Search Results (25)

Cathepsin Z/X (Cat Z/X) is a distinct member of the cysteine cathepsin family, known for its distinctive structural and functional properties, such as strict carboxypeptidase activity and integrin-binding motifs. These features set Cat Z/X apart from other cysteine proteases and underlie its involvement in diverse physiological and pathological processes, including immune regulation, cell signaling, and extracellular matrix remodeling. Dysregulated Cat Z/X expression and activity have been associated with various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. This review summarizes current knowledge on Cat Z/X, focusing on its structural characteristics, biological functions, and roles in disease pathogenesis, particularly in malignancies, neuroinflammation, and metabolic disorders. It also explores natural and synthetic Cat Z/X inhibitors and their potential for therapeutic development. Despite growing research interest, the precise molecular mechanisms and context-specific functions of Cat Z/X are not yet fully understood. Further research is required to elucidate its regulatory networks, refine detection methods, and develop selective modulators targeting its proteolytic and non-proteolytic activities. A deeper understanding of Cat Z/X biology could pave the way for its application as a diagnostic biomarker and therapeutic target in numerous diseases. Full article

The article provides of comprehensive examination of the main examples of typological exegesis that substantiate the eschatological framework of Pseudo-Methodius’s Syriac Apocalypse. In particular, the articles pays attention at Pseudo-Methodius’s original use of earlier Syriac writings (especially the Cave of the Treasures and the corpus of early seventh-century eschatological literature centered around the figure of Alexander the Great) which offered the material for original typological exegesis of crucial events in the universal history; additionally, the article reassesses the most original motif of Pseudo-Methodius’s representation of the “Last World Emperor” as the scion of the “Ethiopian” royal dynasty and provides some final remarks on the possible function and signification of the “unknown East” in Pseudo-Methodius’s historical and eschatological account. Full article

The cause of the systematic daily march of barometric pressure in the tropics, notably the late morning and late evening peaks seen almost every day at all locations, was a puzzle that persisted through the nineteenth and much of the twentieth centuries. The efforts to explain the physics of the prominent 12-h solar tidal variation helped inspire some of the earliest developments in theoretical atmospheric dynamics and ultimately led in the 1960’s to a satisfactory dynamical theory for the atmospheric tides. These important theoretical developments followed the observational discoveries, which date to the late 18th and early 19th centuries, of the surprising character of the barometric daily march and of its resolution into solar and lunar period cycles. These important, if simple, discoveries emerged primarily from the efforts of European scientists to systematically study the environment in remote areas of the globe. The two key figures in initially advancing the scientific community’s understanding of the character of barometric tides were the great German polymath Alexander von Humboldt (1769–1859) and the French naturalist Robert de Lamanon (1752–1787), who each made their discoveries on their most famous and colorful scientific expeditions of their respective careers. This paper examines the history of the early observations of the barometric tide. Full article

Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes. This review provides a comprehensive overview of the current understanding of the structure, biological functions, and pathological implications of cathepsins F and W. Beginning with an introduction to these proteases, we delve into their structural characteristics and elucidate their unique features that dictate their enzymatic activities and substrate specificity. We also explore the intricate involvement of cathepsins F and W in malignancies, highlighting their role as potential biomarkers and therapeutic targets in cancer progression. Furthermore, we discuss the emerging roles of these enzymes in immune response modulation and neurological disorders, shedding light on their implications in autoimmune and neurodegenerative diseases. Finally, we review the landscape of inhibitors targeting these proteases, highlighting their therapeutic potential and challenges in clinical translation. This review brings together the diverse facets of cysteine cathepsins F and W, providing insights into their roles in health and disease and guiding future investigations for therapeutic advances. Full article

Kafka explores many elements in ‘Jackals and Arabs’ that are found in the Judeo-Christian tradition of Gog and Magog, the Alexander Romance, and the Qur’anic story of Dhu’l-Qarnayn. A comparative analysis of these works reveals Kafka’s criticism of the Zionist movement. Kafka rejects Zionist exceptionalism and separatism through the narrator’s rejection of the jackals’ cause. Kafka’s jackals are compared to Gog and Magog, who are portrayed as corruptors of the land in the aforementioned texts. The categorisation of corruptors of the land is significant because this reverses Zionist claims of a profound connection to the land, which Kafka, likewise, reverses when the jackals claim that the desert is their home from which the Arabs should be removed. Zionist avowals of Arab backwardness are countered by Kafka as he makes the Arabs superior, which is also how the indigenous population are depicted in the Judeo-Christian and Muslim traditions since they are contrasted with the barbarity of Gog and Magog. Finally, the Zionist trope of the European Jewish hero who flees persecution is inverted by Kafka who confers on the narrator a quasi-prophetic/royal status similar to that of Dhu’l-Qarnayn and Alexander the Great. Full article

