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Antioxidants
Volume 10
Issue 9
10.3390/antiox10091352
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Review

Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses

by
Lovro Žiberna
1,
Zala Jenko-Pražnikar
2 and
Ana Petelin
2,*
1
Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia
2
Faculty of Health Sciences, University of Primorska, SI-6310 Izola, Slovenia
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(9), 1352; https://doi.org/10.3390/antiox10091352
Submission received: 23 July 2021 / Revised: 22 August 2021 / Accepted: 23 August 2021 / Published: 26 August 2021
(This article belongs to the Special Issue Bilirubin and Oxidative Stress)
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Abstract

Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
Keywords: adipokines; antioxidant; anti-inflammatory; bilirubin; obesity; overweight adipokines; antioxidant; anti-inflammatory; bilirubin; obesity; overweight

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MDPI and ACS Style

Žiberna, L.; Jenko-Pražnikar, Z.; Petelin, A. Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses. Antioxidants 2021, 10, 1352. https://doi.org/10.3390/antiox10091352

AMA Style

Žiberna L, Jenko-Pražnikar Z, Petelin A. Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses. Antioxidants. 2021; 10(9):1352. https://doi.org/10.3390/antiox10091352

Chicago/Turabian Style

Žiberna, Lovro, Zala Jenko-Pražnikar, and Ana Petelin. 2021. "Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses" Antioxidants 10, no. 9: 1352. https://doi.org/10.3390/antiox10091352

APA Style

Žiberna, L., Jenko-Pražnikar, Z., & Petelin, A. (2021). Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses. Antioxidants, 10(9), 1352. https://doi.org/10.3390/antiox10091352

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