Special Issue "The Role of Lipids in RNA Virus Replication"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 20 August 2020.

Special Issue Editors

Dr. Kouacou Konan
Guest Editor
Department of Immunology and Microbial Disease, Albany Medical Center, Albany, NY 12208, USA
Interests: flaviviridae family of viruses; virus genome replication; particle biogenesis and virus pathogenesis; flaviviruses and host lipid metabolism; flaviviruses and the innate immune response
Dr. Eric Yager
Co-Guest Editor
Department of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue, Albany, NY 12208, USA
Interests: RNA viruses; antivirals; influenza; vaccines; viral immunity; host-virus interactions; inflammation; immunosenescence
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Lipids are major constituents of the plasma membrane as well as intracellular membranes. They contribute to a vast array of cellular processes, including membrane integrity, membrane trafficking, energy storage, cell signaling, cell proliferation, apoptosis, cell differentiation, and the modulation of the innate immune response. Hence, major alterations in these lipids can have a deleterious impact on the host. With recent advances in lipidomics, there is a better understanding of how RNA viruses modulate distinct host lipid metabolic pathways to successfully replicate and/or cause pathogenesis. This Special Issue of Viruses seeks to spotlight recent findings on the role of various lipids in RNA virus entry, genome replication, and/or virus particle biogenesis. Research studies of human, animal, or plant importance are within the scope of this Issue. We also invite studies focusing on the role of lipids on innate immune regulation during RNA virus replication.

Dr. Kouacou Konan
Dr. Eric Yager
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessArticle
Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane
Viruses 2020, 12(4), 482; https://doi.org/10.3390/v12040482 - 24 Apr 2020
Cited by 1
Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host cell plasma membrane. VP40 traffics [...] Read more.
Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host cell plasma membrane. VP40 traffics to the plasma membrane inner leaflet, where it assembles to facilitate the budding of viral particles. VP40 is a multifunctional protein that interacts with several host proteins and lipids to complete the viral replication cycle, but many of these host interactions remain unknown or are poorly characterized. In this study, we investigated the role of a hydrophobic loop region in the carboxy-terminal domain (CTD) of mVP40 that shares sequence similarity with the CTD of Ebola virus VP40 (eVP40). These conserved hydrophobic residues in eVP40 have been previously shown to be critical to plasma membrane localization and membrane insertion. An array of cellular experiments and confirmatory in vitro work strongly suggests proper orientation and hydrophobic residues (Phe281, Leu283, and Phe286) in the mVP40 CTD are critical to plasma membrane localization. In line with the different functions proposed for eVP40 and mVP40 CTD hydrophobic residues, molecular dynamics simulations demonstrate large flexibility of residues in the EBOV CTD whereas conserved mVP40 hydrophobic residues are more restricted in their flexibility. This study sheds further light on important amino acids and structural features in mVP40 required for its plasma membrane localization as well as differences in the functional role of CTD amino acids in eVP40 and mVP40. Full article
(This article belongs to the Special Issue The Role of Lipids in RNA Virus Replication)
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