In his 1945 Nobel Prize acceptance speech, Sir Alexander Fleming warned of antimicrobial resistance (AMR) if the necessary precautions were not taken diligently. As the growing threat of AMR continues to loom over humanity, we must look forward to alternative diagnostic tools and preventive measures to thwart looming economic collapse and untold mortality worldwide. The integration of machine learning (ML) methodologies within the framework of such tools/pipelines presents a promising avenue, offering unprecedented insights into the underlying mechanisms of resistance and enabling the development of more targeted and effective treatments. This paper explores the applications of ML in predicting and understanding AMR, highlighting its potential in revolutionizing healthcare practices. From the utilization of supervised-learning approaches to analyze genetic signatures of antibiotic resistance to the development of tools and databases, such as the Comprehensive Antibiotic Resistance Database (CARD), ML is actively shaping the future of AMR research. However, the successful implementation of ML in this domain is not without challenges. The dependence on high-quality data, the risk of overfitting, model selection, and potential bias in training data are issues that must be systematically addressed. Despite these challenges, the synergy between ML and biomedical research shows great promise in combating the growing menace of antibiotic resistance. Full article

The Sagāthāvagga, the Book with Verses, and especially its third chapter, the Kosala-chapter (Kosala Saṃyutta), is presented here as a collection of early Buddhist wisdom literature. As the first book of the Pāli Saṃyutta-nikāya, the Book with Verses seems as an anomaly—the other four books contain some of the denser articulations of early Buddhist philosophy in the canon. Thus, scholars question whether the first book, which normally introduces verses with stories, is a real part of the collection. Scholars are also inclined to assume that the verses are the heart of the text and have shown less interest in the work’s compelling literary style. This article has three aims: First, it shows how the book, and most distinctly its third chapter, is a form of wisdom literature, with protagonist King Pasenadi of Kosala being comparable to wisdom-kings like King Solomon or Alexander the Great, and anticipating the classic Buddhist wisdom-king Aśoka. Second, it shows how this collection was designed for a performance by storytellers or preachers, suggesting that this is a feature of the Buddhist genre of prose that introduces verses. Third, it demonstrates the organic connection between the first book and the other books of the Saṃyutta. Full article

A number of foreign artists received the earliest commissions to represent Napoleon’s Russian Campaign of 1812 for Russian emperors. My paper is a case study of a German artist who served the Russian Imperial court. Peter von Hess trained at the Academy in Munich and served both King Ludwig I of Bavaria and Otto I of Greece. In 1839, Emperor Nicholas I commissioned the artist to complete 12 monumental canvases for the Winter Palace representing key battles that followed Napoleon’s invasion of Russia in 1812. While earlier battle paintings and portraits commissioned by Alexander I dealt only with elite officers and the emperor, Hess’s paintings elevated the common Russian as the bearers of a great sacrifice and as the true defenders of Russia. This representational shift is the product of changing ideas concerning Russia’s involvement in several alliances from 1803 to 1815 that included Austria, England, Sweden, and Prussia. In addition, over the course of Nicholas I’s reign, the concepts of “autocracy, orthodoxy, nationality” crept into representations of the Russian experience of the Napoleonic wars. Full article

This essay proposes a new interpretation of the Pauline expression to “clothe” (ἐνδύω) oneself in Christ (Rom 13:14; Gal 3:27; Eph 4:24; Col 3:10). The phrase has been understood in terms of putting on virtues and godly characteristics. Other understandings of this phrase appear in terms of a new identity (Gal 3:27). There has been relatively limited study, however, on the significance of clothing and how different racial groups were known and characterized by their dress. Clothing was not just something that one “puts on” to protect the body from the elements or analogously understood in terms of adopting virtues. Clothing was a racial signifier, and the putting on or taking off of clothing signaled a racial transformation. The ability to “put on clothes” would have been understood in terms of the malleable nature of racial identity. By drawing on the insights of Herodotus, Aeschylus, Plutarch, and other Greek and Roman writers, this reading proposes a racial interpretation of Paul’s “clothing” phrases in Romans 13:14, Galatians 3:27, Ephesians 4:24, and Colossians 3:10. This essay explores the interpretation of these Pauline passages in contemporary scholarship, describes how the changing of clothing also signified a change of racial identity, and lastly, demonstrates how these insights can impact our understanding of the Pauline expression to “clothe oneself in Christ”. Full article

This article aims to examine one of the myths belonging to the first part of Nonnus’ Dionysiaca, i.e., that of Io. Starting from the philological analysis of the passages dealing with this myth and adopting an intertextual approach, I will argue that the Panopolitan assimilates Io to Isis following Lycophron, one of the authors employed as a model in his poem. Finally, I will also explain the meaning of this choice inside Nonnus’ work, taking into account its historical context. Nonnus wants to emphasize the role of Dionysus’ lineage in the civilization process, giving it an historical relevance. Therefore, the allusion to Lycophron assimilates Cadmus (Dionysus’ grandfather) to Alexander the Great, who is celebrated as a peacemaker in the Alexandra. Furthermore, Cadmus and his offspring can be connected to the Romans, who, at the time of Nonnus, played the same role in the rising Byzantine empire. Full article

