, and depression. However, high heterogeneity across studies and mixed results for some outcomes indicate a need for further high-quality research. Moreover, a more refined analysis of VR-based interventions is essential to explore the specific mechanisms of action associated with each type. This approach would enable us to establish the optimal characteristics of each intervention and their long-term effects. Full article

In this paper, I reflect on human imagination, the intention of technology, and the future of humanity in the era of the Anthropocene. I begin by presenting the environmental crisis and declare a need to protect and safeguard nature. In the first part, I offer an explanation of a dream of an airliner and link it to the Bachelardian theory of aerial imagination and oneiric flight. I show how, today, technology has entered our lives profoundly and how it has become closely intertwined with us human beings. Based on this, the second part is dedicated to Martin Heidegger and his question concerning technology. By analyzing Heidegger’s seminal essay on technology, I argue for an alternative possibility of thinking about human artefacts (such as various tools or even an airliner) beyond them being merely a standing-reserve and thus rather as a mode of unconcealement. The third and last part of this essay is dedicated to Ilia Delio’s Teilhardian cosmic vision of the future of technological progress. Technology, for Delio, is a part of this cosmic narrative and human beings represent the thinking portion of the universe. I conclude with a thought on a new elemental consciousness and imagination, in which nature, its life force, and the most advanced technology, including AI, would become a part of a new panentheistic whole. Full article

In a multicenter prospective cohort of cancer patients (CP; n = 840) and healthcare workers (HCWs; n = 935) vaccinated against COVID-19, we noticed the following: i/after vaccination, 4.4% of HCWs and 5.8% of CP were infected; ii/no characteristic was associated with post-vaccine COVID-19 infections among HCWs; iii/CP who developed infections were younger, more frequently women (NS), more frequently had gastrointestinal, gynecological, or breast cancer and a localized cancer stage; iv/CP vaccinated while receiving chemotherapy or targeted therapy had (NS) more breakthrough infections after vaccination than those vaccinated after these treatments; the opposite was noted with radiotherapy, immunotherapy, or hormonotherapy; v/most COVID-19 infections occurred either during the Alpha wave (11/41 HCW, 20/49 CP), early after the first vaccination campaign started, or during the Omicron wave (21/41 HCW, 20/49 CP), more than 3 months after the second dose; vi/risk of infection was not associated with values of antibody titers; vii/the outcome of these COVID-19 infections after vaccination was not severe in all cases. To conclude, around 5% of our CPs or HCWs developed a COVID-19 infection despite previous vaccination. The outcome of these infections was not severe. Full article

This work studies two copper-based alloys as potential antimicrobial weapons for sectors where surface hygiene is essential. Effects of different alloying elements addition at the same Cu content (92.5% by weight) on the corrosion resistance and the antibacterial performance of two copper alloys were studied in an aerated disinfectant solution (0.25% v/v Aniosurf Premium (D)) by electrochemical corrosion, X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectroscopy (ToF-SIMS) and antibacterial tests. Results showed that the nature of the alloying elements had a clear influence on the corrosion resistance and antibacterial performance. Electrochemical impedance results and surface analyses demonstrate the presence of organic compounds bound on the substrate and that a film covers part of the total active surface and may act as a protective barrier by preventing the interaction between metal and solution, decreasing the antimicrobial performance of copper-based materials. Low zinc and silicon contents in copper alloys allows for better aging behavior in D solution while maintaining good antibacterial performance. The XPS and ToF-SIMS results indicated that artificial aging in disinfectant enhanced Cu enrichment in the organic film formed, which could effectively stimulate the release of Cu ions from the surface. Full article

