Search Results (220)

Background/Objectives: Endometrial cancer (EC) is the most prevalent gynecological malignancy, with increasing incidence and mortality. HOXA5, a developmental transcription factor, has been linked to prognosis in various cancers, but its role in EC remains unclear. This study aimed to evaluate the prognostic potential of HOXA5 in EC and to explore its association with common tumor-related proteins. Methods: We analyzed 75 EC tissue samples using immunohistochemistry to evaluate HOXA5 expression and its association with clinicopathological features and tumor-related biomarkers, including Ki-67, CD31, and fibronectin. Statistical analyses included logistic regression and Kaplan–Meier survival analysis. Results: High HOXA5 expression was significantly associated with elevated Ki-67 levels (p = 0.001) but paradoxically correlated with improved overall survival (p = 0.026). CD31 and fibronectin levels were significantly lower in the high-HOXA5 group (p = 0.007 and p = 0.001, respectively), suggesting reduced angiogenic and invasive potential. However, neither marker remained significant in multivariable analysis. Conclusions: HOXA5 may exert a dual role in EC by promoting proliferation while limiting tumor progression via suppression of angiogenesis and matrix remodeling. It holds potential as a prognostic biomarker and therapeutic target. Full article

We investigated the application of artificial intelligence (AI) technology for the inspection of semiconductor process equipment to address key issues such as low production efficiency and high equipment failure rates. The semiconductor industry, being central to modern technology, requires complex and precise processes where even minor defects lead to product failures, negatively impacting yield and increasing costs. Traditional inspection methods are not adequate for modern high-precision, high-efficiency production demands. By integrating advanced AI technologies, such as machine learning, deep learning, and pattern recognition, large volumes of experimental data are collected and analyzed to optimize process parameters, enhance stability, and improve product yield. By using AI, the identification and classification of defects are automated to predict potential equipment failures and reduce downtime and overall costs. By combining AI with automated optical inspection (AOI) systems, a widely used defect detection tool has been developed for semiconductor manufacturing. However, under complex conditions, AOI systems are prone to producing false positives, resulting in overkill rates above 20%. This wastes perfect products and increases the cost due to the need for manual re-inspection, hindering production efficiency. This study aims to improve wafer inspection accuracy using AI technology and reduce false alarms and overkill rates. By developing intelligent detection models, the system automatically filters out false defects and minimizes manual intervention, boosting inspection efficiency. We explored how AI is used to analyze inspection data to identify process issues and optimize workflows. The results contribute to the reduction in labor and time costs, improving equipment performance, and significantly benefitting semiconductor production management. The AI-driven method can be applied to other manufacturing processes to enhance efficiency and product quality and support the sustainable growth of the semiconductor industry. Full article

This study develops an algorithm and a system for steel straightness detection, which combines object detection, edge detection, line detection, clustering, stitching, and bending recognition. The algorithm detects the contour of U-shaped steel bars with widths of 100 mm, named U100, or 150 mm, named U150, and lengths of 8, 10, 12 m. The algorithm uses object detection to extract the center point of the U-shaped bottom as a reference point and line detection to extract lines in the contour. The algorithm selects one-stage or two-stage edge detection based on the light source. Two-stage edge detection enhances the contour features when the light source is insufficient. After contour detection, some parts of the contour disappear due to the light source. The algorithm stitches all lines with an angle difference within $∆\theta$ degrees into one straight line L based on the angle of the longest line. If the length of L exceeds the threshold value $MLL$, the steel bar is straight; otherwise, it is bent. $∆\theta$ and $MLL$ are used to set the acceptable bending degree. The experiment results show that the algorithm detects 123,128 steel bars in 193 h with an average accuracy of 99.64% for straight steel and an average recall of 95.70% for bent steel. The contribution of this study is the development of a real-time algorithm and its corresponding system for steel straightness determination in a steel factory, ensuring accurate and efficient assessment of steel quality in an industrial setting. Full article

