Search Results (62)

Pressure-controlled intermittent coronary sinus occlusion (PICSO) was initially developed to salvage ischemic myocardium. However, recent evidence suggests a more profound role: reawakening embryonic molecular pathways that facilitate myocardial regeneration. This review examines the paradigm shift in PICSO’s mechanism—from its traditional focus on infarct size reduction to its emerging role as a catalyst for myocardial repair through the reactivation of embryonic signaling. Findings suggested that myocardial decay could be ameliorated beyond salvage, revealing that PICSO enhances vascular activation in the coronary venous system, thereby influencing the fate of endothelial and myocardial cells. The theorem “embryonic recall” posits that PICSO induces molecular signals reminiscent of early cardiac development, offering a novel approach to cardiac repair in myocardial jeopardy. Noncoding RNA serves as a universal signaling event, thereby supporting the hypothesis. Yet, conflicting clinical outcomes highlight the need to redefine PICSO’s objectives, optimize device settings, and realize interventional strategies. The evolution of PICSO demands a radical shift in scientific perspective. Beyond ischemic salvage, its true potential may lie in harnessing regenerative mechanisms within the failing heart. Modern cardiology must adopt this dual role, bridging mechanical intervention with molecular rejuvenation to ensure its continued viability as a therapeutic option. PICSO, like the phoenix, may yet rise anew as a transformative force in cardiovascular medicine. Full article

Endometriosis is traditionally regarded as a condition predominantly affecting women of reproductive age, often associated with infertility and cyclical pelvic pain. As a result, a significant body of research and clinical attention has been directed toward the younger patient population. However, there is growing recognition that endometriosis can persist or even arise anew in peri-menopausal and post-menopausal women, yet the impact of the disease in this group remains underappreciated. Many women may have lived with undiagnosed or misdiagnosed endometriosis for decades, often being reassured that period pain and pelvic discomfort were normal aspects of menstruation, and therefore not subjected to appropriate investigation or intervention. This review aims to highlight the clinical significance of endometriosis in peri-menopausal and post-menopausal women. We will examine the common symptoms encountered in this population, discuss current strategies and challenges in diagnosis, and review evidence-based approaches to management. Special consideration will be given to the complex interface between endometriosis and HRT, as well as the potential risk of malignant transformation. Finally, drawing from existing guidelines and expert opinion, we propose recommendations for the diagnosis, treatment, and long-term follow-up of these patients, with the goal of improving outcomes and quality of life for this often overlooked cohort of women. Full article

Ridge and furrow planting is a prevalent drought-resistant cultivation technique in dryland regions. Notably, the effects of this technology on crop grain yield and quality in dryland maize–wheat double-cropping systems remain limited. This study utilized a long-term positioning experiment initiated in 2004, which included five treatments: a permanent ridge and furrow with a border ridge of 133 cm row space (PRFBR); a ridge and furrow created each year with a border ridge of 133 cm row space (EYRFBR); a permanent ridge with a normal ridge of 100 cm row space (PRFNR); a ridge and furrow created each year with a normal ridge of 100 cm row space (EYRFNR), and a conventional flat planting pattern according to the local farmer (CF). The crop grain yield in 2015–2021, as well as the protein and phosphorus (P) and potassium (K) content in maize and wheat grains, and the protein components in winter wheat grains in 2020–2021 were investigated. The results showed that, compared to CF, all four ridge and furrow planting patterns significantly enhanced crop yield in dry and normal years, and the effects varied depending on crop species, with increases of 45.3–97.8% for wheat and 11.0–33.8% increases annually in dry years; and 24.5–51.6% increases for maize and 12.2–37.5% increases annually in the normal years. EYRFBR treatment increased wheat grain P and K content by 24.3% and 13.7%, as well as increasing the total protein, albumin, gliadin, soluble protein, and storage protein content by 9.7%, 22.3%, 9.6%, 14.5%, and 5.6%, whereas PRFNR reduced the glutenin content and glutenin/gliadin ratio in winter wheat grains by 5.1% and 10.9%, respectively. The yield achieved with a permanent ridge and furrow (PRF) surpassed that achieved when the ridge and furrow was created anew each year (EYRF), yet the normal ridge width (NR) outperformed the border ridge width (BR). However, the P, K, protein, and protein component content in wheat grains under EYRF was superior to that under PRF. Comprehensive evaluations through principal component analysis (PCA) and TOPSIS analysis consistently demonstrated that the EYRFBR treatment delivered optimal performance in yield and quality for winter and annual, while PRFNR achieved superior yield for summer maize. Consequently, in dryland maize–wheat double-cropping systems, an EYRFBR planting pattern should be recommended for high-yield and high-quality wheat production; however, the PRFNR planting pattern is more suitable for summer maize production. Full article

