Neuromodulation for Brain Disorders: Mechanisms, Biomarkers and Precision Interventions

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: 31 October 2026

Special Issue Editors


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Guest Editor
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
Interests: neuroscience; brain stimulation; neurology; cognitive; psychology; rehabilitation; motor control; TMS; tDCS; Parkinson; neurological disease; cerebellum; EEG; motor cortex; motor reserve; motor rehabilitation; telemedicine

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Guest Editor
CNC—Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
Interests: brain development; neurodegeneration; neuromodulation; purinergic receptors; NMDA receptors; adenosine; ATP; glutamate; neuronal migration; epilepsy
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Special Issue Information

Dear Colleagues,

Recent advances in neuromodulation technologies—including invasive and non-invasive stimulation, pharmacological agents, and molecular interventions—have opened new avenues for treating a wide range of brain disorders, from neuropsychiatric conditions to neurodegenerative diseases. Despite their growing clinical potential, key challenges remain in elucidating the mechanisms of action, identifying reliable biomarkers of response, and personalizing therapeutic protocols across modalities.

This Special Issue, "Neuromodulation for Brain Disorders: Mechanisms, Biomarkers and Precision Interventions", aims to bring together cutting-edge research and comprehensive reviews addressing the fundamental principles, translational applications, and clinical outcomes of neuromodulation techniques. Topics of interest include, but are not limited to, the following:

  • Identification and validation of neurophysiological, imaging, and molecular biomarkers of neuromodulation efficacy in psychiatric and neurologic diseases;
  • Development of adaptive and closed-loop stimulation paradigms in patients;
  • Advances in precision and personalized neuromodulation approaches;
  • Integration of computational modeling, machine learning, and neuroinformatics for individualized treatment optimization;
  • Novel mechanisms and interventional strategies for pharmacological and molecular neuromodulation;
  • Ethical, technical, and clinical challenges in translating neuromodulation into routine care.

This Special Issue seeks to advance our understanding of how targeted neuromodulation can improve brain function and promote precision interventions for neurological and psychiatric disorders.

Dr. Andreina Giustiniani
Dr. Ricardo Rodrigues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. NeuroSci is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuromodulation
  • brain disorders
  • biomarkers
  • precision medicine
  • deep brain stimulation
  • transcranial magnetic stimulation
  • pharmacological modulation
  • neuroimaging

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Published Papers

This special issue is now open for submission.
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