Recessive variants of SLC26A4 are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic SLC26A4 variants often suffer from fluctuating hearing loss and recurrent vertigo, ultimately leading to severe to profound hearing impairment. However, there are currently no satisfactory prevention or treatment options for this condition. The CRISPR/Cas9 genome-editing technique is a well-known tool for correcting point mutations or manipulating genes and shows potential therapeutic applications for hereditary disorders. In this study, we used the homology-independent targeted integration (HITI) strategy to correct the SLC26A4 c.919-2A>G variant, the most common SLC26A4 variant in the Han Chinese population. Next-generation sequencing was performed to evaluate the editing efficiency of the HITI strategy. The results showed that only 0.15% of the reads successfully exhibited HITI integration, indicating that the c.919-2 region may not be a suitable region for HITI selection. This suggests that other site selection or insertion strategies may be needed to improve the efficiency of correcting the SLC26A4 c.919-2A>G variant. This experience may serve as a valuable reference for other researchers considering CRISPR target design in this region. Full article

Background/Objectives: This novel compression screw design offers potential benefits due to its two-part structure and can be used for various bone types, much like a conventional single-piece compression screw. However, full engagement may not always occur after final compression in clinical practice. This study aimed to verify the hypothesized optimal mechanical strength when the two parts are nearly fully combined and to determine a recommended engagement range based on stress distribution and concentration using finite element analysis. Methods: Ten models representing different combinations of the two screw parts (ranging from 10% to 100% of the engagement length, at 10% intervals) were simulated to determine the acceptable engagement percentage. Pull-out and bending load simulations were performed using finite element models. Extreme clinical loading conditions were simulated, including 1000 N pull-out forces and a 1 Nm bending moment at the screw head. Results: Finite element analysis revealed two stress concentration points. The pull-out load simulation showed that combinations with 100% engagement merged the two stress concentrations into one without force superposition, while combinations with less than 30% engagement should be avoided. In the bending load simulation, higher stress was observed for combinations with less than 90% engagement. A lower level of engagement increases the bending moment, which might be the major factor affecting the von Mises stress. Conclusions: Surgeons should be instructed on how to use the screw correctly and select the most appropriate screw size or length for the two parts to achieve an effective combination. Excessive bending or pull-out forces, or improper use with poor combinations, may cause the middle interval to strip or the screw to break or pull out. An engagement of more than 90% is recommended, while less than 30% is considered dangerous. This study provides biomechanical insights into this novel two-part screw design and its important clinical implications. Full article

Background/Objectives: The pullout failure of conventional locking screws (LSs, screws with a locking mechanism) may occur in patients with osteoporosis, particularly when inserted near joints or across periarticular fractures (e.g., proximal humerus). The two-part locking cancellous screw modification (TP-LCS, screws composed of two parts) in metaphyseal cancellous bone is hypothesized to increase bone purchase and holding power. This study aimed to test the hypothesized advantages of TP-LCS over LSs. Methods: An MTS 370 series frame with an axial/torsional load cell was used to test driving torque and axial pullout strength, following ASTM F543-07 standards. The TP-LCS group featured a newly modified screw design made from titanium alloy (Ti6Al4V), while conventional LSs (Synthes) were used for the control group. Statistical significance was assessed for selected comparisons relevant to the research objectives, including driving torque and axial pullout strength. Results: The driving torque test showed that TP-LCS had a significantly higher maximum insertion torque (4.9 ± 0.4 N·cm) compared to LSs (4.2 ± 0.4 N·cm) (p = 0.0269), although no significant difference was found in maximum removal torque (p = 0.1046). The axial pullout test revealed that TP-LCS had significantly higher pullout strength (223.5 ± 12.2 N) compared to LSs (203.5 ± 11.5 N) (p = 0.0284). Failure during the axial pullout test often involved cracking of the test block material around the screw threads, causing the screw to pull out. Conclusions: These results support the hypothesis that TP-LCS may offer improved axial pullout resistance compared to LSs, making it a potentially beneficial modification for LSs in osteoporotic metaphyseal regions or near joints. This study provides biomechanical insights into the advantages of the modified screw design over conventional LSs. Full article