We present a measurement-driven model in which the black hole horizon functions as a classical apparatus, with Planck-scale patches acting as detectors for quantum field modes. This approach reproduces the Bekenstein–Hawking area law $S_{\mathrm{BH}}={\displaystyle \frac{A}{4{\mathsf{\ell }}_p^2}}$ and provides a concrete statistical interpretation of the $1/4$ factor, while adhering to established principles rather than deriving the entropy anew from first principles. Each patch generates a thermal ensemble (∼0.25 nat per mode), and summing over area-scaling patches yields the total entropy. Quantum simulations incorporating a realistic Hawking spectrum produce $⟨S_k⟩=0.257$ nat (3% above 0.25 nat), and we outline testable predictions for analogue systems. Our main contribution is the horizon-as-apparatus mechanism and its information-theoretic bookkeeping. Full article

In the period between 2021 and 2022 immediately following the COVID-19 lockdowns, there were 37 professional or academic productions of The Tempest in the United States. The play was by far the most produced of Shakespeare’s works in this timespan, and those 37 productions represent a 280% increase compared to 2019, in which there were 13 such productions. Considering The Tempest’s hyper-popularity within the context of the Black Lives Matter Movement and the birth of We See You White American Theatre’s calls for reform in 2020, this paper seeks to understand anew the way in which Shakespeare constructs blackness in the play. Indeed for all of its beauty and magic, The Tempest stages a violent anti-blackness in its treatment of Caliban. In particular, I argue an unexplored connection between The Tempest and Ben Jonson’s 1605 court masque, The Masque of Blackness, itself an exploration of the construction of race for a particular early modern audience. My exploration here began as a partial answer to a question posed by Robin Alfriend Kello: “how do you balance [an] attraction to the richness of Shakespearian verse against these layered histories of racial violence and exclusion?” A deeper understanding of Shakespeare’s version of blackness may grant insights into areas of intervention for those theaters reaching for The Tempest amidst national calls for anti-racist theatrical work. Full article

This article discusses the conversion of Hagia Sophia to a mosque in 2020. Examining this act through the prism of the neo-Ottoman political platform and with consideration of the meaning and importance of this historic cultural monument, it is inferred that the reconversion constitutes a political decision par excellence, intended to symbolically mark the beginning of a new era for Turkey while closing the chapter of Kemalism. In doing so, the current political establishment seeks to communicate its resolution to invert the process of secularisation, as a form of revanche for the Westernisation of the country and the identity erosion that it caused. Further, the reconversion symbolically connotes the conquest of Constantinople and the triumph of Islam over Christianity anew, harking back to past glories and upholding them as guidelines for the future, thus hinting to a revisionist political agenda, applicable both domestically and abroad, intended, according to rhetoric at least, to consolidate Turkey as a regional power and a worthy successor of the Ottoman Empire. Full article

In Marie-Elena John’s 2006 novel Unburnable, Lillian Baptiste returns to Dominica from the United States intending to confront the secrets and traumas of her maternal family line. The novel structures Lillian’s developing apprehension of who her mother and grandmother were and what they endured in late-colonial Dominica around a series of revelations regarding each woman’s imbrication within the realm of the magico-spiritual, which includes magic, Obeah and their cognates; Catholicism; spells and curses; ghosts and other spirit manifestations; and extra-sensory perception. The reader comes to understand Lillian as (and sometimes before) Lillian comes to understand herself: the last in a line of magico-spiritually powerful women whose encounters with colonial catastrophe and its heteropatriarchal, racist–classist machinations are both figured through and navigated by way of that power. Where socioeconomic and political power may conventionally be regarded as the proper subject of realist fiction and social-science inquiry, and magico-spiritual power as within the ambit of magical-realist fiction and folklore studies, Unburnable proposes worldly and magico-spiritual power as inhabiting the same material, political and psycho-social plane of Caribbean reality: as mutually entangled, co-constituting, reciprocally illuminating and, above all, dually heritable forces. In this way, the novel issues an invitation to rethink questions of power in the shadow of the Caribbean plantation and consider anew the ways in which it is, on the one hand, hoarded, bequeathed and weaponized against the vulnerable and, on the other, fluid, arcane in its sources and workings, and susceptible to insurgent counter-deployments. Full article

