Search Results (37)

Smart suspensions have significantly improved passenger comfort and vehicle stability compared to their passive counterparts. This manuscript explores the integration of artificial intelligence (AI) into hybrid suspension control systems to enhance vehicle stability and ride comfort under conditions where suspended mass changes. A one-quarter-vehicle model is employed to simulate and evaluate the performance of a hybrid control strategy, which combines skyhook and groundhook methods using a dynamic weighting factor ($\alpha$). This investigation considers an everyday situation where the sprung mass of a vehicle changes considerably when passengers enter or exit the automobile, impacting the suspension performance. Reinforcement learning techniques are utilized to optimize $\alpha$, achieving an acceptable balance between passenger comfort and vehicle stability. Simulation results show significant improvements in the dynamic response of the sprung mass compared to traditional passive systems, while keeping vehicle stability. Although improvements in road holding are incremental, simulation effort validates the AI-based hybrid system’s potential for refinement and practical application. Validation in MATLAB-Simulink demonstrates the system’s adaptability to varying road conditions and load distributions. The findings highlight the transformative role of AI in suspension control, paving the way for real-time implementation, advanced algorithms, and integration into full-vehicle models. This study contributes to the ongoing development of intelligent suspension systems toward vehicle performance advancement by improving passenger comfort and road holding. Full article

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity, mortality, and healthcare utilization. Lung volume reduction surgery improves outcomes in a select cohort but portends high morbidity. Bronchoscopic lung volume reduction (BLVR) is a less invasive, reversible manner of lung volume reduction, using one-way valves to improve lung function, quality of life, and exercise capacity. Nevertheless, knowledge gaps persist regarding factors that predict procedural success. Methods: We retrospectively reviewed 142 patients who underwent BLVR at the University of Chicago between December 2018 and July 2024 to assess the relationship between comorbidities and procedural outcomes. Using logistic and multinomial regression, we determined odds ratios (ORs) for a binary outcome of success and failure and relative risk ratios (RRRs) for failure sub-categories relative to procedural success. Results: We observed a procedural success rate of 48.1% and pneumothorax prevalence of 21.8%. After adjusting for age, sex, race, and body mass index (BMI), comorbidities associated with procedural failure included chronic kidney disease (CKD), congestive heart failure (CHF), anemia, and a BMI, Obstruction, Dyspnea and Exercise (BODE) Index of 5 or greater. Obstructive sleep apnea (OSA) was associated with procedural success. Conclusions: Comorbidities associated with dyspnea appear to have a significant effect on procedural success in BLVR. Full article

Fish are widely recognized as effective bioindicators in ecotoxicological studies due to their repeated exposure to aquatic pollutants that accumulate in metabolically active organs, often leading to histopathological changes. In aquaculture, cage-farmed fish experience continuous environmental and culture-related stress, which can affect renal integrity. The kidney, a central osmoregulatory organ, is particularly sensitive to such conditions. Renal tissues were collected from different growth stages of cage-farmed rainbow trout. Hematoxylin and eosin staining was performed to detect morphological alterations, while transmission electron microscopy was used to assess cellular damage at the ultrastructural level. The expression of fibronectin and caspase-3, markers of extracellular matrix remodeling and apoptosis, respectively, was also evaluated. TEM examination showed pronounced alterations in both the glomeruli and renal tubules, accompanied by increased expression of fibronectin and caspase-3, indicating ongoing tissue remodeling and cellular stress. This study demonstrates that cage-farmed rainbow trout exhibit progressive ultrastructural kidney alterations that appear to be associated with environmental confinement, nutritional practices, and prophylactic treatments. These conditions collectively contribute to renal stress and the onset of nephropathic changes in aquaculture settings. Further research should focus on molecular marker expression to better understand renal adaptation and injury progression under intensive farming conditions. Full article

