The Role of Molecular Hydrogen in Mitigating Oxidative Stress and Radiation Damage: Mechanistic Insights, Biological Effects, and Therapeutic Applications
A special issue of Radiation (ISSN 2673-592X).
Deadline for manuscript submissions: 30 June 2026 | Viewed by 12
Special Issue Editor
Interests: water radiolysis; early events in radiobiology; free radicals; radioprotectors/antioxidants; FLASH radiobiology/radiotherapy; monte carlo multi-track chemistry simulations; water chemistry in small modular reactors; supercritical water
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Molecular hydrogen (H2) has emerged as a promising antioxidant and radioprotector with diverse therapeutic potential for mitigating oxidative stress and radiation-induced damage. This Special Issue aims to gather contributions that explore the latest insights into the mechanisms through which H2 exerts its protective effects across various biological contexts, including neuroprotection, cancer therapy, radiation protection, and disease management. A particular emphasis will be placed on H2’s ability to selectively scavenge reactive oxygen species (ROS), such as hydroxyl radicals (•OH) and peroxynitrite (ONOO−).
The biological effects of H2, including its potential to cross the blood–brain barrier and mitigate radiation-induced injury, will be thoroughly examined. In addition, the therapeutic applications of hydrogen-rich water, hydrogen inhalation, and intravenous H2 as delivery methods will be discussed. This Special Issue will also explore the integration of molecular hydrogen into clinical practices, particularly in radiotherapy, where it holds promise for enhancing treatment outcomes.
By bringing together insights from various fields, this Special Issue provides a comprehensive overview of current research on the mechanisms, biological effects, and growing therapeutic applications of molecular hydrogen in combating oxidative stress and radiation damage.
Prof. Dr. Jean Paul Jay-Gerin
Guest Editor
Manuscript Submission Information
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Keywords
- molecular hydrogen (H2)
- H2 as an antioxidant and radioprotective agent
- molecular and cellular mechanisms of action
- reactive oxygen and nitrogen species: hydroxyl radicals and peroxynitrite
- modulation of oxidative stress in diverse pathological conditions
- anti-inflammatory processes and neuroprotection
- radiobiology and radiotherapy
- therapeutic applications
- modeling and experiments
- dose-rate effects and FLASH particle therapy
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