Just war theory, significantly shaped by Christian moral theology, has provided a prominent ethical framework for discussions on the justice of war. Numerous works have been published on classical Chinese counterparts, including passages from the Mengzi, Mozi, Xunzi, and Huangdi Sijing. Although the Zhuangzi frequently discusses warfare, it has been largely overlooked in this field of research because its war ethics do not revolve around any concept similar to that of justice. Based on Zhuangzian critiques of Confucian and Mohist views on justice, this paper tentatively reconstructs Zhuangzian war ethics. This reconstruction reveals a perspective that the concept of just war or justified war is inherently problematic, and promoting such ideas can be perilous and even morally questionable. The belief that just war theory can help us identify a “just side” to morally condemn or legally restrain aggressors is a dangerous illusion. In practice, this approach fails to prevent wars and often exacerbates conflict. According to the Zhuangzian perspective, during wars, states do not operate as traditional political entities with universal jurisdiction and centralized authority. Instead, they resemble rivers and lakes with indistinct boundaries, rendering the concepts of justice and punishment largely irrelevant. A practical peace strategy, therefore, must abandon the pursuit of administering justice and punishing wrongdoers. Instead, it should focus on strategies that facilitate the involved parties to “forget” their grudges and start their peaceful relationship anew. Full article

We revisit Weyl’s unified field theory, which arose in 1918, shortly after general relativity was discovered. As is well known, in order to extend the program of the geometrization of physics started by Einstein to include the electromagnetic field, H. Weyl developed a new geometry which constitutes a kind of generalization of Riemannian geometry. In this paper, our aim is to discuss Weyl’s proposal anew and examine its consistency and completeness as a physical theory. We propose new directions and possible conceptual changes in the original work. Among these, we investigate with some detail the propagation of gravitational waves, and the new features arising in this recent modified gravity theory, in which the presence of a massive vector field appears somewhat unexpectedly. We also speculate whether the results could be examined in the context of primordial gravitational waves. Full article

During the energy transition period and the increased supply of developed land, an analysis was conducted on the economic viability of transforming post-mining buildings. This study sought to answer the following questions: Does the circular economy create new conditions for adapting these specific industrial facilities? Should mining buildings be adapted or should they be demolished and built anew? The objectives of the article were to perform a comparative analysis (financial, environmental, and social) of these alternatives and to develop a decision-making model for managing obsolete mining facilities using circular economy principles. Decision-making regarding mining buildings should occur as part of revitalising post-mining areas. Consequently, the method used was research through design followed by comparative analyses: financial, environmental, and social. As a result, the study demonstrated the potential for adapting buildings on a defunct mining site, mainly compressor and fan station. The financial, environmental, and social profitability of investing in the adaptive reuse of historic buildings was established. The entire process was encapsulated in a universal decision-making model. The analytical results presented in the article indicate that mining buildings represent a significant resource in a circular economy and their adaptation should be prioritised. Full article

It is an irony of history that since texts transcend the intentions and purposes of their authors, their meaning and significance are often contested anew as they enter new historical contexts; even historical texts are thus subject to reading and criticism over time. This article discusses the posthumous fate of Henry Stubbe’s own text on Islamic history, The Rise and Progress of Mahometanism—seen by some to represent a Copernican revolution in the study of Islam. The fate of this work is a clear example of the critical contingencies and fluctuating fortunes experienced by a corpus of texts. The continuing existence of a text as an object open to reconfiguration and re-evaluation is termed its after-history (Nachgeschichte) or afterlife (Nachleben). This notion of the afterlife of an object as a period of critical appreciation and political appropriation aptly defines the fate and fame of The Rise and Progress of Mahometanism. The present study seeks to explore the narrative surrounding a publication authored by Stubbe in the 17th century and finally published by Hafiz Mahmud Khan Shairani, with the critical support of Ottoman intellectual Halil Halid Bey, nearly two centuries later. Its objective is to investigate how the life and contributions of a figure whose work has transcended generations was resurrected within the political backdrop of the 20th century, as evidenced in the columns of Ottoman newspapers. Full article

