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Flavonoids: Chemistry and Bioactivity
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Flavonoids: Chemistry and Bioactivity

A special issue of Medicines (ISSN 2305-6320).

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 4078

Special Issue Editors

Dr. Vladimir Chobot

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Guest Editor
Division of Molecular Systems Biology, Department of Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
Interests: chromatography; electroanalysis; natural product chemistry; pharmacobotany; pharmacognosy; phytochemistry; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Dr. Lenka Kubicova

E-Mail Website
Guest Editor
Division of Molecular Systems Biology, Department of Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
Interests: medicinal chemistry; organic chemistry; organometallic chemistry; organic synthesis; mass spectrometry; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

We invite you to publish your manuscripts in this Special Issue which deals with chemical structure and properties in relation to pharmacological activities of naturally occurring flavonoids or their synthetic analogs.

Flavonoids are very common plant phenols with many bioactivities, such as antioxidant, anti-inflammatory, anticancer, antimicrobial, and antiviral. This group of secondary metabolites forms an important part of the human diet that shows beneficial effects on human health. Many studies have proven the protective activities of flavonoids in the case of various pathological processes associated with degenerative diseases and aging. In addition, flavonoids attract interest due to their cardioprotective and neuroprotective properties. Therefore, flavonoids and related compounds have recently become one of the most extensively investigated plant secondary metabolites.

The editors welcome original research or review articles related to medicinal chemistry, pharmacognosy, phytochemistry, food chemistry, cosmetology, and bioactivities of natural flavonoids or their synthetic and semisynthetic structural analogs in connection to their potential effects on human health.

Dr. Vladimir Chobot
Dr. Lenka Kubicova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • anti-inflammatory
  • antioxidant
  • antidegenerative
  • antimicrobial
  • cardioprotective
  • cosmetics
  • neuroprotective
  • oxidative stress
  • transition metals chelation

Published Papers (1 paper)

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Research

11 pages, 491 KiB  
Article
Antioxidant and α-amylase Inhibitory Activities and Phytocompounds of Clausena indica Fruits
by La Hoang Anh, Tran Dang Xuan, Nguyen Thi Dieu Thuy, Nguyen Van Quan and Le Thu Trang
Medicines 2020, 7(3), 10; https://doi.org/10.3390/medicines7030010 - 28 Feb 2020
Cited by 18 | Viewed by 3645
Abstract
Background: Clausena indica fruit is commonly used for food ingredients and traditional medicines in tropical countries, however, information about its biological activities and chemical profiles has been inadequately reported. Methods: In this study, a bio-guided fractionation of antioxidants and α-amylase inhibitors from hexane [...] Read more.
Background: Clausena indica fruit is commonly used for food ingredients and traditional medicines in tropical countries, however, information about its biological activities and chemical profiles has been inadequately reported. Methods: In this study, a bio-guided fractionation of antioxidants and α-amylase inhibitors from hexane (MH) and ethyl acetate (ME) extracts of C. indica fruit (pericarp and seed) was carried out. Eleven fractions from MH (D1–D11) and 17 fractions from ME (T1–T17) were obtained from column chromatography over silica gel, which were then examined for anti-radical capacity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, and pancreatic α-amylase inhibition, a key enzyme linked to type 2 diabetes. Results: Of isolated fractions, the fraction T4 revealed the most potent anti-DPPH activity (IC50 = 0.13 mg/mL), whereas T2 exhibits the strongest ABTS cation scavenging ability (IC50 = 0.31 mg/mL). In the enzymatic assay, the fractions D3 and T4 significantly inhibit the α-amylase reaction with IC50 values of 0.34 and 0.86 mg/mL, respectively. Remarkably, α-amylase suppression of T4 is close to acarbose and over four times stronger than palmitic acid, which are the well-known α-amylase inhibitors (IC50 = 0.07 and 1.52 mg/mL, respectively). The active constituents from fractions were identified by gas chromatography-mass spectrometry (GC-MS). The results show that the fraction D3 contains five major compounds, which are grouped in five classes consisting of fatty acids, phenols, benzodioxoles, alcohols, and sesquiterpenes. Among them, palmitic acid is the most dominant compound (32.64%), followed by 2R-acetoxymethyl-1,3,3-trimethyl-4t-(3-methyl-2-buten-1-yl)-1t-cyclohexanol (16.69%). Whilst, six major compounds belonging to fatty acid and coumarin classes are identified in the fraction T4. The most abundant compound in T4 is dentatin (47.32%), followed by palmitic acid (15.11%). Conclusions: This is the first finding that C. indica fruit can be a promising source for the development of natural antioxidant and antidiabetic agents. Additionally, the outcome reveals that dentatin, a known natural antineoplastic agent, can be feasibly exploited from C. indica fruit. Full article
(This article belongs to the Special Issue Flavonoids: Chemistry and Bioactivity)
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