Recent Advances in Cell-Based Evaluation Systems for Unique Pharmacological Effects, Drug Metabolism and Pharmacokinetics, and Drug Toxicity Applicable for New Drug Development
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (10 November 2021) | Viewed by 450
Special Issue Editors
Interests: drug metabolism and disposition; cytochrome P450s; conjugation enzymes; pharmacogenetics; epigenetics; drug toxicity
Special Issue Information
Dear Colleagues,
So far, drug target proteins encoded by various genes include G protein-coupled receptors, ion channels, kinases, nuclear receptors, enzymes, etc. Selective toxicity should also be considered to develop anti-microbial, anti-viral, and anti-cancer drugs. Novel drug target proteins should be devised in order to develop pharmacologically new drugs. On the other hand, drug absorption, distribution, metabolism and excretion (ADME), drug metabolism and pharmacokinetics (DMPK), and drug toxicity are also very important issues to be considered for safe and effective drug development.
Cellular-based evaluation systems have long been developed and are useful for screening for candidate drugs, which exhibit some affinity and exert pharmacological activities.
On the other hand, human or rodent primary hepatocytes have been a gold standard for the investigation of drug metabolizing enzymes that metabolize candidate drugs. ADME–toxicity systems have been extremely useful for predicting the DMPK of various chemicals including therapeutic drugs. Drug toxicity assay systems have also been developed for various organ toxicities.
This Special Issue is intended to collect high-level research articles or review articles, and to feature the contemporary progress in various assay systems for new drug development and/or for drug safety.
We invite articles on all aspects of cellular-based evaluation systems for the above-mentioned area for this Special Issue.
Prof. Dr. Shogo Ozawa
Prof. Dr. Seiichi Ishida
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacology
- cellular function
- receptor agonist/antagonist
- enzyme inducer/inhibitor
- signal transduction
- orphan receptor
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
