Special Issue "Viral RNA Structural Biology"
Deadline for manuscript submissions: 15 July 2021.
Interests: retrovirus replication; nucleoprotein complexes; antiviral strategies; regulatory RNAs; RNA therapeutics; chemical biology
Pathogenic RNA viruses are, without reservation, emerging as the most important group implicated in zoonotic transmission. This is perhaps best exemplified by SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, which is presenting a major challenge to global disease control. Understanding their genome organization, replication strategies, and the host factors they usurp to accomplish this will likely provide a foundation for successful immunological and small molecule interventions. In order to achieve this, complementary, biochemical, and biophysical strategies in the form of high throughput, high resolution structural analyses are expected make important contributions. Constant improvements to techniques such as small angle X-ray scattering, X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy are providing detailed information on individual regulatory domains, while chemoenzymatic probing (SHAPE-MaP) can now provide exciting glimpses of communication between elements of RNA genomes separated by several thousand nucleotides. It is also important to recognize the contribution of molecular modeling and molecular dynamics simulations, which are finding increased use as a complement biochemical and biophysical approaches in delineating the structure of regulatory RNAs. A final section of this Special Edition will address the structural features of single-stranded plant RNA viruses, the main agents of many serious diseases of agriculturally important crops.
Dr. Stuart F.J. Le Grice
Prof. Dr. Anne Simon
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- viral polymerases
- RNA genome packaging
- RNA structure
- NMR spectroscopy
- X-ray crystallography
- molecular modelingcircular RNA
- RNA vaccines