Cardiovascular Disease and Sleep Disordered Breathing—Case Report

Dear Colleagues,

Cardiovascular disease (CVD) and sleep-disordered breathing (SDB), particularly obstructive sleep apnea (OSA), share a complex bidirectional relationship that significantly impacts patient outcomes. Emerging evidence highlights how SDB exacerbates CVD progression through mechanisms such as hypoxia-induced sympathetic activation, endothelial dysfunction, and systemic inflammation, while CVD itself can worsen SDB severity. This Topical Collection will collate case reports and clinical studies that elucidate these interactions, offering insights into diagnosis, pathophysiology, and innovative management strategies.

Recent guidelines emphasize the importance of screening for OSA in high-risk CVD populations, such as those with atrial fibrillation or heart failure, underscoring the clinical relevance of this intersection. Case reports detailing unique presentations, such as cardiovascular complications linked to untreated OSA or therapeutic interventions improving both conditions, are particularly encouraged. Submissions may explore topics such as the role of CPAP therapy in reducing CVD mortality, pediatric cases of SDB contributing to early-onset hypertension, or atypical manifestations of CVD in patients with sleep disorders.

This Topical Collection will also address disparities in sleep health and CVD outcomes across diverse populations, including gender- and ethnicity-specific risk profiles. By integrating multidisciplinary perspectives, we aim to advance risk stratification and personalized treatment approaches.

Submissions should provide actionable clinical insights and contribute to bridging gaps in current evidence. We welcome global contributions to foster a comprehensive understanding of this critical health nexus.

Dr. Takatoshi Kasai
Collection Editor

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