Background: Wrist immobilization is a common clinical intervention for wrist injuries; however, its repercussions on gait parameters and plantar support have not been extensively investigated. Objectives: The purpose of the study was to determine whether wrist immobilization causes alterations in foot pressure and center of gravity, considering hand dominance and visual conditions (eyes open or closed). Methods: The research experiment was conducted using the PodoPrint S4 platform. Basic descriptive statistics were calculated to summarize the variables. Additionally, in the mixed linear model (t-tests use Satterthwaite’s method) an analysis of variance for repeated measures (ANOVA-RM) was conducted for the determination of the objectives of the study. Results: This study included a total of 44 participants (29 females and 15 males), with an average age of 36.5 years (SD = 17.5). Immobilization, independent of eye condition, resulted in significant alterations in antero-posterior oscillation and in a larger plantar support area. In addition, the results suggest that the eye state significantly influences plantar support, independent of limb immobilization or dominance. Conclusions: Our findings reveal significant alterations in antero-posterior oscillation and plantar support due to immobilization, suggesting a dynamic interplay between wrist function and lower limb biomechanics. Full article

This study investigates the susceptibility of beaches to jellyfish arrivals, focusing on the summer seasons from 2015 to 2020. The objective was to develop a predictive model that identifies the characteristics of beaches prone to higher jellyfish presence. This research utilized data from the Infomedusa application, with a focus on key structural and circumstantial variables, such as beach orientation, coastal currents, and morphology. Binomial logistic regression was applied to two models to assess the influence of these variables on jellyfish occurrence. The results showed that beaches oriented toward the east and south, with protection from natural or artificial barriers, and those with limited open sea exposure are more likely to experience jellyfish arrivals. Conversely, beaches facing southwest, with opposing currents and freshwater inflows, tend to have lower risks. Although the models’ predictive capacity was moderate, with a 76% validation rate against empirical data, they provided valuable insights for coastal management and risk prevention. The findings highlight the importance of beach-specific characteristics in forecasting jellyfish presence, contributing to more effective coastal protection strategies. Full article

Social media plays a crucial role in health information dissemination, yet it also raises concerns about misinformation. This study examines the role of Spanish health centers in promoting influenza vaccination on social networks, particularly X (formerly Twitter), during the 2023–2024 campaign. An observational, retrospective study analyzed the activity of 832 Spanish health centers on X. Data collection focused on the existence of official accounts, follower engagement and the nature of messages posted. Metrics were obtained using X Analytics, and statistical analysis was performed using JAMOVI v2.4 software. Of the 832 centers, 607 had readable X accounts. Collective accounts were more prevalent (351) than individual ones (239). Collective accounts had significantly more followers and posts but showed less engagement compared to individual accounts. The most followed accounts belonged to public entities, like the Community of Madrid and private organizations, such as Sanitas. An analysis of the vaccination campaign revealed that most posts had a political focus with limited health information, resulting in minimal interaction with the public. As a conclusion, the study highlights the fragmented nature of health communication through social networks in Spain. Despite the higher visibility of collective accounts, their engagement with the public is low, often due to the political nature of posts. A unified national strategy is essential for enhancing public health communication, focusing on interactive and relevant content. Full article

ChatGPT, a generative artificial intelligence model, can provide useful and reliable responses in the field of ophthalmology, comparable to those of medical professionals. Twelve frequently asked questions from ophthalmology patients were selected, and responses were generated both in the role of an expert user and a non-expert user. The responses were evaluated by ophthalmologists using three scales: Global Quality Score (GQS), Reliability Score (RS), and Usefulness Score (US), and analyzed statistically through descriptive study, association, and comparison. The results indicate that there are no significant differences between the responses of expert and non-expert users, although the responses from the expert user tend to be slightly better rated. ChatGPT’s responses proved to be reliable and useful, suggesting its potential as a complementary tool to enhance health literacy and alleviate the informational burden on healthcare professionals. Full article