Herein, we designed chitosan–coated Fe₃O₄ nanocomposites for the control release of drugs by an alternating magnetic field (AMF). The chitosan-coated Fe₃O₄ nanoparticles (Fe₃O₄@CS) were prepared by a alkaline co-precipitation method, and then, the model drug toluidine blue (TB) was covalently grafted onto the surface of the nanocomposite by a two-step amide reaction with the thermosensitive molecule 4,4′-azobis (4-cyanovaleric acid) (ACVA) as the linker group. The prepared nanocomposites were superparamagnetic and showed high magnetization saturation (about 54.0 emu g⁻¹). In vitro hydrothermal release studies showed that most parts of the TB would be effectively enclosed within the nanocarriers at lower ambient temperatures (23 or 37 °C) due to the molecular bonding of ACVA. The results of kinetic fitting of hydrothermal release data showed that TB released from nanoparticles followed first-order kinetics (R² > 0.99) and the Korsemeyer–Peppas model (R² > 0.99, n < 0.5). Most importantly, a single magnetron release experiment demonstrated an approximately linear relationship between the cumulative release of the drug and the duration of action of AMF (R² = 0.9712). Moreover, the increase in the cumulative release of the drug can be controlled by controlling the switch of the AMF generation device. Therefore, the ACVA-modified Fe₃O₄@CS nanocarrier designed in this study is a promising model for drug delivery that enables the control of drug release dose by AMF. Full article

There are at least four traumatic events that likely lie behind the Gospel of John: (1) Jesus’ death and inaccessibility, (2) the destruction of the Jerusalem Temple, (3) the Johannine community’s excommunication from the synagogue, and (4) the loss of the Beloved Disciple. Evidence of all of these traumas can be found in the Gospel itself and, as extant, the Gospel exhibits a number of strategies for addressing these experiences of suffering. Working from Gaston Bachelard’s observations regarding literature produced in response to suffering, this paper outlines the textual evidence for each of these experiences of suffering, notes the responses to them that the Gospel displays, and seeks briefly to evaluate the responses for the TYPOI (patterns/examples/warnings) they provide. In short, the Fourth Gospel employs psychologically attractive, compensatory responses to experiences of loss. However, it deploys in parallel a toxic cocktail of anti-Jewish polemic, condemnation of “the world”, and self-protective, sectarian insularity. Regarding whether the text’s trauma response can be viewed as exemplary for ethically-minded Christians, Desmond Tutu’s 2009 statement, “there are certain parts [of the Bible] which you have to say no to”, is directly applicable, while the warning the text’s example suggests is significant. Full article

In this prospective, real-life cohort study, we followed 523 cancer patients (CP) and 579 healthcare workers (HCW) from two cancer centers to evaluate the biological and clinical results of the COVID-19 vaccination campaign. Seventy percent of the CP and 90% of the HCW received an mRNA vaccine or the AZD1222 vaccine. Seropositivity was high after the first vaccine among HCW and poor among CP. The second dose resulted in almost 100% seropositivity in both cohorts. Antibody response was higher after the second injection than the first in both populations. Despite at least two doses, 8 CP (1.5%) and 14 HCW (2.4%) were infected, corresponding either to a weak level of antibody or a new strain of virus (particularly the Omicron variant of concern). Sixteen CP and three HCW were hospitalized but none of them died from COVID-19. To conclude, this study showed that two doses of COVID-19 vaccines were crucially necessary to attain sufficient seropositivity. However, the post-vaccination antibody level declines in individuals from the two cohorts and could not totally prevent new SARS-CoV-2 infections. Full article

The absorption of pazopanib depends on gastric pH. PPIs are frequently prescribed for cancer patients to modify gastric acidity, decreasing pazopanib absorption. The aim of our study was, retrospectively, to investigate the impact of PPIs on the clinical efficacy and safety of pazopanib in a cohort of patients treated in our health center. Of the 147 patients who were included retrospectively, 79 (54%) did not take PPIs concomitantly with pazopanib (cohort 1), while 68 (46%) patients did take PPIs concomitantly with pazopanib (cohort 2). The efficacy parameters were lower in patients taking pazopanib and PPIs: the i/tumor response was statistically different between the two cohorts (p = 0.008), in particular, with 19% vs. 3% of the objective response and 24% vs. 43% of progression in cohorts 1 and 2, respectively; ii/median overall survival was 17.6 (95% CI: 12.5–32.8) months in cohort 1 and 8.6 months (95% CI: 5.9–18.6) in cohort 2 (HR = 1.7 [95% CI: 1.2–2.5]; p < 0.006); on multivariable analysis, overall survival was associated with performance status, PPI intake, tumor location, hemoglobin, and PMN/lymphocyte ratio. In contrast, the dose reduction for toxicity and severe adverse events were (non-significantly) less frequent in cohort 1. To conclude, our study shows that combining PPIs with pazopanib has an adverse effect on overall survival. The clinical modifications that were observed are in line with a decrease in pazopanib absorption due to PPIs. This co-medication should be avoided. Full article

