Glial Regulation in Neurooncology
A special issue of Neuroglia (ISSN 2571-6980).
Deadline for manuscript submissions: 30 December 2026 | Viewed by 130
Editor
Special Issue Information
Dear Colleagues,
Glial cells play a pivotal role in shaping the neural microenvironment, actively regulating tumor growth, invasion, immune responses, and therapeutic resistance in the central nervous system. A better understanding of glial cell contributions can potentially reshape neurooncology beyond the traditional tumor-centric paradigm. Recent advances in molecular profiling, single-cell technologies, spatial transcriptomics, and neuroimmunology have revealed that astrocytes, microglia, oligodendrocyte lineage cells, and other glial populations are key drivers of dynamic tumor–microenvironment interactions in gliomas, brain metastases, and other central nervous system malignancies, offering new opportunities for mechanistic discovery and therapeutic innovation.
This Special Issue, entitled “Glial Regulation in Neurooncology”, aims to provide a comprehensive platform for emerging insights into the multifaceted roles of glial cells in brain tumor biology and to highlight innovative strategies that leverage glial mechanisms for diagnostic and therapeutic advancements. We welcome original research, systematic reviews, and comprehensive reviews addressing molecular signaling pathways, tumor–glia crosstalk, neuroinflammatory regulation, microenvironmental remodeling, immunomodulation, and glia-driven resistance mechanisms in gliomas, brain metastases, and other neurooncological conditions. Contributions exploring advanced imaging and omics technologies, single-cell and spatial transcriptomics, computational modeling, and translational approaches targeting glial pathways are particularly encouraged. By integrating basic, translational, and clinical perspectives, this issue seeks to identify glia-driven biomarkers, advance therapeutic strategies, and strengthen precision medicine approaches in neurooncology.
Dr. Michael Karsy
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neuroglia is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurooncology
- glial cells
- tumor microenvironment
- tumor–glia crosstalk
- ımmunomodulation
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