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Medical Sciences
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Endovascular Management of Complex Aortic Pathologies and Complications
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Endovascular Management of Complex Aortic Pathologies and Complications

A special issue of Medical Sciences (ISSN 2076-3271). This special issue belongs to the section "Cardiovascular Disease".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 2318

Special Issue Editor

Dr. Mafalda Massara

E-Mail Website
Guest Editor
Unit of Vascular Surgery, Grande Ospedale Metropolitano “Bianchi-Melacrino-Morelli”, 89124 Reggio Calabria, Italy
Interests: abdominal aortic aneurysm; thoracic aortic aneurysm; thoraco-abdominal aortic aneurysm/dissection; carotid artery stenosis; critical limb ischemia; vascular access for hemodialysis

Special Issue Information

Dear Colleagues,

It is a great honor for me to participate as Guest Editor for the Special Issue of the prestigious journal Medical Sciences. The Special Issue aims to analyze the modalities of treatment of complex aortic diseases in elective and urgent time. Actually, the development of technologies allow vascular surgeons to treat these pathologies according to different strategies depending on urgency, the experience of surgeons and the availability of materials. Reporting the analysis of the various centers in the current literature is important to compare the various types of treatment.

Dr. Mafalda Massara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medical Sciences is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endovascular aortic diseases repair
  • thoraco-abdominal aortic diseases management
  • juxtarenal abdominal aortic diseases
  • pararenal abdominal aortic diseases
  • complex aortic pathologies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

27 pages, 2917 KB  
Review
Microbiome and Heart Failure: A Comprehensive Review of Gut Health and Microbiota-Derived Metabolites in Heart Failure Progression
by Chukwudi Kingsley Orjichukwu, Rita Ogochukwu Orjichukwu, Peter Kanayochukwu Akpunonu, Paul Chikwado Ugwu and Somtochukwu Godfrey Nnabuife
Med. Sci. 2025, 13(4), 302; https://doi.org/10.3390/medsci13040302 - 4 Dec 2025
Viewed by 1906
Abstract
A multifaceted clinical disease, heart failure (HF) is typified by decreased cardiac function and systemic symptoms caused by anatomical or functional abnormalities in the heart. Although traditional studies have concentrated on hemodynamic and neurohormonal processes, new data highlight the vital role that the [...] Read more.
A multifaceted clinical disease, heart failure (HF) is typified by decreased cardiac function and systemic symptoms caused by anatomical or functional abnormalities in the heart. Although traditional studies have concentrated on hemodynamic and neurohormonal processes, new data highlight the vital role that the gut microbiota and its byproducts play in the pathogenesis of HF. An imbalance in the microbial structure known as gut dysbiosis is common in HF patients and is linked to increased gut permeability, systemic inflammation, and changed bioactive metabolite synthesis. Prominent metabolites generated by the microbiota, including phenylacetylglutamine, short-chain fatty acids (SCFAs), secondary bile acids, and trimethylamine N-oxide (TMAO), have a major impact on endothelial function, cardiac remodeling, and inflammation. Together with gut-derived lipopolysaccharides, these metabolites interact with host systems to exacerbate the course of HF. Further impacting HF outcomes are comorbidities such as diabetes, obesity, and chronic renal disease, which intensify gut dysbiosis. The importance of metabolites originating from the microbiota in the progression of HF is highlighted in this review, which summarizes recent findings regarding the gut-heart axis. Additionally, it investigates how dietary changes, probiotics, prebiotics, and multi-omics techniques can all be used to improve the management of HF. This thorough analysis emphasizes the necessity of integrative therapy approaches and longitudinal research to better address the complex link between HF and the gut microbiota. Full article
(This article belongs to the Special Issue Endovascular Management of Complex Aortic Pathologies and Complications)
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