Molecular and Translational Advances in Hearing Loss and Cochlear Disorders
A special issue of Medical Sciences (ISSN 2076-3271).
Deadline for manuscript submissions: 15 September 2026 | Viewed by 395
Editor
Interests: inner ear; cochlea; hearing loss; hearing disorders; otology; audiology; deafness; vestibular implant; vertigo
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hearing disorders represent a major global health challenge, affecting more than 1.5 billion individuals worldwide. While substantial progress has been achieved in understanding cochlear degeneration and sensorineural hearing loss, advances in tympanic membrane regeneration, middle ear inflammation and inflammatory inner ear disorders remain dispersed across disciplines. This Special Issue aims to integrate molecular, cellular and translational perspectives in otology, with particular emphasis on: (1) regenerative strategies for tympanic membrane repair; (2) the molecular pathophysiology of otitis media, tympanofibrosis and tympanosclerosis; (3) immune and inflammatory mechanisms underlying inner ear dysfunction, including labyrinthitis and cochlear homeostasis disruption.
Recent innovations in biomaterials, growth factor delivery, stem cell biology and tissue engineering have expanded the therapeutic possibilities for tympanic membrane reconstruction. Concurrently, progress in molecular otology and immunology has clarified the roles of fibrosis, epithelial migration, cholesterol metabolism and innate immune signaling in chronic middle and inner ear disorders.
By bringing together basic researchers and clinician-scientists, this Special Issue seeks to bridge mechanistic discoveries with surgical and regenerative innovation. It complements existing literature by emphasizing translational continuity from molecular pathways to therapeutic intervention, thereby accelerating the development of evidence-based treatments in hearing science.
Dr. Toru Miwa
Guest Editor
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Keywords
- tympanic membrane regeneration
- otitis media
- inner ear inflammation
- labyrinthitis
- cochlear homeostasis
- tympanofibrosis
- tympanosclerosis
- molecular otology
- translational research
- hearing loss mechanisms
- regenerative medicine in otology
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