The Role of Dendritic Cells and Macrophages in HIV Infection

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: closed (15 November 2024) | Viewed by 1496

Special Issue Editors


E-Mail Website
Guest Editor
Université Paris Cité, CNRS, Inserm, Institut Cochin, F-75014 Paris, France
Interests: dendritic cells; HIV; antigen processing and presentation

E-Mail Website
Guest Editor
Laboratory of Mucosal Entry of HIV-1 and Mucosal Immunity, Department of Infection, Immunity and Inflammation, Cochin Institute, CNRS UMR 8104, Paris, France
Interests: mucosal immunity; HIV-1; SARS-CoV-2

E-Mail Website
Guest Editor
Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia
Interests: mucosal immunity; HIV-1; HSV

E-Mail Website
Guest Editor
CHUM-Research Centre, Montreal, QC H2X 0A9, Canada
Interests: HIV-1; Th17; myeloid cells; circadian clock

Special Issue Information

Dear Colleagues,

The role of dendritic cells and macrophages in HIV infection should be frequently re-evaluated, as it evolves constantly. As the first cells with HIV receptors and co-receptors encountered by the virus at contamination sites, dendritic cells and macrophages are reservoirs and can transfer the virus to CD4+ T cells and activate them for full-blown replication. As innate immune cells, they detect the virus and initiate intrinsic, innate, and adaptive immune responses. They are major sources of interferons and other antiviral cytokines and can be cytotoxic. As antigen-presenting cells, they are necessary for constant adaptation to viral escape from T- and B-cell responses, and they are targeted or sometimes used by themselves for vaccination. During chronic, antiretroviral-treated infection, their constant activation is a source of metabolic complications and comorbidities. Understanding how to use their properties to achieve immune control over HIV-1 is key to obtaining a functional cure for HIV and removing the necessity for life-long antiretroviral treatments.

We are pleased to invite you to participate in a Special Issue of Viruses on “The Role of Dendritic Cells and Macrophages in HIV Infection”. Research areas may include (but are not limited to) defining the roles of new populations of dendritic cells and macrophages or monocytes in HIV infection, their cross-talk with other cell populations, their roles as reservoirs, strategies to stimulate them in order to eliminate HIV reservoirs and boost innate and adaptive immunity, and any other new, exciting results that you would like to share or discuss.

Original research articles and reviews are welcome.

Dr. Anne Hosmalin
Dr. Morgane Bomsel
Prof. Anthony Cunningham
Prof. Dr. Petronela Ancuta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reservoirs
  • viral control
  • vaccination
  • cell interactions
  • interferons
  • cytokines
  • mucosa
  • lymphoid organs

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

27 pages, 2509 KiB  
Review
Recent Advances in Our Understanding of Human Inflammatory Dendritic Cells in Human Immunodeficiency Virus Infection
by Freja A. Warner van Dijk, Kirstie M. Bertram, Thomas R. O’Neil, Yuchen Li, Daniel J. Buffa, Andrew N. Harman, Anthony L. Cunningham and Najla Nasr
Viruses 2025, 17(1), 105; https://doi.org/10.3390/v17010105 - 14 Jan 2025
Viewed by 1041
Abstract
Anogenital inflammation is a critical risk factor for HIV acquisition. The primary preventative HIV intervention, pre-exposure prophylaxis (PrEP), is ineffective in blocking transmission in anogenital inflammation. Pre-existing sexually transmitted diseases (STIs) and anogenital microbiota dysbiosis are the leading causes of inflammation, where inflammation [...] Read more.
Anogenital inflammation is a critical risk factor for HIV acquisition. The primary preventative HIV intervention, pre-exposure prophylaxis (PrEP), is ineffective in blocking transmission in anogenital inflammation. Pre-existing sexually transmitted diseases (STIs) and anogenital microbiota dysbiosis are the leading causes of inflammation, where inflammation is extensive and often asymptomatic and undiagnosed. Dendritic cells (DCs), as potent antigen-presenting cells, are among the first to capture HIV upon its entry into the mucosa, and they subsequently transport the virus to CD4 T cells, the primary HIV target cells. This increased HIV susceptibility in inflamed tissue likely stems from a disrupted epithelial barrier integrity, phenotypic changes in resident DCs and an influx of inflammatory HIV target cells, including DCs and CD4 T cells. Gaining insight into how HIV interacts with specific inflammatory DC subsets could inform the development of new therapeutic strategies to block HIV transmission. However, little is known about the early stages of HIV capture and transmission in inflammatory environments. Here, we review the currently characterised inflammatory-tissue DCs and their interactions with HIV. Full article
(This article belongs to the Special Issue The Role of Dendritic Cells and Macrophages in HIV Infection)
Show Figures

Figure 1

Back to TopTop