Background: There was little knowledge of the dietary diversity of older adults in rural areas, with limited studies examining their nutritional status and related factors. This study aimed to assess the nutritional status of older adults in rural communities in Taiwan and explore the association between characteristics and the dietary diversity score (DDS). Methods: We collected data on sociodemographic, nutritional status, and DDS. The DDS was estimated based on nutritional intake using a 24 h dietary recall (24HR). Participants were grouped by distance from the city center into three categories (0–4 km, 4–8 km, and >8 km) to assess their correlation with food diversity. Results: A total of 567 participants were included, of whom 81.3% were women, and 65.5% were over 75 years of age. Of the participants, 154 lived within 4 km of the city center, 255 lived 4–8 km away, and 158 resided in remote communities (>8 km from the city center). Out of 538 participants who completed the dietary questionnaire, 274 (50.9%) were categorized as having low dietary diversity (DDS ≤ 4), while 264 (49.1%) were categorized as having high dietary diversity (DDS > 4). Conclusions: Our results showed the distance from the community to the city center significantly influences the DDS of the residents in rural communities. Nearly half of the rural population has a low DDS. The implementation of the research project aimed to determine the feasibility of daily nutrition evaluation and optimization programs for the elderly in rural areas is crucial in the future. Full article

This study investigates the chemical composition and antioxidant and antifungal activities of essential oils (EOs) extracted from different parts of Alpinia uraiensis Hayata, an endemic species of Taiwan. EOs were obtained from flowers, leaves, stems, roots, and rhizomes using hydrodistillation, and their compositions were analyzed by gas chromatography–mass spectrometry (GC-MS). Monoterpene hydrocarbons and oxygenated monoterpenes were predominant, with flower and leaf EOs rich in γ-terpinene, terpinen-4-ol, and 1,8-cineole, while root EO was characterized by fenchyl acetate (72.2%). Antioxidant activity was evaluated using the DPPH assay, where the flower EO exhibited the highest radical scavenging activity (99.5% at 100 mg/mL), followed by rhizome and stem EOs, while root EO showed moderate activity. Antifungal activity against Phellinus noxius, a major wood-decaying pathogen, was assessed using the agar dilution method. Root EO exhibited the strongest antifungal effect, achieving complete inhibition at 400 and 800 μg/mL, while other EOs showed weaker activity. These findings suggest that A. uraiensis EOs possess potential antioxidant and antifungal properties, particularly the root EO, which may serve as a natural antifungal agent. Further studies are needed to elucidate the key bioactive compounds and their mechanisms for potential pharmaceutical and industrial applications. Full article

Multithreading is widely used in microcontroller unit (MCU) chips. Multithreaded hardware is composed of multiple identical single threads and provides instructions to different threads. Using the concept of thread-level parallelism (TLP), pauses are compensated for during single-thread operation to increase the throughput at the same unit. The principle of pipelined management is to use instruction-level parallelism (ILP) to split the MCU into multiple stages. When an instruction is given in a certain stage, other instructions are provided to operate in other idle stages and improve their execution efficiency. Based on the four-thread and pipelined RISC-V MCU architecture, we analyzed the instruction types of three benchmarks, i.e., Coremark, SHA, and Dijkstra. A total of 94% of the instructions use the arithmetic logic unit (ALU). Based on the executable four-thread architecture, we developed two to four RISC-V architectures with different numbers of ALUs and a dispatch algorithm. This architecture allows for the simultaneous delivery of multiple instructions, enabling parallel processing of instructions and increasing efficiency. Compared to the traditional RISC-V architecture with only one ALU, the test results showed that the instructions per clock (IPCs) of RISC-V architectures with two, three, and four ALUs increased efficiency by 76, 128.9, and 154.3%, while the area increased by 12, 22.3, and 32.6% and the static power consumption increased by 5.1, 9.2, and 13.3%. The results showed a significant improvement in performance with only a slight increase in the area. Due to the limited area of chips, a two-thread microcontroller architecture was used for the IC design and tape-out. TSMC’s 180nm process with a chip area of 1190 × 1190 μm at 133 MHz was used in this study. Full article

