Special Issue "Molecular Basis of Neuromuscular Diseases"

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: 15 July 2021.

Special Issue Editor

Dr. Pasquale Scarcia
Guest Editor
Dep. Biosciences, Biotechnologies and Biopharmaceutics - Università degli Studi di Bari, Bari, Italy
Interests: mitochondrial carriers, bioenergetics, mitochondrial metabolism; rare diseases; gene expression; Saccharomyces cerevisiae
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Neuromuscular diseases (NMDs) are caused by impairment of the functioning of the muscles, with many different forms that vary in onset, severity, and prognosis. NMDs can be classified into hereditary or acquired disorders with sensory impairment, motor impairment, or both.

Muscular impairment, generally manifested as muscle weakness and fatigue, can be linked to motor neuron disease (such as amyotrophic lateral sclerosis), peripheral neuropathy, neuromuscular junction disorders (like myasthenia gravis), and myopathy. These alterations can be determined by pathologies of the muscle or by alterations of the nerves or of the neuro-muscular junctions. Furthermore, NMDs can be also age-related neurodegenerative disorders. To date, many neuromuscular diseases have no cure, and their pathogeneses are not well known.

The alterations of many cellular processes and metabolic pathways underlie the onset of NMDs. The development of omics techniques (i.e., metabolomics, transcriptomics, and lipidomics) shed new light on various factors and disease-causing mechanisms that contribute to NMDs.

The Special Issue will focus on understanding the molecular basis and metabolic alterations underlie neuromuscular pathologies. Original manuscripts and reviews concerning with special attention of pathophysiology of muscular diseases, the prognostic and diagnostic biomarkers of NMDs, or the development of new synthetic or naturally originating molecules for the treatment of neuromuscular pathologies are very welcome.

Dr. Pasquale Scarcia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. NeuroSci is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biomarkers
  • neuromuscular junctions
  • bioenergetics
  • neuromuscular diseases
  • disease mechanisms
  • skeletal muscle
  • therapies
  • molecular diagnosis
  • omics techniques
  • myopathy amyotrophic lateral sclerosis
  • myasthenia gravis
  • muscular dystrophies
  • myalgia

Published Papers

This special issue is now open for submission.
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