Introduction: Bronchoscopic lung volume reduction (BLVR) with endobronchial valves has been shown to be a safe and effective treatment for patients with severe lung emphysema. Previous studies have reported a benefit in pulmonary function, exercise capacity, and quality of life after BLVR-treatment. The effect of BLVR with valves on the pulmonary gas exchange and its association with clinical outcomes has not been analyzed to date. The primary goal of this study was to investigate the impact of BLVR on the pulmonary gas exchange and the impact of the target lobe selection in patients with discordant target lobes in high-resolution computed tomography (HRCT) scan and perfusion scan on the pulmonary gas exchange and clinical outcomes. Methods: In this single-center study, we retrospectively analyzed pulmonary function tests, 6-min-walk-tests, HRCT scans, perfusion scans, and blood gas analyses in 77 patients over the course of 6 months following BLVR treatment. Results: We observed that complete lobar occlusion with bronchoscopic valves leads to a transient impairment of pulmonary gas exchange. Despite this, an overall positive clinical outcome could be shown in patients treated with endobronchial valves. If the target lobe selection based on HRCT and perfusion scans is discrepant, a selection based on the HRCT scan tends to be associated with a better outcome than a selection based on the perfusion scan. Conclusions: Complete lobar occlusion with bronchoscopic valves leads to a transient impairment of pulmonary gas exchange but nevertheless results in an overall positive clinical outcome. Full article

Bronchoscopic lung volume reduction (BLVR) is a minimally invasive treatment for emphysema. Lung cancer may be associated with emphysema due to common risk factors. Thus, a growing number of patients undergoing BLVR may develop lung cancer. Herein, we evaluated the effects of lung resection for non-small cell lung cancer in patients undergoing BLVR. The clinical data of patients undergoing BLVR followed by lung resection for NSCLC were retrospectively reviewed. For each patient, surgical and oncological outcomes were recorded to define the effects of this strategy. Eight patients were included in our series. In all cases but one, emphysema was localized within upper lobes; the tumor was detected during routine follow-up following BLVR and it did not involve the treated lobe. The comparison of pre- and post-BLVR data showed a significant improvement in FEV1 (29.7 ± 4.9 vs. 33.7 ± 6.7, p = 0.01); in FVC (28.5 ± 6.6 vs. 32.4 ± 6.1, p = 0.01); in DLCO (31.5 ± 4.9 vs. 38.7 ± 5.7, p = 0.02); in 6MWT (237 ± 14 m vs. 271 ± 15 m, p = 0.01); and a reduction in RV (198 ± 11 vs. 143 ± 9.8, p = 0.01). Surgical resection of lung cancer included wedge resection (n = 6); lobectomy (n = 1); and segmentectomy (n = 1). No major complications were observed and the comparison of pre- and post-operative data showed no significant reduction in FEV1% (33.7 ± 6.7 vs. 31.5 ± 5.3; p = 0.15) and in DLCO (38.7 ± 5.7 vs. 36.1 ± 5.4; p = 0.15). Median survival was 35 months and no cancer relapses were observed. The improved lung function obtained with BLVR allowed nonsurgical candidates to undergo lung resection for lung cancer. Full article

Although Mediterranean coastal regions in southern Spain have high floristic diversity and numerous Habitats of Community Interest (HCIs) identified by the European Union Directive Council, they are also vulnerable to invasive plants. In our study, we aimed to create a checklist of terrestrial alien taxa in the Iberian area of the Alboran coast, assess each species’ current invasion, analyse the influence of environmental attributes on invasion, estimate the richness of alien species per HCI group, and evaluate each species’ potential invasiveness based on its reproductive and dispersal attributes. The checklist that we developed includes 123 alien taxa, most belonging to the Asteraceae, Asparagaceae, and Poaceae families. Notably, 20% of the species are super invaders that occupy more than 20% of HCIs. We also identified Aloe vera, Cylindropuntia spp., Agave salmiana, Opuntia spp., and Paspalum spp. as incipient invaders with the potential for future expansion. Although most alien flora in the HCIs are not regulated by Spanish legislation (RDL 630/2013), monitoring and eradication plans are crucial. Advocating the cessation of using those plants in gardens and reducing anthropogenic pressure are also essential, as human activities worsen invasion dynamics and facilitate the introduction and establishment of invasive species. Full article