Multikinase inhibitors (MKIs), and particularly tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (CPIs), are currently some of the major breakthroughs in cancer treatment. Proton pump inhibitors (PPIs) revolutionised the treatment of acid-related diseases, but are frequently overused for epigastric pain or heartburn. However, long-term acid suppression from using PPIs may lead to safety concerns, and could have a greater impact in cancer patients undergoing therapy, like bone fractures, renal toxicities, enteric infections, and micronutrient deficiencies (iron and magnesium). Moreover, acid suppression may also affect the pharmacokinetics of drugs (at least during acid suppression) and decrease the absorption of many molecularly-targeted anticancer therapies, which are mostly weak bases with pH-dependent absorption. This type of drug-drug interaction may have detrimental effects on efficacy, with major clinical impacts described for some orally administrated targeted therapies (erlotinib, gefitinib, pazopanib, palbociclib), and conflicting results with many others, including capecitabine. Furthermore, the long-term use of PPIs results in severe alterations to the gut microbiome and recent retrospective analyses have shown that the benefit of using CPIs was suppressed in patients treated with PPIs. These very expensive drugs are of great importance because of their efficacy. As the use of PPIs is not essential, we must apply the precautionary principle. All these data should encourage medical oncologists to refrain from prescribing PPIs, explaining to patients the risks of interaction in order to prevent inappropriate prescription by another physician. Full article

This critical note addresses two key features of eco-theology with regard to future prospect: that literary analysis is an important mode of eco-theological work and that an important function of eco-theology is to expand readers’ spheres of concern to include even the most remote of global environmental issues. Working from Tweed’s contention in Crossing and Dwelling that a central function of religion is the process of making homes, the note emphasizes the home as the primary sphere of concern and the need for eco-theological work to extend the concern naturally associated with the private home to the broadest possible sphere: the whole earth as conceived as human home. As pertaining to literary-analytical resources for this eco-theological endeavor, the note highlights the importance of Gaston Bachelard’s The Poetics of Space. Bachelard’s work offers a compelling exploration of the psychological connection between the most intimate spheres of concern (the private home) and the most extended ones (the broader world). Broader eco-theological engagement with his work will employ resources both for understanding relations between the relative scales of human ecology and for expanding spheres of concern, particularly in extending that concern often reserved for the most intimate ecological sphere to the most expansive. Full article

Bradykinin (BK) has various physiological and pathological roles. Medicinal chemistry efforts targeted toward the widely expressed BK B₂ receptor (B₂R), a G-protein-coupled receptor, were primarily aimed at developing antagonists. The only B₂R antagonist in clinical use is the peptide icatibant, approved to abort attacks of hereditary angioedema. However, the anti-inflammatory applications of B₂R antagonists are potentially wider. Furthermore, the B₂R antagonists notoriously exhibit species-specific pharmacological profiles. Classical smooth muscle contractility assays are exploited over a time scale of several hours and support determining potency, competitiveness, residual agonist activity, specificity, and reversibility of pharmacological agents. The contractility assay based on the isolated human umbilical vein, expressing B₂R at physiological density, was introduced when investigating the first non-peptide B₂R antagonist (WIN 64338). Small ligand molecules characterized using the assay include the exquisitely potent competitive antagonist, Pharvaris Compound 3 or the partial agonist Fujisawa Compound 47a. The umbilical vein assay is also useful to verify pharmacologic properties of special peptide B₂R ligands, such as the carboxypeptidase-activated latent agonists and fluorescent probes. Furthermore, the proposed agonist effect of tissue kallikrein on the B₂R has been disproved using the vein. This assay stands in between cellular and molecular pharmacology and in vivo studies. Full article

