Search Results (25)

Atopic dermatitis (AD) is a chronic, multifactorial inflammatory skin disease characterized by persistent pruritus, immune system dysregulation, and an increased expression of cyclooxygenase-2 (COX-2), an enzyme that plays a central role in the production of prostaglandins and the promotion of inflammatory responses. In this study, we employed a comprehensive computational pipeline to identify phytocompounds capable of inhibiting COX-2 activity, offering an alternative to traditional non-steroidal anti-inflammatory drugs. The African and Traditional Chinese Medicine natural product databases were subjected to molecular screening, which identified six top compounds, namely, Tophit1 (−16.528 kcal/mol), Tophit2 (−10.879 kcal/mol), Tophit3 (−9.760 kcal/mol), Tophit4 (−9.752 kcal/mol), Tophit5 (−8.742 kcal/mol), and Tophit6 (−8.098 kcal/mol), with stronger binding affinities to COX-2 than the control drug rofecoxib (−7.305 kcal/mol). Molecular dynamics simulations over 200 ns, combined with MM/GBSA binding free energy calculations, consistently identified Tophit1 and Tophit2 as the most stable complexes, exhibiting exceptional structural integrity and a strong binding affinity to the target protein. ADMET profiling via SwissADME and pkCSM validated the drug-likeness, oral bioavailability, and safety of the lead compounds, with no Lipinski rule violations and favorable pharmacokinetic and toxicity profiles. These findings underscore the therapeutic potential of the selected phytocompounds as novel COX-2 inhibitors for the management of atopic-prone skin and warrant further experimental validation. Full article

The call to decolonize South African university curricula continues to shape academic discourse, highlighting the urgency of integrating African Indigenous Knowledge Systems (AIKSs) into theological education. While Western epistemologies have long dominated theology in Africa, this article argues for a paradigm shift by positioning public theology as a viable framework for engaging AIKS in meaningful and transformative ways. The article examines how AIKSs—expressed through oral traditions, communal spiritualities, and indigenous ethics—can enrich theological discourse, enhance contextual relevance, and address issues such as social justice, identity, and community cohesion. Drawing on the decoloniality discourse, this study critically explores the epistemological, institutional, and pedagogical challenges hindering integration and proposes concrete strategies including curriculum reform, faculty training, and community-based theological formation. The article contributes to the decolonization of theological education by offering a context-specific framework that repositions AIKSs as legitimate theological resources. In doing so, it advances a model of public theology that is inclusive, rooted in African realities, and responsive to the transformative needs of Southern African societies. Full article

This study proposes Tewahedo epistemology, an Ethiopian knowledge system grounded in the Ge’ez language, as a decolonial framework for re-visualizing academic literacy in higher education. Tewahedo, meaning “oneness” or “unity”, integrates multiliteracies—written, oral, spatial, and visual—within a communal and culturally embedded ethos through its Tergwame (ትርጓሜ) epistemes and Andǝmta (አንድምታ) traditions. The aim of the article is to challenge the dominance of skills-based literacy models by positioning Tewahedo as a decolonized alternative, emphasizing contextualized knowledge, communal meaning-making, and epistemic belonging. Through a literature review, the study explores Andəmta as a communal and dialogic system of knowledge sharing, rooted in Ge’ez and Amharic hermeneutics. This framework serves as a template for Africanizing and decolonizing contemporary academic literacy development. Findings reveal that Tewahedo epistemology offers ancient yet innovative strategies for fostering interpretive, explanatory, and multimodal competencies in academia. The study argues that adopting a unified Tewahedo-based academic literacy framework can cultivate intellectual agency, decolonize educational spaces, and center Indigenous Knowledge Systems. It calls for educational reforms that promote cultural diversity, legitimize Indigenous Knowledge Systems, and nurture academic belonging for students in multilingual and multicultural contexts. Full article

