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Separations
Special Issues
Research on Sustainable Extraction and Purification of Compounds
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Research on Sustainable Extraction and Purification of Compounds

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Materials in Separation Science".

Deadline for manuscript submissions: closed (10 February 2023) | Viewed by 3431

Special Issue Editors

Dr. Ana M. Ferreira

E-Mail Website
Guest Editor
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: biorefinery; biomass valorisation; green chemistry; ionic liquids; deep eutectic solvents; extraction techniques; purification techniques; integrated processes; circular economy
Dr. Vanessa Vieira

E-Mail Website
Guest Editor
Deifil Technology Lda, 4830-704 Póvoa de Lanhoso, Portugal
Interests: biomass valorisation; green and bio-based solvents; biocompatible applications; extraction methodologies; bioactive extracts and compounds; natural ingredients
Dr. Fabiane Oliveira Farias

E-Mail Website
Guest Editor
School of Food Engineering, University of Campinas, Campinas, Brazil
Interests: green chemistry; deep eutectic solvents; ionic liquids; biorefinery; separation techniques; bioactive compounds; food preservation; natural matrices; purification techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of natural bioactive compounds in different commercial sectors today, such as in the pharmaceutical, nutraceutical, and cosmetic industries, has seen a significant increase, mainly due to their anticancer, antimicrobial, and antioxidant properties (among others). To cover such a demand, the circular economy and bioeconomy have been implemented to encourage the use and reuse of renewable resources, such as biomass feedstocks. However, conventional techniques for the extraction and purification of bioactive compounds may display several disadvantages, such as low efficiency and non-selectivity, slow speed, high energetic input, and degradation of the targeted compounds. Moreover, most of the techniques used generally involve the use of volatile and often toxic organic solvents, leading to environmental and human concerns. Thus, it is crucial to explore alternative solvents with more environmentally friendly characteristics and to develop cost-effective and sustainable extraction and purification techniques, ideally incorporated as an integrated process, while also contributing to the change from a non-renewable and polluting fossil-based economy towards a bioeconomy based on sustainable processes.

In this context, this Special Issue, entitled “Research on Sustainable Extraction and Purification of Compounds“, aims to gather studies and innovative technologies on the extraction and purification of naturally occurring compounds assisted by green chemistry tools (e.g., ionic liquids, deep eutectic solvents, supercritical fluids, aqueous biphasic systems) with the potential to be integrated into biorefinery platforms.

We look forward to receiving your work.

Dr. Ana M. Ferreira
Dr. Vanessa Vieira
Dr. Fabiane Oliveira Farias
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Green solvents
  • Biorefinery
  • Extraction methods
  • Purification methods
  • Solvent recycling
  • Integrated processes
  • Circular economy
  • Biocompatible solutions
  • Natural-based applications

Published Papers (1 paper)

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Research

14 pages, 4619 KiB  
Article
Aqueous Biphasic Systems Comprising Natural Organic Acid-Derived Ionic Liquids
by Maria V. Quental, Matheus M. Pereira, Francisca A. e Silva, João A. P. Coutinho and Mara G. Freire
Separations 2022, 9(2), 46; https://doi.org/10.3390/separations9020046 - 7 Feb 2022
Cited by 2 | Viewed by 2683
Abstract
Despite the progress achieved by aqueous biphasic systems (ABSs) comprising ionic liquids (ILs) in extracting valuable proteins, the quest for bio-based and protein-friendly ILs continues. To address this need, this work uses natural organic acids as precursors in the synthesis of four ILs, [...] Read more.
Despite the progress achieved by aqueous biphasic systems (ABSs) comprising ionic liquids (ILs) in extracting valuable proteins, the quest for bio-based and protein-friendly ILs continues. To address this need, this work uses natural organic acids as precursors in the synthesis of four ILs, namely tetrabutylammonium formate ([N4444][HCOO]), tetrabutylammonium acetate ([N4444][CH3COO]), tetrabutylphosphonium formate ([P4444][HCOO]), and tetrabutylphosphonium acetate ([P4444][CH3COO]). It is shown that ABSs can be prepared using all four organic acid-derived ILs paired with the salts potassium phosphate dibasic (K2HPO4) and tripotassium citrate (C6H5K3O7). According to the ABSs phase diagrams, [P4444]-based ILs outperform their ammonium congeners in their ability to undergo liquid–liquid demixing in the presence of salts due to their lower hydrogen-bond acidity. However, deviations to the Hofmeister series were detected in the salts’ effect, which may be related to the high charge density of the studied IL anions. As a proof of concept for their extraction potential, these ABSs were evaluated in extracting human transferrin, allowing extraction efficiencies of 100% and recovery yields ranging between 86 and 100%. To further disclose the molecular-level mechanisms behind the extraction of human transferrin, molecular docking studies were performed. Overall, the salting-out exerted by the salt is the main mechanism responsible for the complete extraction of human transferrin toward the IL-rich phase, whereas the recovery yield and protein-friendly nature of these systems depend on specific “IL-transferrin” interactions. Full article
(This article belongs to the Special Issue Research on Sustainable Extraction and Purification of Compounds)
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