Community revitalization is a complex, multifaceted process, studied conceptually and empirically in the vast multidisciplinary literature. Among the cited elements of community revitalization are housing; school, civic, and retail spaces; street networks; parks; and green spaces. However, the elements are commonly studied in isolation, not considering their interrelated qualities as all-of-a-piece of the community revitalization process. In this paper, we draw on the concept of the neighborhood unit that facilities a holistic approach to community revitalization. We show how the neighborhood unit is metamorphosed and thereby endured from the classic to the contemporary. We argue that the neighborhood unit informs, as well as being challenged by, community revitalization. Furthermore, inadequate attention is given to how urban revitalization challenges the efficacy of the neighborhood unit itself. The inner-city blight provides an impetus to look beyond the neighborhood to the metropolitan region as a whole. The neighborhood unit’s fundamental limitation is posed by its cellular autonomy, in favor of alternatives that connect the neighborhood to the metropolitan region’s jobs–housing–services–mobility opportunity holistically. Our literature review of the impactful elements of community revitalization is aided by AI (ChatGPT) as an expeditious search engine. It is found that the AI-aided search of the universal poses anew the significance of the particular—the site- and context-specific. We conclude with universal “performance dimensions” of Good City Form that are calibrated locally, reflecting the goodness of the city form, of which the neighborhood is a building block. Full article

This paper introduces a novel natural language processing (NLP) model as an original approach to sentiment analysis, with a focus on understanding emotional responses during major disasters or conflicts. The model was created specifically for Croatian and is based on unigrams, but it can be used with any language that supports the n-gram model and expanded to multiple word sequences. The presented model generates a sentiment score aligned with discrete and dimensional emotion models, reliability metrics, and individual word scores using affective datasets Extended ANEW and NRC WordEmotion Association Lexicon. The sentiment analysis model incorporates different methodologies, including lexicon-based, machine learning, and hybrid approaches. The process of preprocessing includes translation, lemmatization, and data refinement, utilized automated translation services as well as the CLARIN Knowledge Centre for South Slavic languages (CLASSLA) library, with a particular emphasis on diacritical mark correction and tokenization. The presented model was experimentally evaluated on three simultaneous major natural crises that recently affected Croatia. The study’s findings reveal a significant shift in emotional dimensions during the COVID-19 pandemic, particularly a decrease in valence, arousal, and dominance, which corresponded with the two-month recovery period. Furthermore, the 2020 Croatian earthquakes elicited a wide range of negative discrete emotions, including anger, fear, and sadness, with the recuperation period much longer than in the case of COVID-19. This study represents an advancement in sentiment analysis, particularly in linguistically specific contexts, and provides insights into the emotional landscape shaped by major societal events. Full article

Today, the growing ecological contamination by microwave irradiation requires new devices and information systems to monitor dangerous situations, especially in big cities, and provide safety for the population. This work is focused on the design of anew antenna unit for advanced portable personal microwave dosimeters and irradiation monitoring systems. Full article

This essay brings psychoanalytic theory on trauma together with film and television criticism on rape narrative in an analysis of Michael Coel’s 2020 series I May Destroy You. Beyond the limited carceral framework of the police procedural, which dislocates the act of violence from the survivor’s history and context, Coel’s polyvalent, looping narrative metabolizes rape television’s forms and genres in order to stage and restage both trauma and genre again and anew. Contesting common conceptions of vulnerability and susceptibility that prefigure a violent breach of autonomy, Coel’s series and her interviews about it invite an ethics of looking that embraces a curiosity in the unknowable and untreatable kernel of subjective experience and defies and resists a policing of the survivor’s thoughts and emotions. By emphasizing and exploring what psychoanalysis calls the “afterwardness” of trauma, Coel foregrounds her main character’s subjectivity prior to her victimization, widens the sphere of consequence beyond the victim and criminal justice system to the survivor’s larger community, and entreats that community to preserve a space for her to look and look again at everything, without judgment. Full article