The long-term stability of orally transmitted ethnopharmacopoeias is of interest, but difficult to study for lack of information on plants used by a specific past culture. Similarities between modern Italian ethnopharmacopoeias and Dioscorides’ classical text have been proposed to derive from modern replacement of traditional practices with those from published translations of Dioscorides. Ibn al-Baytar produced the best compendium of medicinal substances in medieval Islamic science. He gave “Berber” common names for some plants, which were presumptively used by North African Amazigh people. Since Amazigh traditional knowledge was largely transmitted orally, with little access to medieval literature, this allows comparison of historic (>750 years ago) practices and modern practices that are unlikely to be causally derived. Presumptive identities for Ibn al-Baytar’s plants with Berber names were obtained from key references. Recent ethnomedicinal publications from Amazigh-populated areas in North Africa were surveyed for reports of those species and homologous common names. Of 46 historically used plants, an estimated 60.9% are still used in Amazigh regions, 78.6% with homologous common names. This is likely to underestimate persistence of species use across the entire local pharmacopoeia. Second, emulating a published analysis of Dioscorides, plants reported by three large recent studies in Amazigh regions were compared with plants recorded by Ibn al-Baytar and in a comprehensive modern Moroccan reference. Between 58.2% and 73.8% of species included in individual studies were recorded by Ibn al-Baytar; of the 46 shared among all three, 82.6% were recorded by Ibn al-Baytar and 100% by the modern reference. An historical compilation may be more likely to mention plants that are widely used today simply because a thorough author could document most plants that were widely used at the time; use of such data to assess causality should take that effect into consideration. Full article

Neoplastic diseases are common in African pygmy hedgehogs (Atelerix albiventris), with squamous cell carcinoma (SCC) being the most prevalent oral tumor. Traditional imaging techniques like computed tomography (CT) have limitations in accurately defining tumor extent and detecting metastasis. In this study, a hedgehog with a suspected oral tumor underwent 18F-FDG PET/CT imaging, revealing a hypermetabolic lesion consistent with SCC and indications of metastatic activity. The lesion was too extensive for a lumpectomy, and suspected metastasis led to the decision for euthanasia due to the impracticability of further treatment. A histopathological examination after autopsy confirmed the diagnosis and metastatic spread, as suggested by PET/CT findings. This is the first case report demonstrating the potential use of 18F-FDG PET/CT in hedgehogs, facilitating the accurate staging and management of oral SCC. Further research is needed to establish PET/CT as a standard diagnostic tool for neoplastic diseases in hedgehogs. Full article

Local ecological knowledge has been shown to convey key information about elusive mammal species. Many of Africa’s nocturnal mammals are not yet considered globally threatened, yet behavioural ecology and population trends across their diverse ranges remain effectively unknown. We conducted semi-structured oral and visual interviews with eight groups of Ba’Aka in three villages (n = 53 males; n = 17 females) using trigger cards, to gain insights into beliefs about nocturnal mammals in the Central African Republic (CAR). We aimed to (1) explore the presence and local knowledge of nocturnal mammals; (2) determine cultural attitudes regarding nocturnal species; and (3) report on Traditional Ecological Knowledge (TEK) in the CAR. Using trigger cards, interviewees identified nine nocturnal mammals. Frequency of key words was measured and presented in word clouds, depicting that angwantibos (Arctocebus aureus) (n = 14), genets (Genetta spp.) (n = 11) and tree hyrax (Dendrohyrax dorsalis) (n = 6) were strongly associated with the supernatural (witchcraft; spiritual protection). The traditional uses of cryptic nocturnal mammals in Ba’Aka culture, including as meat and medicine, may affect the conservation of these species. We suggest a need to protect and include nocturnal mammals with unknown or decreasing populations in wildlife management strategies and community conservation programmes. Full article

Mimusops zeyheri Sond. (Milkwood) is an indigenous fruit tree species with considerable ecological, cultural, and nutritional significance that remains underexploited. This review synthesizes current knowledge on its distribution, taxonomy, phytochemistry, ethnomedicinal applications, ecological functions, genetic diversity, and biotechnological potential. A systematic literature search, spanning 1949 to April 2024, yielded 87 relevant publications from an initial 155. Mimusops zeyheri plays a crucial role in supporting the cultural traditions and economic activities of Indigenous Southern African Communities. Its distribution encompasses South, East, and Southern Tropical Africa, with substantial populations across South African provinces. Ethnomedicinally, various plant parts treat conditions including wounds, gastrointestinal issues, and diabetes. The leaves (34%) and roots (32%) are used, with infusion (33%) and decoction (31%) as primary preparation methods. Oral administration (70%) is the most common, primarily addressing skin conditions (18%). Despite its nutritional richness, a standardized nutrient profile is lacking. Limited genetic diversity studies underscore the need for further research. This study highlights Mimusops zeyheri’s multifaceted importance and research gaps, particularly in other Southern African countries. Future investigations should focus on comprehensive phytochemical analysis, ethnomedicinal validation, ecological conservation, genetic diversity assessment, and biotechnological applications. Multidisciplinary collaborations are recommended to promote sustainable utilization while preserving traditional practices. Full article