Background: The selection of women with hormone receptor-positive (HR+) early breast cancer (EBC) at high risk of relapse after five years (yrs.) of adjuvant aromatase inhibitors (AIs) is crucial, as the benefit of extending AIs is counterbalanced by toxicity. We developed a clinicopathological tool to estimate the residual risk of relapse after five years of adjuvant AIs. Methods: The Institut de Cancérologie de l’Ouest (ICO) database was used to determine a prognostic score of post-five-year AI relapse. Cox regression models estimated our score’s prognostic performance. Results: In total, 1105 women were included. Median follow-up was 44 months (IQR = 21–70) post-AI treatment. From the Cox models, we designed a dichotomous prognostic score including the number of macrometastases, age (>70 yrs. vs. ≤70 yrs.), tumor size (≥T2 vs. not), and mitotic activity (≥2 vs. not). Overall, 77.5% of patients were classified as being at low risk and 22.5% at high risk of late recurrence. Low-risk patients had a five- to ten-year local or distant recurrence risk of 7.6% (95% CI, 5.4% to 10.6%) as compared with 26.9% (95% CI, 19.9% to 35.7%) for the high-risk roup. Conclusion: In this study, we developed a simple tool to identify women at high risk of relapse despite completing five years of AIs. Full article

Kinins (peptides related to bradykinin, BK) are formed from circulating substrates, the kininogens, by the action of two proteases, the kallikreins. The only clinical application of a BK receptor ligand, the B₂ receptor antagonist icatibant, is the treatment of the rare hereditary angioedema (HAE) caused by the deficiency of C1-esterase inhibitor (C1-INH). Less common forms of HAE (genetic variants of factor XII, plasminogen, kininogen) are presumably mediated by increased BK formation. Acquired forms of BK-mediated angioedema, such as that associated with angiotensin-I converting enzyme (ACE) inhibition, are also known. Antibody-based analytical techniques are briefly reviewed, and support that kinins are extremely short-lived, prominently cleared by ACE. Despite evidence of continuous activation of the kallikrein–kinin system in HAE, patients are not symptomatic most of the time and their blood or plasma obtained during remission does not generate excessive immunoreactive BK (iBK), suggesting effective homeostatic mechanisms. HAE-C1-INH and HAE-FXII plasmas are both hyperresponsive to fibrinolysis activation. On another hand, we suggested a role for the alternate tissue kallikrein–kinin system in patients with a plasminogen mutation. The role of the BK B₁ receptor is still uncertain in angioedema states. iBK profiles under in vitro stimulation provide fresh insight into the physiopathology of angioedema. Full article

The poetry of Sylvia Plath (1932–1963) has received a considerable number of critical responses, among which spatial analysis occupies a minor position, although her texts explore complex relationships between subject and context. Drawing from a threefold theoretical apparatus (Bachelard’s theory of the poetic space, the Foucauldian concept of heterotopia, and the trope of liminality), this article focuses on the analysis of Plath’s increasing use of in-between spaces and objects of transition and transformations (mirrors, thresholds, windows), as well as on her predilection for heterotopic and alienating sceneries (hospital rooms, cemeteries), in both her poetry and prose. The study first acknowledges Plath’s choice of spatial imagery as a progressive orientation towards transitional states and places of otherness and ambivalence. Then, it highlights the specific role of heterotopic and liminal spaces in the process of reconfiguration of female identity. Given the impossibility for the female subject to rely on imprisoning domestic spheres to suture the edges of her fragmented self, reconceptualization of her own consciousness only becomes possible in the movement across a threshold. The analysis finally determines that the poetic evocation of spaces of conflict and difference paradoxically contributes to the shaping of female identity. Full article