The recent COVID-19 pandemic has catalysed a new awareness of what living and working spaces should look like from a different perspective, and healthier cities and architecture have arisen because of inescapable public demand. Society has become clearly aware that there are still unhealthy concentrations within its environment. Spaces in cities are still being built that can favour the spread of diseases, in addition to using harmful construction materials. Living spaces must not only be sustainable, functional, and aesthetically beautiful but also comfortable, safe, and accessible, and, above all, they must be healthy. Healthy architecture has emerged as a new paradigm. This is the subject area of this work. This paper describes and develops the nature of this concept and proposes a novel definition of healthy architecture, aiming to compile state-of-the-art knowledge with a qualitative empirical and multi-method process, using case studies. This article provides a global perspective on new approaches and proposes a Decalogue with the basic principles that an environment or building must comply with in order to be healthy. The main contribution is to establish the basis for the creation of a new healthy architecture epistemology, focussing on cognitive, emotional, and physiological stimuli. This paper can help health professionals, designers, and architects, as well as companies and public administrations, to follow an innovative path in the planning of healthier cities and buildings. Full article

The current digital revolution is causing a paradigm shift encompassing all environments in which human beings conduct their daily activities. Technology is starting to govern the world, gradually modifying not only individual and social behaviour, but also ways of living. The necessary adaptation to new information and communication technologies forces societies to rethink both public and private spaces, in which evolution is slower than rapid social transformation. As part of this change, the concept of Active Assisted Living (AAL) has developed. Assisted spaces can be designed to provide older adults, carers, or people who have cognitive disabilities, such as Alzheimer’s disease or other dementias, with a healthier, safer, and more comfortable life, while also affording them greater personal autonomy. AAL aims to improve people’s quality of life and allow them to remain in their own homes for as long as possible, not in residences. This study conducted a critical review about AAL from an architectural point of view. The research adopted a qualitative approach in which we collected the studies during the last twenty years, then used descriptive, narrative and critical analysis methods. Based on these, this paper aims to explain this new technological paradigm, its characteristics, its main development trends, and its implementation limitations. The results obtained show how the development of AAL will be in the next ten years, and how this concept, and its application, can influence architecture and provide the bases for further research into the design of buildings and cities. Full article

Chronic Obstructive Pulmonary Disease (COPD) is a highly prevalent and morbid disease marked by irreversible structural changes in the lungs. Bronchoscopic therapies have significantly expanded the treatment armamentarium for patients with persistent symptoms by reducing the physiologic detriments of hyperinflation in a less invasive fashion than surgical lung volume reduction. The spectrum of bronchoscopic techniques to reduce hyperinflation includes endobronchial valves, coils, thermal ablation, and biologic sealants. Other therapies focus on reducing parasympathetic tone and mucus hypersecretion and include targeted lung denervation, bronchial rheoplasty, and cryospray techniques. In this article, we will review the variety of techniques for bronchoscopic lung volume reduction, both established and investigational, along with their respective benefits and complications and will briefly review other investigational therapies for COPD. Full article

This study analyzes the quality and reliability of videos related to nutrition and cancer on YouTube. Study Design: An observational, retrospective, cross-sectional, time-limited study analyzing activity on the social network YouTube was proposed. Methods: The information from the videos was extracted through an API search tool, using the NodeXL software. The criteria to select the videos on YouTube were the keywords “real food”, “realfood”, and “cancer” and the hashtags #realfood and #cancer were present, videos in English and videos available on 1 December 2022. Results: The DISCERN value in the total number of videos viewed was 2.25 (±0.88) points, indicating low reliability. The videos uploaded by HRU represented only 20.8%. Videos suggesting that the use of foods defined as “real food” could cure cancer without the intervention of any other treatment accounted for 12.5%. Videos that provided external links to scientific/technical evidence verifying the information represented only 13.89% of the total number of videos. Of these videos, 70% corresponded to HRU. The DISCERN value for videos from HRU users was 3.05 (0.88), a value that reflects a good reliability of videos from these users. Conclusions: This study provides information on the content and quality of the videos that we can find on YouTube. We found videos of non-health users who do not base their content on any scientific evidence, with the danger that this entails for the population, but it also highlights that the videos published by HRU have greater reliability and quality, being better perceived by the population, so it is important to encourage healthcare professionals and health institutions to share verified information on YouTube. Full article