Chromatin Proteomes

Dear Colleagues,

Chromatin is a nucleoprotein complex composed of a large diversity of proteins that dynamically interact with DNA to control its compaction and to regulate gene expression. The main protein component of chromatin is represented by histones, around which the DNA wraps to form nucleosomes. Histone N-termini can be modified in multiple ways to adjust DNA folding and to regulate association with transcription factors and transcriptional regulators. In addition, the transcriptional machinery and chromatin-modifying proteins assemble into protein complexes to regulate transcription, often in a gene-specific manner. Importantly, many chromatin-associated proteins operate under the control of signaling pathways, serving as intermediates to convert upstream signaling activities into a transcriptional response. As a consequence, chromatin factors are key determinants of many cellular processes, and therefore, the detailed characterization of the composition, interaction, and modification of chromatin proteins is essential to understand regulatory processes both in physiological conditions and disease.

For this Special Issue of Proteomes, we are inviting manuscript submissions that illuminate proteomic aspects of chromatin in the widest sense and in any format (original research, technical notes, methods papers, and reviews). This may include (but is not restricted to) analysis of post-translational modifications of individual chromatin proteins, characterization of protein interactions (with DNA, RNA, or with other proteins) in a chromatin context, or deciphering the role of chromatin proteins in any aspect of cellular signaling. Novel methodologies to address these questions as well as applications in any biological context will be equally welcome.

Prof. Dr. Jeroen Krijgsveld
Dr. Tiziana Bonaldi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• chromatin
• proteomics
• histones
• post-translational modifications
• mass spectrometry
• protein interactions
• epigenetics