Molecular and Multi-OMICS Approaches to Study Leishmania Parasites
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Parasitology".
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 443
Special Issue Editors
Interests: leishmania; Trypanosoma cruzi; protozoal protein; mass spectrometry; isotope labeling; esophageal squamous cell carcinoma; esophageal neoplasms; mutation
Interests: amino acid transport and sensing; the molecular mechanism of Leishmania development
Special Issue Information
Dear Colleagues,
The kinetoplastid protozoan parasite of the genus Leishmania are the causative agent of a wide spectrum of diseases commonly referred to as “Leishmaniasis”. These diseases range in their clinical manifestation from self-healing cutaneous lesions of cutaneous leishmaniasis to potentially deadly visceral leishmaniasis. The parasite leads a digenetic life-cycle as a flagellated promastigote in the mid-gut of sand fly vectors and as intracellular aflagellated amastigotes within infected macrophages of host including humans. Leishmaniasis is a major challenge especially in the developing world due to limited therapeutic medications and no available vaccines. Last three decades have seen major advances in our understanding of Leishmania parasite biology and its interaction with the host/vector micro-environment. The availability of complete reference genome sequences of most Leishmania species and the following in-depth proteomic studies have unravelled interesting aspects of the Leishmania parasites.
This Special Issue of Microorganisms aims to gather relevant research from world leading experts in the field of Leishmaniasis. We would like invite you to contribute original research articles and reviews, covering different aspects of Leishmania research, including molecular and cell biology. Specifically, multi-OMICS approaches including genomics, proteomics, proteogenomics and bioinformatics to unravel Leishmania biology. Articles focused on the following aspects are highly encouraged:
- Genomics and improvements in genome annotations
- Nutrient uptake and transport
- Leishmania life stage specific differentiation
- Subcellular organellar biology
- Leishmania-vector interaction
- Anti-leishmanial activity and drug resistance
- Post kala-azar dermal leishmaniasis and cutaneous leishmaniasis
- Cellular signalling in Leishmania parasites
Dr. Harsh Pawar
Dr. Dan Zilberstein
Dr. Milind Patole
Guest Editors
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Keywords
- proteomics
- proteogenomics
- genomics
- subcellular organelles
- anti-leishmanial activity
- leishmania differentiation
- nutrient transport and post kala-azar dermal leishmaniasis (PKDL)
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