MicroRNAs as Biomarkers of Brain Dysfunction in Aging, Dementias, and Psychoses
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 685
Special Issue Editors
Interests: neuropathology; biomarkers of neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative disease; epigenetics; non-coding RNA; genome-environment interactions
Special Issue Information
Dear Colleagues,
Small non-coding RNA molecules (microRNAs, miRNAs) regulate genes involved in brain functions negatively affected in normal aging well as in neurodegenerative and neuropsychiatric diseases.
Although aging is the greatest risk for major neurodegenerative diseases, sociological, medical, and nutritional factors are thought to play a role and modulate the pace of cognitive decline and influence the risk for psychoses development.
Animal models suggest specific pathways through which genomic and epigenomic interaction affects neuroinflammation, cerebral lipid metabolism, brain insulin resistance, and myelin disintegration. Small non-coding RNAs (ncRNAs) regulate gene expression in response to genome–environment interactions. There is now accumulated evidence that microRNAs (miRNAs) may serve as prognostic and diagnostic biomarkers with mechanistic insights into the pathophysiologic processes, especially in the case of Alzheimer’s disease-associated cognitive decline, years before the clinical manifestation of the disease. Mechanistic approaches towards the design of novel preventive and therapeutic interventions will be enabled by the integration of the data from: (1) the ongoing large epidemiologic studies on the correlation of cognitive and behavioral changes in densely phenotyped individuals with plasma miRNAome; (2) the studies evaluating the relationship between the expression of a circulating miRNA biomarker and the expression of that biomarker in the brain cells; and (3) the investigation of the functional consequences of a human disease miRNA biomarker in animal models.
Prof. Dr. Ivana Delalle
Prof. Dr. André Fischer
Guest Editors
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Keywords
- neurodegeneration
- cognitive decline
- biomarker
- small non-coding RNA
- circulating microRNAs
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