For at least a century the Bible played a significant, positive role in Native American letters starting with the eighteenth-century writings of Samson Occom. A product of the Great Awakening, Occom’s engagements with the Bible resembled those of other Protestant thinkers and writers of his time, although his sermons were sometimes specifically tailored for Indian audiences and topics. After Occom, Indian authors in the nineteenth century such as Elias Boudinot and William Apess drew upon the Bible to make arguments against removal and “scientific racism.” In the twentieth century writers like Zitkala-Ša and Charles Alexander Eastman cast a critical eye on Christianity and reconsidered the virtues of traditionalism. John G. Neihardt’s Black Elk Speaks (1932) was the century’s fullest literary depiction of a traditional religion, but it came at the cost of concealing Black Elk’s actual religion, Catholicism. During the 1960s and 70s oral tradition was privileged over sacred scripture, as seen in N. Scott Momaday’s House Made of Dawn (1968). While the Bible makes fewer appearances than it used to in Native American literature, it would be premature to suggest that Christianity is finished in Indian country. Full article

Cathepsin K (CatK) is a part of the family of cysteine proteases involved in many important processes, including the degradation activity of collagen 1 and elastin in bone resorption. Changes in levels of CatK are associated with various pathological conditions, primarily related to bone and cartilage degradation, such as pycnodysostosis (associated with CatK deficiency), osteoporosis, and osteoarthritis (associated with CatK overexpression). Recently, the increased secretion of CatK is being highly correlated to vascular inflammation, hypersensitivity pneumonitis, Wegener granulomatosis, berylliosis, tuberculosis, as well as with tumor progression. Due to the wide spectrum of diseases in which CatK is involved, the design and validation of active site-specific inhibitors has been a subject of keen interest in pharmaceutical companies in recent decades. In this review, we summarized the molecular background of CatK and its involvement in various diseases, as well as its clinical significance for diagnosis and therapy. Full article

The existence of high potential onshore and offshore active faults capable to trigger large earthquakes in the broader area of Thrace, Greece in correlation with the critical infrastructures constructed on the recent and Holocene sediments of Nestos river delta plain, was the motivation for this research. The goal of this study is twofold; compilation of a new geomorphological map of the study area and the assessment of the liquefaction susceptibility of the surficial geological units. Liquefaction susceptibility at regional scale is assessed by taking into account information dealing with the depositional environment and age of the surficial geological units. In our case, available geological mapping shows a deficient depiction of Pleistocene and Holocene deposits. Taking into consideration the heterogeneously behavior of active floodplains and deltas in terms of liquefaction, a detailed classification of geological units was mandatory. Using data provided by satellite and aerial imagery, and topographic maps, dated before the 1970’s when extensive modifications and land reclamation occurred in the area, we were able to trace fluvial and coastal geomorphological features like abandoned stream/meanders, estuaries, dunes, lagoons and ox-bow lakes. This geomorphological-oriented approach clearly classified the geological units according to their depositional environment and resulted in a more reliable liquefaction susceptibility map of 4 classes of susceptibility; Low, Moderate, High and Very High. The sediments classified as very high liquefaction susceptibility are related to fluvial landforms, the high to moderate liquefaction susceptibility ones in coastal and floodplain landforms, and low susceptibility in zones of marshes. The sediments classified in the highest group of liquefaction susceptibility cover 85.56 km² of the study area (16.6%). Particular attention was drawn to critical infrastructure (Kavala International Airport “Alexander the Great”) constructed on the most prone to liquefaction areas. Full article

Macedonia is a region in the Balkans with traditional boundaries at the lower Néstos (Mesta in Bulgaria) River and the Rhodope Mountains to the east; the Skopska Crna Gora and Shar mountains, bordering Southern Serbia, in the north; the Korab range and Ohrid and Prespa Lakes in the west; and the Pindus Mountains and the Aliákmon River in the south. Illyrian heraldry consists of manuscript collections with coats of arms—armorials that appeared on the Dalmatian coast, and in Italy, Spain, and Austria, in the late sixteenth and early seventeenth centuries. The two Stematographias of Pavle Ritter Vitezovich and Hristofor Zhefarovich are traditionally added to this group, as well as a number of other documents directly or indirectly related to the armorials. There is a possibility of a third: two different sources with relatively similar blazons, resulting in the simplification and inverse coloring of the both coats of arms. This would mean that it is quite possible that the Macedonian coat of arms was taken over by Capaccio, who took it from another older source. First of all, the coats of arms with a lion attributed to Alexander the Great should be taken into consideration. Full article