Background: Although nutritional status plays a critical role in maintaining muscle strength, limited evidence exists regarding its association with dynapenia. Objectives: We aimed to investigate the association between different nutritional statuses and dynapenia among Taiwanese older adults, and assessed whether age modifies this relationship. Methods: In this study, we enrolled individuals aged 65 years and older living in community settings through convenience sampling from 2020 to 2021, following a cross-sectional design. The Mini-Nutritional Assessment Short Form (MNA-SF) was used to assess whether the participants were at nutritional risk. Standardized assessments measured muscle strength (handgrip measurement), physical performance (6 m walking test), and muscle mass (bioelectrical impedance analysis) to confirm dynapenia classifications. The interaction terms were tested using likelihood ratio tests to examine for dynapenia between nutritional status and age. For overall sample and subgroup analyses, binary logistic regression was employed. Results: Among 211 participants (mean age: 80.7 ± 7.1 years), after adjusting for potential confounders, those at nutritional risk (OR: 3.11; 95% CI: 1.31–7.36) were positively associated with dynapenia, whereas higher MNA-SF scores (OR: 0.73; 95% CI: 0.57–0.93) were negatively associated. Interactions regarding dynapenia were observed between nutritional status and age group (p = 0.014), with nutritional risk significantly associated with dynapenia only in the old–old group (≥75 years) (OR = 4.11, 95% CI: 1.39–12.15). Conclusions: Age is a potential moderator of nutritional status and dynapenia among older populations. Nutritional status appeared to be more profound in the old–old group in terms of the risk of dynapenia. These findings offer insights for monitoring nutritional status and implementing targeted interventions to prevent dynapenia in those aged over 75 years. Future studies using prospective designs should explore the underlying mechanisms linking nutritional status to dynapenia and assess the effectiveness of nutritional interventions in preventing muscle strength decline. Full article

This study investigates the benefits of innovative full-contact insoles, crafted using polyester fabric sheets of thermoplastic extruded materials, for individuals with hallux valgus-induced plantar pain. Thirty-five individuals with hallux valgus-induced foot pain were randomly allocated to either the experimental group, wearing innovative full-contact insoles 6 h daily, or the control group, using regular foot insoles, over a period of 12 weeks. Data collection occurred at baseline, and at 1 week, 2 months, and 3 months after the initial fitting. Results indicated that the innovative full-contact insoles significantly reduced anteroposterior displacement by an average of 0.9 cm (p = 0.025) and displacement area by 0.79 cm² (p = 0.012). Gait improvements included an increase in the swing phase (36.46%, p = 0.008) and a reduction in stance phase duration (63.54%, p = 0.019). Pressure peaks at critical foot regions like the second metatarsal and medial heel were reduced by up to 39.45 kPa (p = 0.016) and 104.07 kPa (p = 0.031), while contact areas in the midfoot increased by 6.17 cm² (p = 0.039). Foot pain decreased by an average score of 1.28 points on a 10-point scale across various measures (p = 0.041). These findings suggest that the innovative full-contact insoles effectively enhance pressure distribution and gait dynamics in patients with hallux valgus, providing a viable option for managing foot discomfort. Full article

In today’s era of rapid computing, advanced big data analytics enables precise results and efficient trend analysis. By leveraging these tools, the influence of various film thicknesses of Colored Solar Selective Absorbers (CSSAs) on solar absorption efficiency (α_s) and chromaticity was investigated. A clear and visually informative Chromaticity Coordinate Distribution (CCD) versus α_s diagram was constructed within the CIE xy chromaticity diagram, establishing a correlation between chromaticity and α_s. Photo-Thermal Conversion Efficiency (PTCE) ≈ α_s − 2% when α_s ≥ 90%. Subsequently, utilizing colored CCD-α_s diagrams, seven SiO₂/Cr/SiO₂ CSSAs, each with unique colors and α_s, were designed, fabricated, and subjected to an analysis of their optical and material properties. We explored the influence of oxygen atom infiltration into the CSSA, leading to the oxidation of the Cr layer and consequent alterations in CSSA properties. Additionally, this study delved into analyzing the effect of substrate surface roughness on the oxidation resistance, α_s, color, and corrosion resistance of CSSAs. Full article

