The Future of Neurorehabilitation: Novel Approaches and Personalized Medicine

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1350

Special Issue Editor


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Guest Editor
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan
Interests: rehabilitation; regenerative medicine; stroke; transcranial magnetic stimulation; functional MRI

Special Issue Information

Dear Colleagues,

Neurorehabilitation plays a critical role in improving functional outcomes and the quality of life for individuals with neurological disorders, including stroke, traumatic brain injury, spinal cord injury, multiple sclerosis, and neurodegenerative diseases. With the growing understanding of neuroplasticity and the development of innovative therapeutic approaches, the field of neurorehabilitation is rapidly evolving. However, challenges remain in translating research findings into effective, personalized rehabilitation strategies.

This Special Issue aims to bring together cutting-edge research and comprehensive reviews that explore the mechanisms, methodologies, and clinical applications of neurorehabilitation. We welcome submissions that address both fundamental and translational aspects to advance rehabilitation science and practice.

The scope of this Special Issue includes, but is not limited to, the following:

  • Mechanisms of neuroplasticity in recovery;
  • Novel assessment tools for rehabilitation outcomes;
  • Technological innovations in neurorehabilitation;
  • Cognitive and motor rehabilitation strategies;
  • Psychosocial and quality of life aspects in neurorehabilitation.

We look forward to your contributions to this Special Issue.

Dr. Naoki Yamada
Guest Editor

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Keywords

  • neurorehabilitation
  • neuroplasticity
  • neuromodulation
  • personalized medicine
  • movement disorders
  • stroke
  • traumatic brain injury (TBI)
  • neurodegenerative diseases
  • children
  • older patients
  • quality of life

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Published Papers (1 paper)

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Research

14 pages, 1945 KB  
Article
Multiuser Exercise-Based Telerehabilitation Intervention for Older Adults with Frailty: A Pilot Study
by Naoki Yamada, Itsuki Sato, Shoji Kinoshita, Atsushi Muraji, Seiki Tokunaga, Taro Naka and Ryo Okubo
NeuroSci 2026, 7(1), 11; https://doi.org/10.3390/neurosci7010011 - 13 Jan 2026
Viewed by 889
Abstract
Objectives: This pilot study examined telerehabilitation, which has emerged as a crucial modality in light of recent global challenges such as the COVID-19 pandemic. We examined the effectiveness of a mobile health telerehabilitation intervention developed for older adults with frailty. Methods: Six participants [...] Read more.
Objectives: This pilot study examined telerehabilitation, which has emerged as a crucial modality in light of recent global challenges such as the COVID-19 pandemic. We examined the effectiveness of a mobile health telerehabilitation intervention developed for older adults with frailty. Methods: Six participants received a telerehabilitation intervention (Rehab Studio) that included exercise training videos. The participants were aged ≥65 years, had no history of dementia or psychiatric disorders, and had mild-to-moderate care needs. For 1 month, the participants received 1 h live online rehabilitation sessions with real-time communication with rehabilitation specialists (physical therapists and occupational therapists: PTs/OTs). The quality of life (QoL) (EuroQol 5 dimensions 5-level [EQ-5D-5L] questionnaire) and self-rated health scores were recorded before and after the intervention, and the data were analyzed using paired t-tests to determine whether the service was effective. Results: Significant differences were found in the total EQ-5D-5L and self-rated health scores (p < 0.05). The mean EQ-5D-5L score increased from 0.63 ± 0.13 before the intervention to 0.77 ± 0.14 after the intervention (p = 0.010), while the mean self-rated health score increased from 66.0 ± 18.0 to 83.3 ± 10.3, respectively (p = 0.019). Conclusions: This study revealed that the mobile health telerehabilitation intervention is safe and can improve QoL for older adults with frailty. However, the effectiveness of the intervention needs to be further investigated in patients with poor performance in daily living activities. Telerehabilitation could help to reduce the burden of nursing care in aging societies with declining birthrates. However, given the extremely small sample size (N = 6), these p-values should be interpreted with considerable caution. Statistical significance in such a small sample does not provide strong evidence for population-level effects, and our findings should be regarded as hypothesis-generating rather than confirmatory. Full article
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