This article is a reflection on the history of enslaved children (Pon pekpen) in African slavery and post-slavery societies, such as the Bamum Kingdom. This traditional monarchy of the Grassfields of Cameroon, founded in 1394 by Nchare Yen, was one of the largest providers of captives transported to the Atlantic coast and used locally to meet the needs of traditional slavery. In this kingdom, slaves and their descendants, as well as enslaved peoples, represented nearly 80% of the total population. The trade of captives and servile practices left indelible traces, particularly where enslaved children were concerned. So, what did enslaved children represent in African slavery and post-slavery societies, such as the Bamum Kingdom? The aim of this study is to show that the enslaved children were the most vulnerable and dependent members of slavery and post-slavery systems. This study is based on oral, archival iconographic, written and electronic sources, using theories of social dominance and subaltern studies. It clearly shows that the vulnerability and dependence of enslaved children (Pon pekpen) made them special, weak and hopeful links in the slavery system and the persistence of slavery practices. They were mainly victims of traditional slavery and of the trans-Saharan and transatlantic slave trades. Despite the formal abolition of the slave trade and slavery between the 19th and 20th centuries, enslaved children and the descendants of enslaved people continue to be victims of a kind of subalternisation because they are usually considered second-class citizens. Full article

(1) This research paper aims to conduct a comprehensive review of the existing scientific literature on intentional dental modifications within the African population. By synthesizing and analysing studies, this paper aims to shed light on the prevalence, cultural significance, and forensic implications of intentional dental modifications. (2) A scoping review was conducted according to PRISMA for Scoping Reviews and a search performed in June 2023 on the three electronic databases Scopus, PubMed, and Web of Science. (3) The search resulted in 30 studies and showed that intentional dental modifications, also referred to as nontherapeutic dental modifications, are prevalent across the African population for reasons linked to traditional medicine, ethnic affiliation, and individualism, with the highest-reported modification being infant oral mutilation at 53%, followed by tooth filing at 10%, and others such as lip plates, diastema piercings, dental avulsion, dental tattooing, crowns, and oral piercings. (4) The quality and quantity of the available literature on intentional dental modifications in the African population is limited due to bias in reporting, as most studies are those of individuals with severe health complications. The data gathered from this study could further aid in the analysis and identification of nontherapeutic dental modifications, be used in profiling, and assist in the estimation of population affiliation. Full article

The land, ‘things’/objects, and memory in the form of narratives and metaphors are intricately bound together. They all constitute the iconography of a shared set of ideas, beliefs, feelings, values, practices, and performances that objectify collective identities. Respectively, these complex entangled tangible and spiritual/invisible indices of identities situated in places deserve special archaeological devotion. However, since African archaeology and history remains trapped in Eurocentric colonial metanarratives, indigenous epistemologies and ontologies have somehow remained on the margins of knowledge production processes. This deliberate erasure and silencing continues to impede archaeology’s capacity to explore hidden meanings and values that people imbue to places and landscapes through time. Owing to this setback, multiple precolonial group identities in parts of Zimbabwe, South Africa, Botswana, and Mozambique such as Torwa, Twamamba, Rozvi, Singo, and Venda, among others, remain vague and subjectively tied to the archaeology of Butua/Torwa (AD 1400–1644) and Rozvi (AD 1685–1830) state systems. The failure to read the landscape as both a repository of memory and an agent for collective identities continues to compound our archaeological challenges. Against this background, Rozvi oral narratives and the Insiza cluster Khami-phase sites in southwestern Zimbabwe are subjected to renewed scrutiny. Following a critical review of colonial archives and Rozvi traditions, it turned out that instead of contradicting ‘science’, oral traditions actually amplify our reading of the archaeological record, only if handled properly. Full article

Toni Morrison represents the improvisations of life in the 1920s and posits her novel Jazz as a work that negotiates sound as a distinguishing characteristic of her writing genre. Many critics have described Morrison’s approach as a Jazzthetic strategy and as such, her rhetorical move enables a renovation of traditional aspects of the novel to render life as complex as a jazz composition itself. This article analyzes Morison’s methods and posits the use of jazz strategies to mimic the displacement, fragmentation, and strife experienced by African Americans during the Great Migration. This essay also intervenes in the debate between the relationship of language and music to examine the ways that Morrison oralizes fiction and engages in a form of cultural circularity, thereby asserting the authenticity of jazz alongside the tension of the Great Migration. Additionally, this essay explains the ways that Morrison makes clear the implications of migrant cultural expression in service of identity formation, suggesting that the micro-novels in the novel Jazz are contributors to a larger ensemble that functions epistemologically to render the African American experience as central to American identity. Full article