Background/Objectives: Subjective cognitive decline (SCD) may serve as an early indicator of Alzheimer’s disease (AD). This study investigates regional cerebral blood flow (rCBF) alterations in individuals with SCD using single photon emission computed tomography (SPECT). To characterize rCBF patterns in SCD patients compared to healthy controls and examine the relationship between rCBF and cognitive function. Methods: We compared rCBF in 20 SCD patients and 20 age- and sex-matched healthy controls using 99mTc-ECD SPECT imaging. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Geriatric Depression Scale (GDS), and Cognitive Abilities Screening Instrument (CASI). Results: SCD patients demonstrated significantly reduced rCBF in the right superior temporal gyrus (rSTG) (mean uptake ratio [UR] = 0.864 ± 0.090 vs. 1.030 ± 0.074, p < 0.001) and right caudate (mean UR = 0.783 ± 0.068 vs. 0.947 ± 0.062, p < 0.001) compared to controls. Additionally, negative correlations were observed between rCBF in these regions and CDR scores, particularly in the memory domain (rSTG: r = −0.37, p = 0.016; right caudate: r = −0.39, p = 0.011). Conclusions: Reduced rCBF in the rSTG and right caudate may represent early biomarkers for SCD, which could aid in the early detection of AD. These findings suggest that SPECT imaging might be a valuable tool for identifying individuals at risk of cognitive decline, potentially allowing for earlier intervention and targeted preventive strategies in the management of AD. Full article

Balance control, a complex sensorimotor skill, declines with age. Assessing balance is crucial for identifying fall risk and implementing interventions in the older population. This study aimed to measure age-dependent changes in static and dynamic balance using inertial measurement units in a clinical setting. This study included 82 healthy participants aged 20–85 years. For the dynamic balance test, participants stood on a horizontally swaying balance board. For the static balance test, they stood on one leg. Inertial measurement units attached to their bodies recorded kinematic data, with average absolute angular velocities assessing balance capabilities. In the dynamic test, the younger participants had smaller average absolute angular velocities in most body parts than those of the middle-aged and older groups, with no significant differences between the middle-aged and older groups. Conversely, in the single-leg stance tests, the young and middle-aged groups outperformed the older group, with no significant differences between the young and middle-aged groups. Thus, dynamic and static balance decline at different stages with age. These results highlight the complementary role of inertial measurement unit-based evaluation in understanding the effect of age on postural control mechanisms, offering valuable insights for tailoring rehabilitation protocols in clinical settings. Full article

This study investigates the efficacy of ozone treatment combined with different packaging methods on the preservation of Taiwanese domestically produced beef during refrigerated storage. The preservation of fresh beef is crucial for ensuring food safety and quality; we do not know whether changing the packaging method can mitigate the negative effects of ozone on meat and even enhance its positive impact. Beef samples were treated with ozone and packaged using the vacuum or PVDC-tray methods, then stored at 4 °C for 7 days. The results show that ozone treatment effectively inhibited microbial (total plate count, Salmonella, and Escherichia coli) growth (p < 0.05). Vacuum packaging maintained lower TBARS values (p < 0.05) and metmyoglobin percentages compared to PVDC-tray packaging (p < 0.05). The L* values of all treatments increased over storage time, with significant differences observed between days 0 and 7. Ozone treatment combined with vacuum packaging demonstrated promising results in inhibiting microbial growth and preserving beef quality during refrigerated storage. These findings contribute to enhancing the safety and shelf life of Taiwanese domestically produced beef, potentially benefiting both producers and consumers. Full article