Mass Spectrometry-Based Metabolomics in Disease Biomarker Discovery
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".
Deadline for manuscript submissions: 29 May 2026 | Viewed by 31
Special Issue Editors
Interests: multidimensional liquid chromatography mass spectrometry methodology development; LC-MS based metabolomics; lipidomics and epitranscriptomics
Interests: cancer immunotherapy; cancer metabolism and microbiota-tumor interaction
Interests: metabolomics; mass spectrometry; metabolites identification; biomarker discovery; stable isotope flux; cancer metabolism; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The discovery of disease biomarkers enables us to detect, diagnose, or monitor diseases. It even benefits us in the diagnosis of early-stage disease and ultimately helps at-risk individuals take preventive action before the disease progresses unnoticed. Mass spectrometry technique brings us to a new era of metabolomics, which is one of the exciting study areas for biomarker discovery, improving our deeper understanding of various disease mechanisms. However, the shortages and challenges of mass spectrometry-based metabolomics for biomarker discovery are evident and need to be properly addressed, including sample preparation complexity, limited metabolite coverage, a qualification bottleneck, and quantification issues, as well as data complexity and interpretation. We are accelerating our pace to develop higher-throughput and more efficient metabolomics platforms, increase the reliability and reproducibility of metabolite detection, and generate more convenient bioinformatics tools for accurate data analysis, among other objectives, to aid in disease biomarker discovery.
Therefore, this Special Issue is dedicated to Mass spectrometry-based Metabolomics in Disease Biomarker Discovery. The topic will be covered in a wide range of areas, including, but not limited to: novel biomarker discovery using MS-based metabolomics; method development and optimization for MS analysis; advances in sample preparation and derivatization techniques; and bioinformatic software development for complex MS data interpretation and analysis.
This Special Issue aims to highlight cutting-edge research and explore innovative strategies for MS-based disease biomarker discovery from multiple perspectives.
Dr. Raobo Xu
Dr. Yingzhao Wang
Dr. Yunping Qiu
Guest Editors
Manuscript Submission Information
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Keywords
- metabolomics
- lipidomics
- LC/GC/CE-MS methodology development
- mass spectrometry
- MS-based multiomics integration
- biomarker discovery
- early-stage disease diagnosis
- isotope-labeled metabolomics
- pathway dysregulation
- bioinformatics and data analysis
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