Dried leaves of Lannea velutina A. Rich. and Sorindeia juglandifolia (A. Rich.) Planch. ex Oliv. (family Anacardiaceae) are used in African traditional medicine. Although these medicinal plants have widespread use in the treatment of inflammatory diseases, there is no scientific data concerning their preclinical or clinical safety. This work aimed to investigate the phytochemical properties of the leaves of both species using HPLC-UV/DAD, as well as the in vivo oral repeated-dose toxicity of 70% hydroethanolic leaf extract of S. juglandifolia and the in vitro genotoxicity of 70% hydroethanolic leaf extracts of L. velutina and S. juglandifolia. Clinical signs of toxicity, body weight variations, and changes in food consumption, mortality, and blood biochemical parameters were monitored. Genotoxicity was assessed using the bacterial reverse mutation assay (Ames test) with and without metabolic activation, according to OECD guidelines. The obtained results showed the presence of gallic acid and anacardic acid as the main marker constituents in both species. No significant changes in general body weight or food intake were observed; small significant changes with no critical relevance were observed in the blood biochemistry of animals treated with S. juglandifolia hydroethanolic extract (50, 400, and 1000 mg/kg body weight) compared to those in the control group. No genotoxicity was observed in the bacterial reverse mutation assay with S. juglandifolia and L. velutina extracts (up to 5 mg/plate). The safety data obtained in vivo and lack of genotoxic potential in vitro points to the safe medicinal use of S. juglandifolia and L. velutina extracts. Full article

The historical value of the oral tradition permeates literature as represented in multiple disciplines, including theology. An aspect of this tradition has proven viable in spiritual conversations with older adults. This paper will discuss the oral tradition’s medium of storytelling and listening to demonstrate its relevance in therapeutic conversations with older adults. Therapeutic storytelling is a distinct intervention prevalent in the African oral tradition This approach is also gaining attention in the contemporary context, blending seamlessly within the narrative approach. Using the quantitative research method of ethnography and autoethnography, I analyze specific therapeutic encounters that employ a storytelling/listening approach in spiritual conversations. The analysis reveals the relevance of storytelling in specific therapeutic encounters. Storytelling is gaining interest and reclaiming space in therapeutic settings with diverse populations, but mostly with older adults. The study also highlights the apparent similarities between the traditional approach to storytelling and the narrative approach in the contemporary therapeutic milieu. Full article

A South African traditional formulation, PHELA^®, is consumed by the traditional people for severe chest problems with coughing, diarrhea, oral ulcers etc. The present study focused on establishing the anti-infective properties of a safe and standardized poly-herbal formulation through a series of criteria and specifications. Full article

The use of medicinal plants for contraception remains a common practice among South African ethnic groups. The present study assessed the phytochemical profile, cytotoxicity, acute oral toxicity and efficacy of a herbal mixture used for contraception by the Batswana of South Africa. An aqueous extract was prepared from equal quantities (in terms of weight) of Bulbine frutescens (roots), Helichrysum caespititium (leaves) and Teucrium trifidum (leaves) based on a recipe used by traditional health practitioners. The phytochemical profiles of the freeze-dried herbal mixture were analyzed using gas chromatography–mass spectrometry (GC-MS). In addition, cytotoxicity was determined using an MTT assay on Vero cells and in vivo contraceptive efficacy was evaluated using seven Sprague Dawley rats per control and treatment groups. The control group received distilled water while test groups received 5, 50 and 300 mg/kg of the herbal mixture, which was administered orally once a day for three consecutive days. Subsequently, female rats were paired 1:1 with males for 3 days. Their weights were measured weekly and incidence of pregnancy was recorded. The GC-MS chromatogram revealed the presence of 12 identified and 9 unidentified compounds. In terms of safety, the herbal mixture had an IC₅₀ value of 755.2 μg/mL and 2000 mg/kg, which was the highest tested dose that caused no mortality or morbidity in the rats. A contraceptive efficacy of 14.5% was exerted with 50 mg/kg herbal mixture extract while other doses had no effects given that all the rats were pregnant. Based on a chi-square test (p < 0.05), there was no correlation between the tested herbal mixture doses and contraception, nor on the weight of the rats. Overall, the herbal mixture extract was found to be safe but had limited contraceptive efficacy at the tested doses. In future studies, exploring increased dose range, solvent extract types and hormonal analysis will be pertinent. Full article